Amino acid dipepetide frequency for Blastococcus saxobsidens (strain DD2)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.711AlaAla: 23.711 ± 0.209	0.998AlaCys: 0.998 ± 0.034	9.187AlaAsp: 9.187 ± 0.097	9.079AlaGlu: 9.079 ± 0.101	3.346AlaPhe: 3.346 ± 0.046	14.873AlaGly: 14.873 ± 0.115	2.57AlaHis: 2.57 ± 0.042	3.854AlaIle: 3.854 ± 0.062	1.836AlaLys: 1.836 ± 0.041	14.803AlaLeu: 14.803 ± 0.133	2.56AlaMet: 2.56 ± 0.044	1.697AlaAsn: 1.697 ± 0.036	7.294AlaPro: 7.294 ± 0.102	3.828AlaGln: 3.828 ± 0.059	10.866AlaArg: 10.866 ± 0.097	5.544AlaSer: 5.544 ± 0.066	7.578AlaThr: 7.578 ± 0.082	13.798AlaVal: 13.798 ± 0.115	1.858AlaTrp: 1.858 ± 0.043	2.169AlaTyr: 2.169 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	0.927CysAla: 0.927 ± 0.029	0.095CysCys: 0.095 ± 0.009	0.457CysAsp: 0.457 ± 0.017	0.356CysGlu: 0.356 ± 0.015	0.188CysPhe: 0.188 ± 0.01	0.9CysGly: 0.9 ± 0.023	0.158CysHis: 0.158 ± 0.01	0.18CysIle: 0.18 ± 0.011	0.077CysLys: 0.077 ± 0.008	0.637CysLeu: 0.637 ± 0.021	0.105CysMet: 0.105 ± 0.009	0.104CysAsn: 0.104 ± 0.009	0.498CysPro: 0.498 ± 0.018	0.16CysGln: 0.16 ± 0.011	0.646CysArg: 0.646 ± 0.024	0.419CysSer: 0.419 ± 0.017	0.487CysThr: 0.487 ± 0.02	0.552CysVal: 0.552 ± 0.021	0.11CysTrp: 0.11 ± 0.009	0.125CysTyr: 0.125 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	8.127AspAla: 8.127 ± 0.08	0.367AspCys: 0.367 ± 0.016	4.291AspAsp: 4.291 ± 0.065	4.2AspGlu: 4.2 ± 0.063	1.331AspPhe: 1.331 ± 0.036	6.488AspGly: 6.488 ± 0.074	1.21AspHis: 1.21 ± 0.033	1.67AspIle: 1.67 ± 0.039	0.739AspLys: 0.739 ± 0.029	6.884AspLeu: 6.884 ± 0.082	0.777AspMet: 0.777 ± 0.023	0.699AspAsn: 0.699 ± 0.031	4.765AspPro: 4.765 ± 0.06	1.615AspGln: 1.615 ± 0.036	5.584AspArg: 5.584 ± 0.071	2.283AspSer: 2.283 ± 0.048	2.81AspThr: 2.81 ± 0.052	6.262AspVal: 6.262 ± 0.084	0.943AspTrp: 0.943 ± 0.026	1.019AspTyr: 1.019 ± 0.026	0.0AspXaa: 0.0 ± 0.0
Glu	7.071GluAla: 7.071 ± 0.079	0.328GluCys: 0.328 ± 0.017	3.042GluAsp: 3.042 ± 0.05	3.549GluGlu: 3.549 ± 0.06	1.486GluPhe: 1.486 ± 0.033	4.075GluGly: 4.075 ± 0.061	1.592GluHis: 1.592 ± 0.034	2.091GluIle: 2.091 ± 0.043	0.99GluLys: 0.99 ± 0.032	7.052GluLeu: 7.052 ± 0.079	0.874GluMet: 0.874 ± 0.025	0.933GluAsn: 0.933 ± 0.025	3.48GluPro: 3.48 ± 0.052	2.563GluGln: 2.563 ± 0.045	5.251GluArg: 5.251 ± 0.065	2.393GluSer: 2.393 ± 0.044	2.83GluThr: 2.83 ± 0.045	5.343GluVal: 5.343 ± 0.08	0.758GluTrp: 0.758 ± 0.024	0.899GluTyr: 0.899 ± 0.024	0.0GluXaa: 0.0 ± 0.0
Phe	3.529PheAla: 3.529 ± 0.05	0.243PheCys: 0.243 ± 0.012	1.915PheAsp: 1.915 ± 0.032	1.293PheGlu: 1.293 ± 0.028	0.856PhePhe: 0.856 ± 0.027	2.946PheGly: 2.946 ± 0.048	0.46PheHis: 0.46 ± 0.02	0.653PheIle: 0.653 ± 0.021	0.323PheLys: 0.323 ± 0.015	2.566PheLeu: 2.566 ± 0.05	0.328PheMet: 0.328 ± 0.016	0.406PheAsn: 0.406 ± 0.017	1.353PhePro: 1.353 ± 0.032	0.626PheGln: 0.626 ± 0.022	1.675PheArg: 1.675 ± 0.035	1.379PheSer: 1.379 ± 0.031	1.795PheThr: 1.795 ± 0.038	2.44PheVal: 2.44 ± 0.049	0.404PheTrp: 0.404 ± 0.019	0.503PheTyr: 0.503 ± 0.02	0.0PheXaa: 0.0 ± 0.0
Gly	11.61GlyAla: 11.61 ± 0.113	0.829GlyCys: 0.829 ± 0.025	5.455GlyAsp: 5.455 ± 0.069	5.226GlyGlu: 5.226 ± 0.06	2.718GlyPhe: 2.718 ± 0.046	8.875GlyGly: 8.875 ± 0.112	2.067GlyHis: 2.067 ± 0.041	3.529GlyIle: 3.529 ± 0.058	1.723GlyLys: 1.723 ± 0.037	10.006GlyLeu: 10.006 ± 0.101	2.217GlyMet: 2.217 ± 0.041	1.531GlyAsn: 1.531 ± 0.04	5.231GlyPro: 5.231 ± 0.067	2.817GlyGln: 2.817 ± 0.049	8.378GlyArg: 8.378 ± 0.08	5.488GlySer: 5.488 ± 0.062	5.947GlyThr: 5.947 ± 0.067	8.296GlyVal: 8.296 ± 0.075	1.805GlyTrp: 1.805 ± 0.037	2.14GlyTyr: 2.14 ± 0.04	0.0GlyXaa: 0.0 ± 0.0
His	2.473HisAla: 2.473 ± 0.051	0.185HisCys: 0.185 ± 0.012	1.22HisAsp: 1.22 ± 0.031	1.154HisGlu: 1.154 ± 0.029	0.524HisPhe: 0.524 ± 0.018	2.18HisGly: 2.18 ± 0.041	0.597HisHis: 0.597 ± 0.02	0.451HisIle: 0.451 ± 0.018	0.219HisLys: 0.219 ± 0.014	2.281HisLeu: 2.281 ± 0.042	0.287HisMet: 0.287 ± 0.014	0.276HisAsn: 0.276 ± 0.012	1.717HisPro: 1.717 ± 0.035	0.558HisGln: 0.558 ± 0.019	1.996HisArg: 1.996 ± 0.041	0.845HisSer: 0.845 ± 0.028	0.935HisThr: 0.935 ± 0.026	1.833HisVal: 1.833 ± 0.034	0.3HisTrp: 0.3 ± 0.014	0.384HisTyr: 0.384 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	4.747IleAla: 4.747 ± 0.053	0.251IleCys: 0.251 ± 0.012	2.35IleAsp: 2.35 ± 0.046	1.924IleGlu: 1.924 ± 0.041	0.612IlePhe: 0.612 ± 0.023	3.539IleGly: 3.539 ± 0.051	0.451IleHis: 0.451 ± 0.017	0.78IleIle: 0.78 ± 0.027	0.466IleLys: 0.466 ± 0.019	2.181IleLeu: 2.181 ± 0.04	0.368IleMet: 0.368 ± 0.015	0.619IleAsn: 0.619 ± 0.023	1.699IlePro: 1.699 ± 0.037	0.661IleGln: 0.661 ± 0.023	2.168IleArg: 2.168 ± 0.039	1.717IleSer: 1.717 ± 0.036	1.967IleThr: 1.967 ± 0.037	2.736IleVal: 2.736 ± 0.052	0.326IleTrp: 0.326 ± 0.016	0.503IleTyr: 0.503 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	1.906LysAla: 1.906 ± 0.042	0.065LysCys: 0.065 ± 0.007	0.82LysAsp: 0.82 ± 0.025	0.737LysGlu: 0.737 ± 0.026	0.292LysPhe: 0.292 ± 0.015	1.144LysGly: 1.144 ± 0.033	0.312LysHis: 0.312 ± 0.013	0.525LysIle: 0.525 ± 0.022	0.461LysLys: 0.461 ± 0.027	1.368LysLeu: 1.368 ± 0.036	0.251LysMet: 0.251 ± 0.013	0.311LysAsn: 0.311 ± 0.016	0.879LysPro: 0.879 ± 0.028	0.513LysGln: 0.513 ± 0.019	1.087LysArg: 1.087 ± 0.027	0.743LysSer: 0.743 ± 0.025	0.903LysThr: 0.903 ± 0.027	1.307LysVal: 1.307 ± 0.031	0.175LysTrp: 0.175 ± 0.012	0.295LysTyr: 0.295 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	16.79LeuAla: 16.79 ± 0.135	0.683LeuCys: 0.683 ± 0.021	6.938LeuAsp: 6.938 ± 0.083	5.046LeuGlu: 5.046 ± 0.065	2.537LeuPhe: 2.537 ± 0.053	9.898LeuGly: 9.898 ± 0.104	2.019LeuHis: 2.019 ± 0.04	2.878LeuIle: 2.878 ± 0.048	1.222LeuLys: 1.222 ± 0.03	12.102LeuLeu: 12.102 ± 0.147	1.447LeuMet: 1.447 ± 0.034	1.366LeuAsn: 1.366 ± 0.034	6.789LeuPro: 6.789 ± 0.078	2.636LeuGln: 2.636 ± 0.043	8.806LeuArg: 8.806 ± 0.095	5.322LeuSer: 5.322 ± 0.059	6.799LeuThr: 6.799 ± 0.076	10.468LeuVal: 10.468 ± 0.118	1.166LeuTrp: 1.166 ± 0.031	1.431LeuTyr: 1.431 ± 0.03	0.0LeuXaa: 0.0 ± 0.0
Met	2.344MetAla: 2.344 ± 0.041	0.131MetCys: 0.131 ± 0.009	0.808MetAsp: 0.808 ± 0.025	0.65MetGlu: 0.65 ± 0.023	0.401MetPhe: 0.401 ± 0.016	1.314MetGly: 1.314 ± 0.029	0.36MetHis: 0.36 ± 0.014	0.567MetIle: 0.567 ± 0.019	0.332MetLys: 0.332 ± 0.014	1.622MetLeu: 1.622 ± 0.036	0.233MetMet: 0.233 ± 0.016	0.349MetAsn: 0.349 ± 0.015	1.098MetPro: 1.098 ± 0.028	0.49MetGln: 0.49 ± 0.019	1.381MetArg: 1.381 ± 0.03	1.362MetSer: 1.362 ± 0.033	1.668MetThr: 1.668 ± 0.034	1.408MetVal: 1.408 ± 0.031	0.181MetTrp: 0.181 ± 0.012	0.26MetTyr: 0.26 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	1.899AsnAla: 1.899 ± 0.041	0.127AsnCys: 0.127 ± 0.008	0.802AsnAsp: 0.802 ± 0.026	0.687AsnGlu: 0.687 ± 0.023	0.418AsnPhe: 0.418 ± 0.019	1.462AsnGly: 1.462 ± 0.033	0.296AsnHis: 0.296 ± 0.016	0.46AsnIle: 0.46 ± 0.02	0.229AsnLys: 0.229 ± 0.013	1.511AsnLeu: 1.511 ± 0.029	0.267AsnMet: 0.267 ± 0.015	0.302AsnAsn: 0.302 ± 0.016	1.173AsnPro: 1.173 ± 0.031	0.394AsnGln: 0.394 ± 0.016	1.184AsnArg: 1.184 ± 0.028	0.731AsnSer: 0.731 ± 0.028	0.847AsnThr: 0.847 ± 0.025	1.253AsnVal: 1.253 ± 0.031	0.23AsnTrp: 0.23 ± 0.014	0.299AsnTyr: 0.299 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	9.531ProAla: 9.531 ± 0.102	0.331ProCys: 0.331 ± 0.016	4.628ProAsp: 4.628 ± 0.066	4.3ProGlu: 4.3 ± 0.061	1.576ProPhe: 1.576 ± 0.034	6.939ProGly: 6.939 ± 0.077	1.188ProHis: 1.188 ± 0.029	1.507ProIle: 1.507 ± 0.036	0.777ProLys: 0.777 ± 0.026	5.456ProLeu: 5.456 ± 0.066	1.015ProMet: 1.015 ± 0.028	0.77ProAsn: 0.77 ± 0.025	4.036ProPro: 4.036 ± 0.074	1.509ProGln: 1.509 ± 0.033	4.246ProArg: 4.246 ± 0.056	3.112ProSer: 3.112 ± 0.046	3.434ProThr: 3.434 ± 0.057	6.16ProVal: 6.16 ± 0.072	0.898ProTrp: 0.898 ± 0.029	1.007ProTyr: 1.007 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.85GlnAla: 3.85 ± 0.061	0.144GlnCys: 0.144 ± 0.01	1.255GlnAsp: 1.255 ± 0.029	1.462GlnGlu: 1.462 ± 0.034	0.708GlnPhe: 0.708 ± 0.025	2.023GlnGly: 2.023 ± 0.043	0.641GlnHis: 0.641 ± 0.022	1.045GlnIle: 1.045 ± 0.032	0.445GlnLys: 0.445 ± 0.02	3.439GlnLeu: 3.439 ± 0.058	0.528GlnMet: 0.528 ± 0.019	0.4GlnAsn: 0.4 ± 0.016	1.764GlnPro: 1.764 ± 0.037	1.245GlnGln: 1.245 ± 0.032	2.654GlnArg: 2.654 ± 0.045	1.132GlnSer: 1.132 ± 0.026	1.331GlnThr: 1.331 ± 0.033	2.925GlnVal: 2.925 ± 0.043	0.395GlnTrp: 0.395 ± 0.018	0.491GlnTyr: 0.491 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	10.476ArgAla: 10.476 ± 0.108	0.617ArgCys: 0.617 ± 0.02	4.441ArgAsp: 4.441 ± 0.065	4.502ArgGlu: 4.502 ± 0.057	2.279ArgPhe: 2.279 ± 0.045	6.277ArgGly: 6.277 ± 0.074	1.877ArgHis: 1.877 ± 0.033	2.875ArgIle: 2.875 ± 0.046	1.183ArgLys: 1.183 ± 0.03	9.077ArgLeu: 9.077 ± 0.1	1.888ArgMet: 1.888 ± 0.04	1.243ArgAsn: 1.243 ± 0.027	5.687ArgPro: 5.687 ± 0.063	2.537ArgGln: 2.537 ± 0.045	8.827ArgArg: 8.827 ± 0.105	4.556ArgSer: 4.556 ± 0.065	4.955ArgThr: 4.955 ± 0.058	6.477ArgVal: 6.477 ± 0.07	1.531ArgTrp: 1.531 ± 0.033	1.773ArgTyr: 1.773 ± 0.03	0.0ArgXaa: 0.0 ± 0.0
Ser	6.583SerAla: 6.583 ± 0.066	0.395SerCys: 0.395 ± 0.016	2.674SerAsp: 2.674 ± 0.041	2.269SerGlu: 2.269 ± 0.041	1.43SerPhe: 1.43 ± 0.032	5.544SerGly: 5.544 ± 0.069	0.87SerHis: 0.87 ± 0.025	1.539SerIle: 1.539 ± 0.03	0.643SerLys: 0.643 ± 0.022	4.797SerLeu: 4.797 ± 0.055	1.122SerMet: 1.122 ± 0.03	0.683SerAsn: 0.683 ± 0.018	3.299SerPro: 3.299 ± 0.052	1.17SerGln: 1.17 ± 0.03	3.884SerArg: 3.884 ± 0.056	2.953SerSer: 2.953 ± 0.056	3.099SerThr: 3.099 ± 0.057	4.283SerVal: 4.283 ± 0.059	0.874SerTrp: 0.874 ± 0.03	1.014SerTyr: 1.014 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	8.656ThrAla: 8.656 ± 0.081	0.431ThrCys: 0.431 ± 0.019	3.617ThrAsp: 3.617 ± 0.055	3.098ThrGlu: 3.098 ± 0.05	1.576ThrPhe: 1.576 ± 0.033	6.614ThrGly: 6.614 ± 0.074	1.062ThrHis: 1.062 ± 0.031	1.805ThrIle: 1.805 ± 0.039	0.774ThrLys: 0.774 ± 0.025	5.517ThrLeu: 5.517 ± 0.06	0.903ThrMet: 0.903 ± 0.027	0.865ThrAsn: 0.865 ± 0.026	3.9ThrPro: 3.9 ± 0.056	1.219ThrGln: 1.219 ± 0.033	4.018ThrArg: 4.018 ± 0.058	3.062ThrSer: 3.062 ± 0.049	3.879ThrThr: 3.879 ± 0.06	6.264ThrVal: 6.264 ± 0.069	0.866ThrTrp: 0.866 ± 0.024	1.039ThrTyr: 1.039 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	13.229ValAla: 13.229 ± 0.105	0.666ValCys: 0.666 ± 0.024	6.169ValAsp: 6.169 ± 0.068	5.418ValGlu: 5.418 ± 0.06	2.433ValPhe: 2.433 ± 0.046	7.921ValGly: 7.921 ± 0.075	2.062ValHis: 2.062 ± 0.038	2.794ValIle: 2.794 ± 0.047	1.184ValLys: 1.184 ± 0.031	11.267ValLeu: 11.267 ± 0.101	1.337ValMet: 1.337 ± 0.031	1.465ValAsn: 1.465 ± 0.033	5.996ValPro: 5.996 ± 0.069	2.328ValGln: 2.328 ± 0.036	7.411ValArg: 7.411 ± 0.071	4.342ValSer: 4.342 ± 0.055	5.982ValThr: 5.982 ± 0.071	10.556ValVal: 10.556 ± 0.113	1.113ValTrp: 1.113 ± 0.029	1.427ValTyr: 1.427 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.691TrpAla: 1.691 ± 0.035	0.147TrpCys: 0.147 ± 0.011	0.754TrpAsp: 0.754 ± 0.026	0.638TrpGlu: 0.638 ± 0.021	0.471TrpPhe: 0.471 ± 0.02	1.003TrpGly: 1.003 ± 0.032	0.341TrpHis: 0.341 ± 0.017	0.459TrpIle: 0.459 ± 0.017	0.215TrpLys: 0.215 ± 0.011	1.834TrpLeu: 1.834 ± 0.043	0.272TrpMet: 0.272 ± 0.013	0.291TrpAsn: 0.291 ± 0.014	0.856TrpPro: 0.856 ± 0.025	0.534TrpGln: 0.534 ± 0.019	1.409TrpArg: 1.409 ± 0.032	0.931TrpSer: 0.931 ± 0.025	0.976TrpThr: 0.976 ± 0.03	1.095TrpVal: 1.095 ± 0.031	0.324TrpTrp: 0.324 ± 0.017	0.282TrpTyr: 0.282 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.3TyrAla: 2.3 ± 0.04	0.148TyrCys: 0.148 ± 0.011	1.241TyrAsp: 1.241 ± 0.035	1.011TyrGlu: 1.011 ± 0.029	0.51TyrPhe: 0.51 ± 0.018	1.873TyrGly: 1.873 ± 0.033	0.282TyrHis: 0.282 ± 0.013	0.402TyrIle: 0.402 ± 0.017	0.255TyrLys: 0.255 ± 0.014	1.943TyrLeu: 1.943 ± 0.037	0.18TyrMet: 0.18 ± 0.013	0.259TyrAsn: 0.259 ± 0.014	0.908TyrPro: 0.908 ± 0.025	0.476TyrGln: 0.476 ± 0.019	1.606TyrArg: 1.606 ± 0.038	0.812TyrSer: 0.812 ± 0.024	0.945TyrThr: 0.945 ± 0.028	1.642TyrVal: 1.642 ± 0.032	0.265TyrTrp: 0.265 ± 0.013	0.34TyrTyr: 0.34 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4791 proteins (1451551 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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