Amino acid dipepetide frequency for Piura virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.102AlaAla: 5.102 ± 0.076
0.34AlaCys: 0.34 ± 0.171
2.041AlaAsp: 2.041 ± 0.934
3.061AlaGlu: 3.061 ± 1.698
3.401AlaPhe: 3.401 ± 1.06
2.721AlaGly: 2.721 ± 0.746
1.701AlaHis: 1.701 ± 0.853
3.061AlaIle: 3.061 ± 0.956
1.701AlaLys: 1.701 ± 0.974
8.163AlaLeu: 8.163 ± 2.758
3.061AlaMet: 3.061 ± 0.894
1.701AlaAsn: 1.701 ± 0.423
2.041AlaPro: 2.041 ± 1.875
1.361AlaGln: 1.361 ± 0.682
3.061AlaArg: 3.061 ± 2.978
5.102AlaSer: 5.102 ± 0.076
2.721AlaThr: 2.721 ± 0.544
4.762AlaVal: 4.762 ± 3.655
0.34AlaTrp: 0.34 ± 0.171
2.381AlaTyr: 2.381 ± 0.611
0.0AlaXaa: 0.0 ± 0.0
Cys
1.361CysAla: 1.361 ± 0.682
0.0CysCys: 0.0 ± 0.0
1.02CysAsp: 1.02 ± 0.512
1.02CysGlu: 1.02 ± 0.467
1.361CysPhe: 1.361 ± 0.682
0.34CysGly: 0.34 ± 0.171
1.701CysHis: 1.701 ± 1.028
0.34CysIle: 0.34 ± 0.171
2.381CysLys: 2.381 ± 0.611
2.041CysLeu: 2.041 ± 0.497
1.361CysMet: 1.361 ± 0.412
1.361CysAsn: 1.361 ± 0.682
0.68CysPro: 0.68 ± 0.341
0.34CysGln: 0.34 ± 0.171
1.02CysArg: 1.02 ± 0.512
2.041CysSer: 2.041 ± 1.023
0.68CysThr: 0.68 ± 0.341
2.041CysVal: 2.041 ± 0.934
0.0CysTrp: 0.0 ± 0.0
0.34CysTyr: 0.34 ± 0.7
0.0CysXaa: 0.0 ± 0.0
Asp
5.782AspAla: 5.782 ± 2.198
2.041AspCys: 2.041 ± 0.497
3.741AspAsp: 3.741 ± 1.208
3.741AspGlu: 3.741 ± 0.907
6.122AspPhe: 6.122 ± 0.454
3.061AspGly: 3.061 ± 1.535
1.701AspHis: 1.701 ± 0.853
4.082AspIle: 4.082 ± 1.369
3.401AspLys: 3.401 ± 0.847
3.741AspLeu: 3.741 ± 0.41
1.361AspMet: 1.361 ± 0.682
0.68AspAsn: 0.68 ± 0.341
2.041AspPro: 2.041 ± 0.497
2.041AspGln: 2.041 ± 0.82
3.401AspArg: 3.401 ± 0.847
5.782AspSer: 5.782 ± 0.415
2.041AspThr: 2.041 ± 1.023
4.762AspVal: 4.762 ± 0.099
0.68AspTrp: 0.68 ± 0.57
2.041AspTyr: 2.041 ± 1.023
0.0AspXaa: 0.0 ± 0.0
Glu
1.701GluAla: 1.701 ± 0.853
1.361GluCys: 1.361 ± 0.682
2.381GluAsp: 2.381 ± 1.194
1.701GluGlu: 1.701 ± 0.853
2.041GluPhe: 2.041 ± 0.934
2.381GluGly: 2.381 ± 1.194
1.701GluHis: 1.701 ± 1.028
4.422GluIle: 4.422 ± 1.533
5.782GluLys: 5.782 ± 1.218
7.483GluLeu: 7.483 ± 2.04
1.361GluMet: 1.361 ± 0.682
2.381GluAsn: 2.381 ± 0.818
1.361GluPro: 1.361 ± 0.682
1.361GluGln: 1.361 ± 0.682
3.401GluArg: 3.401 ± 0.78
3.401GluSer: 3.401 ± 0.847
2.381GluThr: 2.381 ± 1.291
3.401GluVal: 3.401 ± 1.706
