Amino acid dipepetide frequency for Tobacco mosaic virus (strain vulgare) (TMV) (Tobacco mosaic virus (strain U1))

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.366AlaAla: 6.366 ± 1.739
0.979AlaCys: 0.979 ± 0.491
2.938AlaAsp: 2.938 ± 1.064
2.449AlaGlu: 2.449 ± 1.289
2.938AlaPhe: 2.938 ± 1.171
4.407AlaGly: 4.407 ± 1.384
0.979AlaHis: 0.979 ± 0.491
2.938AlaIle: 2.938 ± 2.834
5.387AlaLys: 5.387 ± 1.493
8.325AlaLeu: 8.325 ± 1.685
2.449AlaMet: 2.449 ± 0.709
2.449AlaAsn: 2.449 ± 1.173
1.959AlaPro: 1.959 ± 0.981
0.979AlaGln: 0.979 ± 0.491
2.449AlaArg: 2.449 ± 1.173
4.407AlaSer: 4.407 ± 2.208
4.407AlaThr: 4.407 ± 4.524
6.856AlaVal: 6.856 ± 2.381
1.469AlaTrp: 1.469 ± 1.321
2.449AlaTyr: 2.449 ± 1.227
0.0AlaXaa: 0.0 ± 0.0
Cys
0.979CysAla: 0.979 ± 0.491
0.49CysCys: 0.49 ± 0.245
0.979CysAsp: 0.979 ± 0.491
0.979CysGlu: 0.979 ± 0.491
0.49CysPhe: 0.49 ± 0.245
1.469CysGly: 1.469 ± 0.736
0.979CysHis: 0.979 ± 0.491
1.959CysIle: 1.959 ± 0.696
0.979CysLys: 0.979 ± 0.491
1.959CysLeu: 1.959 ± 1.798
0.979CysMet: 0.979 ± 0.436
0.49CysAsn: 0.49 ± 0.245
0.979CysPro: 0.979 ± 0.899
1.469CysGln: 1.469 ± 0.736
0.49CysArg: 0.49 ± 1.073
0.979CysSer: 0.979 ± 0.899
0.49CysThr: 0.49 ± 1.612
0.49CysVal: 0.49 ± 0.245
0.0CysTrp: 0.0 ± 0.0
0.49CysTyr: 0.49 ± 0.245
0.0CysXaa: 0.0 ± 0.0
Asp
4.407AspAla: 4.407 ± 2.274
0.49AspCys: 0.49 ± 0.245
3.428AspAsp: 3.428 ± 1.787
4.407AspGlu: 4.407 ± 1.384
3.428AspPhe: 3.428 ± 0.852
1.959AspGly: 1.959 ± 0.696
0.49AspHis: 0.49 ± 0.245
4.407AspIle: 4.407 ± 2.208
4.897AspLys: 4.897 ± 1.418
4.407AspLeu: 4.407 ± 1.334
2.938AspMet: 2.938 ± 1.472
0.979AspAsn: 0.979 ± 0.899
2.449AspPro: 2.449 ± 2.766
1.469AspGln: 1.469 ± 0.736
2.449AspArg: 2.449 ± 0.709
8.815AspSer: 8.815 ± 0.918
3.428AspThr: 3.428 ± 1.219
6.856AspVal: 6.856 ± 1.898
0.979AspTrp: 0.979 ± 0.491
0.49AspTyr: 0.49 ± 0.245
0.0AspXaa: 0.0 ± 0.0
Glu
2.938GluAla: 2.938 ± 1.531
0.0GluCys: 0.0 ± 0.0
3.918GluAsp: 3.918 ± 1.132
3.428GluGlu: 3.428 ± 0.949
4.897GluPhe: 4.897 ± 2.202
1.959GluGly: 1.959 ± 0.981
0.49GluHis: 0.49 ± 0.245
3.918GluIle: 3.918 ± 1.963
3.428GluLys: 3.428 ± 1.443
4.897GluLeu: 4.897 ± 2.111
1.469GluMet: 1.469 ± 0.736
2.449GluAsn: 2.449 ± 1.289
0.979GluPro: 0.979 ± 0.491
2.449GluGln: 2.449 ± 1.227
2.449GluArg: 2.449 ± 0.709
5.387GluSer: 5.387 ± 0.821
3.428GluThr: 3.428 ± 1.219
6.856GluVal: 6.856 ± 1.704
0.979GluTrp: 0.979 ± 0.899
2.449GluTyr: 2.449 ± 1.227
0.0GluXaa: 0.0 ± 0.0
Phe
1.469PheAla: 1.469 ± 0.736
1.959PheCys: 1.959 ± 0.696
3.918PheAsp: 3.918 ± 1.313
1.959PheGlu: 1.959 ± 1.225
1.469PhePhe: 1.469 ± 0.736
3.428PheGly: 3.428 ± 0.949
1.959PheHis: 1.959 ± 0.981
2.449PheIle: 2.449 ± 0.709
3.428PheLys: 3.428 ± 1.787
2.938PheLeu: 2.938 ± 1.171
1.469PheMet: 1.469 ± 1.603
0.979PheAsn: 0.979 ± 0.491
3.428PhePro: 3.428 ± 1.219
2.449PheGln: 2.449 ± 1.289
1.469PheArg: 1.469 ± 0.766
4.897PheSer: 4.897 ± 1.599
1.959PheThr: 1.959 ± 0.696
3.918PheVal: 3.918 ± 0.662
0.0PheTrp: 0.0 ± 0.0
1.959PheTyr: 1.959 ± 0.981
0.0PheXaa: 0.0 ± 0.0
Gly
2.938GlyAla: 2.938 ± 1.171
1.959GlyCys: 1.959 ± 0.981
4.407GlyAsp: 4.407 ± 2.208
2.449GlyGlu: 2.449 ± 0.709
1.959GlyPhe: 1.959 ± 0.696
3.428GlyGly: 3.428 ± 2.548
0.49GlyHis: 0.49 ± 0.245
1.469GlyIle: 1.469 ± 0.736
3.918GlyLys: 3.918 ± 2.413
3.918GlyLeu: 3.918 ± 1.544
0.49GlyMet: 0.49 ± 1.073
2.938GlyAsn: 2.938 ± 1.171
1.959GlyPro: 1.959 ± 1.519
0.979GlyGln: 0.979 ± 0.491
1.469GlyArg: 1.469 ± 0.736
3.918GlySer: 3.918 ± 0.662
0.979GlyThr: 0.979 ± 1.453
3.918GlyVal: 3.918 ± 1.392
0.0GlyTrp: 0.0 ± 0.0
1.469GlyTyr: 1.469 ± 0.766
0.0GlyXaa: 0.0 ± 0.0
His
0.979HisAla: 0.979 ± 0.491
0.979HisCys: 0.979 ± 0.491
0.979HisAsp: 0.979 ± 0.491
1.469HisGlu: 1.469 ± 0.766
0.979HisPhe: 0.979 ± 0.491
0.49HisGly: 0.49 ± 0.245
0.49HisHis: 0.49 ± 0.245
0.979HisIle: 0.979 ± 0.491
0.979HisLys: 0.979 ± 0.491
0.979HisLeu: 0.979 ± 0.491
0.979HisMet: 0.979 ± 0.491
0.49HisAsn: 0.49 ± 0.245
0.49HisPro: 0.49 ± 0.245
0.49HisGln: 0.49 ± 0.245
0.49HisArg: 0.49 ± 0.245
2.449HisSer: 2.449 ± 1.227
2.449HisThr: 2.449 ± 1.227
2.449HisVal: 2.449 ± 1.227
0.0HisTrp: 0.0 ± 0.0
0.979HisTyr: 0.979 ± 0.491
0.0HisXaa: 0.0 ± 0.0
Ile
2.449IleAla: 2.449 ± 1.227
0.0IleCys: 0.0 ± 0.0
4.897IleAsp: 4.897 ± 2.202
2.938IleGlu: 2.938 ± 2.642
0.49IlePhe: 0.49 ± 0.245
1.469IleGly: 1.469 ± 0.736
0.49IleHis: 0.49 ± 0.245
3.918IleIle: 3.918 ± 1.313
3.918IleLys: 3.918 ± 1.132
3.918IleLeu: 3.918 ± 1.132
0.979IleMet: 0.979 ± 0.899
3.918IleAsn: 3.918 ± 2.45
2.449IlePro: 2.449 ± 1.227
0.49IleGln: 0.49 ± 0.245
5.877IleArg: 5.877 ± 2.129
4.407IleSer: 4.407 ± 2.208
1.959IleThr: 1.959 ± 2.519
3.918IleVal: 3.918 ± 0.662
0.979IleTrp: 0.979 ± 0.491
0.49IleTyr: 0.49 ± 0.245
0.0IleXaa: 0.0 ± 0.0
Lys
1.959LysAla: 1.959 ± 0.981
0.49LysCys: 0.49 ± 0.245
4.897LysAsp: 4.897 ± 1.549
3.428LysGlu: 3.428 ± 1.717
2.938LysPhe: 2.938 ± 0.801
4.407LysGly: 4.407 ± 2.297
0.49LysHis: 0.49 ± 0.245
3.428LysIle: 3.428 ± 2.548
3.918LysLys: 3.918 ± 2.413
5.877LysLeu: 5.877 ± 1.602
1.959LysMet: 1.959 ± 1.798
3.918LysAsn: 3.918 ± 3.597
2.449LysPro: 2.449 ± 1.173
2.938LysGln: 2.938 ± 1.472
3.428LysArg: 3.428 ± 1.443
5.387LysSer: 5.387 ± 1.493
5.387LysThr: 5.387 ± 2.699
5.387LysVal: 5.387 ± 2.068
0.49LysTrp: 0.49 ± 0.245
2.449LysTyr: 2.449 ± 1.227
0.0LysXaa: 0.0 ± 0.0
Leu
5.877LeuAla: 5.877 ± 1.602
1.469LeuCys: 1.469 ± 1.321
6.856LeuAsp: 6.856 ± 2.439
8.815LeuGlu: 8.815 ± 3.42
4.897LeuPhe: 4.897 ± 2.453
3.918LeuGly: 3.918 ± 3.039
1.959LeuHis: 1.959 ± 0.981
6.366LeuIle: 6.366 ± 3.686
3.918LeuLys: 3.918 ± 1.132
9.305LeuLeu: 9.305 ± 2.286
1.469LeuMet: 1.469 ± 0.736
3.428LeuAsn: 3.428 ± 1.717
2.449LeuPro: 2.449 ± 1.652
2.449LeuGln: 2.449 ± 1.227
3.918LeuArg: 3.918 ± 1.132
7.346LeuSer: 7.346 ± 0.287
5.387LeuThr: 5.387 ± 1.493
10.774LeuVal: 10.774 ± 1.643
0.0LeuTrp: 0.0 ± 0.0
2.449LeuTyr: 2.449 ± 1.227
0.0LeuXaa: 0.0 ± 0.0
Met
2.449MetAla: 2.449 ± 0.709
1.469MetCys: 1.469 ± 0.766
0.979MetAsp: 0.979 ± 0.491
3.428MetGlu: 3.428 ± 3.759
0.49MetPhe: 0.49 ± 1.073
0.0MetGly: 0.0 ± 0.0
0.0MetHis: 0.0 ± 0.0
0.979MetIle: 0.979 ± 0.491
1.959MetLys: 1.959 ± 0.696
0.979MetLeu: 0.979 ± 0.491
1.469MetMet: 1.469 ± 0.736
0.979MetAsn: 0.979 ± 0.491
1.469MetPro: 1.469 ± 0.736
1.469MetGln: 1.469 ± 0.736
1.959MetArg: 1.959 ± 0.981
4.407MetSer: 4.407 ± 2.519
0.979MetThr: 0.979 ± 0.491
1.959MetVal: 1.959 ± 0.696
0.49MetTrp: 0.49 ± 0.245
1.469MetTyr: 1.469 ± 0.736
0.0MetXaa: 0.0 ± 0.0
Asn
4.407AsnAla: 4.407 ± 2.386
0.979AsnCys: 0.979 ± 0.899
0.979AsnAsp: 0.979 ± 0.899
2.449AsnGlu: 2.449 ± 1.652
4.897AsnPhe: 4.897 ± 2.453
0.979AsnGly: 0.979 ± 0.491
0.49AsnHis: 0.49 ± 0.245
1.959AsnIle: 1.959 ± 3.035
0.979AsnLys: 0.979 ± 0.899
5.877AsnLeu: 5.877 ± 2.983
0.0AsnMet: 0.0 ± 0.0
2.938AsnAsn: 2.938 ± 2.031
0.979AsnPro: 0.979 ± 1.453
0.979AsnGln: 0.979 ± 3.223
3.428AsnArg: 3.428 ± 2.536
2.449AsnSer: 2.449 ± 0.709
2.449AsnThr: 2.449 ± 1.227
4.897AsnVal: 4.897 ± 3.304
0.0AsnTrp: 0.0 ± 0.0
1.959AsnTyr: 1.959 ± 1.798
0.0AsnXaa: 0.0 ± 0.0
Pro
4.407ProAla: 4.407 ± 1.442
0.0ProCys: 0.0 ± 0.0
1.959ProAsp: 1.959 ± 1.519
1.959ProGlu: 1.959 ± 0.981
0.0ProPhe: 0.0 ± 0.0
1.959ProGly: 1.959 ± 0.981
0.979ProHis: 0.979 ± 0.491
1.469ProIle: 1.469 ± 1.321
2.938ProLys: 2.938 ± 1.472
3.918ProLeu: 3.918 ± 0.662
3.428ProMet: 3.428 ± 1.443
2.449ProAsn: 2.449 ± 1.652
0.49ProPro: 0.49 ± 0.245
0.49ProGln: 0.49 ± 1.612
0.49ProArg: 0.49 ± 0.245
2.449ProSer: 2.449 ± 3.037
1.959ProThr: 1.959 ± 1.225
0.979ProVal: 0.979 ± 0.899
0.0ProTrp: 0.0 ± 0.0
1.469ProTyr: 1.469 ± 0.736
0.0ProXaa: 0.0 ± 0.0
Gln
1.959GlnAla: 1.959 ± 2.906
0.0GlnCys: 0.0 ± 0.0
0.979GlnAsp: 0.979 ± 0.899
1.469GlnGlu: 1.469 ± 0.736
3.918GlnPhe: 3.918 ± 4.24
1.469GlnGly: 1.469 ± 0.736
0.979GlnHis: 0.979 ± 0.491
2.938GlnIle: 2.938 ± 1.472
1.959GlnLys: 1.959 ± 0.981
2.449GlnLeu: 2.449 ± 1.227
1.469GlnMet: 1.469 ± 0.736
0.979GlnAsn: 0.979 ± 0.491
0.979GlnPro: 0.979 ± 0.491
1.959GlnGln: 1.959 ± 1.225
0.979GlnArg: 0.979 ± 1.453
1.959GlnSer: 1.959 ± 0.981
3.428GlnThr: 3.428 ± 1.219
1.469GlnVal: 1.469 ± 1.754
0.0GlnTrp: 0.0 ± 0.0
0.979GlnTyr: 0.979 ± 0.491
0.49GlnXaa: 0.49 ± 0.245
Arg
1.959ArgAla: 1.959 ± 0.696
0.979ArgCys: 0.979 ± 0.491
2.938ArgAsp: 2.938 ± 0.801
2.449ArgGlu: 2.449 ± 0.709
1.469ArgPhe: 1.469 ± 1.754
3.428ArgGly: 3.428 ± 0.852
1.959ArgHis: 1.959 ± 0.981
1.469ArgIle: 1.469 ± 1.321
5.877ArgLys: 5.877 ± 2.001
4.897ArgLeu: 4.897 ± 1.549
0.49ArgMet: 0.49 ± 1.073
2.938ArgAsn: 2.938 ± 3.216
0.979ArgPro: 0.979 ± 0.491
1.959ArgGln: 1.959 ± 1.225
5.387ArgArg: 5.387 ± 1.776
4.407ArgSer: 4.407 ± 2.807
3.428ArgThr: 3.428 ± 0.852
4.407ArgVal: 4.407 ± 1.442
0.49ArgTrp: 0.49 ± 0.245
1.959ArgTyr: 1.959 ± 1.225
0.0ArgXaa: 0.0 ± 0.0
Ser
3.428SerAla: 3.428 ± 2.638
0.49SerCys: 0.49 ± 0.245
4.897SerAsp: 4.897 ± 1.06
6.366SerGlu: 6.366 ± 0.371
3.428SerPhe: 3.428 ± 1.787
4.407SerGly: 4.407 ± 2.274
1.469SerHis: 1.469 ± 0.736
4.407SerIle: 4.407 ± 0.522
5.877SerLys: 5.877 ± 2.001
13.712SerLeu: 13.712 ± 4.934
2.449SerMet: 2.449 ± 0.709
2.938SerAsn: 2.938 ± 0.801
0.979SerPro: 0.979 ± 1.453
1.959SerGln: 1.959 ± 1.225
5.877SerArg: 5.877 ± 2.001
7.835SerSer: 7.835 ± 4.732
1.959SerThr: 1.959 ± 0.981
7.346SerVal: 7.346 ± 2.824
0.0SerTrp: 0.0 ± 0.0
3.918SerTyr: 3.918 ± 2.45
0.0SerXaa: 0.0 ± 0.0
Thr
7.346ThrAla: 7.346 ± 1.643
1.959ThrCys: 1.959 ± 0.981
0.49ThrAsp: 0.49 ± 0.245
2.449ThrGlu: 2.449 ± 0.709
4.407ThrPhe: 4.407 ± 2.208
3.428ThrGly: 3.428 ± 1.787
0.979ThrHis: 0.979 ± 0.491
0.979ThrIle: 0.979 ± 0.491
1.959ThrLys: 1.959 ± 0.696
4.407ThrLeu: 4.407 ± 0.522
1.469ThrMet: 1.469 ± 0.89
0.979ThrAsn: 0.979 ± 1.991
2.449ThrPro: 2.449 ± 1.289
3.918ThrGln: 3.918 ± 0.662
4.897ThrArg: 4.897 ± 2.346
2.938ThrSer: 2.938 ± 1.171
3.428ThrThr: 3.428 ± 2.638
5.877ThrVal: 5.877 ± 3.564
0.49ThrTrp: 0.49 ± 0.245
2.449ThrTyr: 2.449 ± 1.227
0.0ThrXaa: 0.0 ± 0.0
Val
8.325ValAla: 8.325 ± 1.809
2.938ValCys: 2.938 ± 2.698
8.325ValAsp: 8.325 ± 0.986
3.918ValGlu: 3.918 ± 2.45
1.959ValPhe: 1.959 ± 1.225
0.49ValGly: 0.49 ± 0.245
3.428ValHis: 3.428 ± 0.949
3.428ValIle: 3.428 ± 1.717
5.387ValLys: 5.387 ± 4.343
5.877ValLeu: 5.877 ± 0.703
2.449ValMet: 2.449 ± 0.709
4.897ValAsn: 4.897 ± 2.202
4.407ValPro: 4.407 ± 2.297
1.959ValGln: 1.959 ± 1.225
3.428ValArg: 3.428 ± 1.787
6.366ValSer: 6.366 ± 1.739
6.366ValThr: 6.366 ± 1.744
5.877ValVal: 5.877 ± 3.12
2.938ValTrp: 2.938 ± 2.834
4.897ValTyr: 4.897 ± 0.475
0.0ValXaa: 0.0 ± 0.0
Trp
0.49TrpAla: 0.49 ± 1.612
0.0TrpCys: 0.0 ± 0.0
0.979TrpAsp: 0.979 ± 0.491
0.979TrpGlu: 0.979 ± 0.491
0.979TrpPhe: 0.979 ± 0.491
0.49TrpGly: 0.49 ± 0.245
0.49TrpHis: 0.49 ± 0.245
0.0TrpIle: 0.0 ± 0.0
0.979TrpLys: 0.979 ± 1.453
0.979TrpLeu: 0.979 ± 0.491
0.0TrpMet: 0.0 ± 0.0
0.979TrpAsn: 0.979 ± 0.899
0.0TrpPro: 0.0 ± 0.0
0.49TrpGln: 0.49 ± 1.073
0.979TrpArg: 0.979 ± 0.491
0.0TrpSer: 0.0 ± 0.0
0.49TrpThr: 0.49 ± 1.612
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.49TrpTyr: 0.49 ± 0.245
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.449TyrAla: 2.449 ± 0.709
0.49TyrCys: 0.49 ± 0.245
3.428TyrAsp: 3.428 ± 1.717
0.979TyrGlu: 0.979 ± 0.491
1.469TyrPhe: 1.469 ± 0.736
1.469TyrGly: 1.469 ± 0.736
0.979TyrHis: 0.979 ± 0.491
0.49TyrIle: 0.49 ± 0.245
2.938TyrLys: 2.938 ± 1.472
3.428TyrLeu: 3.428 ± 1.717
0.49TyrMet: 0.49 ± 0.245
1.959TyrAsn: 1.959 ± 2.906
1.469TyrPro: 1.469 ± 0.736
0.979TyrGln: 0.979 ± 0.491
1.959TyrArg: 1.959 ± 2.519
2.938TyrSer: 2.938 ± 1.171
3.428TyrThr: 3.428 ± 0.949
3.428TyrVal: 3.428 ± 0.949
0.49TyrTrp: 0.49 ± 0.245
2.449TyrTyr: 2.449 ± 0.709
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.49XaaGln: 0.49 ± 0.245
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (2043 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski