Amino acid dipepetide frequency for Paenibacillus mucilaginosus 3016

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.88AlaAla: 12.88 ± 0.127	0.815AlaCys: 0.815 ± 0.021	4.784AlaAsp: 4.784 ± 0.054	6.922AlaGlu: 6.922 ± 0.08	3.528AlaPhe: 3.528 ± 0.04	9.418AlaGly: 9.418 ± 0.09	1.586AlaHis: 1.586 ± 0.028	4.096AlaIle: 4.096 ± 0.053	4.009AlaLys: 4.009 ± 0.046	9.413AlaLeu: 9.413 ± 0.071	2.369AlaMet: 2.369 ± 0.037	2.239AlaAsn: 2.239 ± 0.034	3.754AlaPro: 3.754 ± 0.052	2.989AlaGln: 2.989 ± 0.039	4.48AlaArg: 4.48 ± 0.056	5.645AlaSer: 5.645 ± 0.055	2.989AlaThr: 2.989 ± 0.045	7.788AlaVal: 7.788 ± 0.064	1.212AlaTrp: 1.212 ± 0.025	3.201AlaTyr: 3.201 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.612CysAla: 0.612 ± 0.017	0.115CysCys: 0.115 ± 0.007	0.337CysAsp: 0.337 ± 0.012	0.402CysGlu: 0.402 ± 0.015	0.276CysPhe: 0.276 ± 0.012	0.803CysGly: 0.803 ± 0.02	0.164CysHis: 0.164 ± 0.009	0.45CysIle: 0.45 ± 0.016	0.208CysLys: 0.208 ± 0.01	0.789CysLeu: 0.789 ± 0.019	0.213CysMet: 0.213 ± 0.011	0.171CysAsn: 0.171 ± 0.009	0.377CysPro: 0.377 ± 0.014	0.179CysGln: 0.179 ± 0.009	0.629CysArg: 0.629 ± 0.02	0.624CysSer: 0.624 ± 0.017	0.445CysThr: 0.445 ± 0.015	0.454CysVal: 0.454 ± 0.014	0.089CysTrp: 0.089 ± 0.006	0.254CysTyr: 0.254 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	4.26AspAla: 4.26 ± 0.041	0.364AspCys: 0.364 ± 0.013	1.987AspAsp: 1.987 ± 0.039	3.377AspGlu: 3.377 ± 0.044	1.889AspPhe: 1.889 ± 0.031	4.444AspGly: 4.444 ± 0.062	1.042AspHis: 1.042 ± 0.024	2.701AspIle: 2.701 ± 0.038	2.117AspLys: 2.117 ± 0.039	4.837AspLeu: 4.837 ± 0.048	1.115AspMet: 1.115 ± 0.023	1.335AspAsn: 1.335 ± 0.029	2.779AspPro: 2.779 ± 0.04	1.545AspGln: 1.545 ± 0.026	3.195AspArg: 3.195 ± 0.041	2.57AspSer: 2.57 ± 0.035	2.536AspThr: 2.536 ± 0.035	3.16AspVal: 3.16 ± 0.037	0.854AspTrp: 0.854 ± 0.019	1.943AspTyr: 1.943 ± 0.028	0.0AspXaa: 0.0 ± 0.0
Glu	7.574GluAla: 7.574 ± 0.083	0.366GluCys: 0.366 ± 0.014	3.092GluAsp: 3.092 ± 0.038	5.994GluGlu: 5.994 ± 0.068	2.024GluPhe: 2.024 ± 0.029	5.308GluGly: 5.308 ± 0.055	1.529GluHis: 1.529 ± 0.024	3.693GluIle: 3.693 ± 0.044	3.447GluLys: 3.447 ± 0.046	7.804GluLeu: 7.804 ± 0.083	1.751GluMet: 1.751 ± 0.027	2.006GluAsn: 2.006 ± 0.035	2.784GluPro: 2.784 ± 0.039	3.176GluGln: 3.176 ± 0.046	4.602GluArg: 4.602 ± 0.064	3.369GluSer: 3.369 ± 0.037	3.363GluThr: 3.363 ± 0.037	4.632GluVal: 4.632 ± 0.056	0.934GluTrp: 0.934 ± 0.02	1.921GluTyr: 1.921 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	3.268PheAla: 3.268 ± 0.04	0.335PheCys: 0.335 ± 0.012	2.142PheAsp: 2.142 ± 0.034	2.34PheGlu: 2.34 ± 0.038	1.749PhePhe: 1.749 ± 0.034	3.319PheGly: 3.319 ± 0.038	0.937PheHis: 0.937 ± 0.021	2.243PheIle: 2.243 ± 0.039	1.547PheLys: 1.547 ± 0.024	3.979PheLeu: 3.979 ± 0.054	0.959PheMet: 0.959 ± 0.022	1.201PheAsn: 1.201 ± 0.026	1.639PhePro: 1.639 ± 0.029	1.304PheGln: 1.304 ± 0.032	2.403PheArg: 2.403 ± 0.03	2.499PheSer: 2.499 ± 0.033	2.415PheThr: 2.415 ± 0.034	2.76PheVal: 2.76 ± 0.035	0.529PheTrp: 0.529 ± 0.016	1.41PheTyr: 1.41 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	7.169GlyAla: 7.169 ± 0.075	0.817GlyCys: 0.817 ± 0.021	3.75GlyAsp: 3.75 ± 0.047	5.585GlyGlu: 5.585 ± 0.06	3.342GlyPhe: 3.342 ± 0.039	7.167GlyGly: 7.167 ± 0.08	1.614GlyHis: 1.614 ± 0.026	5.172GlyIle: 5.172 ± 0.056	3.696GlyLys: 3.696 ± 0.041	8.378GlyLeu: 8.378 ± 0.068	2.568GlyMet: 2.568 ± 0.034	2.206GlyAsn: 2.206 ± 0.04	2.651GlyPro: 2.651 ± 0.042	2.911GlyGln: 2.911 ± 0.036	5.471GlyArg: 5.471 ± 0.061	5.533GlySer: 5.533 ± 0.061	5.329GlyThr: 5.329 ± 0.062	5.705GlyVal: 5.705 ± 0.053	1.319GlyTrp: 1.319 ± 0.029	2.956GlyTyr: 2.956 ± 0.038	0.0GlyXaa: 0.0 ± 0.0
His	1.769HisAla: 1.769 ± 0.028	0.205HisCys: 0.205 ± 0.01	0.923HisAsp: 0.923 ± 0.024	1.285HisGlu: 1.285 ± 0.025	0.965HisPhe: 0.965 ± 0.02	1.742HisGly: 1.742 ± 0.029	0.642HisHis: 0.642 ± 0.024	1.194HisIle: 1.194 ± 0.022	0.711HisLys: 0.711 ± 0.017	2.225HisLeu: 2.225 ± 0.028	0.522HisMet: 0.522 ± 0.015	0.556HisAsn: 0.556 ± 0.015	1.39HisPro: 1.39 ± 0.027	0.701HisGln: 0.701 ± 0.018	1.344HisArg: 1.344 ± 0.029	1.17HisSer: 1.17 ± 0.024	1.104HisThr: 1.104 ± 0.021	1.32HisVal: 1.32 ± 0.022	0.356HisTrp: 0.356 ± 0.013	0.918HisTyr: 0.918 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	5.098IleAla: 5.098 ± 0.05	0.465IleCys: 0.465 ± 0.015	2.936IleAsp: 2.936 ± 0.036	3.519IleGlu: 3.519 ± 0.044	1.861IlePhe: 1.861 ± 0.033	4.908IleGly: 4.908 ± 0.048	1.276IleHis: 1.276 ± 0.025	2.855IleIle: 2.855 ± 0.047	2.03IleLys: 2.03 ± 0.036	5.191IleLeu: 5.191 ± 0.059	1.206IleMet: 1.206 ± 0.028	1.669IleAsn: 1.669 ± 0.027	2.891IlePro: 2.891 ± 0.039	1.933IleGln: 1.933 ± 0.03	3.951IleArg: 3.951 ± 0.044	3.34IleSer: 3.34 ± 0.04	3.246IleThr: 3.246 ± 0.041	4.059IleVal: 4.059 ± 0.045	0.617IleTrp: 0.617 ± 0.018	1.719IleTyr: 1.719 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	4.047LysAla: 4.047 ± 0.045	0.173LysCys: 0.173 ± 0.009	2.465LysAsp: 2.465 ± 0.039	3.741LysGlu: 3.741 ± 0.042	1.278LysPhe: 1.278 ± 0.023	3.33LysGly: 3.33 ± 0.039	0.96LysHis: 0.96 ± 0.02	2.287LysIle: 2.287 ± 0.037	2.537LysLys: 2.537 ± 0.048	4.801LysLeu: 4.801 ± 0.05	1.172LysMet: 1.172 ± 0.022	1.55LysAsn: 1.55 ± 0.029	2.115LysPro: 2.115 ± 0.032	1.882LysGln: 1.882 ± 0.037	2.509LysArg: 2.509 ± 0.038	2.326LysSer: 2.326 ± 0.032	2.344LysThr: 2.344 ± 0.04	3.175LysVal: 3.175 ± 0.045	0.582LysTrp: 0.582 ± 0.014	1.447LysTyr: 1.447 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	9.701LeuAla: 9.701 ± 0.078	0.905LeuCys: 0.905 ± 0.023	4.769LeuAsp: 4.769 ± 0.046	6.711LeuGlu: 6.711 ± 0.071	4.525LeuPhe: 4.525 ± 0.053	7.809LeuGly: 7.809 ± 0.065	2.35LeuHis: 2.35 ± 0.041	5.644LeuIle: 5.644 ± 0.061	4.833LeuLys: 4.833 ± 0.05	12.542LeuLeu: 12.542 ± 0.121	2.492LeuMet: 2.492 ± 0.032	3.125LeuAsn: 3.125 ± 0.036	5.507LeuPro: 5.507 ± 0.062	4.634LeuGln: 4.634 ± 0.056	6.139LeuArg: 6.139 ± 0.064	6.998LeuSer: 6.998 ± 0.063	6.134LeuThr: 6.134 ± 0.051	6.57LeuVal: 6.57 ± 0.065	1.223LeuTrp: 1.223 ± 0.029	3.331LeuTyr: 3.331 ± 0.035	0.0LeuXaa: 0.0 ± 0.0
Met	2.293MetAla: 2.293 ± 0.035	0.138MetCys: 0.138 ± 0.008	1.356MetAsp: 1.356 ± 0.025	1.829MetGlu: 1.829 ± 0.027	0.93MetPhe: 0.93 ± 0.021	1.715MetGly: 1.715 ± 0.029	0.477MetHis: 0.477 ± 0.015	1.627MetIle: 1.627 ± 0.026	1.739MetLys: 1.739 ± 0.031	2.779MetLeu: 2.779 ± 0.037	0.761MetMet: 0.761 ± 0.019	1.291MetAsn: 1.291 ± 0.023	1.129MetPro: 1.129 ± 0.025	0.909MetGln: 0.909 ± 0.021	1.353MetArg: 1.353 ± 0.027	1.587MetSer: 1.587 ± 0.029	1.69MetThr: 1.69 ± 0.029	1.684MetVal: 1.684 ± 0.026	0.225MetTrp: 0.225 ± 0.01	0.751MetTyr: 0.751 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	2.483AsnAla: 2.483 ± 0.037	0.189AsnCys: 0.189 ± 0.01	1.369AsnAsp: 1.369 ± 0.025	1.824AsnGlu: 1.824 ± 0.032	1.048AsnPhe: 1.048 ± 0.023	2.813AsnGly: 2.813 ± 0.042	0.669AsnHis: 0.669 ± 0.019	1.651AsnIle: 1.651 ± 0.028	1.359AsnLys: 1.359 ± 0.025	2.882AsnLeu: 2.882 ± 0.04	0.772AsnMet: 0.772 ± 0.018	1.053AsnAsn: 1.053 ± 0.026	1.866AsnPro: 1.866 ± 0.034	1.084AsnGln: 1.084 ± 0.022	1.949AsnArg: 1.949 ± 0.027	1.546AsnSer: 1.546 ± 0.029	1.695AsnThr: 1.695 ± 0.032	2.07AsnVal: 2.07 ± 0.035	0.436AsnTrp: 0.436 ± 0.015	1.137AsnTyr: 1.137 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	5.095ProAla: 5.095 ± 0.059	0.261ProCys: 0.261 ± 0.011	2.702ProAsp: 2.702 ± 0.037	3.937ProGlu: 3.937 ± 0.051	1.898ProPhe: 1.898 ± 0.029	4.103ProGly: 4.103 ± 0.05	1.012ProHis: 1.012 ± 0.019	1.963ProIle: 1.963 ± 0.029	1.811ProLys: 1.811 ± 0.036	4.761ProLeu: 4.761 ± 0.055	1.119ProMet: 1.119 ± 0.023	1.321ProAsn: 1.321 ± 0.026	1.836ProPro: 1.836 ± 0.038	1.77ProGln: 1.77 ± 0.029	1.851ProArg: 1.851 ± 0.027	2.787ProSer: 2.787 ± 0.038	1.716ProThr: 1.716 ± 0.029	3.972ProVal: 3.972 ± 0.046	0.671ProTrp: 0.671 ± 0.02	1.697ProTyr: 1.697 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	3.765GlnAla: 3.765 ± 0.044	0.193GlnCys: 0.193 ± 0.009	1.588GlnAsp: 1.588 ± 0.029	2.848GlnGlu: 2.848 ± 0.035	1.292GlnPhe: 1.292 ± 0.025	3.001GlnGly: 3.001 ± 0.041	0.746GlnHis: 0.746 ± 0.022	1.933GlnIle: 1.933 ± 0.032	1.621GlnLys: 1.621 ± 0.028	3.821GlnLeu: 3.821 ± 0.05	1.001GlnMet: 1.001 ± 0.022	0.998GlnAsn: 0.998 ± 0.021	1.827GlnPro: 1.827 ± 0.034	1.61GlnGln: 1.61 ± 0.033	2.112GlnArg: 2.112 ± 0.036	2.05GlnSer: 2.05 ± 0.036	1.981GlnThr: 1.981 ± 0.032	2.53GlnVal: 2.53 ± 0.037	0.576GlnTrp: 0.576 ± 0.015	1.225GlnTyr: 1.225 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	4.158ArgAla: 4.158 ± 0.045	0.457ArgCys: 0.457 ± 0.014	2.622ArgAsp: 2.622 ± 0.037	4.734ArgGlu: 4.734 ± 0.064	2.538ArgPhe: 2.538 ± 0.033	3.866ArgGly: 3.866 ± 0.048	1.319ArgHis: 1.319 ± 0.028	4.054ArgIle: 4.054 ± 0.047	2.724ArgLys: 2.724 ± 0.041	6.742ArgLeu: 6.742 ± 0.071	1.953ArgMet: 1.953 ± 0.029	1.584ArgAsn: 1.584 ± 0.028	2.431ArgPro: 2.431 ± 0.041	2.362ArgGln: 2.362 ± 0.033	4.096ArgArg: 4.096 ± 0.053	3.888ArgSer: 3.888 ± 0.047	3.494ArgThr: 3.494 ± 0.044	3.653ArgVal: 3.653 ± 0.036	0.901ArgTrp: 0.901 ± 0.022	2.001ArgTyr: 2.001 ± 0.031	0.0ArgXaa: 0.0 ± 0.0
Ser	5.391SerAla: 5.391 ± 0.058	0.438SerCys: 0.438 ± 0.014	2.699SerAsp: 2.699 ± 0.035	3.546SerGlu: 3.546 ± 0.038	2.774SerPhe: 2.774 ± 0.036	6.012SerGly: 6.012 ± 0.059	1.163SerHis: 1.163 ± 0.025	3.39SerIle: 3.39 ± 0.046	2.515SerLys: 2.515 ± 0.038	6.439SerLeu: 6.439 ± 0.058	1.707SerMet: 1.707 ± 0.028	1.602SerAsn: 1.602 ± 0.028	2.78SerPro: 2.78 ± 0.041	1.793SerGln: 1.793 ± 0.029	3.739SerArg: 3.739 ± 0.037	4.022SerSer: 4.022 ± 0.051	2.965SerThr: 2.965 ± 0.038	4.513SerVal: 4.513 ± 0.046	0.929SerTrp: 0.929 ± 0.021	2.126SerTyr: 2.126 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	5.725ThrAla: 5.725 ± 0.063	0.344ThrCys: 0.344 ± 0.013	2.718ThrAsp: 2.718 ± 0.036	3.326ThrGlu: 3.326 ± 0.035	2.19ThrPhe: 2.19 ± 0.03	5.184ThrGly: 5.184 ± 0.064	0.977ThrHis: 0.977 ± 0.017	2.881ThrIle: 2.881 ± 0.042	2.114ThrLys: 2.114 ± 0.033	5.665ThrLeu: 5.665 ± 0.052	1.314ThrMet: 1.314 ± 0.026	1.592ThrAsn: 1.592 ± 0.026	2.78ThrPro: 2.78 ± 0.041	1.536ThrGln: 1.536 ± 0.03	2.388ThrArg: 2.388 ± 0.029	2.975ThrSer: 2.975 ± 0.045	2.682ThrThr: 2.682 ± 0.046	4.769ThrVal: 4.769 ± 0.055	0.681ThrTrp: 0.681 ± 0.019	1.951ThrTyr: 1.951 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	4.837ValAla: 4.837 ± 0.053	0.642ValCys: 0.642 ± 0.015	3.32ValAsp: 3.32 ± 0.042	4.411ValGlu: 4.411 ± 0.042	2.877ValPhe: 2.877 ± 0.039	4.518ValGly: 4.518 ± 0.044	1.559ValHis: 1.559 ± 0.025	4.291ValIle: 4.291 ± 0.047	3.536ValLys: 3.536 ± 0.043	7.878ValLeu: 7.878 ± 0.072	1.933ValMet: 1.933 ± 0.03	2.493ValAsn: 2.493 ± 0.041	3.613ValPro: 3.613 ± 0.043	2.757ValGln: 2.757 ± 0.037	4.284ValArg: 4.284 ± 0.047	4.746ValSer: 4.746 ± 0.051	4.806ValThr: 4.806 ± 0.068	4.822ValVal: 4.822 ± 0.048	0.978ValTrp: 0.978 ± 0.026	2.533ValTyr: 2.533 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.034TrpAla: 1.034 ± 0.019	0.103TrpCys: 0.103 ± 0.007	0.717TrpAsp: 0.717 ± 0.018	0.879TrpGlu: 0.879 ± 0.019	0.582TrpPhe: 0.582 ± 0.017	0.982TrpGly: 0.982 ± 0.024	0.283TrpHis: 0.283 ± 0.011	0.859TrpIle: 0.859 ± 0.021	0.754TrpLys: 0.754 ± 0.02	1.51TrpLeu: 1.51 ± 0.03	0.456TrpMet: 0.456 ± 0.014	0.684TrpAsn: 0.684 ± 0.019	0.433TrpPro: 0.433 ± 0.014	0.521TrpGln: 0.521 ± 0.018	0.728TrpArg: 0.728 ± 0.02	0.896TrpSer: 0.896 ± 0.023	0.842TrpThr: 0.842 ± 0.022	0.893TrpVal: 0.893 ± 0.022	0.208TrpTrp: 0.208 ± 0.01	0.47TrpTyr: 0.47 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.957TyrAla: 2.957 ± 0.041	0.264TyrCys: 0.264 ± 0.01	1.77TyrAsp: 1.77 ± 0.032	2.159TyrGlu: 2.159 ± 0.033	1.414TyrPhe: 1.414 ± 0.024	2.895TyrGly: 2.895 ± 0.036	0.74TyrHis: 0.74 ± 0.02	1.785TyrIle: 1.785 ± 0.031	1.415TyrLys: 1.415 ± 0.025	3.505TyrLeu: 3.505 ± 0.039	0.882TyrMet: 0.882 ± 0.02	1.221TyrAsn: 1.221 ± 0.023	1.703TyrPro: 1.703 ± 0.027	1.117TyrGln: 1.117 ± 0.023	2.354TyrArg: 2.354 ± 0.03	1.97TyrSer: 1.97 ± 0.035	2.016TyrThr: 2.016 ± 0.035	2.306TyrVal: 2.306 ± 0.03	0.515TyrTrp: 0.515 ± 0.016	1.349TyrTyr: 1.349 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7018 proteins (2302481 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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