0.68GluTrp: 0.68 ± 0.341
3.061GluTyr: 3.061 ± 0.442
0.0GluXaa: 0.0 ± 0.0
Phe
2.381PheAla: 2.381 ± 0.675
2.041PheCys: 2.041 ± 0.934
5.102PheAsp: 5.102 ± 0.901
3.741PheGlu: 3.741 ± 0.907
4.422PhePhe: 4.422 ± 1.936
3.401PheGly: 3.401 ± 0.847
1.701PheHis: 1.701 ± 0.423
3.061PheIle: 3.061 ± 0.956
2.381PheLys: 2.381 ± 0.818
6.122PheLeu: 6.122 ± 2.677
2.381PheMet: 2.381 ± 1.023
3.061PheAsn: 3.061 ± 0.894
2.381PhePro: 2.381 ± 1.596
0.68PheGln: 0.68 ± 0.341
3.401PheArg: 3.401 ± 0.391
5.782PheSer: 5.782 ± 0.977
2.721PheThr: 2.721 ± 0.544
5.782PheVal: 5.782 ± 2.19
0.68PheTrp: 0.68 ± 0.341
1.361PheTyr: 1.361 ± 1.14
0.0PheXaa: 0.0 ± 0.0
Gly
2.041GlyAla: 2.041 ± 2.095
0.68GlyCys: 0.68 ± 0.57
4.422GlyAsp: 4.422 ± 1.533
2.041GlyGlu: 2.041 ± 1.023
1.701GlyPhe: 1.701 ± 0.423
2.381GlyGly: 2.381 ± 0.611
0.68GlyHis: 0.68 ± 0.341
3.061GlyIle: 3.061 ± 1.535
2.721GlyLys: 2.721 ± 1.121
4.082GlyLeu: 4.082 ± 1.253
1.361GlyMet: 1.361 ± 0.682
2.381GlyAsn: 2.381 ± 0.818
1.701GlyPro: 1.701 ± 0.853
1.02GlyGln: 1.02 ± 0.467
2.041GlyArg: 2.041 ± 0.497
3.061GlySer: 3.061 ± 1.401
1.701GlyThr: 1.701 ± 0.974
4.762GlyVal: 4.762 ± 1.698
0.0GlyTrp: 0.0 ± 0.0
1.701GlyTyr: 1.701 ± 0.811
0.0GlyXaa: 0.0 ± 0.0
His
1.701HisAla: 1.701 ± 0.423
1.02HisCys: 1.02 ± 0.467
2.041HisAsp: 2.041 ± 0.934
1.701HisGlu: 1.701 ± 0.974
1.701HisPhe: 1.701 ± 0.853
0.68HisGly: 0.68 ± 0.57
0.34HisHis: 0.34 ± 0.171
0.68HisIle: 0.68 ± 0.341
1.02HisLys: 1.02 ± 0.512
0.68HisLeu: 0.68 ± 0.341
0.68HisMet: 0.68 ± 0.341
0.68HisAsn: 0.68 ± 0.341
1.701HisPro: 1.701 ± 1.833
1.361HisGln: 1.361 ± 1.132
1.02HisArg: 1.02 ± 0.512
2.381HisSer: 2.381 ± 0.675
2.721HisThr: 2.721 ± 0.824
3.401HisVal: 3.401 ± 1.049
0.0HisTrp: 0.0 ± 0.0
0.68HisTyr: 0.68 ± 1.4
0.0HisXaa: 0.0 ± 0.0
Ile
3.061IleAla: 3.061 ± 0.818
1.02IleCys: 1.02 ± 0.512
4.082IleAsp: 4.082 ± 1.369
4.422IleGlu: 4.422 ± 1.533
4.422IlePhe: 4.422 ± 0.268
2.381IleGly: 2.381 ± 0.611
0.0IleHis: 0.0 ± 0.0
3.061IleIle: 3.061 ± 0.818
4.762IleLys: 4.762 ± 1.698
2.041IleLeu: 2.041 ± 0.497
1.701IleMet: 1.701 ± 0.974
1.02IleAsn: 1.02 ± 0.512
4.082IlePro: 4.082 ± 0.994
1.361IleGln: 1.361 ± 0.682
3.741IleArg: 3.741 ± 1.876
4.082IleSer: 4.082 ± 0.994
2.721IleThr: 2.721 ± 1.364
3.741IleVal: 3.741 ± 0.41
0.0IleTrp: 0.0 ± 0.0
1.02IleTyr: 1.02 ± 0.467
0.0IleXaa: 0.0 ± 0.0
Lys
2.041LysAla: 2.041 ± 0.82
1.02LysCys: 1.02 ± 0.512
3.061LysAsp: 3.061 ± 0.894
3.741LysGlu: 3.741 ± 1.876
3.401LysPhe: 3.401 ± 0.78
2.041LysGly: 2.041 ± 1.023
1.361LysHis: 1.361 ± 0.682
3.401LysIle: 3.401 ± 0.391
2.721LysLys: 2.721 ± 2.89
7.823LysLeu: 7.823 ± 1.438
1.361LysMet: 1.361 ± 0.682
2.721LysAsn: 2.721 ± 1.492
3.741LysPro: 3.741 ± 1.957
1.361LysGln: 1.361 ± 0.682
3.741LysArg: 3.741 ± 1.208
3.401LysSer: 3.401 ± 1.06
5.102LysThr: 5.102 ± 2.316
3.061LysVal: 3.061 ± 0.818
0.68LysTrp: 0.68 ± 1.457
1.701LysTyr: 1.701 ± 0.811
0.0LysXaa: 0.0 ± 0.0
Leu
5.442LeuAla: 5.442 ± 4.693
2.041LeuCys: 2.041 ± 1.023
4.082LeuAsp: 4.082 ± 0.994
4.422LeuGlu: 4.422 ± 1.45
4.082LeuPhe: 4.082 ± 2.091
2.381LeuGly: 2.381 ± 0.675
3.061LeuHis: 3.061 ± 0.95
5.102LeuIle: 5.102 ± 1.864
3.741LeuLys: 3.741 ± 1.208
9.864LeuLeu: 9.864 ± 0.805
2.381LeuMet: 2.381 ± 0.611
5.782LeuAsn: 5.782 ± 2.392
2.041LeuPro: 2.041 ± 0.934
2.381LeuGln: 2.381 ± 1.791
6.122LeuArg: 6.122 ± 0.454
9.864LeuSer: 9.864 ± 1.724
6.122LeuThr: 6.122 ± 1.38
6.803LeuVal: 6.803 ± 5.799
0.68LeuTrp: 0.68 ± 1.038
3.741LeuTyr: 3.741 ± 0.41
0.0LeuXaa: 0.0 ± 0.0
Met
2.041MetAla: 2.041 ± 0.497
0.68MetCys: 0.68 ± 0.341
1.701MetAsp: 1.701 ± 0.423
0.0MetGlu: 0.0 ± 0.0
2.721MetPhe: 2.721 ± 1.492
0.68MetGly: 0.68 ± 1.457
1.02MetHis: 1.02 ± 0.467
1.361MetIle: 1.361 ± 0.412
1.701MetLys: 1.701 ± 0.423
2.381MetLeu: 2.381 ± 0.818
0.34MetMet: 0.34 ± 0.171
1.701MetAsn: 1.701 ± 0.811
1.701MetPro: 1.701 ± 0.853
1.361MetGln: 1.361 ± 0.412
1.361MetArg: 1.361 ± 0.682
2.721MetSer: 2.721 ± 0.746
1.701MetThr: 1.701 ± 0.853
2.041MetVal: 2.041 ± 2.095
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
2.381AsnAla: 2.381 ± 0.611
2.381AsnCys: 2.381 ± 0.611
1.701AsnAsp: 1.701 ± 0.423
1.361AsnGlu: 1.361 ± 0.682
1.701AsnPhe: 1.701 ± 1.028
4.082AsnGly: 4.082 ± 0.492
0.68AsnHis: 0.68 ± 0.341
3.061AsnIle: 3.061 ± 0.894
1.361AsnLys: 1.361 ± 0.86
3.061AsnLeu: 3.061 ± 0.818
0.34AsnMet: 0.34 ± 0.171
1.02AsnAsn: 1.02 ± 0.512
2.721AsnPro: 2.721 ± 1.364
1.02AsnGln: 1.02 ± 0.937
5.102AsnArg: 5.102 ± 1.745
5.102AsnSer: 5.102 ± 2.497
2.041AsnThr: 2.041 ± 0.797
3.741AsnVal: 3.741 ± 0.907
0.0AsnTrp: 0.0 ± 0.0
2.041AsnTyr: 2.041 ± 1.023
0.0AsnXaa: 0.0 ± 0.0
Pro
3.061ProAla: 3.061 ± 1.663
1.02ProCys: 1.02 ± 0.512
2.041ProAsp: 2.041 ± 0.82
2.041ProGlu: 2.041 ± 0.797
1.361ProPhe: 1.361 ± 0.412
1.701ProGly: 1.701 ± 0.811
0.68ProHis: 0.68 ± 0.57
1.701ProIle: 1.701 ± 1.833
3.061ProLys: 3.061 ± 2.105
2.721ProLeu: 2.721 ± 0.544
1.02ProMet: 1.02 ± 0.512
2.381ProAsn: 2.381 ± 0.611
1.701ProPro: 1.701 ± 0.423
0.68ProGln: 0.68 ± 1.038
3.061ProArg: 3.061 ± 1.535
3.401ProSer: 3.401 ± 1.049
3.741ProThr: 3.741 ± 0.907
4.762ProVal: 4.762 ± 2.423
0.34ProTrp: 0.34 ± 0.171
2.041ProTyr: 2.041 ± 0.934
0.0ProXaa: 0.0 ± 0.0
Gln
2.041GlnAla: 2.041 ± 1.875
0.0GlnCys: 0.0 ± 0.0
1.02GlnAsp: 1.02 ± 0.937
2.041GlnGlu: 2.041 ± 0.497
2.041GlnPhe: 2.041 ± 0.797
1.02GlnGly: 1.02 ± 0.467
0.68GlnHis: 0.68 ± 0.341
1.701GlnIle: 1.701 ± 0.423
1.701GlnLys: 1.701 ± 0.423
3.061GlnLeu: 3.061 ± 0.818
0.68GlnMet: 0.68 ± 0.57
1.361GlnAsn: 1.361 ± 0.412
0.34GlnPro: 0.34 ± 0.171
1.02GlnGln: 1.02 ± 2.188
2.041GlnArg: 2.041 ± 0.497
3.061GlnSer: 3.061 ± 2.812
1.02GlnThr: 1.02 ± 0.512
1.701GlnVal: 1.701 ± 0.974
0.0GlnTrp: 0.0 ± 0.0
1.02GlnTyr: 1.02 ± 0.512
0.0GlnXaa: 0.0 ± 0.0
Arg
2.721ArgAla: 2.721 ± 0.873
1.02ArgCys: 1.02 ± 0.467
4.082ArgAsp: 4.082 ± 1.369
4.422ArgGlu: 4.422 ± 1.533
3.061ArgPhe: 3.061 ± 0.894
2.041ArgGly: 2.041 ± 1.023
2.721ArgHis: 2.721 ± 0.746
4.082ArgIle: 4.082 ± 1.369
3.741ArgLys: 3.741 ± 1.179
6.803ArgLeu: 6.803 ± 0.899
2.041ArgMet: 2.041 ± 0.934
4.422ArgAsn: 4.422 ± 0.268
1.701ArgPro: 1.701 ± 1.97
1.02ArgGln: 1.02 ± 0.512
2.041ArgArg: 2.041 ± 1.023
3.061ArgSer: 3.061 ± 0.956
3.401ArgThr: 3.401 ± 0.847
5.782ArgVal: 5.782 ± 1.194
0.34ArgTrp: 0.34 ± 0.171
1.701ArgTyr: 1.701 ± 0.853
0.0ArgXaa: 0.0 ± 0.0
Ser
4.762SerAla: 4.762 ± 2.409
0.34SerCys: 0.34 ± 0.171
5.782SerAsp: 5.782 ± 0.977
3.401SerGlu: 3.401 ± 0.847
5.102SerPhe: 5.102 ± 0.791
5.102SerGly: 5.102 ± 1.201
1.02SerHis: 1.02 ± 1.265
3.741SerIle: 3.741 ± 0.907
4.082SerLys: 4.082 ± 0.492
6.463SerLeu: 6.463 ± 1.282
2.041SerMet: 2.041 ± 1.023
4.082SerAsn: 4.082 ± 1.369
4.762SerPro: 4.762 ± 3.078
3.741SerGln: 3.741 ± 1.957
5.442SerArg: 5.442 ± 0.245
8.163SerSer: 8.163 ± 2.029
6.463SerThr: 6.463 ± 0.816
5.102SerVal: 5.102 ± 0.791
0.68SerTrp: 0.68 ± 0.341
5.442SerTyr: 5.442 ± 0.245
0.0SerXaa: 0.0 ± 0.0
Thr
3.401ThrAla: 3.401 ± 1.706
1.361ThrCys: 1.361 ± 0.412
3.401ThrAsp: 3.401 ± 0.847
2.381ThrGlu: 2.381 ± 0.864
6.122ThrPhe: 6.122 ± 1.38
2.381ThrGly: 2.381 ± 0.864
1.361ThrHis: 1.361 ± 1.132
3.061ThrIle: 3.061 ± 1.535
3.741ThrLys: 3.741 ± 1.876
4.422ThrLeu: 4.422 ± 1.3
0.68ThrMet: 0.68 ± 0.341
2.381ThrAsn: 2.381 ± 1.291
2.041ThrPro: 2.041 ± 0.797
1.701ThrGln: 1.701 ± 0.974
3.061ThrArg: 3.061 ± 0.442
6.122ThrSer: 6.122 ± 1.227
3.061ThrThr: 3.061 ± 0.442
4.422ThrVal: 4.422 ± 1.094
0.34ThrTrp: 0.34 ± 0.171
1.361ThrTyr: 1.361 ± 0.412
0.0ThrXaa: 0.0 ± 0.0
Val
6.122ValAla: 6.122 ± 2.46
2.041ValCys: 2.041 ± 0.497
6.463ValAsp: 6.463 ± 2.534
4.422ValGlu: 4.422 ± 1.223
4.762ValPhe: 4.762 ± 2.582
2.721ValGly: 2.721 ± 1.908
2.381ValHis: 2.381 ± 0.675
2.381ValIle: 2.381 ± 0.864
5.102ValLys: 5.102 ± 2.479
6.122ValLeu: 6.122 ± 4.479
2.381ValMet: 2.381 ± 3.307
3.741ValAsn: 3.741 ± 1.876
5.102ValPro: 5.102 ± 0.076
2.381ValGln: 2.381 ± 0.818
4.422ValArg: 4.422 ± 1.45
5.782ValSer: 5.782 ± 4.556
3.061ValThr: 3.061 ± 0.894
10.544ValVal: 10.544 ± 5.222
0.0ValTrp: 0.0 ± 0.0
4.422ValTyr: 4.422 ± 1.223
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
0.34TrpAsp: 0.34 ± 0.171
1.02TrpGlu: 1.02 ± 0.512
0.68TrpPhe: 0.68 ± 0.57
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
0.0TrpLys: 0.0 ± 0.0
0.34TrpLeu: 0.34 ± 0.171
0.0TrpMet: 0.0 ± 0.0
0.34TrpAsn: 0.34 ± 0.171
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.34TrpArg: 0.34 ± 0.171
0.34TrpSer: 0.34 ± 0.171
0.68TrpThr: 0.68 ± 0.341
0.68TrpVal: 0.68 ± 2.309
0.0TrpTrp: 0.0 ± 0.0
0.68TrpTyr: 0.68 ± 0.57
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.68TyrAla: 0.68 ± 0.57
1.02TyrCys: 1.02 ± 0.512
3.741TyrAsp: 3.741 ± 1.208
3.061TyrGlu: 3.061 ± 0.894
2.721TyrPhe: 2.721 ± 1.824
2.041TyrGly: 2.041 ± 0.497
1.701TyrHis: 1.701 ± 1.028
1.361TyrIle: 1.361 ± 0.412
2.381TyrLys: 2.381 ± 1.194
2.721TyrLeu: 2.721 ± 1.121
0.34TyrMet: 0.34 ± 0.7
1.701TyrAsn: 1.701 ± 0.423
0.68TyrPro: 0.68 ± 0.341
1.361TyrGln: 1.361 ± 0.412
2.381TyrArg: 2.381 ± 0.611
3.061TyrSer: 3.061 ± 0.894
2.721TyrThr: 2.721 ± 1.492
3.061TyrVal: 3.061 ± 1.663
0.0TyrTrp: 0.0 ± 0.0
0.68TyrTyr: 0.68 ± 0.341
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (2941 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski