Amino acid dipepetide frequency for Sporosarcina pasteurii (Bacillus pasteurii)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.05AlaAla: 6.05 ± 0.097	0.633AlaCys: 0.633 ± 0.029	3.721AlaAsp: 3.721 ± 0.076	5.356AlaGlu: 5.356 ± 0.091	3.575AlaPhe: 3.575 ± 0.072	5.644AlaGly: 5.644 ± 0.097	1.462AlaHis: 1.462 ± 0.038	6.758AlaIle: 6.758 ± 0.096	4.564AlaLys: 4.564 ± 0.075	7.65AlaLeu: 7.65 ± 0.099	2.265AlaMet: 2.265 ± 0.053	2.938AlaAsn: 2.938 ± 0.057	2.18AlaPro: 2.18 ± 0.044	2.294AlaGln: 2.294 ± 0.054	2.97AlaArg: 2.97 ± 0.059	4.267AlaSer: 4.267 ± 0.072	4.114AlaThr: 4.114 ± 0.062	5.753AlaVal: 5.753 ± 0.104	0.632AlaTrp: 0.632 ± 0.027	2.535AlaTyr: 2.535 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	0.453CysAla: 0.453 ± 0.025	0.066CysCys: 0.066 ± 0.009	0.372CysAsp: 0.372 ± 0.02	0.439CysGlu: 0.439 ± 0.022	0.282CysPhe: 0.282 ± 0.02	0.678CysGly: 0.678 ± 0.028	0.177CysHis: 0.177 ± 0.014	0.474CysIle: 0.474 ± 0.024	0.302CysLys: 0.302 ± 0.026	0.54CysLeu: 0.54 ± 0.03	0.165CysMet: 0.165 ± 0.013	0.254CysAsn: 0.254 ± 0.018	0.354CysPro: 0.354 ± 0.021	0.205CysGln: 0.205 ± 0.017	0.271CysArg: 0.271 ± 0.018	0.455CysSer: 0.455 ± 0.027	0.382CysThr: 0.382 ± 0.02	0.39CysVal: 0.39 ± 0.02	0.059CysTrp: 0.059 ± 0.008	0.203CysTyr: 0.203 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	3.848AspAla: 3.848 ± 0.07	0.355AspCys: 0.355 ± 0.024	2.615AspAsp: 2.615 ± 0.058	4.999AspGlu: 4.999 ± 0.085	2.383AspPhe: 2.383 ± 0.048	3.642AspGly: 3.642 ± 0.07	1.088AspHis: 1.088 ± 0.035	4.148AspIle: 4.148 ± 0.072	2.956AspLys: 2.956 ± 0.056	4.677AspLeu: 4.677 ± 0.082	1.449AspMet: 1.449 ± 0.043	1.788AspAsn: 1.788 ± 0.044	1.854AspPro: 1.854 ± 0.046	1.504AspGln: 1.504 ± 0.045	2.186AspArg: 2.186 ± 0.045	2.445AspSer: 2.445 ± 0.062	2.393AspThr: 2.393 ± 0.052	4.247AspVal: 4.247 ± 0.075	0.6AspTrp: 0.6 ± 0.029	2.021AspTyr: 2.021 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	6.143GluAla: 6.143 ± 0.098	0.36GluCys: 0.36 ± 0.026	4.021GluAsp: 4.021 ± 0.074	7.724GluGlu: 7.724 ± 0.131	2.567GluPhe: 2.567 ± 0.055	4.587GluGly: 4.587 ± 0.073	1.573GluHis: 1.573 ± 0.037	5.698GluIle: 5.698 ± 0.083	6.429GluLys: 6.429 ± 0.088	7.179GluLeu: 7.179 ± 0.104	2.49GluMet: 2.49 ± 0.052	3.65GluAsn: 3.65 ± 0.059	2.123GluPro: 2.123 ± 0.041	3.577GluGln: 3.577 ± 0.083	3.93GluArg: 3.93 ± 0.075	3.698GluSer: 3.698 ± 0.072	4.131GluThr: 4.131 ± 0.066	5.499GluVal: 5.499 ± 0.086	0.815GluTrp: 0.815 ± 0.03	1.962GluTyr: 1.962 ± 0.045	0.0GluXaa: 0.0 ± 0.0
