Amino acid dipepetide frequency for Leviviridae sp.

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.627AlaAla: 1.627 ± 1.097
0.814AlaCys: 0.814 ± 0.548
4.068AlaAsp: 4.068 ± 3.89
2.441AlaGlu: 2.441 ± 0.734
4.068AlaPhe: 4.068 ± 2.373
4.068AlaGly: 4.068 ± 3.036
0.814AlaHis: 0.814 ± 0.69
2.441AlaIle: 2.441 ± 1.032
4.068AlaLys: 4.068 ± 2.373
7.323AlaLeu: 7.323 ± 1.372
0.814AlaMet: 0.814 ± 0.548
2.441AlaAsn: 2.441 ± 2.689
0.0AlaPro: 0.0 ± 0.0
3.255AlaGln: 3.255 ± 1.214
2.441AlaArg: 2.441 ± 1.032
3.255AlaSer: 3.255 ± 2.609
7.323AlaThr: 7.323 ± 4.818
6.509AlaVal: 6.509 ± 2.327
0.814AlaTrp: 0.814 ± 0.548
4.068AlaTyr: 4.068 ± 1.616
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.814CysCys: 0.814 ± 1.437
1.627CysAsp: 1.627 ± 0.455
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
1.627CysGly: 1.627 ± 0.455
0.0CysHis: 0.0 ± 0.0
0.814CysIle: 0.814 ± 0.69
0.814CysLys: 0.814 ± 0.69
2.441CysLeu: 2.441 ± 1.032
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.814CysPro: 0.814 ± 0.548
0.0CysGln: 0.0 ± 0.0
0.814CysArg: 0.814 ± 0.69
2.441CysSer: 2.441 ± 1.032
0.814CysThr: 0.814 ± 0.69
0.814CysVal: 0.814 ± 1.437
0.0CysTrp: 0.0 ± 0.0
1.627CysTyr: 1.627 ± 1.097
0.0CysXaa: 0.0 ± 0.0
Asp
5.696AspAla: 5.696 ± 3.805
1.627AspCys: 1.627 ± 0.455
4.882AspAsp: 4.882 ± 1.366
3.255AspGlu: 3.255 ± 0.85
1.627AspPhe: 1.627 ± 0.455
4.882AspGly: 4.882 ± 3.057
1.627AspHis: 1.627 ± 0.455
9.764AspIle: 9.764 ± 3.315
1.627AspLys: 1.627 ± 0.455
4.882AspLeu: 4.882 ± 1.364
0.814AspMet: 0.814 ± 1.437
1.627AspAsn: 1.627 ± 1.097
0.814AspPro: 0.814 ± 1.437
1.627AspGln: 1.627 ± 1.097
2.441AspArg: 2.441 ± 1.645
3.255AspSer: 3.255 ± 1.214
4.068AspThr: 4.068 ± 2.404
2.441AspVal: 2.441 ± 1.032
1.627AspTrp: 1.627 ± 0.455
2.441AspTyr: 2.441 ± 1.645
0.0AspXaa: 0.0 ± 0.0
Glu
5.696GluAla: 5.696 ± 1.667
0.0GluCys: 0.0 ± 0.0
2.441GluAsp: 2.441 ± 1.027
4.882GluGlu: 4.882 ± 3.057
3.255GluPhe: 3.255 ± 1.695
1.627GluGly: 1.627 ± 0.455
1.627GluHis: 1.627 ± 0.455
3.255GluIle: 3.255 ± 1.667
4.068GluLys: 4.068 ± 0.996
4.068GluLeu: 4.068 ± 0.675
1.627GluMet: 1.627 ± 0.604
1.627GluAsn: 1.627 ± 1.379
2.441GluPro: 2.441 ± 1.027
0.814GluGln: 0.814 ± 0.548
4.068GluArg: 4.068 ± 0.675
3.255GluSer: 3.255 ± 1.214
0.814GluThr: 0.814 ± 0.69
4.882GluVal: 4.882 ± 1.593
1.627GluTrp: 1.627 ± 0.455
5.696GluTyr: 5.696 ± 0.522
0.0GluXaa: 0.0 ± 0.0
Phe
0.814PheAla: 0.814 ± 0.69
1.627PheCys: 1.627 ± 0.455
4.882PheAsp: 4.882 ± 2.195
1.627PheGlu: 1.627 ± 0.455
2.441PhePhe: 2.441 ± 1.032
0.814PheGly: 0.814 ± 0.548
0.0PheHis: 0.0 ± 0.0
0.814PheIle: 0.814 ± 0.548
0.814PheLys: 0.814 ± 0.548
4.882PheLeu: 4.882 ± 2.063
0.0PheMet: 0.0 ± 0.0
0.814PheAsn: 0.814 ± 1.437
1.627PhePro: 1.627 ± 1.097
2.441PheGln: 2.441 ± 2.069
2.441PheArg: 2.441 ± 1.645
4.068PheSer: 4.068 ± 1.091
4.068PheThr: 4.068 ± 1.091
3.255PheVal: 3.255 ± 1.695
0.0PheTrp: 0.0 ± 0.0
0.0PheTyr: 0.0 ± 0.0
0.0PheXaa: 0.0 ± 0.0
Gly
3.255GlyAla: 3.255 ± 0.909
1.627GlyCys: 1.627 ± 0.455
4.068GlyAsp: 4.068 ± 0.675
2.441GlyGlu: 2.441 ± 0.734
1.627GlyPhe: 1.627 ± 0.455
1.627GlyGly: 1.627 ± 1.097
0.0GlyHis: 0.0 ± 0.0
3.255GlyIle: 3.255 ± 1.667
4.882GlyLys: 4.882 ± 0.396
4.068GlyLeu: 4.068 ± 0.675
0.814GlyMet: 0.814 ± 0.45
4.068GlyAsn: 4.068 ± 2.731
1.627GlyPro: 1.627 ± 0.455
1.627GlyGln: 1.627 ± 1.379
3.255GlyArg: 3.255 ± 1.214
5.696GlySer: 5.696 ± 1.866
3.255GlyThr: 3.255 ± 0.909
3.255GlyVal: 3.255 ± 1.953
1.627GlyTrp: 1.627 ± 1.097
3.255GlyTyr: 3.255 ± 2.164
0.0GlyXaa: 0.0 ± 0.0
His
0.0HisAla: 0.0 ± 0.0
0.814HisCys: 0.814 ± 0.69
0.0HisAsp: 0.0 ± 0.0
0.814HisGlu: 0.814 ± 0.69
0.814HisPhe: 0.814 ± 0.548
1.627HisGly: 1.627 ± 1.097
0.814HisHis: 0.814 ± 0.548
2.441HisIle: 2.441 ± 1.027
0.0HisLys: 0.0 ± 0.0
0.0HisLeu: 0.0 ± 0.0
0.0HisMet: 0.0 ± 0.0
0.0HisAsn: 0.0 ± 0.0
2.441HisPro: 2.441 ± 1.393
0.814HisGln: 0.814 ± 0.548
2.441HisArg: 2.441 ± 1.032
0.814HisSer: 0.814 ± 0.548
1.627HisThr: 1.627 ± 1.409
4.068HisVal: 4.068 ± 1.091
0.0HisTrp: 0.0 ± 0.0
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
7.323IleAla: 7.323 ± 1.372
0.814IleCys: 0.814 ± 0.548
1.627IleAsp: 1.627 ± 1.305
3.255IleGlu: 3.255 ± 0.85
0.814IlePhe: 0.814 ± 0.548
1.627IleGly: 1.627 ± 0.455
0.814IleHis: 0.814 ± 0.548
0.814IleIle: 0.814 ± 0.548
2.441IleLys: 2.441 ± 0.734
4.882IleLeu: 4.882 ± 3.29
0.814IleMet: 0.814 ± 0.548
2.441IleAsn: 2.441 ± 1.032
2.441IlePro: 2.441 ± 0.734
3.255IleGln: 3.255 ± 1.214
4.068IleArg: 4.068 ± 0.675
6.509IleSer: 6.509 ± 3.35
8.137IleThr: 8.137 ± 2.809
4.068IleVal: 4.068 ± 1.734
0.814IleTrp: 0.814 ± 0.548
0.814IleTyr: 0.814 ± 0.69
0.0IleXaa: 0.0 ± 0.0
Lys
3.255LysAla: 3.255 ± 2.759
0.814LysCys: 0.814 ± 0.69
0.814LysAsp: 0.814 ± 0.548
2.441LysGlu: 2.441 ± 1.032
2.441LysPhe: 2.441 ± 0.734
4.068LysGly: 4.068 ± 2.373
0.814LysHis: 0.814 ± 1.437
4.882LysIle: 4.882 ± 1.468
3.255LysLys: 3.255 ± 0.909
4.068LysLeu: 4.068 ± 0.996
0.0LysMet: 0.0 ± 0.0
4.068LysAsn: 4.068 ± 0.996
0.814LysPro: 0.814 ± 0.548
0.0LysGln: 0.0 ± 0.0
4.882LysArg: 4.882 ± 1.468
6.509LysSer: 6.509 ± 2.316
4.068LysThr: 4.068 ± 0.996
1.627LysVal: 1.627 ± 1.379
0.814LysTrp: 0.814 ± 0.548
3.255LysTyr: 3.255 ± 0.909
0.0LysXaa: 0.0 ± 0.0
Leu
4.068LeuAla: 4.068 ± 1.091
0.814LeuCys: 0.814 ± 0.69
4.068LeuAsp: 4.068 ± 1.734
4.882LeuGlu: 4.882 ± 2.063
0.0LeuPhe: 0.0 ± 0.0
4.882LeuGly: 4.882 ± 2.786
4.068LeuHis: 4.068 ± 0.675
5.696LeuIle: 5.696 ± 1.502
6.509LeuLys: 6.509 ± 2.316
4.882LeuLeu: 4.882 ± 2.155
2.441LeuMet: 2.441 ± 1.393
3.255LeuAsn: 3.255 ± 0.85
3.255LeuPro: 3.255 ± 1.695
4.882LeuGln: 4.882 ± 2.155
8.95LeuArg: 8.95 ± 2.372
5.696LeuSer: 5.696 ± 0.677
7.323LeuThr: 7.323 ± 1.832
5.696LeuVal: 5.696 ± 3.839
0.814LeuTrp: 0.814 ± 0.69
3.255LeuTyr: 3.255 ± 0.909
0.0LeuXaa: 0.0 ± 0.0
Met
0.0MetAla: 0.0 ± 0.0
0.0MetCys: 0.0 ± 0.0
0.814MetAsp: 0.814 ± 0.69
0.814MetGlu: 0.814 ± 0.69
0.814MetPhe: 0.814 ± 1.437
2.441MetGly: 2.441 ± 0.734
0.0MetHis: 0.0 ± 0.0
0.0MetIle: 0.0 ± 0.0
0.814MetLys: 0.814 ± 0.548
0.814MetLeu: 0.814 ± 0.548
0.814MetMet: 0.814 ± 1.437
0.0MetAsn: 0.0 ± 0.0
0.0MetPro: 0.0 ± 0.0
0.0MetGln: 0.0 ± 0.0
3.255MetArg: 3.255 ± 2.456
1.627MetSer: 1.627 ± 1.409
0.0MetThr: 0.0 ± 0.0
0.814MetVal: 0.814 ± 0.548
0.0MetTrp: 0.0 ± 0.0
2.441MetTyr: 2.441 ± 0.734
0.0MetXaa: 0.0 ± 0.0
Asn
2.441AsnAla: 2.441 ± 1.393
0.0AsnCys: 0.0 ± 0.0
0.814AsnAsp: 0.814 ± 0.69
1.627AsnGlu: 1.627 ± 0.455
0.814AsnPhe: 0.814 ± 0.69
3.255AsnGly: 3.255 ± 1.214
0.0AsnHis: 0.0 ± 0.0
4.882AsnIle: 4.882 ± 1.068
0.0AsnLys: 0.0 ± 0.0
4.068AsnLeu: 4.068 ± 1.091
0.814AsnMet: 0.814 ± 0.99
1.627AsnAsn: 1.627 ± 1.305
1.627AsnPro: 1.627 ± 0.455
0.0AsnGln: 0.0 ± 0.0
3.255AsnArg: 3.255 ± 0.909
1.627AsnSer: 1.627 ± 1.379
5.696AsnThr: 5.696 ± 2.202
4.882AsnVal: 4.882 ± 7.031
0.0AsnTrp: 0.0 ± 0.0
4.882AsnTyr: 4.882 ± 1.366
0.0AsnXaa: 0.0 ± 0.0
Pro
0.814ProAla: 0.814 ± 1.437
0.814ProCys: 0.814 ± 1.437
3.255ProAsp: 3.255 ± 1.214
0.814ProGlu: 0.814 ± 1.437
2.441ProPhe: 2.441 ± 1.032
2.441ProGly: 2.441 ± 1.032
0.814ProHis: 0.814 ± 0.548
2.441ProIle: 2.441 ± 1.645
2.441ProLys: 2.441 ± 1.645
2.441ProLeu: 2.441 ± 1.645
0.814ProMet: 0.814 ± 0.69
0.814ProAsn: 0.814 ± 1.437
0.814ProPro: 0.814 ± 0.548
1.627ProGln: 1.627 ± 0.455
0.814ProArg: 0.814 ± 0.548
4.068ProSer: 4.068 ± 2.742
1.627ProThr: 1.627 ± 1.409
2.441ProVal: 2.441 ± 1.032
0.814ProTrp: 0.814 ± 0.548
1.627ProTyr: 1.627 ± 0.455
0.0ProXaa: 0.0 ± 0.0
Gln
0.0GlnAla: 0.0 ± 0.0
1.627GlnCys: 1.627 ± 0.455
1.627GlnAsp: 1.627 ± 1.097
3.255GlnGlu: 3.255 ± 1.214
1.627GlnPhe: 1.627 ± 1.097
2.441GlnGly: 2.441 ± 1.032
3.255GlnHis: 3.255 ± 0.909
0.814GlnIle: 0.814 ± 0.548
0.814GlnLys: 0.814 ± 0.69
2.441GlnLeu: 2.441 ± 1.393
0.814GlnMet: 0.814 ± 0.548
1.627GlnAsn: 1.627 ± 1.305
0.0GlnPro: 0.0 ± 0.0
0.0GlnGln: 0.0 ± 0.0
0.0GlnArg: 0.0 ± 0.0
4.068GlnSer: 4.068 ± 1.091
4.068GlnThr: 4.068 ± 2.373
0.0GlnVal: 0.0 ± 0.0
0.814GlnTrp: 0.814 ± 0.69
3.255GlnTyr: 3.255 ± 0.85
0.0GlnXaa: 0.0 ± 0.0
Arg
0.814ArgAla: 0.814 ± 1.437
0.814ArgCys: 0.814 ± 0.69
4.882ArgAsp: 4.882 ± 2.268
4.068ArgGlu: 4.068 ± 2.742
4.882ArgPhe: 4.882 ± 1.364
2.441ArgGly: 2.441 ± 2.069
0.0ArgHis: 0.0 ± 0.0
4.068ArgIle: 4.068 ± 0.996
3.255ArgLys: 3.255 ± 2.759
4.882ArgLeu: 4.882 ± 2.155
0.814ArgMet: 0.814 ± 0.69
3.255ArgAsn: 3.255 ± 1.214
1.627ArgPro: 1.627 ± 1.305
2.441ArgGln: 2.441 ± 2.069
8.95ArgArg: 8.95 ± 1.676
8.137ArgSer: 8.137 ± 3.005
5.696ArgThr: 5.696 ± 1.93
5.696ArgVal: 5.696 ± 1.502
0.0ArgTrp: 0.0 ± 0.0
5.696ArgTyr: 5.696 ± 1.502
0.0ArgXaa: 0.0 ± 0.0
Ser
7.323SerAla: 7.323 ± 1.769
1.627SerCys: 1.627 ± 0.455
7.323SerAsp: 7.323 ± 1.693
7.323SerGlu: 7.323 ± 0.581
4.068SerPhe: 4.068 ± 2.373
3.255SerGly: 3.255 ± 1.214
0.0SerHis: 0.0 ± 0.0
3.255SerIle: 3.255 ± 1.165
4.068SerLys: 4.068 ± 2.055
8.137SerLeu: 8.137 ± 2.273
0.814SerMet: 0.814 ± 0.69
4.068SerAsn: 4.068 ± 0.996
2.441SerPro: 2.441 ± 0.734
1.627SerGln: 1.627 ± 0.455
5.696SerArg: 5.696 ± 3.524
3.255SerSer: 3.255 ± 1.165
6.509SerThr: 6.509 ± 1.7
7.323SerVal: 7.323 ± 2.732
0.0SerTrp: 0.0 ± 0.0
5.696SerTyr: 5.696 ± 1.502
0.0SerXaa: 0.0 ± 0.0
Thr
8.137ThrAla: 8.137 ± 6.109
0.814ThrCys: 0.814 ± 0.69
4.882ThrAsp: 4.882 ± 0.396
7.323ThrGlu: 7.323 ± 2.732
4.882ThrPhe: 4.882 ± 1.366
2.441ThrGly: 2.441 ± 1.027
1.627ThrHis: 1.627 ± 0.455
4.068ThrIle: 4.068 ± 2.742
4.068ThrLys: 4.068 ± 1.091
6.509ThrLeu: 6.509 ± 1.157
2.441ThrMet: 2.441 ± 1.027
2.441ThrAsn: 2.441 ± 1.027
3.255ThrPro: 3.255 ± 0.909
2.441ThrGln: 2.441 ± 1.393
3.255ThrArg: 3.255 ± 0.909
4.882ThrSer: 4.882 ± 3.786
4.882ThrThr: 4.882 ± 4.228
4.882ThrVal: 4.882 ± 1.364
0.814ThrTrp: 0.814 ± 0.69
2.441ThrTyr: 2.441 ± 1.393
0.0ThrXaa: 0.0 ± 0.0
Val
4.068ValAla: 4.068 ± 1.734
0.0ValCys: 0.0 ± 0.0
2.441ValAsp: 2.441 ± 1.032
4.882ValGlu: 4.882 ± 2.155
0.0ValPhe: 0.0 ± 0.0
4.882ValGly: 4.882 ± 2.063
0.814ValHis: 0.814 ± 1.437
3.255ValIle: 3.255 ± 0.85
5.696ValLys: 5.696 ± 2.72
8.95ValLeu: 8.95 ± 2.086
0.0ValMet: 0.0 ± 0.0
4.882ValAsn: 4.882 ± 0.396
3.255ValPro: 3.255 ± 1.667
2.441ValGln: 2.441 ± 1.645
4.882ValArg: 4.882 ± 1.468
8.95ValSer: 8.95 ± 1.649
4.068ValThr: 4.068 ± 0.996
1.627ValVal: 1.627 ± 1.305
1.627ValTrp: 1.627 ± 0.455
2.441ValTyr: 2.441 ± 0.734
0.0ValXaa: 0.0 ± 0.0
Trp
1.627TrpAla: 1.627 ± 0.455
0.0TrpCys: 0.0 ± 0.0
3.255TrpAsp: 3.255 ± 1.695
0.814TrpGlu: 0.814 ± 0.69
0.0TrpPhe: 0.0 ± 0.0
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.814TrpIle: 0.814 ± 0.548
0.814TrpLys: 0.814 ± 0.548
1.627TrpLeu: 1.627 ± 0.455
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
2.441TrpPro: 2.441 ± 1.645
0.814TrpGln: 0.814 ± 0.548
0.0TrpArg: 0.0 ± 0.0
0.814TrpSer: 0.814 ± 0.548
0.0TrpThr: 0.0 ± 0.0
0.814TrpVal: 0.814 ± 0.69
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
5.696TyrAla: 5.696 ± 0.677
0.0TyrCys: 0.0 ± 0.0
3.255TyrAsp: 3.255 ± 1.214
1.627TyrGlu: 1.627 ± 1.379
0.814TyrPhe: 0.814 ± 0.548
4.882TyrGly: 4.882 ± 0.396
2.441TyrHis: 2.441 ± 1.645
0.0TyrIle: 0.0 ± 0.0
2.441TyrLys: 2.441 ± 1.027
4.068TyrLeu: 4.068 ± 1.091
0.814TyrMet: 0.814 ± 0.69
3.255TyrAsn: 3.255 ± 1.214
2.441TyrPro: 2.441 ± 0.734
2.441TyrGln: 2.441 ± 1.032
6.509TyrArg: 6.509 ± 1.157
4.882TyrSer: 4.882 ± 1.068
2.441TyrThr: 2.441 ± 0.734
3.255TyrVal: 3.255 ± 0.85
1.627TyrTrp: 1.627 ± 0.455
1.627TyrTyr: 1.627 ± 1.097
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (1230 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski