Amino acid dipepetide frequency for Flavobacterium fluvii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.51AlaAla: 4.51 ± 0.085
0.578AlaCys: 0.578 ± 0.025
3.434AlaAsp: 3.434 ± 0.072
3.862AlaGlu: 3.862 ± 0.068
3.299AlaPhe: 3.299 ± 0.062
4.376AlaGly: 4.376 ± 0.087
0.972AlaHis: 0.972 ± 0.03
5.329AlaIle: 5.329 ± 0.075
5.245AlaLys: 5.245 ± 0.092
6.069AlaLeu: 6.069 ± 0.076
1.507AlaMet: 1.507 ± 0.04
3.994AlaAsn: 3.994 ± 0.073
2.06AlaPro: 2.06 ± 0.058
2.426AlaGln: 2.426 ± 0.049
1.86AlaArg: 1.86 ± 0.044
4.27AlaSer: 4.27 ± 0.07
4.307AlaThr: 4.307 ± 0.097
4.334AlaVal: 4.334 ± 0.057
0.674AlaTrp: 0.674 ± 0.027
2.386AlaTyr: 2.386 ± 0.051
0.0AlaXaa: 0.0 ± 0.0
Cys
0.457CysAla: 0.457 ± 0.019
0.105CysCys: 0.105 ± 0.009
0.449CysAsp: 0.449 ± 0.023
0.477CysGlu: 0.477 ± 0.03
0.438CysPhe: 0.438 ± 0.021
0.626CysGly: 0.626 ± 0.03
0.196CysHis: 0.196 ± 0.016
0.631CysIle: 0.631 ± 0.025
0.491CysLys: 0.491 ± 0.023
0.666CysLeu: 0.666 ± 0.026
0.15CysMet: 0.15 ± 0.011
0.479CysAsn: 0.479 ± 0.026
0.358CysPro: 0.358 ± 0.023
0.234CysGln: 0.234 ± 0.013
0.213CysArg: 0.213 ± 0.013
0.631CysSer: 0.631 ± 0.035
0.492CysThr: 0.492 ± 0.035
0.473CysVal: 0.473 ± 0.019
0.075CysTrp: 0.075 ± 0.009
0.327CysTyr: 0.327 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
3.802AspAla: 3.802 ± 0.068
0.449AspCys: 0.449 ± 0.025
2.528AspAsp: 2.528 ± 0.05
3.388AspGlu: 3.388 ± 0.058
3.643AspPhe: 3.643 ± 0.059
3.77AspGly: 3.77 ± 0.073
0.705AspHis: 0.705 ± 0.03
3.943AspIle: 3.943 ± 0.058
4.469AspLys: 4.469 ± 0.071
4.935AspLeu: 4.935 ± 0.073
0.989AspMet: 0.989 ± 0.03
3.202AspAsn: 3.202 ± 0.062
1.602AspPro: 1.602 ± 0.037
1.474AspGln: 1.474 ± 0.032
1.651AspArg: 1.651 ± 0.039
3.053AspSer: 3.053 ± 0.057
2.461AspThr: 2.461 ± 0.044
3.491AspVal: 3.491 ± 0.059
0.803AspTrp: 0.803 ± 0.025
2.758AspTyr: 2.758 ± 0.043
0.0AspXaa: 0.0 ± 0.0
Glu
4.114GluAla: 4.114 ± 0.065
0.348GluCys: 0.348 ± 0.02
3.013GluAsp: 3.013 ± 0.053
4.206GluGlu: 4.206 ± 0.086
2.801GluPhe: 2.801 ± 0.05
3.48GluGly: 3.48 ± 0.063
0.956GluHis: 0.956 ± 0.032
5.528GluIle: 5.528 ± 0.089
6.214GluLys: 6.214 ± 0.1
5.621GluLeu: 5.621 ± 0.084
1.669GluMet: 1.669 ± 0.044
4.729GluAsn: 4.729 ± 0.072
1.475GluPro: 1.475 ± 0.037
1.966GluGln: 1.966 ± 0.042
2.081GluArg: 2.081 ± 0.048
3.326GluSer: 3.326 ± 0.054
3.619GluThr: 3.619 ± 0.055
3.877GluVal: 3.877 ± 0.068
0.648GluTrp: 0.648 ± 0.025
2.279GluTyr: 2.279 ± 0.046
0.0GluXaa: 0.0 ± 0.0
Phe
3.198PheAla: 3.198 ± 0.051
0.485PheCys: 0.485 ± 0.021
3.295PheAsp: 3.295 ± 0.052
3.402PheGlu: 3.402 ± 0.065
2.785PhePhe: 2.785 ± 0.055
3.714PheGly: 3.714 ± 0.052
0.861PheHis: 0.861 ± 0.025
3.736PheIle: 3.736 ± 0.061
3.739PheLys: 3.739 ± 0.074
4.734PheLeu: 4.734 ± 0.079
1.192PheMet: 1.192 ± 0.03
3.173PheAsn: 3.173 ± 0.055
1.873PhePro: 1.873 ± 0.046
1.666PheGln: 1.666 ± 0.036
1.505PheArg: 1.505 ± 0.038
4.059PheSer: 4.059 ± 0.065
3.075PheThr: 3.075 ± 0.064
3.285PheVal: 3.285 ± 0.057
0.66PheTrp: 0.66 ± 0.02
2.193PheTyr: 2.193 ± 0.043
0.0PheXaa: 0.0 ± 0.0
Gly
4.137GlyAla: 4.137 ± 0.075
0.669GlyCys: 0.669 ± 0.041
3.173GlyAsp: 3.173 ± 0.055
3.384GlyGlu: 3.384 ± 0.055
3.782GlyPhe: 3.782 ± 0.07
4.703GlyGly: 4.703 ± 0.087
1.096GlyHis: 1.096 ± 0.031
5.702GlyIle: 5.702 ± 0.072
5.435GlyLys: 5.435 ± 0.075
5.711GlyLeu: 5.711 ± 0.08
1.686GlyMet: 1.686 ± 0.039
4.016GlyAsn: 4.016 ± 0.075
1.388GlyPro: 1.388 ± 0.035
2.013GlyGln: 2.013 ± 0.039
1.958GlyArg: 1.958 ± 0.043
4.297GlySer: 4.297 ± 0.088
4.63GlyThr: 4.63 ± 0.136
4.293GlyVal: 4.293 ± 0.077
0.84GlyTrp: 0.84 ± 0.032
2.953GlyTyr: 2.953 ± 0.055
0.0GlyXaa: 0.0 ± 0.0
His
0.817HisAla: 0.817 ± 0.029
0.163HisCys: 0.163 ± 0.013
0.801HisAsp: 0.801 ± 0.026
0.868HisGlu: 0.868 ± 0.027
1.169HisPhe: 1.169 ± 0.029
1.019HisGly: 1.019 ± 0.034
0.432HisHis: 0.432 ± 0.023
1.21HisIle: 1.21 ± 0.031
1.112HisLys: 1.112 ± 0.035
1.647HisLeu: 1.647 ± 0.042
0.269HisMet: 0.269 ± 0.016
0.976HisAsn: 0.976 ± 0.028
0.85HisPro: 0.85 ± 0.026
0.656HisGln: 0.656 ± 0.027
0.551HisArg: 0.551 ± 0.021
1.032HisSer: 1.032 ± 0.026
0.81HisThr: 0.81 ± 0.025
0.811HisVal: 0.811 ± 0.026
0.221HisTrp: 0.221 ± 0.015
0.821HisTyr: 0.821 ± 0.029
0.0HisXaa: 0.0 ± 0.0
Ile
5.761IleAla: 5.761 ± 0.072
0.677IleCys: 0.677 ± 0.027
4.616IleAsp: 4.616 ± 0.062
5.187IleGlu: 5.187 ± 0.084
3.491IlePhe: 3.491 ± 0.055
5.205IleGly: 5.205 ± 0.07
1.342IleHis: 1.342 ± 0.039
6.17IleIle: 6.17 ± 0.091
6.054IleLys: 6.054 ± 0.08
6.913IleLeu: 6.913 ± 0.102
1.51IleMet: 1.51 ± 0.036
4.799IleAsn: 4.799 ± 0.059
3.348IlePro: 3.348 ± 0.046
2.684IleGln: 2.684 ± 0.047
2.529IleArg: 2.529 ± 0.047
5.54IleSer: 5.54 ± 0.064
4.974IleThr: 4.974 ± 0.097
5.116IleVal: 5.116 ± 0.071
0.781IleTrp: 0.781 ± 0.025
2.83IleTyr: 2.83 ± 0.055
0.0IleXaa: 0.0 ± 0.0
Lys
5.113LysAla: 5.113 ± 0.086
0.381LysCys: 0.381 ± 0.021
4.346LysAsp: 4.346 ± 0.071
5.928LysGlu: 5.928 ± 0.104
3.062LysPhe: 3.062 ± 0.057
4.907LysGly: 4.907 ± 0.069
1.22LysHis: 1.22 ± 0.031
6.952LysIle: 6.952 ± 0.094
7.123LysLys: 7.123 ± 0.116
6.569LysLeu: 6.569 ± 0.081
2.292LysMet: 2.292 ± 0.049
5.831LysAsn: 5.831 ± 0.09
2.766LysPro: 2.766 ± 0.052
2.594LysGln: 2.594 ± 0.053
2.426LysArg: 2.426 ± 0.049
4.928LysSer: 4.928 ± 0.072
5.314LysThr: 5.314 ± 0.07
4.896LysVal: 4.896 ± 0.066
0.861LysTrp: 0.861 ± 0.026
3.142LysTyr: 3.142 ± 0.06
0.0LysXaa: 0.0 ± 0.0
Leu
5.896LeuAla: 5.896 ± 0.085
0.703LeuCys: 0.703 ± 0.022
4.866LeuAsp: 4.866 ± 0.067
5.665LeuGlu: 5.665 ± 0.094
5.019LeuPhe: 5.019 ± 0.076
5.803LeuGly: 5.803 ± 0.084
1.477LeuHis: 1.477 ± 0.039
6.598LeuIle: 6.598 ± 0.095
7.445LeuLys: 7.445 ± 0.099
8.252LeuLeu: 8.252 ± 0.123
2.078LeuMet: 2.078 ± 0.041
5.475LeuAsn: 5.475 ± 0.074
3.5LeuPro: 3.5 ± 0.053
2.965LeuGln: 2.965 ± 0.06
2.812LeuArg: 2.812 ± 0.051
6.369LeuSer: 6.369 ± 0.077
5.052LeuThr: 5.052 ± 0.077
5.462LeuVal: 5.462 ± 0.063
0.852LeuTrp: 0.852 ± 0.03
3.138LeuTyr: 3.138 ± 0.056
0.0LeuXaa: 0.0 ± 0.0
Met
1.61MetAla: 1.61 ± 0.04
0.145MetCys: 0.145 ± 0.01
1.181MetAsp: 1.181 ± 0.033
1.424MetGlu: 1.424 ± 0.036
0.842MetPhe: 0.842 ± 0.029
1.499MetGly: 1.499 ± 0.036
0.386MetHis: 0.386 ± 0.019
1.513MetIle: 1.513 ± 0.038
2.325MetLys: 2.325 ± 0.043
1.842MetLeu: 1.842 ± 0.042
0.627MetMet: 0.627 ± 0.025
1.399MetAsn: 1.399 ± 0.032
0.854MetPro: 0.854 ± 0.028
0.804MetGln: 0.804 ± 0.025
0.815MetArg: 0.815 ± 0.025
1.471MetSer: 1.471 ± 0.04
1.239MetThr: 1.239 ± 0.032
1.386MetVal: 1.386 ± 0.037
0.203MetTrp: 0.203 ± 0.014
0.69MetTyr: 0.69 ± 0.024
0.0MetXaa: 0.0 ± 0.0
Asn
4.031AsnAla: 4.031 ± 0.07
0.579AsnCys: 0.579 ± 0.039
3.222AsnAsp: 3.222 ± 0.051
3.686AsnGlu: 3.686 ± 0.061
3.157AsnPhe: 3.157 ± 0.056
4.474AsnGly: 4.474 ± 0.092
1.077AsnHis: 1.077 ± 0.03
4.874AsnIle: 4.874 ± 0.067
4.671AsnLys: 4.671 ± 0.071
5.545AsnLeu: 5.545 ± 0.079
1.257AsnMet: 1.257 ± 0.031
4.109AsnAsn: 4.109 ± 0.083
3.202AsnPro: 3.202 ± 0.055
2.359AsnGln: 2.359 ± 0.046
1.981AsnArg: 1.981 ± 0.041
4.247AsnSer: 4.247 ± 0.076
3.784AsnThr: 3.784 ± 0.072
3.793AsnVal: 3.793 ± 0.078
0.92AsnTrp: 0.92 ± 0.03
2.994AsnTyr: 2.994 ± 0.055
0.0AsnXaa: 0.0 ± 0.0
Pro
2.274ProAla: 2.274 ± 0.046
0.208ProCys: 0.208 ± 0.012
1.966ProAsp: 1.966 ± 0.046
2.812ProGlu: 2.812 ± 0.049
2.018ProPhe: 2.018 ± 0.04
2.026ProGly: 2.026 ± 0.051
0.562ProHis: 0.562 ± 0.021
2.814ProIle: 2.814 ± 0.052
2.751ProLys: 2.751 ± 0.057
2.909ProLeu: 2.909 ± 0.043
0.778ProMet: 0.778 ± 0.026
2.384ProAsn: 2.384 ± 0.048
0.833ProPro: 0.833 ± 0.027
1.112ProGln: 1.112 ± 0.03
0.855ProArg: 0.855 ± 0.03
2.327ProSer: 2.327 ± 0.047
2.252ProThr: 2.252 ± 0.061
2.618ProVal: 2.618 ± 0.046
0.384ProTrp: 0.384 ± 0.016
1.397ProTyr: 1.397 ± 0.037
0.0ProXaa: 0.0 ± 0.0
Gln
1.985GlnAla: 1.985 ± 0.043
0.212GlnCys: 0.212 ± 0.014
1.571GlnAsp: 1.571 ± 0.036
2.23GlnGlu: 2.23 ± 0.047
1.69GlnPhe: 1.69 ± 0.037
1.756GlnGly: 1.756 ± 0.036
0.521GlnHis: 0.521 ± 0.02
2.781GlnIle: 2.781 ± 0.049
3.04GlnLys: 3.04 ± 0.057
3.218GlnLeu: 3.218 ± 0.055
0.8GlnMet: 0.8 ± 0.024
2.385GlnAsn: 2.385 ± 0.048
1.047GlnPro: 1.047 ± 0.031
1.328GlnGln: 1.328 ± 0.048
1.048GlnArg: 1.048 ± 0.032
1.976GlnSer: 1.976 ± 0.044
1.994GlnThr: 1.994 ± 0.047
1.836GlnVal: 1.836 ± 0.036
0.407GlnTrp: 0.407 ± 0.022
1.361GlnTyr: 1.361 ± 0.035
0.0GlnXaa: 0.0 ± 0.0
Arg
1.888ArgAla: 1.888 ± 0.04
0.226ArgCys: 0.226 ± 0.014
1.615ArgAsp: 1.615 ± 0.039
1.963ArgGlu: 1.963 ± 0.046
1.734ArgPhe: 1.734 ± 0.033
1.719ArgGly: 1.719 ± 0.041
0.511ArgHis: 0.511 ± 0.023
2.694ArgIle: 2.694 ± 0.054
2.554ArgLys: 2.554 ± 0.049
2.885ArgLeu: 2.885 ± 0.055
0.816ArgMet: 0.816 ± 0.028
1.993ArgAsn: 1.993 ± 0.044
1.023ArgPro: 1.023 ± 0.035
0.935ArgGln: 0.935 ± 0.029
1.04ArgArg: 1.04 ± 0.035
1.649ArgSer: 1.649 ± 0.038
1.779ArgThr: 1.779 ± 0.043
1.926ArgVal: 1.926 ± 0.04
0.41ArgTrp: 0.41 ± 0.021
1.311ArgTyr: 1.311 ± 0.031
0.0ArgXaa: 0.0 ± 0.0
Ser
3.952SerAla: 3.952 ± 0.064
0.669SerCys: 0.669 ± 0.024
3.326SerAsp: 3.326 ± 0.047
3.619SerGlu: 3.619 ± 0.059
3.883SerPhe: 3.883 ± 0.054
5.023SerGly: 5.023 ± 0.098
1.118SerHis: 1.118 ± 0.035
5.389SerIle: 5.389 ± 0.081
5.068SerLys: 5.068 ± 0.076
5.832SerLeu: 5.832 ± 0.072
1.285SerMet: 1.285 ± 0.03
4.032SerAsn: 4.032 ± 0.069
2.262SerPro: 2.262 ± 0.049
2.251SerGln: 2.251 ± 0.044
2.015SerArg: 2.015 ± 0.043
4.458SerSer: 4.458 ± 0.078
3.795SerThr: 3.795 ± 0.08
4.146SerVal: 4.146 ± 0.067
0.753SerTrp: 0.753 ± 0.029
2.725SerTyr: 2.725 ± 0.054
0.0SerXaa: 0.0 ± 0.0
Thr
4.343ThrAla: 4.343 ± 0.119
0.369ThrCys: 0.369 ± 0.024
3.285ThrAsp: 3.285 ± 0.058
3.19ThrGlu: 3.19 ± 0.052
3.195ThrPhe: 3.195 ± 0.056
4.301ThrGly: 4.301 ± 0.092
0.917ThrHis: 0.917 ± 0.028
5.337ThrIle: 5.337 ± 0.101
4.213ThrLys: 4.213 ± 0.057
5.369ThrLeu: 5.369 ± 0.084
1.059ThrMet: 1.059 ± 0.032
3.702ThrAsn: 3.702 ± 0.088
2.753ThrPro: 2.753 ± 0.061
1.894ThrGln: 1.894 ± 0.042
1.573ThrArg: 1.573 ± 0.038
3.92ThrSer: 3.92 ± 0.077
4.181ThrThr: 4.181 ± 0.127
4.184ThrVal: 4.184 ± 0.116
0.673ThrTrp: 0.673 ± 0.033
2.368ThrTyr: 2.368 ± 0.067
0.0ThrXaa: 0.0 ± 0.0
Val
4.415ValAla: 4.415 ± 0.072
0.561ValCys: 0.561 ± 0.021
3.496ValAsp: 3.496 ± 0.057
3.762ValGlu: 3.762 ± 0.068
3.572ValPhe: 3.572 ± 0.05
3.901ValGly: 3.901 ± 0.068
0.93ValHis: 0.93 ± 0.031
4.805ValIle: 4.805 ± 0.067
4.68ValLys: 4.68 ± 0.072
5.998ValLeu: 5.998 ± 0.081
1.272ValMet: 1.272 ± 0.037
3.863ValAsn: 3.863 ± 0.059
2.251ValPro: 2.251 ± 0.044
1.885ValGln: 1.885 ± 0.039
1.854ValArg: 1.854 ± 0.042
4.514ValSer: 4.514 ± 0.068
3.906ValThr: 3.906 ± 0.127
4.444ValVal: 4.444 ± 0.074
0.66ValTrp: 0.66 ± 0.022
2.545ValTyr: 2.545 ± 0.05
0.0ValXaa: 0.0 ± 0.0
Trp
0.732TrpAla: 0.732 ± 0.025
0.11TrpCys: 0.11 ± 0.01
0.674TrpAsp: 0.674 ± 0.028
0.705TrpGlu: 0.705 ± 0.023
0.592TrpPhe: 0.592 ± 0.024
0.781TrpGly: 0.781 ± 0.029
0.225TrpHis: 0.225 ± 0.013
0.798TrpIle: 0.798 ± 0.029
0.945TrpLys: 0.945 ± 0.033
0.998TrpLeu: 0.998 ± 0.032
0.302TrpMet: 0.302 ± 0.017
0.82TrpAsn: 0.82 ± 0.027
0.296TrpPro: 0.296 ± 0.018
0.438TrpGln: 0.438 ± 0.018
0.404TrpArg: 0.404 ± 0.018
0.737TrpSer: 0.737 ± 0.027
0.707TrpThr: 0.707 ± 0.034
0.623TrpVal: 0.623 ± 0.022
0.171TrpTrp: 0.171 ± 0.014
0.458TrpTyr: 0.458 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.457TyrAla: 2.457 ± 0.047
0.33TyrCys: 0.33 ± 0.016
2.259TyrAsp: 2.259 ± 0.047
2.192TyrGlu: 2.192 ± 0.045
2.46TyrPhe: 2.46 ± 0.048
2.783TyrGly: 2.783 ± 0.048
0.735TyrHis: 0.735 ± 0.024
2.724TyrIle: 2.724 ± 0.048
3.078TyrLys: 3.078 ± 0.055
3.715TyrLeu: 3.715 ± 0.056
0.717TyrMet: 0.717 ± 0.023
2.601TyrAsn: 2.601 ± 0.052
1.535TyrPro: 1.535 ± 0.035
1.5TyrGln: 1.5 ± 0.045
1.498TyrArg: 1.498 ± 0.043
2.797TyrSer: 2.797 ± 0.06
2.457TyrThr: 2.457 ± 0.072
2.319TyrVal: 2.319 ± 0.044
0.521TyrTrp: 0.521 ± 0.02
1.846TyrTyr: 1.846 ± 0.051
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3488 proteins (1237016 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski