Amino acid dipepetide frequency for Streptococcus phage Javan144

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.905AlaAla: 3.905 ± 1.072
0.293AlaCys: 0.293 ± 0.157
5.077AlaAsp: 5.077 ± 0.58
5.761AlaGlu: 5.761 ± 0.724
2.636AlaPhe: 2.636 ± 0.42
4.784AlaGly: 4.784 ± 1.162
0.781AlaHis: 0.781 ± 0.299
7.03AlaIle: 7.03 ± 1.046
6.932AlaLys: 6.932 ± 0.939
5.761AlaLeu: 5.761 ± 0.668
1.465AlaMet: 1.465 ± 0.463
4.687AlaAsn: 4.687 ± 0.658
1.66AlaPro: 1.66 ± 0.362
2.246AlaGln: 2.246 ± 0.404
2.343AlaArg: 2.343 ± 0.472
3.613AlaSer: 3.613 ± 0.6
4.003AlaThr: 4.003 ± 0.635
4.784AlaVal: 4.784 ± 0.658
0.781AlaTrp: 0.781 ± 0.316
2.05AlaTyr: 2.05 ± 0.488
0.0AlaXaa: 0.0 ± 0.0
Cys
0.195CysAla: 0.195 ± 0.117
0.195CysCys: 0.195 ± 0.133
0.293CysAsp: 0.293 ± 0.211
0.683CysGlu: 0.683 ± 0.25
0.488CysPhe: 0.488 ± 0.193
0.391CysGly: 0.391 ± 0.196
0.195CysHis: 0.195 ± 0.118
0.293CysIle: 0.293 ± 0.246
0.586CysLys: 0.586 ± 0.222
0.879CysLeu: 0.879 ± 0.252
0.195CysMet: 0.195 ± 0.141
0.293CysAsn: 0.293 ± 0.17
0.0CysPro: 0.0 ± 0.0
0.098CysGln: 0.098 ± 0.102
0.098CysArg: 0.098 ± 0.102
0.391CysSer: 0.391 ± 0.195
0.0CysThr: 0.0 ± 0.0
0.391CysVal: 0.391 ± 0.207
0.0CysTrp: 0.0 ± 0.0
0.293CysTyr: 0.293 ± 0.19
0.0CysXaa: 0.0 ± 0.0
Asp
3.613AspAla: 3.613 ± 0.784
0.586AspCys: 0.586 ± 0.257
4.491AspAsp: 4.491 ± 0.491
4.687AspGlu: 4.687 ± 0.785
2.831AspPhe: 2.831 ± 0.486
5.761AspGly: 5.761 ± 0.834
0.586AspHis: 0.586 ± 0.209
4.198AspIle: 4.198 ± 0.463
6.249AspLys: 6.249 ± 0.674
6.737AspLeu: 6.737 ± 0.806
0.976AspMet: 0.976 ± 0.33
3.905AspAsn: 3.905 ± 0.465
1.562AspPro: 1.562 ± 0.433
1.172AspGln: 1.172 ± 0.328
2.343AspArg: 2.343 ± 0.387
3.613AspSer: 3.613 ± 0.613
3.808AspThr: 3.808 ± 0.853
4.296AspVal: 4.296 ± 0.536
1.074AspTrp: 1.074 ± 0.289
2.441AspTyr: 2.441 ± 0.502
0.0AspXaa: 0.0 ± 0.0
Glu
5.663GluAla: 5.663 ± 0.708
0.293GluCys: 0.293 ± 0.152
3.027GluAsp: 3.027 ± 0.647
5.761GluGlu: 5.761 ± 1.035
2.929GluPhe: 2.929 ± 0.528
3.222GluGly: 3.222 ± 0.509
1.172GluHis: 1.172 ± 0.334
6.151GluIle: 6.151 ± 0.884
6.737GluLys: 6.737 ± 1.0
7.909GluLeu: 7.909 ± 1.096
2.246GluMet: 2.246 ± 0.445
3.515GluAsn: 3.515 ± 0.675
1.855GluPro: 1.855 ± 0.43
3.613GluGln: 3.613 ± 0.693
2.246GluArg: 2.246 ± 0.546
3.71GluSer: 3.71 ± 0.53
4.784GluThr: 4.784 ± 0.801
4.198GluVal: 4.198 ± 0.77
0.976GluTrp: 0.976 ± 0.26
2.539GluTyr: 2.539 ± 0.531
0.0GluXaa: 0.0 ± 0.0
Phe
2.929PheAla: 2.929 ± 0.545
0.293PheCys: 0.293 ± 0.177
3.124PheAsp: 3.124 ± 0.457
3.613PheGlu: 3.613 ± 0.843
1.562PhePhe: 1.562 ± 0.356
2.929PheGly: 2.929 ± 0.438
0.488PheHis: 0.488 ± 0.182
1.562PheIle: 1.562 ± 0.412
3.222PheLys: 3.222 ± 0.503
2.831PheLeu: 2.831 ± 0.483
1.172PheMet: 1.172 ± 0.39
2.05PheAsn: 2.05 ± 0.44
0.683PhePro: 0.683 ± 0.292
1.465PheGln: 1.465 ± 0.358
2.246PheArg: 2.246 ± 0.49
2.539PheSer: 2.539 ± 0.773
2.246PheThr: 2.246 ± 0.473
3.222PheVal: 3.222 ± 0.615
0.195PheTrp: 0.195 ± 0.135
2.05PheTyr: 2.05 ± 0.53
0.0PheXaa: 0.0 ± 0.0
Gly
4.296GlyAla: 4.296 ± 0.904
0.195GlyCys: 0.195 ± 0.123
4.394GlyAsp: 4.394 ± 0.656
3.71GlyGlu: 3.71 ± 0.997
3.32GlyPhe: 3.32 ± 0.598
4.003GlyGly: 4.003 ± 0.715
1.269GlyHis: 1.269 ± 0.406
5.761GlyIle: 5.761 ± 0.885
6.054GlyLys: 6.054 ± 0.812
4.491GlyLeu: 4.491 ± 1.091
2.148GlyMet: 2.148 ± 0.495
4.101GlyAsn: 4.101 ± 0.612
1.953GlyPro: 1.953 ± 1.374
2.831GlyGln: 2.831 ± 0.643
1.465GlyArg: 1.465 ± 0.418
3.613GlySer: 3.613 ± 0.668
3.808GlyThr: 3.808 ± 0.564
3.515GlyVal: 3.515 ± 0.757
1.269GlyTrp: 1.269 ± 0.428
3.905GlyTyr: 3.905 ± 0.658
0.0GlyXaa: 0.0 ± 0.0
His
0.879HisAla: 0.879 ± 0.33
0.195HisCys: 0.195 ± 0.143
0.293HisAsp: 0.293 ± 0.208
1.172HisGlu: 1.172 ± 0.36
0.391HisPhe: 0.391 ± 0.19
1.074HisGly: 1.074 ± 0.287
0.293HisHis: 0.293 ± 0.171
0.781HisIle: 0.781 ± 0.27
0.683HisLys: 0.683 ± 0.231
1.757HisLeu: 1.757 ± 0.436
0.293HisMet: 0.293 ± 0.164
0.879HisAsn: 0.879 ± 0.341
0.586HisPro: 0.586 ± 0.236
0.683HisGln: 0.683 ± 0.248
0.488HisArg: 0.488 ± 0.17
0.488HisSer: 0.488 ± 0.201
1.172HisThr: 1.172 ± 0.333
0.683HisVal: 0.683 ± 0.243
0.098HisTrp: 0.098 ± 0.089
0.391HisTyr: 0.391 ± 0.207
0.0HisXaa: 0.0 ± 0.0
Ile
4.784IleAla: 4.784 ± 0.704
0.488IleCys: 0.488 ± 0.261
6.737IleAsp: 6.737 ± 0.893
4.589IleGlu: 4.589 ± 0.713
1.66IlePhe: 1.66 ± 0.418
4.101IleGly: 4.101 ± 0.879
1.074IleHis: 1.074 ± 0.31
4.394IleIle: 4.394 ± 0.564
7.225IleLys: 7.225 ± 0.755
4.979IleLeu: 4.979 ± 0.616
1.757IleMet: 1.757 ± 0.486
4.491IleAsn: 4.491 ± 0.615
2.343IlePro: 2.343 ± 0.537
1.66IleGln: 1.66 ± 0.289
2.929IleArg: 2.929 ± 0.469
5.663IleSer: 5.663 ± 1.241
5.077IleThr: 5.077 ± 0.868
4.979IleVal: 4.979 ± 0.695
0.293IleTrp: 0.293 ± 0.163
1.172IleTyr: 1.172 ± 0.32
0.0IleXaa: 0.0 ± 0.0
Lys
5.956LysAla: 5.956 ± 0.922
0.391LysCys: 0.391 ± 0.196
4.882LysAsp: 4.882 ± 0.607
6.835LysGlu: 6.835 ± 1.023
2.539LysPhe: 2.539 ± 0.491
5.858LysGly: 5.858 ± 0.923
1.562LysHis: 1.562 ± 0.46
6.932LysIle: 6.932 ± 1.085
6.932LysLys: 6.932 ± 1.21
5.956LysLeu: 5.956 ± 0.645
2.831LysMet: 2.831 ± 0.576
4.882LysAsn: 4.882 ± 0.696
2.929LysPro: 2.929 ± 0.538
4.394LysGln: 4.394 ± 0.693
5.077LysArg: 5.077 ± 0.718
6.737LysSer: 6.737 ± 0.816
5.272LysThr: 5.272 ± 0.721
5.272LysVal: 5.272 ± 0.84
1.562LysTrp: 1.562 ± 0.428
3.027LysTyr: 3.027 ± 0.511
0.0LysXaa: 0.0 ± 0.0
Leu
6.835LeuAla: 6.835 ± 0.827
0.195LeuCys: 0.195 ± 0.144
6.932LeuAsp: 6.932 ± 0.938
5.272LeuGlu: 5.272 ± 0.68
3.613LeuPhe: 3.613 ± 0.588
4.491LeuGly: 4.491 ± 0.728
0.781LeuHis: 0.781 ± 0.382
4.687LeuIle: 4.687 ± 0.548
9.666LeuLys: 9.666 ± 1.097
5.956LeuLeu: 5.956 ± 0.727
1.269LeuMet: 1.269 ± 0.371
4.394LeuAsn: 4.394 ± 0.635
2.929LeuPro: 2.929 ± 0.567
2.831LeuGln: 2.831 ± 0.681
2.734LeuArg: 2.734 ± 0.605
6.932LeuSer: 6.932 ± 0.93
4.198LeuThr: 4.198 ± 0.59
4.491LeuVal: 4.491 ± 0.657
0.683LeuTrp: 0.683 ± 0.267
3.32LeuTyr: 3.32 ± 0.559
0.0LeuXaa: 0.0 ± 0.0
Met
2.539MetAla: 2.539 ± 0.671
0.098MetCys: 0.098 ± 0.089
1.465MetAsp: 1.465 ± 0.438
1.172MetGlu: 1.172 ± 0.317
0.586MetPhe: 0.586 ± 0.206
1.269MetGly: 1.269 ± 0.629
0.293MetHis: 0.293 ± 0.149
1.757MetIle: 1.757 ± 0.343
1.66MetLys: 1.66 ± 0.339
1.465MetLeu: 1.465 ± 0.336
0.488MetMet: 0.488 ± 0.218
1.367MetAsn: 1.367 ± 0.353
0.683MetPro: 0.683 ± 0.288
1.172MetGln: 1.172 ± 0.309
0.488MetArg: 0.488 ± 0.239
1.953MetSer: 1.953 ± 0.461
2.539MetThr: 2.539 ± 0.533
1.269MetVal: 1.269 ± 0.387
0.195MetTrp: 0.195 ± 0.12
0.976MetTyr: 0.976 ± 0.322
0.0MetXaa: 0.0 ± 0.0
Asn
3.515AsnAla: 3.515 ± 0.596
0.488AsnCys: 0.488 ± 0.179
3.222AsnAsp: 3.222 ± 0.59
3.222AsnGlu: 3.222 ± 0.535
2.539AsnPhe: 2.539 ± 0.64
3.905AsnGly: 3.905 ± 0.569
1.074AsnHis: 1.074 ± 0.357
3.613AsnIle: 3.613 ± 0.589
4.491AsnLys: 4.491 ± 0.758
4.101AsnLeu: 4.101 ± 0.462
1.367AsnMet: 1.367 ± 0.352
3.222AsnAsn: 3.222 ± 0.622
3.027AsnPro: 3.027 ± 0.621
2.441AsnGln: 2.441 ± 0.436
2.734AsnArg: 2.734 ± 0.548
3.222AsnSer: 3.222 ± 0.562
3.124AsnThr: 3.124 ± 0.489
3.124AsnVal: 3.124 ± 0.49
0.976AsnTrp: 0.976 ± 0.314
2.148AsnTyr: 2.148 ± 0.453
0.0AsnXaa: 0.0 ± 0.0
Pro
1.855ProAla: 1.855 ± 0.459
0.098ProCys: 0.098 ± 0.087
1.562ProAsp: 1.562 ± 0.476
1.757ProGlu: 1.757 ± 0.528
1.172ProPhe: 1.172 ± 0.328
1.074ProGly: 1.074 ± 0.39
0.195ProHis: 0.195 ± 0.126
1.66ProIle: 1.66 ± 0.404
3.32ProLys: 3.32 ± 0.54
2.148ProLeu: 2.148 ± 0.38
0.976ProMet: 0.976 ± 0.252
1.367ProAsn: 1.367 ± 0.372
1.172ProPro: 1.172 ± 0.423
1.953ProGln: 1.953 ± 0.485
1.269ProArg: 1.269 ± 0.328
2.343ProSer: 2.343 ± 0.46
1.953ProThr: 1.953 ± 0.477
1.66ProVal: 1.66 ± 0.508
0.293ProTrp: 0.293 ± 0.157
1.172ProTyr: 1.172 ± 0.309
0.0ProXaa: 0.0 ± 0.0
Gln
3.124GlnAla: 3.124 ± 0.591
0.293GlnCys: 0.293 ± 0.145
1.562GlnAsp: 1.562 ± 0.371
2.05GlnGlu: 2.05 ± 0.738
1.562GlnPhe: 1.562 ± 0.331
3.027GlnGly: 3.027 ± 0.607
0.683GlnHis: 0.683 ± 0.255
2.831GlnIle: 2.831 ± 0.831
3.613GlnLys: 3.613 ± 0.716
2.636GlnLeu: 2.636 ± 0.532
0.683GlnMet: 0.683 ± 0.186
2.441GlnAsn: 2.441 ± 0.452
0.976GlnPro: 0.976 ± 0.336
1.66GlnGln: 1.66 ± 0.382
1.757GlnArg: 1.757 ± 0.552
3.222GlnSer: 3.222 ± 0.597
2.734GlnThr: 2.734 ± 0.651
2.831GlnVal: 2.831 ± 0.625
0.586GlnTrp: 0.586 ± 0.29
0.879GlnTyr: 0.879 ± 0.331
0.0GlnXaa: 0.0 ± 0.0
Arg
2.539ArgAla: 2.539 ± 0.538
0.195ArgCys: 0.195 ± 0.147
2.343ArgAsp: 2.343 ± 0.468
2.929ArgGlu: 2.929 ± 0.519
1.757ArgPhe: 1.757 ± 0.423
1.562ArgGly: 1.562 ± 0.63
0.586ArgHis: 0.586 ± 0.232
2.734ArgIle: 2.734 ± 0.712
3.222ArgLys: 3.222 ± 0.705
4.491ArgLeu: 4.491 ± 0.741
0.879ArgMet: 0.879 ± 0.284
1.855ArgAsn: 1.855 ± 0.375
0.879ArgPro: 0.879 ± 0.245
1.562ArgGln: 1.562 ± 0.335
2.05ArgArg: 2.05 ± 0.43
1.66ArgSer: 1.66 ± 0.591
2.636ArgThr: 2.636 ± 0.529
2.636ArgVal: 2.636 ± 0.5
0.488ArgTrp: 0.488 ± 0.185
2.05ArgTyr: 2.05 ± 0.438
0.0ArgXaa: 0.0 ± 0.0
Ser
4.979SerAla: 4.979 ± 1.446
0.586SerCys: 0.586 ± 0.218
4.003SerAsp: 4.003 ± 0.508
4.296SerGlu: 4.296 ± 0.672
4.101SerPhe: 4.101 ± 0.682
5.761SerGly: 5.761 ± 0.662
0.391SerHis: 0.391 ± 0.314
4.003SerIle: 4.003 ± 0.703
4.589SerLys: 4.589 ± 0.636
6.346SerLeu: 6.346 ± 0.876
1.074SerMet: 1.074 ± 0.289
3.613SerAsn: 3.613 ± 0.549
1.562SerPro: 1.562 ± 0.376
2.636SerGln: 2.636 ± 0.584
2.343SerArg: 2.343 ± 0.757
4.003SerSer: 4.003 ± 0.745
3.613SerThr: 3.613 ± 0.468
3.515SerVal: 3.515 ± 0.818
0.683SerTrp: 0.683 ± 0.242
2.05SerTyr: 2.05 ± 0.399
0.0SerXaa: 0.0 ± 0.0
Thr
4.784ThrAla: 4.784 ± 0.59
0.098ThrCys: 0.098 ± 0.091
4.198ThrAsp: 4.198 ± 0.503
4.491ThrGlu: 4.491 ± 0.7
2.636ThrPhe: 2.636 ± 0.418
5.858ThrGly: 5.858 ± 1.196
0.586ThrHis: 0.586 ± 0.271
4.101ThrIle: 4.101 ± 0.569
5.565ThrLys: 5.565 ± 0.66
5.761ThrLeu: 5.761 ± 0.85
1.367ThrMet: 1.367 ± 0.302
3.027ThrAsn: 3.027 ± 0.53
1.172ThrPro: 1.172 ± 0.263
2.636ThrGln: 2.636 ± 0.55
1.562ThrArg: 1.562 ± 0.327
3.613ThrSer: 3.613 ± 0.535
3.808ThrThr: 3.808 ± 0.663
4.687ThrVal: 4.687 ± 0.677
0.488ThrTrp: 0.488 ± 0.2
2.05ThrTyr: 2.05 ± 0.456
0.0ThrXaa: 0.0 ± 0.0
Val
4.296ValAla: 4.296 ± 0.708
0.293ValCys: 0.293 ± 0.154
4.784ValAsp: 4.784 ± 0.75
6.542ValGlu: 6.542 ± 1.087
2.343ValPhe: 2.343 ± 0.474
3.417ValGly: 3.417 ± 0.636
0.391ValHis: 0.391 ± 0.177
4.491ValIle: 4.491 ± 0.637
4.784ValLys: 4.784 ± 0.763
4.784ValLeu: 4.784 ± 0.751
1.465ValMet: 1.465 ± 0.357
2.441ValAsn: 2.441 ± 0.538
1.269ValPro: 1.269 ± 0.293
2.148ValGln: 2.148 ± 0.452
2.539ValArg: 2.539 ± 0.546
4.198ValSer: 4.198 ± 0.571
4.979ValThr: 4.979 ± 0.724
4.296ValVal: 4.296 ± 0.607
0.293ValTrp: 0.293 ± 0.174
2.734ValTyr: 2.734 ± 0.617
0.0ValXaa: 0.0 ± 0.0
Trp
0.781TrpAla: 0.781 ± 0.338
0.195TrpCys: 0.195 ± 0.13
0.488TrpAsp: 0.488 ± 0.212
0.976TrpGlu: 0.976 ± 0.298
0.586TrpPhe: 0.586 ± 0.239
1.269TrpGly: 1.269 ± 0.312
0.195TrpHis: 0.195 ± 0.165
0.976TrpIle: 0.976 ± 0.306
0.098TrpLys: 0.098 ± 0.102
0.586TrpLeu: 0.586 ± 0.256
0.293TrpMet: 0.293 ± 0.156
0.488TrpAsn: 0.488 ± 0.238
0.293TrpPro: 0.293 ± 0.158
0.586TrpGln: 0.586 ± 0.214
0.781TrpArg: 0.781 ± 0.277
1.074TrpSer: 1.074 ± 0.356
0.879TrpThr: 0.879 ± 0.324
0.391TrpVal: 0.391 ± 0.202
0.098TrpTrp: 0.098 ± 0.086
0.391TrpTyr: 0.391 ± 0.154
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.124TyrAla: 3.124 ± 0.496
0.488TyrCys: 0.488 ± 0.195
2.148TyrAsp: 2.148 ± 0.418
3.027TyrGlu: 3.027 ± 0.529
1.172TyrPhe: 1.172 ± 0.312
2.343TyrGly: 2.343 ± 0.343
0.683TyrHis: 0.683 ± 0.356
2.441TyrIle: 2.441 ± 0.436
4.198TyrLys: 4.198 ± 0.793
2.636TyrLeu: 2.636 ± 0.447
0.391TyrMet: 0.391 ± 0.234
2.539TyrAsn: 2.539 ± 0.699
1.465TyrPro: 1.465 ± 0.312
1.367TyrGln: 1.367 ± 0.359
1.562TyrArg: 1.562 ± 0.331
1.562TyrSer: 1.562 ± 0.513
1.855TyrThr: 1.855 ± 0.429
2.246TyrVal: 2.246 ± 0.441
0.391TyrTrp: 0.391 ± 0.151
1.367TyrTyr: 1.367 ± 0.374
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 54 proteins (10243 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski