Amino acid dipepetide frequency for Pyrinomonas methylaliphatogenes

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.523AlaAla: 12.523 ± 0.146	1.045AlaCys: 1.045 ± 0.03	4.941AlaAsp: 4.941 ± 0.064	8.129AlaGlu: 8.129 ± 0.108	3.834AlaPhe: 3.834 ± 0.062	7.434AlaGly: 7.434 ± 0.1	2.181AlaHis: 2.181 ± 0.044	6.777AlaIle: 6.777 ± 0.095	3.299AlaLys: 3.299 ± 0.057	12.672AlaLeu: 12.672 ± 0.134	2.21AlaMet: 2.21 ± 0.05	2.794AlaAsn: 2.794 ± 0.062	4.761AlaPro: 4.761 ± 0.079	4.403AlaGln: 4.403 ± 0.076	11.441AlaArg: 11.441 ± 0.119	5.784AlaSer: 5.784 ± 0.084	5.259AlaThr: 5.259 ± 0.078	7.004AlaVal: 7.004 ± 0.092	1.208AlaTrp: 1.208 ± 0.037	2.57AlaTyr: 2.57 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	1.096CysAla: 1.096 ± 0.032	0.146CysCys: 0.146 ± 0.013	0.514CysAsp: 0.514 ± 0.021	0.598CysGlu: 0.598 ± 0.024	0.384CysPhe: 0.384 ± 0.019	1.002CysGly: 1.002 ± 0.037	0.212CysHis: 0.212 ± 0.016	0.371CysIle: 0.371 ± 0.018	0.173CysLys: 0.173 ± 0.012	0.827CysLeu: 0.827 ± 0.029	0.13CysMet: 0.13 ± 0.01	0.202CysAsn: 0.202 ± 0.015	0.455CysPro: 0.455 ± 0.021	0.254CysGln: 0.254 ± 0.015	0.709CysArg: 0.709 ± 0.025	0.457CysSer: 0.457 ± 0.02	0.315CysThr: 0.315 ± 0.017	0.611CysVal: 0.611 ± 0.025	0.129CysTrp: 0.129 ± 0.01	0.257CysTyr: 0.257 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	5.079AspAla: 5.079 ± 0.074	0.447AspCys: 0.447 ± 0.024	2.733AspAsp: 2.733 ± 0.045	4.533AspGlu: 4.533 ± 0.075	2.164AspPhe: 2.164 ± 0.047	4.657AspGly: 4.657 ± 0.089	0.98AspHis: 0.98 ± 0.031	2.244AspIle: 2.244 ± 0.047	1.324AspLys: 1.324 ± 0.037	5.822AspLeu: 5.822 ± 0.067	0.746AspMet: 0.746 ± 0.026	0.985AspAsn: 0.985 ± 0.033	3.294AspPro: 3.294 ± 0.063	1.639AspGln: 1.639 ± 0.047	4.181AspArg: 4.181 ± 0.056	1.884AspSer: 1.884 ± 0.043	1.723AspThr: 1.723 ± 0.043	3.57AspVal: 3.57 ± 0.059	0.904AspTrp: 0.904 ± 0.034	1.642AspTyr: 1.642 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	8.474GluAla: 8.474 ± 0.107	0.441GluCys: 0.441 ± 0.022	3.057GluAsp: 3.057 ± 0.054	5.654GluGlu: 5.654 ± 0.102	2.341GluPhe: 2.341 ± 0.049	4.45GluGly: 4.45 ± 0.064	1.25GluHis: 1.25 ± 0.035	4.711GluIle: 4.711 ± 0.086	2.683GluLys: 2.683 ± 0.061	7.43GluLeu: 7.43 ± 0.096	1.78GluMet: 1.78 ± 0.038	1.759GluAsn: 1.759 ± 0.036	2.669GluPro: 2.669 ± 0.046	2.41GluGln: 2.41 ± 0.052	8.77GluArg: 8.77 ± 0.111	2.974GluSer: 2.974 ± 0.057	3.582GluThr: 3.582 ± 0.052	4.838GluVal: 4.838 ± 0.078	0.85GluTrp: 0.85 ± 0.027	1.701GluTyr: 1.701 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	4.51PheAla: 4.51 ± 0.071	0.399PheCys: 0.399 ± 0.019	2.68PheAsp: 2.68 ± 0.046	2.382PheGlu: 2.382 ± 0.046	1.781PhePhe: 1.781 ± 0.053	3.556PheGly: 3.556 ± 0.063	0.756PheHis: 0.756 ± 0.028	2.275PheIle: 2.275 ± 0.047	1.217PheLys: 1.217 ± 0.033	3.422PheLeu: 3.422 ± 0.064	0.623PheMet: 0.623 ± 0.023	1.481PheAsn: 1.481 ± 0.048	1.633PhePro: 1.633 ± 0.038	1.026PheGln: 1.026 ± 0.033	2.809PheArg: 2.809 ± 0.046	2.293PheSer: 2.293 ± 0.057	2.042PheThr: 2.042 ± 0.044	2.719PheVal: 2.719 ± 0.05	0.514PheTrp: 0.514 ± 0.021	1.285PheTyr: 1.285 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	8.084GlyAla: 8.084 ± 0.087	0.732GlyCys: 0.732 ± 0.025	3.681GlyAsp: 3.681 ± 0.067	5.446GlyGlu: 5.446 ± 0.076	3.121GlyPhe: 3.121 ± 0.061	6.173GlyGly: 6.173 ± 0.094	1.468GlyHis: 1.468 ± 0.035	4.302GlyIle: 4.302 ± 0.06	2.702GlyLys: 2.702 ± 0.056	7.146GlyLeu: 7.146 ± 0.083	1.648GlyMet: 1.648 ± 0.037	1.882GlyAsn: 1.882 ± 0.046	2.76GlyPro: 2.76 ± 0.057	2.554GlyGln: 2.554 ± 0.054	6.885GlyArg: 6.885 ± 0.092	4.045GlySer: 4.045 ± 0.073	4.144GlyThr: 4.144 ± 0.067	5.476GlyVal: 5.476 ± 0.084	1.221GlyTrp: 1.221 ± 0.033	2.339GlyTyr: 2.339 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	1.905HisAla: 1.905 ± 0.039	0.164HisCys: 0.164 ± 0.013	0.91HisAsp: 0.91 ± 0.031	1.256HisGlu: 1.256 ± 0.038	0.767HisPhe: 0.767 ± 0.029	1.518HisGly: 1.518 ± 0.038	0.532HisHis: 0.532 ± 0.022	0.964HisIle: 0.964 ± 0.032	0.476HisLys: 0.476 ± 0.021	2.181HisLeu: 2.181 ± 0.05	0.306HisMet: 0.306 ± 0.017	0.526HisAsn: 0.526 ± 0.022	1.294HisPro: 1.294 ± 0.036	0.58HisGln: 0.58 ± 0.023	1.561HisArg: 1.561 ± 0.036	0.832HisSer: 0.832 ± 0.026	0.88HisThr: 0.88 ± 0.028	1.257HisVal: 1.257 ± 0.035	0.256HisTrp: 0.256 ± 0.017	0.624HisTyr: 0.624 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	7.421IleAla: 7.421 ± 0.087	0.564IleCys: 0.564 ± 0.025	3.093IleAsp: 3.093 ± 0.055	5.299IleGlu: 5.299 ± 0.081	2.483IlePhe: 2.483 ± 0.052	4.865IleGly: 4.865 ± 0.072	0.934IleHis: 0.934 ± 0.03	3.687IleIle: 3.687 ± 0.069	2.003IleLys: 2.003 ± 0.046	4.52IleLeu: 4.52 ± 0.078	0.855IleMet: 0.855 ± 0.025	1.982IleAsn: 1.982 ± 0.055	2.637IlePro: 2.637 ± 0.047	1.28IleGln: 1.28 ± 0.036	3.794IleArg: 3.794 ± 0.06	3.271IleSer: 3.271 ± 0.054	2.941IleThr: 2.941 ± 0.057	4.752IleVal: 4.752 ± 0.074	0.586IleTrp: 0.586 ± 0.024	1.743IleTyr: 1.743 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	2.873LysAla: 2.873 ± 0.059	0.208LysCys: 0.208 ± 0.015	1.483LysAsp: 1.483 ± 0.042	2.179LysGlu: 2.179 ± 0.052	0.94LysPhe: 0.94 ± 0.032	2.167LysGly: 2.167 ± 0.045	0.582LysHis: 0.582 ± 0.026	2.079LysIle: 2.079 ± 0.047	1.193LysLys: 1.193 ± 0.042	3.544LysLeu: 3.544 ± 0.065	0.755LysMet: 0.755 ± 0.028	0.903LysAsn: 0.903 ± 0.03	1.519LysPro: 1.519 ± 0.039	1.05LysGln: 1.05 ± 0.035	3.457LysArg: 3.457 ± 0.065	1.484LysSer: 1.484 ± 0.036	1.579LysThr: 1.579 ± 0.039	2.19LysVal: 2.19 ± 0.047	0.312LysTrp: 0.312 ± 0.018	0.829LysTyr: 0.829 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	12.034LeuAla: 12.034 ± 0.12	1.048LeuCys: 1.048 ± 0.031	5.469LeuAsp: 5.469 ± 0.082	6.49LeuGlu: 6.49 ± 0.095	4.068LeuPhe: 4.068 ± 0.066	7.173LeuGly: 7.173 ± 0.092	1.804LeuHis: 1.804 ± 0.043	6.292LeuIle: 6.292 ± 0.081	3.329LeuLys: 3.329 ± 0.064	10.627LeuLeu: 10.627 ± 0.133	1.798LeuMet: 1.798 ± 0.041	2.928LeuAsn: 2.928 ± 0.062	5.291LeuPro: 5.291 ± 0.071	3.036LeuGln: 3.036 ± 0.062	9.546LeuArg: 9.546 ± 0.118	6.066LeuSer: 6.066 ± 0.087	5.146LeuThr: 5.146 ± 0.067	6.752LeuVal: 6.752 ± 0.091	1.23LeuTrp: 1.23 ± 0.039	2.456LeuTyr: 2.456 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	1.97MetAla: 1.97 ± 0.048	0.151MetCys: 0.151 ± 0.013	0.767MetAsp: 0.767 ± 0.028	1.083MetGlu: 1.083 ± 0.033	0.53MetPhe: 0.53 ± 0.022	1.384MetGly: 1.384 ± 0.038	0.298MetHis: 0.298 ± 0.016	1.222MetIle: 1.222 ± 0.033	0.869MetLys: 0.869 ± 0.028	1.992MetLeu: 1.992 ± 0.042	0.456MetMet: 0.456 ± 0.02	0.668MetAsn: 0.668 ± 0.023	0.927MetPro: 0.927 ± 0.03	0.605MetGln: 0.605 ± 0.025	2.234MetArg: 2.234 ± 0.042	1.24MetSer: 1.24 ± 0.037	1.126MetThr: 1.126 ± 0.034	1.206MetVal: 1.206 ± 0.034	0.164MetTrp: 0.164 ± 0.011	0.262MetTyr: 0.262 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.93AsnAla: 2.93 ± 0.065	0.267AsnCys: 0.267 ± 0.016	1.404AsnAsp: 1.404 ± 0.041	1.772AsnGlu: 1.772 ± 0.038	1.284AsnPhe: 1.284 ± 0.046	2.412AsnGly: 2.412 ± 0.055	0.46AsnHis: 0.46 ± 0.018	1.5AsnIle: 1.5 ± 0.039	0.745AsnLys: 0.745 ± 0.03	3.099AsnLeu: 3.099 ± 0.064	0.483AsnMet: 0.483 ± 0.021	0.909AsnAsn: 0.909 ± 0.043	1.937AsnPro: 1.937 ± 0.052	0.89AsnGln: 0.89 ± 0.035	2.308AsnArg: 2.308 ± 0.053	1.363AsnSer: 1.363 ± 0.036	1.18AsnThr: 1.18 ± 0.038	2.178AsnVal: 2.178 ± 0.047	0.374AsnTrp: 0.374 ± 0.017	0.971AsnTyr: 0.971 ± 0.035	0.0AsnXaa: 0.0 ± 0.0
Pro	4.278ProAla: 4.278 ± 0.067	0.373ProCys: 0.373 ± 0.019	2.888ProAsp: 2.888 ± 0.058	3.859ProGlu: 3.859 ± 0.067	2.132ProPhe: 2.132 ± 0.046	3.37ProGly: 3.37 ± 0.064	1.045ProHis: 1.045 ± 0.03	2.622ProIle: 2.622 ± 0.056	1.488ProLys: 1.488 ± 0.037	4.688ProLeu: 4.688 ± 0.06	0.826ProMet: 0.826 ± 0.025	1.709ProAsn: 1.709 ± 0.047	2.624ProPro: 2.624 ± 0.061	1.976ProGln: 1.976 ± 0.046	3.513ProArg: 3.513 ± 0.067	2.767ProSer: 2.767 ± 0.049	2.694ProThr: 2.694 ± 0.056	3.568ProVal: 3.568 ± 0.068	0.49ProTrp: 0.49 ± 0.021	1.361ProTyr: 1.361 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	3.638GlnAla: 3.638 ± 0.071	0.188GlnCys: 0.188 ± 0.012	1.182GlnAsp: 1.182 ± 0.031	1.826GlnGlu: 1.826 ± 0.046	1.12GlnPhe: 1.12 ± 0.032	2.067GlnGly: 2.067 ± 0.042	0.574GlnHis: 0.574 ± 0.024	2.275GlnIle: 2.275 ± 0.045	1.169GlnLys: 1.169 ± 0.036	3.421GlnLeu: 3.421 ± 0.061	0.821GlnMet: 0.821 ± 0.03	0.941GlnAsn: 0.941 ± 0.031	1.671GlnPro: 1.671 ± 0.043	1.337GlnGln: 1.337 ± 0.043	3.278GlnArg: 3.278 ± 0.06	1.654GlnSer: 1.654 ± 0.04	2.091GlnThr: 2.091 ± 0.047	2.103GlnVal: 2.103 ± 0.05	0.342GlnTrp: 0.342 ± 0.018	0.774GlnTyr: 0.774 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	11.311ArgAla: 11.311 ± 0.12	0.718ArgCys: 0.718 ± 0.027	4.571ArgAsp: 4.571 ± 0.07	6.993ArgGlu: 6.993 ± 0.08	3.879ArgPhe: 3.879 ± 0.066	5.979ArgGly: 5.979 ± 0.079	1.718ArgHis: 1.718 ± 0.042	5.18ArgIle: 5.18 ± 0.063	2.446ArgLys: 2.446 ± 0.052	9.772ArgLeu: 9.772 ± 0.107	1.88ArgMet: 1.88 ± 0.037	2.386ArgAsn: 2.386 ± 0.046	3.682ArgPro: 3.682 ± 0.058	2.95ArgGln: 2.95 ± 0.059	8.78ArgArg: 8.78 ± 0.118	4.537ArgSer: 4.537 ± 0.066	4.184ArgThr: 4.184 ± 0.06	6.372ArgVal: 6.372 ± 0.086	1.204ArgTrp: 1.204 ± 0.034	2.633ArgTyr: 2.633 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	5.534SerAla: 5.534 ± 0.075	0.474SerCys: 0.474 ± 0.021	2.791SerAsp: 2.791 ± 0.051	3.234SerGlu: 3.234 ± 0.054	2.556SerPhe: 2.556 ± 0.054	4.626SerGly: 4.626 ± 0.074	0.918SerHis: 0.918 ± 0.027	2.765SerIle: 2.765 ± 0.052	1.449SerLys: 1.449 ± 0.036	5.788SerLeu: 5.788 ± 0.078	0.919SerMet: 0.919 ± 0.03	1.571SerAsn: 1.571 ± 0.041	2.884SerPro: 2.884 ± 0.06	1.464SerGln: 1.464 ± 0.042	3.732SerArg: 3.732 ± 0.056	3.431SerSer: 3.431 ± 0.067	2.51SerThr: 2.51 ± 0.051	3.73SerVal: 3.73 ± 0.06	0.682SerTrp: 0.682 ± 0.026	1.548SerTyr: 1.548 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	4.909ThrAla: 4.909 ± 0.07	0.391ThrCys: 0.391 ± 0.019	2.671ThrAsp: 2.671 ± 0.052	3.063ThrGlu: 3.063 ± 0.053	1.97ThrPhe: 1.97 ± 0.054	4.581ThrGly: 4.581 ± 0.068	0.979ThrHis: 0.979 ± 0.026	3.161ThrIle: 3.161 ± 0.057	1.409ThrLys: 1.409 ± 0.034	5.295ThrLeu: 5.295 ± 0.074	0.829ThrMet: 0.829 ± 0.029	1.514ThrAsn: 1.514 ± 0.045	3.022ThrPro: 3.022 ± 0.055	1.395ThrGln: 1.395 ± 0.041	3.633ThrArg: 3.633 ± 0.062	2.714ThrSer: 2.714 ± 0.06	2.59ThrThr: 2.59 ± 0.06	3.957ThrVal: 3.957 ± 0.066	0.538ThrTrp: 0.538 ± 0.023	1.283ThrTyr: 1.283 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	7.773ValAla: 7.773 ± 0.093	0.719ValCys: 0.719 ± 0.023	3.396ValAsp: 3.396 ± 0.053	5.467ValGlu: 5.467 ± 0.086	2.418ValPhe: 2.418 ± 0.056	5.24ValGly: 5.24 ± 0.082	1.209ValHis: 1.209 ± 0.034	4.385ValIle: 4.385 ± 0.067	2.216ValLys: 2.216 ± 0.046	6.155ValLeu: 6.155 ± 0.08	1.396ValMet: 1.396 ± 0.039	2.113ValAsn: 2.113 ± 0.051	3.426ValPro: 3.426 ± 0.064	2.136ValGln: 2.136 ± 0.049	6.545ValArg: 6.545 ± 0.08	3.797ValSer: 3.797 ± 0.054	3.817ValThr: 3.817 ± 0.066	5.113ValVal: 5.113 ± 0.068	0.823ValTrp: 0.823 ± 0.03	1.861ValTyr: 1.861 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	1.093TrpAla: 1.093 ± 0.031	0.105TrpCys: 0.105 ± 0.01	0.565TrpAsp: 0.565 ± 0.026	0.709TrpGlu: 0.709 ± 0.028	0.468TrpPhe: 0.468 ± 0.023	0.817TrpGly: 0.817 ± 0.027	0.285TrpHis: 0.285 ± 0.017	0.634TrpIle: 0.634 ± 0.03	0.386TrpLys: 0.386 ± 0.019	1.337TrpLeu: 1.337 ± 0.04	0.289TrpMet: 0.289 ± 0.017	0.367TrpAsn: 0.367 ± 0.02	0.537TrpPro: 0.537 ± 0.021	0.602TrpGln: 0.602 ± 0.023	1.487TrpArg: 1.487 ± 0.04	0.697TrpSer: 0.697 ± 0.027	0.78TrpThr: 0.78 ± 0.028	0.697TrpVal: 0.697 ± 0.021	0.251TrpTrp: 0.251 ± 0.018	0.351TrpTyr: 0.351 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.833TyrAla: 2.833 ± 0.052	0.263TyrCys: 0.263 ± 0.019	1.755TyrAsp: 1.755 ± 0.059	1.853TyrGlu: 1.853 ± 0.039	1.162TyrPhe: 1.162 ± 0.03	2.334TyrGly: 2.334 ± 0.05	0.605TyrHis: 0.605 ± 0.025	1.264TyrIle: 1.264 ± 0.033	0.747TyrLys: 0.747 ± 0.032	2.847TyrLeu: 2.847 ± 0.054	0.404TyrMet: 0.404 ± 0.019	0.844TyrAsn: 0.844 ± 0.03	1.247TyrPro: 1.247 ± 0.031	0.888TyrGln: 0.888 ± 0.031	2.512TyrArg: 2.512 ± 0.045	1.318TyrSer: 1.318 ± 0.034	1.321TyrThr: 1.321 ± 0.04	1.912TyrVal: 1.912 ± 0.045	0.378TyrTrp: 0.378 ± 0.018	0.906TyrTyr: 0.906 ± 0.035	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3179 proteins (1112582 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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