Amino acid dipepetide frequency for Paracoccus subflavus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.041AlaAla: 19.041 ± 0.197	1.08AlaCys: 1.08 ± 0.035	7.952AlaAsp: 7.952 ± 0.111	8.247AlaGlu: 8.247 ± 0.119	4.163AlaPhe: 4.163 ± 0.079	11.873AlaGly: 11.873 ± 0.124	2.38AlaHis: 2.38 ± 0.058	6.381AlaIle: 6.381 ± 0.094	2.784AlaLys: 2.784 ± 0.076	13.975AlaLeu: 13.975 ± 0.155	4.088AlaMet: 4.088 ± 0.061	2.533AlaAsn: 2.533 ± 0.054	6.379AlaPro: 6.379 ± 0.117	4.773AlaGln: 4.773 ± 0.075	10.723AlaArg: 10.723 ± 0.127	5.506AlaSer: 5.506 ± 0.079	6.124AlaThr: 6.124 ± 0.086	9.236AlaVal: 9.236 ± 0.105	1.698AlaTrp: 1.698 ± 0.042	2.326AlaTyr: 2.326 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	1.003CysAla: 1.003 ± 0.036	0.112CysCys: 0.112 ± 0.011	0.568CysAsp: 0.568 ± 0.024	0.365CysGlu: 0.365 ± 0.021	0.289CysPhe: 0.289 ± 0.017	0.906CysGly: 0.906 ± 0.032	0.276CysHis: 0.276 ± 0.018	0.389CysIle: 0.389 ± 0.023	0.175CysLys: 0.175 ± 0.013	0.865CysLeu: 0.865 ± 0.031	0.178CysMet: 0.178 ± 0.015	0.19CysAsn: 0.19 ± 0.015	0.547CysPro: 0.547 ± 0.025	0.221CysGln: 0.221 ± 0.016	0.614CysArg: 0.614 ± 0.027	0.41CysSer: 0.41 ± 0.022	0.387CysThr: 0.387 ± 0.02	0.544CysVal: 0.544 ± 0.023	0.132CysTrp: 0.132 ± 0.011	0.166CysTyr: 0.166 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.759AspAla: 7.759 ± 0.098	0.517AspCys: 0.517 ± 0.02	3.671AspAsp: 3.671 ± 0.06	3.362AspGlu: 3.362 ± 0.06	2.277AspPhe: 2.277 ± 0.05	5.706AspGly: 5.706 ± 0.097	1.604AspHis: 1.604 ± 0.047	2.873AspIle: 2.873 ± 0.058	1.443AspLys: 1.443 ± 0.043	7.276AspLeu: 7.276 ± 0.104	1.612AspMet: 1.612 ± 0.039	1.261AspAsn: 1.261 ± 0.039	4.303AspPro: 4.303 ± 0.066	2.139AspGln: 2.139 ± 0.046	5.738AspArg: 5.738 ± 0.082	2.314AspSer: 2.314 ± 0.046	2.759AspThr: 2.759 ± 0.058	3.692AspVal: 3.692 ± 0.059	1.3AspTrp: 1.3 ± 0.041	1.51AspTyr: 1.51 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	7.433GluAla: 7.433 ± 0.119	0.321GluCys: 0.321 ± 0.017	2.908GluAsp: 2.908 ± 0.063	2.549GluGlu: 2.549 ± 0.063	1.632GluPhe: 1.632 ± 0.051	4.529GluGly: 4.529 ± 0.072	0.922GluHis: 0.922 ± 0.036	3.108GluIle: 3.108 ± 0.066	1.473GluLys: 1.473 ± 0.047	4.355GluLeu: 4.355 ± 0.073	1.514GluMet: 1.514 ± 0.039	1.482GluAsn: 1.482 ± 0.042	2.507GluPro: 2.507 ± 0.056	1.784GluGln: 1.784 ± 0.046	4.315GluArg: 4.315 ± 0.072	2.131GluSer: 2.131 ± 0.046	3.205GluThr: 3.205 ± 0.066	3.773GluVal: 3.773 ± 0.07	0.74GluTrp: 0.74 ± 0.031	0.978GluTyr: 0.978 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	4.362PheAla: 4.362 ± 0.081	0.377PheCys: 0.377 ± 0.021	2.681PheAsp: 2.681 ± 0.051	1.704PheGlu: 1.704 ± 0.041	1.279PhePhe: 1.279 ± 0.043	3.594PheGly: 3.594 ± 0.066	0.727PheHis: 0.727 ± 0.033	1.452PheIle: 1.452 ± 0.045	0.704PheLys: 0.704 ± 0.026	3.331PheLeu: 3.331 ± 0.07	0.803PheMet: 0.803 ± 0.029	0.881PheAsn: 0.881 ± 0.037	1.532PhePro: 1.532 ± 0.043	0.999PheGln: 0.999 ± 0.029	2.381PheArg: 2.381 ± 0.046	1.88PheSer: 1.88 ± 0.046	1.809PheThr: 1.809 ± 0.046	2.696PheVal: 2.696 ± 0.051	0.61PheTrp: 0.61 ± 0.028	0.776PheTyr: 0.776 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	10.236GlyAla: 10.236 ± 0.121	0.85GlyCys: 0.85 ± 0.031	5.134GlyAsp: 5.134 ± 0.082	4.18GlyGlu: 4.18 ± 0.068	3.606GlyPhe: 3.606 ± 0.067	7.817GlyGly: 7.817 ± 0.113	2.178GlyHis: 2.178 ± 0.047	4.828GlyIle: 4.828 ± 0.075	2.653GlyLys: 2.653 ± 0.053	9.819GlyLeu: 9.819 ± 0.108	2.792GlyMet: 2.792 ± 0.055	2.193GlyAsn: 2.193 ± 0.06	4.163GlyPro: 4.163 ± 0.059	3.534GlyGln: 3.534 ± 0.061	6.963GlyArg: 6.963 ± 0.1	4.235GlySer: 4.235 ± 0.069	4.781GlyThr: 4.781 ± 0.078	6.245GlyVal: 6.245 ± 0.082	1.613GlyTrp: 1.613 ± 0.046	2.176GlyTyr: 2.176 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	2.411HisAla: 2.411 ± 0.06	0.22HisCys: 0.22 ± 0.017	1.443HisAsp: 1.443 ± 0.041	0.948HisGlu: 0.948 ± 0.031	0.741HisPhe: 0.741 ± 0.029	2.12HisGly: 2.12 ± 0.056	0.622HisHis: 0.622 ± 0.028	0.835HisIle: 0.835 ± 0.032	0.452HisLys: 0.452 ± 0.021	2.244HisLeu: 2.244 ± 0.054	0.482HisMet: 0.482 ± 0.023	0.391HisAsn: 0.391 ± 0.022	1.545HisPro: 1.545 ± 0.04	0.623HisGln: 0.623 ± 0.024	1.679HisArg: 1.679 ± 0.045	0.87HisSer: 0.87 ± 0.031	0.715HisThr: 0.715 ± 0.029	1.66HisVal: 1.66 ± 0.041	0.336HisTrp: 0.336 ± 0.018	0.53HisTyr: 0.53 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	7.468IleAla: 7.468 ± 0.094	0.518IleCys: 0.518 ± 0.022	3.546IleAsp: 3.546 ± 0.061	3.21IleGlu: 3.21 ± 0.059	1.59IlePhe: 1.59 ± 0.048	4.97IleGly: 4.97 ± 0.074	0.967IleHis: 0.967 ± 0.035	2.046IleIle: 2.046 ± 0.049	0.995IleLys: 0.995 ± 0.032	4.942IleLeu: 4.942 ± 0.084	1.071IleMet: 1.071 ± 0.036	1.166IleAsn: 1.166 ± 0.039	2.503IlePro: 2.503 ± 0.055	1.262IleGln: 1.262 ± 0.038	3.856IleArg: 3.856 ± 0.055	2.464IleSer: 2.464 ± 0.051	2.599IleThr: 2.599 ± 0.049	3.826IleVal: 3.826 ± 0.071	0.697IleTrp: 0.697 ± 0.026	1.03IleTyr: 1.03 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	3.238LysAla: 3.238 ± 0.071	0.137LysCys: 0.137 ± 0.011	1.392LysAsp: 1.392 ± 0.043	1.056LysGlu: 1.056 ± 0.042	0.654LysPhe: 0.654 ± 0.027	2.223LysGly: 2.223 ± 0.054	0.445LysHis: 0.445 ± 0.019	1.222LysIle: 1.222 ± 0.041	0.786LysLys: 0.786 ± 0.038	2.193LysLeu: 2.193 ± 0.053	0.599LysMet: 0.599 ± 0.026	0.62LysAsn: 0.62 ± 0.029	1.507LysPro: 1.507 ± 0.046	0.723LysGln: 0.723 ± 0.03	1.795LysArg: 1.795 ± 0.05	1.345LysSer: 1.345 ± 0.038	1.488LysThr: 1.488 ± 0.049	1.783LysVal: 1.783 ± 0.045	0.298LysTrp: 0.298 ± 0.018	0.481LysTyr: 0.481 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	14.549LeuAla: 14.549 ± 0.143	0.938LeuCys: 0.938 ± 0.032	6.537LeuAsp: 6.537 ± 0.089	4.56LeuGlu: 4.56 ± 0.07	3.388LeuPhe: 3.388 ± 0.07	8.587LeuGly: 8.587 ± 0.112	2.018LeuHis: 2.018 ± 0.047	5.296LeuIle: 5.296 ± 0.086	2.381LeuLys: 2.381 ± 0.055	8.947LeuLeu: 8.947 ± 0.139	2.731LeuMet: 2.731 ± 0.059	2.451LeuAsn: 2.451 ± 0.045	6.253LeuPro: 6.253 ± 0.093	2.601LeuGln: 2.601 ± 0.048	8.181LeuArg: 8.181 ± 0.107	6.442LeuSer: 6.442 ± 0.087	6.191LeuThr: 6.191 ± 0.095	6.994LeuVal: 6.994 ± 0.102	1.359LeuTrp: 1.359 ± 0.042	1.909LeuTyr: 1.909 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	4.005MetAla: 4.005 ± 0.065	0.153MetCys: 0.153 ± 0.013	1.473MetAsp: 1.473 ± 0.037	1.133MetGlu: 1.133 ± 0.041	0.741MetPhe: 0.741 ± 0.026	2.35MetGly: 2.35 ± 0.052	0.433MetHis: 0.433 ± 0.023	1.552MetIle: 1.552 ± 0.041	0.853MetLys: 0.853 ± 0.033	2.7MetLeu: 2.7 ± 0.06	0.77MetMet: 0.77 ± 0.028	0.785MetAsn: 0.785 ± 0.031	1.658MetPro: 1.658 ± 0.042	0.93MetGln: 0.93 ± 0.032	1.984MetArg: 1.984 ± 0.042	1.466MetSer: 1.466 ± 0.038	2.116MetThr: 2.116 ± 0.045	1.875MetVal: 1.875 ± 0.04	0.25MetTrp: 0.25 ± 0.017	0.279MetTyr: 0.279 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	2.966AsnAla: 2.966 ± 0.062	0.23AsnCys: 0.23 ± 0.014	1.42AsnAsp: 1.42 ± 0.042	0.98AsnGlu: 0.98 ± 0.031	0.773AsnPhe: 0.773 ± 0.031	2.198AsnGly: 2.198 ± 0.056	0.494AsnHis: 0.494 ± 0.021	1.231AsnIle: 1.231 ± 0.04	0.511AsnLys: 0.511 ± 0.023	2.333AsnLeu: 2.333 ± 0.054	0.584AsnMet: 0.584 ± 0.022	0.547AsnAsn: 0.547 ± 0.025	1.8AsnPro: 1.8 ± 0.048	0.676AsnGln: 0.676 ± 0.029	1.9AsnArg: 1.9 ± 0.046	1.024AsnSer: 1.024 ± 0.037	1.122AsnThr: 1.122 ± 0.033	1.553AsnVal: 1.553 ± 0.039	0.408AsnTrp: 0.408 ± 0.02	0.515AsnTyr: 0.515 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	7.427ProAla: 7.427 ± 0.104	0.373ProCys: 0.373 ± 0.02	4.773ProAsp: 4.773 ± 0.074	3.728ProGlu: 3.728 ± 0.069	1.921ProPhe: 1.921 ± 0.046	5.397ProGly: 5.397 ± 0.071	1.172ProHis: 1.172 ± 0.035	2.257ProIle: 2.257 ± 0.048	1.199ProLys: 1.199 ± 0.038	5.215ProLeu: 5.215 ± 0.08	1.365ProMet: 1.365 ± 0.041	1.074ProAsn: 1.074 ± 0.034	2.834ProPro: 2.834 ± 0.06	1.888ProGln: 1.888 ± 0.042	3.586ProArg: 3.586 ± 0.067	2.448ProSer: 2.448 ± 0.054	2.345ProThr: 2.345 ± 0.051	4.897ProVal: 4.897 ± 0.065	0.739ProTrp: 0.739 ± 0.036	1.037ProTyr: 1.037 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	4.881GlnAla: 4.881 ± 0.091	0.174GlnCys: 0.174 ± 0.014	1.848GlnAsp: 1.848 ± 0.039	1.356GlnGlu: 1.356 ± 0.038	1.001GlnPhe: 1.001 ± 0.034	3.201GlnGly: 3.201 ± 0.055	0.574GlnHis: 0.574 ± 0.023	1.995GlnIle: 1.995 ± 0.049	0.863GlnLys: 0.863 ± 0.03	2.572GlnLeu: 2.572 ± 0.056	1.146GlnMet: 1.146 ± 0.036	0.899GlnAsn: 0.899 ± 0.031	2.067GlnPro: 2.067 ± 0.048	1.214GlnGln: 1.214 ± 0.043	2.286GlnArg: 2.286 ± 0.049	1.622GlnSer: 1.622 ± 0.047	1.818GlnThr: 1.818 ± 0.046	2.573GlnVal: 2.573 ± 0.055	0.37GlnTrp: 0.37 ± 0.021	0.519GlnTyr: 0.519 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	9.391ArgAla: 9.391 ± 0.094	0.518ArgCys: 0.518 ± 0.022	5.205ArgAsp: 5.205 ± 0.08	3.636ArgGlu: 3.636 ± 0.067	2.927ArgPhe: 2.927 ± 0.06	5.475ArgGly: 5.475 ± 0.076	1.894ArgHis: 1.894 ± 0.044	4.748ArgIle: 4.748 ± 0.071	2.052ArgLys: 2.052 ± 0.054	9.034ArgLeu: 9.034 ± 0.117	2.38ArgMet: 2.38 ± 0.053	1.833ArgAsn: 1.833 ± 0.046	4.407ArgPro: 4.407 ± 0.073	2.947ArgGln: 2.947 ± 0.06	6.455ArgArg: 6.455 ± 0.093	3.441ArgSer: 3.441 ± 0.063	3.368ArgThr: 3.368 ± 0.057	5.151ArgVal: 5.151 ± 0.072	1.083ArgTrp: 1.083 ± 0.037	1.556ArgTyr: 1.556 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	5.584SerAla: 5.584 ± 0.073	0.41SerCys: 0.41 ± 0.021	3.018SerAsp: 3.018 ± 0.056	2.319SerGlu: 2.319 ± 0.051	1.936SerPhe: 1.936 ± 0.052	5.181SerGly: 5.181 ± 0.082	0.998SerHis: 0.998 ± 0.026	2.244SerIle: 2.244 ± 0.054	1.051SerLys: 1.051 ± 0.035	5.029SerLeu: 5.029 ± 0.079	1.222SerMet: 1.222 ± 0.033	1.067SerAsn: 1.067 ± 0.03	2.614SerPro: 2.614 ± 0.053	1.576SerGln: 1.576 ± 0.043	3.698SerArg: 3.698 ± 0.071	2.195SerSer: 2.195 ± 0.05	2.231SerThr: 2.231 ± 0.056	3.42SerVal: 3.42 ± 0.052	0.665SerTrp: 0.665 ± 0.03	1.082SerTyr: 1.082 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	6.469ThrAla: 6.469 ± 0.096	0.465ThrCys: 0.465 ± 0.022	3.215ThrAsp: 3.215 ± 0.053	2.722ThrGlu: 2.722 ± 0.053	1.667ThrPhe: 1.667 ± 0.039	5.534ThrGly: 5.534 ± 0.091	1.02ThrHis: 1.02 ± 0.034	2.639ThrIle: 2.639 ± 0.048	0.999ThrLys: 0.999 ± 0.036	5.671ThrLeu: 5.671 ± 0.084	1.16ThrMet: 1.16 ± 0.031	1.134ThrAsn: 1.134 ± 0.038	3.368ThrPro: 3.368 ± 0.066	1.495ThrGln: 1.495 ± 0.045	3.679ThrArg: 3.679 ± 0.055	2.217ThrSer: 2.217 ± 0.047	2.737ThrThr: 2.737 ± 0.061	4.273ThrVal: 4.273 ± 0.073	0.674ThrTrp: 0.674 ± 0.024	0.987ThrTyr: 0.987 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	9.27ValAla: 9.27 ± 0.11	0.606ValCys: 0.606 ± 0.024	3.977ValAsp: 3.977 ± 0.062	4.048ValGlu: 4.048 ± 0.07	2.69ValPhe: 2.69 ± 0.055	5.276ValGly: 5.276 ± 0.084	1.297ValHis: 1.297 ± 0.039	4.135ValIle: 4.135 ± 0.072	1.745ValLys: 1.745 ± 0.051	7.829ValLeu: 7.829 ± 0.106	2.193ValMet: 2.193 ± 0.042	1.806ValAsn: 1.806 ± 0.047	3.872ValPro: 3.872 ± 0.075	2.242ValGln: 2.242 ± 0.058	4.738ValArg: 4.738 ± 0.07	3.793ValSer: 3.793 ± 0.064	4.583ValThr: 4.583 ± 0.068	5.594ValVal: 5.594 ± 0.094	1.031ValTrp: 1.031 ± 0.037	1.318ValTyr: 1.318 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.44TrpAla: 1.44 ± 0.045	0.13TrpCys: 0.13 ± 0.013	0.83TrpAsp: 0.83 ± 0.031	0.52TrpGlu: 0.52 ± 0.025	0.56TrpPhe: 0.56 ± 0.026	1.088TrpGly: 1.088 ± 0.037	0.354TrpHis: 0.354 ± 0.018	0.725TrpIle: 0.725 ± 0.031	0.407TrpLys: 0.407 ± 0.021	1.867TrpLeu: 1.867 ± 0.056	0.426TrpMet: 0.426 ± 0.025	0.438TrpAsn: 0.438 ± 0.024	0.801TrpPro: 0.801 ± 0.032	0.731TrpGln: 0.731 ± 0.032	1.287TrpArg: 1.287 ± 0.042	0.764TrpSer: 0.764 ± 0.031	0.833TrpThr: 0.833 ± 0.03	0.842TrpVal: 0.842 ± 0.027	0.264TrpTrp: 0.264 ± 0.017	0.265TrpTyr: 0.265 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.327TyrAla: 2.327 ± 0.047	0.207TyrCys: 0.207 ± 0.017	1.525TyrAsp: 1.525 ± 0.044	1.038TyrGlu: 1.038 ± 0.032	0.742TyrPhe: 0.742 ± 0.033	1.971TyrGly: 1.971 ± 0.047	0.496TyrHis: 0.496 ± 0.023	0.769TyrIle: 0.769 ± 0.029	0.459TyrLys: 0.459 ± 0.023	2.115TyrLeu: 2.115 ± 0.05	0.388TyrMet: 0.388 ± 0.023	0.515TyrAsn: 0.515 ± 0.022	1.019TyrPro: 1.019 ± 0.031	0.623TyrGln: 0.623 ± 0.027	1.645TyrArg: 1.645 ± 0.05	0.972TyrSer: 0.972 ± 0.031	0.913TyrThr: 0.913 ± 0.033	1.414TyrVal: 1.414 ± 0.044	0.304TyrTrp: 0.304 ± 0.018	0.513TyrTyr: 0.513 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3059 proteins (961796 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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