Phe	3.219PheAla: 3.219 ± 0.062	0.277PheCys: 0.277 ± 0.02	2.431PheAsp: 2.431 ± 0.05	2.984PheGlu: 2.984 ± 0.057	2.341PhePhe: 2.341 ± 0.064	3.552PheGly: 3.552 ± 0.069	0.991PheHis: 0.991 ± 0.03	4.104PheIle: 4.104 ± 0.089	2.279PheLys: 2.279 ± 0.048	4.279PheLeu: 4.279 ± 0.074	1.231PheMet: 1.231 ± 0.037	1.856PheAsn: 1.856 ± 0.044	1.669PhePro: 1.669 ± 0.045	1.422PheGln: 1.422 ± 0.039	1.555PheArg: 1.555 ± 0.041	3.044PheSer: 3.044 ± 0.063	2.839PheThr: 2.839 ± 0.062	3.219PheVal: 3.219 ± 0.063	0.486PheTrp: 0.486 ± 0.024	1.535PheTyr: 1.535 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	5.423GlyAla: 5.423 ± 0.094	0.544GlyCys: 0.544 ± 0.025	3.411GlyAsp: 3.411 ± 0.058	4.709GlyGlu: 4.709 ± 0.074	3.45GlyPhe: 3.45 ± 0.065	5.014GlyGly: 5.014 ± 0.084	1.488GlyHis: 1.488 ± 0.041	6.184GlyIle: 6.184 ± 0.091	4.79GlyLys: 4.79 ± 0.075	6.685GlyLeu: 6.685 ± 0.091	2.228GlyMet: 2.228 ± 0.046	2.715GlyAsn: 2.715 ± 0.057	1.938GlyPro: 1.938 ± 0.052	2.261GlyGln: 2.261 ± 0.05	2.87GlyArg: 2.87 ± 0.061	3.824GlySer: 3.824 ± 0.074	4.265GlyThr: 4.265 ± 0.076	5.3GlyVal: 5.3 ± 0.083	0.765GlyTrp: 0.765 ± 0.033	2.637GlyTyr: 2.637 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	1.538HisAla: 1.538 ± 0.04	0.203HisCys: 0.203 ± 0.023	1.071HisAsp: 1.071 ± 0.034	1.502HisGlu: 1.502 ± 0.038	0.996HisPhe: 0.996 ± 0.033	1.496HisGly: 1.496 ± 0.043	0.674HisHis: 0.674 ± 0.03	1.546HisIle: 1.546 ± 0.043	0.958HisLys: 0.958 ± 0.034	2.12HisLeu: 2.12 ± 0.051	0.532HisMet: 0.532 ± 0.021	0.73HisAsn: 0.73 ± 0.028	1.121HisPro: 1.121 ± 0.035	0.77HisGln: 0.77 ± 0.031	0.929HisArg: 0.929 ± 0.03	1.2HisSer: 1.2 ± 0.037	1.127HisThr: 1.127 ± 0.031	1.499HisVal: 1.499 ± 0.042	0.204HisTrp: 0.204 ± 0.014	0.821HisTyr: 0.821 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	6.804IleAla: 6.804 ± 0.103	0.558IleCys: 0.558 ± 0.026	4.596IleAsp: 4.596 ± 0.068	6.402IleGlu: 6.402 ± 0.099	3.257IlePhe: 3.257 ± 0.075	6.57IleGly: 6.57 ± 0.096	1.801IleHis: 1.801 ± 0.047	6.165IleIle: 6.165 ± 0.094	3.661IleLys: 3.661 ± 0.061	7.056IleLeu: 7.056 ± 0.112	1.921IleMet: 1.921 ± 0.052	2.844IleAsn: 2.844 ± 0.052	3.578IlePro: 3.578 ± 0.062	3.053IleGln: 3.053 ± 0.061	3.224IleArg: 3.224 ± 0.066	4.746IleSer: 4.746 ± 0.071	4.332IleThr: 4.332 ± 0.067	6.216IleVal: 6.216 ± 0.092	0.658IleTrp: 0.658 ± 0.031	2.358IleTyr: 2.358 ± 0.05	0.0IleXaa: 0.0 ± 0.0
Lys	4.233LysAla: 4.233 ± 0.067	0.305LysCys: 0.305 ± 0.02	3.273LysAsp: 3.273 ± 0.062	6.087LysGlu: 6.087 ± 0.106	1.907LysPhe: 1.907 ± 0.048	3.897LysGly: 3.897 ± 0.065	1.165LysHis: 1.165 ± 0.036	4.356LysIle: 4.356 ± 0.063	4.868LysLys: 4.868 ± 0.089	5.52LysLeu: 5.52 ± 0.087	2.254LysMet: 2.254 ± 0.044	2.977LysAsn: 2.977 ± 0.063	1.987LysPro: 1.987 ± 0.046	2.437LysGln: 2.437 ± 0.061	3.193LysArg: 3.193 ± 0.057	3.375LysSer: 3.375 ± 0.066	3.393LysThr: 3.393 ± 0.056	4.389LysVal: 4.389 ± 0.078	0.747LysTrp: 0.747 ± 0.03	1.936LysTyr: 1.936 ± 0.049	0.0LysXaa: 0.0 ± 0.0
Leu	7.654LeuAla: 7.654 ± 0.095	0.553LeuCys: 0.553 ± 0.026	4.611LeuAsp: 4.611 ± 0.083	6.489LeuGlu: 6.489 ± 0.086	4.825LeuPhe: 4.825 ± 0.086	6.469LeuGly: 6.469 ± 0.1	1.961LeuHis: 1.961 ± 0.052	7.269LeuIle: 7.269 ± 0.116	5.716LeuLys: 5.716 ± 0.08	9.977LeuLeu: 9.977 ± 0.15	2.563LeuMet: 2.563 ± 0.054	4.008LeuAsn: 4.008 ± 0.08	3.982LeuPro: 3.982 ± 0.063	3.556LeuGln: 3.556 ± 0.071	3.734LeuArg: 3.734 ± 0.073	6.449LeuSer: 6.449 ± 0.087	5.838LeuThr: 5.838 ± 0.076	6.332LeuVal: 6.332 ± 0.093	0.797LeuTrp: 0.797 ± 0.029	2.916LeuTyr: 2.916 ± 0.061	0.0LeuXaa: 0.0 ± 0.0
Met	2.071MetAla: 2.071 ± 0.05	0.128MetCys: 0.128 ± 0.011	1.47MetAsp: 1.47 ± 0.043	2.059MetGlu: 2.059 ± 0.053	1.135MetPhe: 1.135 ± 0.043	1.856MetGly: 1.856 ± 0.045	0.522MetHis: 0.522 ± 0.022	2.303MetIle: 2.303 ± 0.052	2.43MetLys: 2.43 ± 0.05	2.658MetLeu: 2.658 ± 0.058	1.021MetMet: 1.021 ± 0.039	1.618MetAsn: 1.618 ± 0.037	1.144MetPro: 1.144 ± 0.036	0.978MetGln: 0.978 ± 0.035	1.29MetArg: 1.29 ± 0.035	1.733MetSer: 1.733 ± 0.046	2.07MetThr: 2.07 ± 0.042	1.701MetVal: 1.701 ± 0.047	0.195MetTrp: 0.195 ± 0.014	0.745MetTyr: 0.745 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	3.033AsnAla: 3.033 ± 0.059	0.296AsnCys: 0.296 ± 0.018	2.244AsnAsp: 2.244 ± 0.049	3.602AsnGlu: 3.602 ± 0.072	1.617AsnPhe: 1.617 ± 0.047	3.149AsnGly: 3.149 ± 0.071	1.042AsnHis: 1.042 ± 0.033	3.185AsnIle: 3.185 ± 0.06	2.513AsnLys: 2.513 ± 0.057	3.626AsnLeu: 3.626 ± 0.066	1.187AsnMet: 1.187 ± 0.04	1.725AsnAsn: 1.725 ± 0.051	2.069AsnPro: 2.069 ± 0.052	1.59AsnGln: 1.59 ± 0.047	2.08AsnArg: 2.08 ± 0.05	1.982AsnSer: 1.982 ± 0.051	2.07AsnThr: 2.07 ± 0.046	2.971AsnVal: 2.971 ± 0.057	0.472AsnTrp: 0.472 ± 0.024	1.401AsnTyr: 1.401 ± 0.038	0.0AsnXaa: 0.0 ± 0.0
Pro	2.505ProAla: 2.505 ± 0.06	0.207ProCys: 0.207 ± 0.015	1.885ProAsp: 1.885 ± 0.047	3.105ProGlu: 3.105 ± 0.059	2.005ProPhe: 2.005 ± 0.046	2.403ProGly: 2.403 ± 0.055	0.859ProHis: 0.859 ± 0.028	3.132ProIle: 3.132 ± 0.058	2.079ProLys: 2.079 ± 0.044	3.516ProLeu: 3.516 ± 0.062	0.952ProMet: 0.952 ± 0.034	1.683ProAsn: 1.683 ± 0.044	0.996ProPro: 0.996 ± 0.036	1.048ProGln: 1.048 ± 0.038	1.119ProArg: 1.119 ± 0.04	2.215ProSer: 2.215 ± 0.049	2.146ProThr: 2.146 ± 0.051	2.98ProVal: 2.98 ± 0.061	0.333ProTrp: 0.333 ± 0.02	1.343ProTyr: 1.343 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	2.793GlnAla: 2.793 ± 0.05	0.185GlnCys: 0.185 ± 0.016	1.541GlnAsp: 1.541 ± 0.043	2.744GlnGlu: 2.744 ± 0.055	1.671GlnPhe: 1.671 ± 0.044	1.87GlnGly: 1.87 ± 0.047	0.717GlnHis: 0.717 ± 0.03	2.416GlnIle: 2.416 ± 0.047	2.367GlnLys: 2.367 ± 0.057	3.795GlnLeu: 3.795 ± 0.065	1.073GlnMet: 1.073 ± 0.033	1.489GlnAsn: 1.489 ± 0.04	1.216GlnPro: 1.216 ± 0.035	1.651GlnGln: 1.651 ± 0.053	1.466GlnArg: 1.466 ± 0.041	2.123GlnSer: 2.123 ± 0.053	2.015GlnThr: 2.015 ± 0.047	2.335GlnVal: 2.335 ± 0.05	0.363GlnTrp: 0.363 ± 0.024	1.218GlnTyr: 1.218 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	2.807ArgAla: 2.807 ± 0.057	0.263ArgCys: 0.263 ± 0.018	2.109ArgAsp: 2.109 ± 0.053	3.353ArgGlu: 3.353 ± 0.061	1.984ArgPhe: 1.984 ± 0.043	2.55ArgGly: 2.55 ± 0.06	0.855ArgHis: 0.855 ± 0.027	3.152ArgIle: 3.152 ± 0.065	3.151ArgLys: 3.151 ± 0.068	4.121ArgLeu: 4.121 ± 0.07	1.384ArgMet: 1.384 ± 0.041	1.945ArgAsn: 1.945 ± 0.047	1.454ArgPro: 1.454 ± 0.041	1.713ArgGln: 1.713 ± 0.054	2.127ArgArg: 2.127 ± 0.059	2.245ArgSer: 2.245 ± 0.052	2.363ArgThr: 2.363 ± 0.057	2.853ArgVal: 2.853 ± 0.053	0.392ArgTrp: 0.392 ± 0.023	1.392ArgTyr: 1.392 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	3.977SerAla: 3.977 ± 0.075	0.373SerCys: 0.373 ± 0.02	2.666SerAsp: 2.666 ± 0.055	3.909SerGlu: 3.909 ± 0.071	3.221SerPhe: 3.221 ± 0.061	4.449SerGly: 4.449 ± 0.068	1.149SerHis: 1.149 ± 0.04	5.102SerIle: 5.102 ± 0.085	3.294SerLys: 3.294 ± 0.065	5.726SerLeu: 5.726 ± 0.08	1.718SerMet: 1.718 ± 0.045	2.298SerAsn: 2.298 ± 0.05	2.111SerPro: 2.111 ± 0.052	1.684SerGln: 1.684 ± 0.042	2.374SerArg: 2.374 ± 0.05	3.562SerSer: 3.562 ± 0.068	3.256SerThr: 3.256 ± 0.061	4.156SerVal: 4.156 ± 0.067	0.573SerTrp: 0.573 ± 0.026	1.965SerTyr: 1.965 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	4.431ThrAla: 4.431 ± 0.066	0.351ThrCys: 0.351 ± 0.02	2.932ThrAsp: 2.932 ± 0.057	3.959ThrGlu: 3.959 ± 0.066	2.767ThrPhe: 2.767 ± 0.058	4.496ThrGly: 4.496 ± 0.066	1.17ThrHis: 1.17 ± 0.034	4.878ThrIle: 4.878 ± 0.075	3.261ThrLys: 3.261 ± 0.059	5.301ThrLeu: 5.301 ± 0.082	1.549ThrMet: 1.549 ± 0.049	2.432ThrAsn: 2.432 ± 0.048	2.325ThrPro: 2.325 ± 0.052	1.346ThrGln: 1.346 ± 0.034	1.975ThrArg: 1.975 ± 0.048	3.271ThrSer: 3.271 ± 0.059	3.213ThrThr: 3.213 ± 0.064	4.662ThrVal: 4.662 ± 0.067	0.497ThrTrp: 0.497 ± 0.024	1.984ThrTyr: 1.984 ± 0.051	0.0ThrXaa: 0.0 ± 0.0
Val	5.436ValAla: 5.436 ± 0.093	0.531ValCys: 0.531 ± 0.026	3.86ValAsp: 3.86 ± 0.076	5.449ValGlu: 5.449 ± 0.097	3.204ValPhe: 3.204 ± 0.068	5.022ValGly: 5.022 ± 0.075	1.426ValHis: 1.426 ± 0.037	5.839ValIle: 5.839 ± 0.085	4.273ValLys: 4.273 ± 0.063	7.048ValLeu: 7.048 ± 0.084	1.993ValMet: 1.993 ± 0.051	3.157ValAsn: 3.157 ± 0.068	2.814ValPro: 2.814 ± 0.061	2.493ValGln: 2.493 ± 0.049	2.922ValArg: 2.922 ± 0.055	4.452ValSer: 4.452 ± 0.069	4.457ValThr: 4.457 ± 0.074	5.303ValVal: 5.303 ± 0.075	0.596ValTrp: 0.596 ± 0.026	2.253ValTyr: 2.253 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	0.633TrpAla: 0.633 ± 0.024	0.075TrpCys: 0.075 ± 0.013	0.511TrpAsp: 0.511 ± 0.024	0.605TrpGlu: 0.605 ± 0.028	0.469TrpPhe: 0.469 ± 0.025	0.674TrpGly: 0.674 ± 0.032	0.223TrpHis: 0.223 ± 0.015	0.795TrpIle: 0.795 ± 0.026	0.636TrpLys: 0.636 ± 0.028	1.074TrpLeu: 1.074 ± 0.04	0.317TrpMet: 0.317 ± 0.019	0.464TrpAsn: 0.464 ± 0.022	0.268TrpPro: 0.268 ± 0.018	0.336TrpGln: 0.336 ± 0.021	0.442TrpArg: 0.442 ± 0.022	0.572TrpSer: 0.572 ± 0.026	0.547TrpThr: 0.547 ± 0.024	0.585TrpVal: 0.585 ± 0.028	0.12TrpTrp: 0.12 ± 0.013	0.306TrpTyr: 0.306 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.31TyrAla: 2.31 ± 0.045	0.254TyrCys: 0.254 ± 0.016	1.857TyrAsp: 1.857 ± 0.048	2.678TyrGlu: 2.678 ± 0.06	1.655TyrPhe: 1.655 ± 0.045	2.488TyrGly: 2.488 ± 0.049	0.697TyrHis: 0.697 ± 0.027	2.295TyrIle: 2.295 ± 0.056	1.773TyrLys: 1.773 ± 0.051	3.149TyrLeu: 3.149 ± 0.057	0.834TyrMet: 0.834 ± 0.032	1.285TyrAsn: 1.285 ± 0.039	1.331TyrPro: 1.331 ± 0.038	1.132TyrGln: 1.132 ± 0.042	1.557TyrArg: 1.557 ± 0.045	1.901TyrSer: 1.901 ± 0.046	1.85TyrThr: 1.85 ± 0.049	2.139TyrVal: 2.139 ± 0.045	0.347TyrTrp: 0.347 ± 0.02	1.292TyrTyr: 1.292 ± 0.041	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3142 proteins (927722 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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