Amino acid dipepetide frequency for Vibrio phage pVp-1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.163AlaAla: 6.163 ± 0.664
0.853AlaCys: 0.853 ± 0.179
4.456AlaAsp: 4.456 ± 0.397
5.847AlaGlu: 5.847 ± 0.462
2.813AlaPhe: 2.813 ± 0.322
4.741AlaGly: 4.741 ± 0.441
1.011AlaHis: 1.011 ± 0.215
4.425AlaIle: 4.425 ± 0.4
7.238AlaLys: 7.238 ± 0.57
6.511AlaLeu: 6.511 ± 0.483
2.118AlaMet: 2.118 ± 0.254
3.887AlaAsn: 3.887 ± 0.489
2.592AlaPro: 2.592 ± 0.336
3.066AlaGln: 3.066 ± 0.247
3.003AlaArg: 3.003 ± 0.299
5.025AlaSer: 5.025 ± 0.381
4.836AlaThr: 4.836 ± 0.424
3.887AlaVal: 3.887 ± 0.291
1.011AlaTrp: 1.011 ± 0.167
2.623AlaTyr: 2.623 ± 0.245
0.0AlaXaa: 0.0 ± 0.0
Cys
0.822CysAla: 0.822 ± 0.16
0.063CysCys: 0.063 ± 0.05
0.79CysAsp: 0.79 ± 0.164
0.759CysGlu: 0.759 ± 0.148
0.253CysPhe: 0.253 ± 0.095
0.695CysGly: 0.695 ± 0.167
0.158CysHis: 0.158 ± 0.085
0.601CysIle: 0.601 ± 0.125
1.011CysLys: 1.011 ± 0.188
0.853CysLeu: 0.853 ± 0.182
0.348CysMet: 0.348 ± 0.099
0.601CysAsn: 0.601 ± 0.143
0.632CysPro: 0.632 ± 0.206
0.632CysGln: 0.632 ± 0.116
0.506CysArg: 0.506 ± 0.127
0.727CysSer: 0.727 ± 0.19
1.043CysThr: 1.043 ± 0.179
0.885CysVal: 0.885 ± 0.171
0.095CysTrp: 0.095 ± 0.053
0.569CysTyr: 0.569 ± 0.138
0.0CysXaa: 0.0 ± 0.0
Asp
4.962AspAla: 4.962 ± 0.402
0.695AspCys: 0.695 ± 0.134
3.54AspAsp: 3.54 ± 0.34
4.425AspGlu: 4.425 ± 0.388
2.75AspPhe: 2.75 ± 0.308
4.488AspGly: 4.488 ± 0.504
0.885AspHis: 0.885 ± 0.162
5.183AspIle: 5.183 ± 0.335
4.899AspLys: 4.899 ± 0.45
5.215AspLeu: 5.215 ± 0.378
1.928AspMet: 1.928 ± 0.248
3.54AspAsn: 3.54 ± 0.375
2.497AspPro: 2.497 ± 0.291
1.58AspGln: 1.58 ± 0.254
2.623AspArg: 2.623 ± 0.315
3.635AspSer: 3.635 ± 0.328
3.635AspThr: 3.635 ± 0.415
3.951AspVal: 3.951 ± 0.305
0.948AspTrp: 0.948 ± 0.15
2.465AspTyr: 2.465 ± 0.309
0.0AspXaa: 0.0 ± 0.0
Glu
5.815GluAla: 5.815 ± 0.508
0.822GluCys: 0.822 ± 0.157
4.298GluAsp: 4.298 ± 0.26
4.678GluGlu: 4.678 ± 0.457
2.718GluPhe: 2.718 ± 0.256
4.172GluGly: 4.172 ± 0.345
1.169GluHis: 1.169 ± 0.191
4.614GluIle: 4.614 ± 0.363
5.405GluLys: 5.405 ± 0.496
7.269GluLeu: 7.269 ± 0.606
1.738GluMet: 1.738 ± 0.241
2.939GluAsn: 2.939 ± 0.344
2.244GluPro: 2.244 ± 0.236
3.635GluGln: 3.635 ± 0.356
2.781GluArg: 2.781 ± 0.34
3.034GluSer: 3.034 ± 0.298
3.635GluThr: 3.635 ± 0.266
5.341GluVal: 5.341 ± 0.453
1.169GluTrp: 1.169 ± 0.174
2.908GluTyr: 2.908 ± 0.303
0.0GluXaa: 0.0 ± 0.0
Phe
2.402PheAla: 2.402 ± 0.316
0.664PheCys: 0.664 ± 0.142
3.603PheAsp: 3.603 ± 0.342
3.413PheGlu: 3.413 ± 0.305
1.485PhePhe: 1.485 ± 0.242
2.781PheGly: 2.781 ± 0.339
1.296PheHis: 1.296 ± 0.2
2.149PheIle: 2.149 ± 0.314
2.623PheLys: 2.623 ± 0.23
2.971PheLeu: 2.971 ± 0.33
0.79PheMet: 0.79 ± 0.165
2.118PheAsn: 2.118 ± 0.237
1.675PhePro: 1.675 ± 0.23
1.169PheGln: 1.169 ± 0.199
1.928PheArg: 1.928 ± 0.254
2.528PheSer: 2.528 ± 0.282
2.56PheThr: 2.56 ± 0.377
1.833PheVal: 1.833 ± 0.226
0.695PheTrp: 0.695 ± 0.118
1.422PheTyr: 1.422 ± 0.193
0.0PheXaa: 0.0 ± 0.0
Gly
4.362GlyAla: 4.362 ± 0.446
1.043GlyCys: 1.043 ± 0.225
4.109GlyAsp: 4.109 ± 0.378
4.425GlyGlu: 4.425 ± 0.367
3.161GlyPhe: 3.161 ± 0.306
3.729GlyGly: 3.729 ± 0.371
1.043GlyHis: 1.043 ± 0.168
4.772GlyIle: 4.772 ± 0.401
5.247GlyLys: 5.247 ± 0.443
4.646GlyLeu: 4.646 ± 0.352
2.054GlyMet: 2.054 ± 0.221
3.161GlyAsn: 3.161 ± 0.303
0.601GlyPro: 0.601 ± 0.154
1.928GlyGln: 1.928 ± 0.259
3.382GlyArg: 3.382 ± 0.41
4.014GlySer: 4.014 ± 0.397
4.267GlyThr: 4.267 ± 0.368
3.951GlyVal: 3.951 ± 0.303
1.422GlyTrp: 1.422 ± 0.222
2.655GlyTyr: 2.655 ± 0.324
0.0GlyXaa: 0.0 ± 0.0
His
0.917HisAla: 0.917 ± 0.155
0.474HisCys: 0.474 ± 0.129
1.233HisAsp: 1.233 ± 0.23
1.264HisGlu: 1.264 ± 0.193
0.759HisPhe: 0.759 ± 0.135
1.391HisGly: 1.391 ± 0.25
0.442HisHis: 0.442 ± 0.133
1.169HisIle: 1.169 ± 0.164
1.391HisLys: 1.391 ± 0.202
1.738HisLeu: 1.738 ± 0.182
0.632HisMet: 0.632 ± 0.149
1.011HisAsn: 1.011 ± 0.176
0.759HisPro: 0.759 ± 0.178
0.506HisGln: 0.506 ± 0.119
0.948HisArg: 0.948 ± 0.173
1.075HisSer: 1.075 ± 0.203
1.075HisThr: 1.075 ± 0.217
1.075HisVal: 1.075 ± 0.209
0.316HisTrp: 0.316 ± 0.101
0.759HisTyr: 0.759 ± 0.165
0.0HisXaa: 0.0 ± 0.0
Ile
4.33IleAla: 4.33 ± 0.431
0.727IleCys: 0.727 ± 0.164
4.52IleAsp: 4.52 ± 0.358
5.563IleGlu: 5.563 ± 0.501
1.865IlePhe: 1.865 ± 0.27
3.287IleGly: 3.287 ± 0.334
0.98IleHis: 0.98 ± 0.162
3.508IleIle: 3.508 ± 0.403
4.93IleLys: 4.93 ± 0.378
5.088IleLeu: 5.088 ± 0.41
1.643IleMet: 1.643 ± 0.258
3.477IleAsn: 3.477 ± 0.405
2.908IlePro: 2.908 ± 0.289
2.497IleGln: 2.497 ± 0.233
2.813IleArg: 2.813 ± 0.294
3.887IleSer: 3.887 ± 0.318
3.824IleThr: 3.824 ± 0.367
3.508IleVal: 3.508 ± 0.322
0.632IleTrp: 0.632 ± 0.133
2.434IleTyr: 2.434 ± 0.301
0.0IleXaa: 0.0 ± 0.0
Lys
6.795LysAla: 6.795 ± 0.581
0.727LysCys: 0.727 ± 0.184
4.456LysAsp: 4.456 ± 0.374
5.752LysGlu: 5.752 ± 0.441
3.477LysPhe: 3.477 ± 0.324
4.772LysGly: 4.772 ± 0.296
1.549LysHis: 1.549 ± 0.216
4.235LysIle: 4.235 ± 0.37
4.583LysLys: 4.583 ± 0.303
7.933LysLeu: 7.933 ± 0.556
2.465LysMet: 2.465 ± 0.285
2.845LysAsn: 2.845 ± 0.327
2.718LysPro: 2.718 ± 0.268
3.003LysGln: 3.003 ± 0.322
3.508LysArg: 3.508 ± 0.382
3.192LysSer: 3.192 ± 0.294
4.614LysThr: 4.614 ± 0.451
5.341LysVal: 5.341 ± 0.418
0.79LysTrp: 0.79 ± 0.132
3.35LysTyr: 3.35 ± 0.329
0.0LysXaa: 0.0 ± 0.0
Leu
6.606LeuAla: 6.606 ± 0.521
0.98LeuCys: 0.98 ± 0.177
6.353LeuAsp: 6.353 ± 0.471
6.985LeuGlu: 6.985 ± 0.488
2.75LeuPhe: 2.75 ± 0.324
5.563LeuGly: 5.563 ± 0.454
2.023LeuHis: 2.023 ± 0.249
5.088LeuIle: 5.088 ± 0.371
5.405LeuLys: 5.405 ± 0.469
6.163LeuLeu: 6.163 ± 0.494
2.181LeuMet: 2.181 ± 0.231
3.793LeuAsn: 3.793 ± 0.358
3.445LeuPro: 3.445 ± 0.382
3.255LeuGln: 3.255 ± 0.31
3.919LeuArg: 3.919 ± 0.364
4.899LeuSer: 4.899 ± 0.372
5.247LeuThr: 5.247 ± 0.522
5.815LeuVal: 5.815 ± 0.398
0.695LeuTrp: 0.695 ± 0.175
2.75LeuTyr: 2.75 ± 0.237
0.0LeuXaa: 0.0 ± 0.0
Met
2.244MetAla: 2.244 ± 0.345
0.316MetCys: 0.316 ± 0.098
1.738MetAsp: 1.738 ± 0.221
1.612MetGlu: 1.612 ± 0.224
1.043MetPhe: 1.043 ± 0.202
1.517MetGly: 1.517 ± 0.224
0.474MetHis: 0.474 ± 0.126
1.422MetIle: 1.422 ± 0.215
2.339MetLys: 2.339 ± 0.306
2.276MetLeu: 2.276 ± 0.288
0.632MetMet: 0.632 ± 0.16
0.98MetAsn: 0.98 ± 0.181
1.075MetPro: 1.075 ± 0.152
1.106MetGln: 1.106 ± 0.179
1.011MetArg: 1.011 ± 0.186
1.77MetSer: 1.77 ± 0.18
2.054MetThr: 2.054 ± 0.239
1.485MetVal: 1.485 ± 0.227
0.442MetTrp: 0.442 ± 0.111
1.359MetTyr: 1.359 ± 0.174
0.0MetXaa: 0.0 ± 0.0
Asn
3.54AsnAla: 3.54 ± 0.314
0.506AsnCys: 0.506 ± 0.132
2.181AsnAsp: 2.181 ± 0.262
2.845AsnGlu: 2.845 ± 0.297
1.454AsnPhe: 1.454 ± 0.233
3.477AsnGly: 3.477 ± 0.347
0.885AsnHis: 0.885 ± 0.2
3.793AsnIle: 3.793 ± 0.434
4.614AsnLys: 4.614 ± 0.355
4.109AsnLeu: 4.109 ± 0.409
1.454AsnMet: 1.454 ± 0.19
2.528AsnAsn: 2.528 ± 0.307
2.655AsnPro: 2.655 ± 0.325
1.454AsnGln: 1.454 ± 0.218
2.181AsnArg: 2.181 ± 0.306
2.939AsnSer: 2.939 ± 0.306
3.066AsnThr: 3.066 ± 0.292
3.129AsnVal: 3.129 ± 0.28
0.695AsnTrp: 0.695 ± 0.127
2.086AsnTyr: 2.086 ± 0.244
0.0AsnXaa: 0.0 ± 0.0
Pro
2.497ProAla: 2.497 ± 0.384
0.506ProCys: 0.506 ± 0.123
2.339ProAsp: 2.339 ± 0.25
2.781ProGlu: 2.781 ± 0.266
1.327ProPhe: 1.327 ± 0.208
1.707ProGly: 1.707 ± 0.276
0.853ProHis: 0.853 ± 0.124
2.181ProIle: 2.181 ± 0.274
2.655ProLys: 2.655 ± 0.319
2.623ProLeu: 2.623 ± 0.266
0.885ProMet: 0.885 ± 0.172
1.833ProAsn: 1.833 ± 0.233
0.664ProPro: 0.664 ± 0.148
1.138ProGln: 1.138 ± 0.169
1.833ProArg: 1.833 ± 0.248
2.118ProSer: 2.118 ± 0.324
2.497ProThr: 2.497 ± 0.341
2.686ProVal: 2.686 ± 0.269
0.316ProTrp: 0.316 ± 0.093
1.233ProTyr: 1.233 ± 0.222
0.0ProXaa: 0.0 ± 0.0
Gln
3.034GlnAla: 3.034 ± 0.358
0.569GlnCys: 0.569 ± 0.127
1.928GlnAsp: 1.928 ± 0.227
2.655GlnGlu: 2.655 ± 0.266
1.359GlnPhe: 1.359 ± 0.163
3.003GlnGly: 3.003 ± 0.357
0.569GlnHis: 0.569 ± 0.138
2.497GlnIle: 2.497 ± 0.243
2.118GlnLys: 2.118 ± 0.228
3.761GlnLeu: 3.761 ± 0.319
1.043GlnMet: 1.043 ± 0.188
1.485GlnAsn: 1.485 ± 0.197
0.98GlnPro: 0.98 ± 0.165
1.675GlnGln: 1.675 ± 0.317
1.896GlnArg: 1.896 ± 0.293
2.086GlnSer: 2.086 ± 0.292
1.991GlnThr: 1.991 ± 0.252
3.224GlnVal: 3.224 ± 0.334
0.664GlnTrp: 0.664 ± 0.14
1.296GlnTyr: 1.296 ± 0.206
0.0GlnXaa: 0.0 ± 0.0
Arg
4.046ArgAla: 4.046 ± 0.363
0.537ArgCys: 0.537 ± 0.13
3.35ArgAsp: 3.35 ± 0.335
2.718ArgGlu: 2.718 ± 0.236
1.707ArgPhe: 1.707 ± 0.219
3.287ArgGly: 3.287 ± 0.311
0.917ArgHis: 0.917 ± 0.185
2.845ArgIle: 2.845 ± 0.358
3.35ArgLys: 3.35 ± 0.354
3.382ArgLeu: 3.382 ± 0.323
1.327ArgMet: 1.327 ± 0.213
2.623ArgAsn: 2.623 ± 0.272
1.201ArgPro: 1.201 ± 0.222
1.865ArgGln: 1.865 ± 0.261
2.023ArgArg: 2.023 ± 0.268
2.086ArgSer: 2.086 ± 0.233
2.37ArgThr: 2.37 ± 0.301
2.56ArgVal: 2.56 ± 0.32
0.727ArgTrp: 0.727 ± 0.126
2.118ArgTyr: 2.118 ± 0.259
0.0ArgXaa: 0.0 ± 0.0
Ser
4.046SerAla: 4.046 ± 0.441
0.885SerCys: 0.885 ± 0.171
3.034SerAsp: 3.034 ± 0.305
2.718SerGlu: 2.718 ± 0.334
2.75SerPhe: 2.75 ± 0.241
4.836SerGly: 4.836 ± 0.446
1.075SerHis: 1.075 ± 0.218
3.54SerIle: 3.54 ± 0.366
4.93SerLys: 4.93 ± 0.325
5.468SerLeu: 5.468 ± 0.356
1.485SerMet: 1.485 ± 0.25
3.034SerAsn: 3.034 ± 0.287
1.77SerPro: 1.77 ± 0.216
1.802SerGln: 1.802 ± 0.272
2.339SerArg: 2.339 ± 0.274
3.919SerSer: 3.919 ± 0.512
3.603SerThr: 3.603 ± 0.354
3.982SerVal: 3.982 ± 0.363
0.664SerTrp: 0.664 ± 0.137
1.991SerTyr: 1.991 ± 0.221
0.0SerXaa: 0.0 ± 0.0
Thr
4.867ThrAla: 4.867 ± 0.409
0.348ThrCys: 0.348 ± 0.104
3.477ThrAsp: 3.477 ± 0.348
3.635ThrGlu: 3.635 ± 0.37
3.287ThrPhe: 3.287 ± 0.281
3.951ThrGly: 3.951 ± 0.431
1.075ThrHis: 1.075 ± 0.182
3.856ThrIle: 3.856 ± 0.387
4.393ThrLys: 4.393 ± 0.388
4.678ThrLeu: 4.678 ± 0.428
1.264ThrMet: 1.264 ± 0.212
3.192ThrAsn: 3.192 ± 0.36
2.939ThrPro: 2.939 ± 0.347
2.307ThrGln: 2.307 ± 0.254
2.181ThrArg: 2.181 ± 0.223
4.109ThrSer: 4.109 ± 0.432
3.887ThrThr: 3.887 ± 0.37
4.425ThrVal: 4.425 ± 0.366
1.169ThrTrp: 1.169 ± 0.23
2.686ThrTyr: 2.686 ± 0.28
0.0ThrXaa: 0.0 ± 0.0
Val
4.962ValAla: 4.962 ± 0.445
0.695ValCys: 0.695 ± 0.148
4.393ValAsp: 4.393 ± 0.371
4.551ValGlu: 4.551 ± 0.391
2.876ValPhe: 2.876 ± 0.321
3.255ValGly: 3.255 ± 0.268
1.233ValHis: 1.233 ± 0.22
3.287ValIle: 3.287 ± 0.297
5.31ValLys: 5.31 ± 0.358
4.678ValLeu: 4.678 ± 0.391
1.169ValMet: 1.169 ± 0.193
3.666ValAsn: 3.666 ± 0.305
1.896ValPro: 1.896 ± 0.208
2.592ValGln: 2.592 ± 0.296
3.666ValArg: 3.666 ± 0.293
4.298ValSer: 4.298 ± 0.412
4.109ValThr: 4.109 ± 0.436
4.551ValVal: 4.551 ± 0.432
0.885ValTrp: 0.885 ± 0.198
2.686ValTyr: 2.686 ± 0.354
0.0ValXaa: 0.0 ± 0.0
Trp
1.201TrpAla: 1.201 ± 0.213
0.19TrpCys: 0.19 ± 0.069
1.169TrpAsp: 1.169 ± 0.213
0.98TrpGlu: 0.98 ± 0.165
0.569TrpPhe: 0.569 ± 0.134
0.98TrpGly: 0.98 ± 0.162
0.379TrpHis: 0.379 ± 0.115
0.822TrpIle: 0.822 ± 0.195
0.885TrpLys: 0.885 ± 0.169
1.391TrpLeu: 1.391 ± 0.2
0.379TrpMet: 0.379 ± 0.12
0.759TrpAsn: 0.759 ± 0.155
0.19TrpPro: 0.19 ± 0.087
0.632TrpGln: 0.632 ± 0.148
0.853TrpArg: 0.853 ± 0.179
0.695TrpSer: 0.695 ± 0.194
0.474TrpThr: 0.474 ± 0.131
0.948TrpVal: 0.948 ± 0.135
0.253TrpTrp: 0.253 ± 0.087
0.474TrpTyr: 0.474 ± 0.149
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.497TyrAla: 2.497 ± 0.27
0.442TyrCys: 0.442 ± 0.124
2.876TyrAsp: 2.876 ± 0.359
2.781TyrGlu: 2.781 ± 0.323
1.707TyrPhe: 1.707 ± 0.224
2.339TyrGly: 2.339 ± 0.275
0.917TyrHis: 0.917 ± 0.206
2.434TyrIle: 2.434 ± 0.274
2.781TyrLys: 2.781 ± 0.29
3.192TyrLeu: 3.192 ± 0.391
1.327TyrMet: 1.327 ± 0.214
2.118TyrAsn: 2.118 ± 0.246
1.233TyrPro: 1.233 ± 0.172
1.991TyrGln: 1.991 ± 0.254
1.643TyrArg: 1.643 ± 0.197
1.833TyrSer: 1.833 ± 0.247
2.939TyrThr: 2.939 ± 0.36
2.181TyrVal: 2.181 ± 0.271
0.632TyrTrp: 0.632 ± 0.166
1.707TyrTyr: 1.707 ± 0.27
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 157 proteins (31641 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski