Amino acid dipepetide frequency for Mesorhizobium sp. LSHC420B00

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.374AlaAla: 17.374 ± 0.131	1.023AlaCys: 1.023 ± 0.028	6.868AlaAsp: 6.868 ± 0.059	7.586AlaGlu: 7.586 ± 0.076	4.629AlaPhe: 4.629 ± 0.057	10.894AlaGly: 10.894 ± 0.096	2.156AlaHis: 2.156 ± 0.037	6.879AlaIle: 6.879 ± 0.07	4.669AlaLys: 4.669 ± 0.057	12.771AlaLeu: 12.771 ± 0.097	3.556AlaMet: 3.556 ± 0.042	3.062AlaAsn: 3.062 ± 0.04	4.965AlaPro: 4.965 ± 0.056	3.417AlaGln: 3.417 ± 0.044	8.238AlaArg: 8.238 ± 0.074	6.608AlaSer: 6.608 ± 0.062	5.842AlaThr: 5.842 ± 0.06	8.996AlaVal: 8.996 ± 0.082	1.507AlaTrp: 1.507 ± 0.032	2.676AlaTyr: 2.676 ± 0.04	0.007AlaXaa: 0.007 ± 0.002
Cys	0.935CysAla: 0.935 ± 0.024	0.126CysCys: 0.126 ± 0.007	0.501CysAsp: 0.501 ± 0.014	0.439CysGlu: 0.439 ± 0.015	0.366CysPhe: 0.366 ± 0.014	0.901CysGly: 0.901 ± 0.021	0.231CysHis: 0.231 ± 0.011	0.399CysIle: 0.399 ± 0.014	0.185CysLys: 0.185 ± 0.01	0.797CysLeu: 0.797 ± 0.021	0.171CysMet: 0.171 ± 0.01	0.215CysAsn: 0.215 ± 0.01	0.416CysPro: 0.416 ± 0.016	0.23CysGln: 0.23 ± 0.011	0.659CysArg: 0.659 ± 0.019	0.499CysSer: 0.499 ± 0.015	0.425CysThr: 0.425 ± 0.017	0.589CysVal: 0.589 ± 0.019	0.138CysTrp: 0.138 ± 0.008	0.2CysTyr: 0.2 ± 0.009	0.002CysXaa: 0.002 ± 0.001
Asp	6.577AspAla: 6.577 ± 0.058	0.493AspCys: 0.493 ± 0.017	3.138AspAsp: 3.138 ± 0.053	3.477AspGlu: 3.477 ± 0.052	2.255AspPhe: 2.255 ± 0.032	5.07AspGly: 5.07 ± 0.059	1.292AspHis: 1.292 ± 0.026	3.25AspIle: 3.25 ± 0.043	1.939AspLys: 1.939 ± 0.034	5.711AspLeu: 5.711 ± 0.058	1.384AspMet: 1.384 ± 0.03	1.436AspAsn: 1.436 ± 0.031	3.316AspPro: 3.316 ± 0.045	1.797AspGln: 1.797 ± 0.031	4.37AspArg: 4.37 ± 0.053	2.13AspSer: 2.13 ± 0.032	2.481AspThr: 2.481 ± 0.042	4.012AspVal: 4.012 ± 0.046	0.967AspTrp: 0.967 ± 0.025	1.455AspTyr: 1.455 ± 0.029	0.005AspXaa: 0.005 ± 0.001
Glu	7.397GluAla: 7.397 ± 0.08	0.363GluCys: 0.363 ± 0.014	2.554GluAsp: 2.554 ± 0.04	2.932GluGlu: 2.932 ± 0.048	1.96GluPhe: 1.96 ± 0.031	3.923GluGly: 3.923 ± 0.046	1.201GluHis: 1.201 ± 0.024	3.631GluIle: 3.631 ± 0.043	2.541GluLys: 2.541 ± 0.044	5.371GluLeu: 5.371 ± 0.066	1.545GluMet: 1.545 ± 0.029	1.608GluAsn: 1.608 ± 0.032	2.855GluPro: 2.855 ± 0.041	2.143GluGln: 2.143 ± 0.033	4.744GluArg: 4.744 ± 0.055	2.218GluSer: 2.218 ± 0.037	3.346GluThr: 3.346 ± 0.041	3.67GluVal: 3.67 ± 0.054	0.724GluTrp: 0.724 ± 0.019	0.967GluTyr: 0.967 ± 0.026	0.007GluXaa: 0.007 ± 0.002
Phe	4.812PheAla: 4.812 ± 0.056	0.399PheCys: 0.399 ± 0.016	2.809PheAsp: 2.809 ± 0.042	2.225PheGlu: 2.225 ± 0.038	1.569PhePhe: 1.569 ± 0.035	3.82PheGly: 3.82 ± 0.05	0.799PheHis: 0.799 ± 0.022	1.834PheIle: 1.834 ± 0.03	1.098PheLys: 1.098 ± 0.025	3.573PheLeu: 3.573 ± 0.047	0.857PheMet: 0.857 ± 0.022	1.072PheAsn: 1.072 ± 0.025	1.665PhePro: 1.665 ± 0.028	1.109PheGln: 1.109 ± 0.022	2.44PheArg: 2.44 ± 0.038	2.475PheSer: 2.475 ± 0.037	1.864PheThr: 1.864 ± 0.031	3.088PheVal: 3.088 ± 0.045	0.588PheTrp: 0.588 ± 0.018	0.947PheTyr: 0.947 ± 0.023	0.001PheXaa: 0.001 ± 0.0
Gly	8.759GlyAla: 8.759 ± 0.073	0.846GlyCys: 0.846 ± 0.025	4.389GlyAsp: 4.389 ± 0.056	4.658GlyGlu: 4.658 ± 0.05	3.689GlyPhe: 3.689 ± 0.045	7.078GlyGly: 7.078 ± 0.078	1.915GlyHis: 1.915 ± 0.033	4.992GlyIle: 4.992 ± 0.062	3.857GlyLys: 3.857 ± 0.048	8.733GlyLeu: 8.733 ± 0.079	2.37GlyMet: 2.37 ± 0.038	2.333GlyAsn: 2.333 ± 0.034	3.47GlyPro: 3.47 ± 0.041	2.747GlyGln: 2.747 ± 0.037	5.964GlyArg: 5.964 ± 0.056	4.802GlySer: 4.802 ± 0.056	4.413GlyThr: 4.413 ± 0.044	5.981GlyVal: 5.981 ± 0.062	1.378GlyTrp: 1.378 ± 0.03	2.29GlyTyr: 2.29 ± 0.034	0.006GlyXaa: 0.006 ± 0.002
His	2.32HisAla: 2.32 ± 0.038	0.25HisCys: 0.25 ± 0.012	1.264HisAsp: 1.264 ± 0.027	1.069HisGlu: 1.069 ± 0.025	0.932HisPhe: 0.932 ± 0.022	1.96HisGly: 1.96 ± 0.035	0.565HisHis: 0.565 ± 0.021	1.017HisIle: 1.017 ± 0.023	0.539HisLys: 0.539 ± 0.017	2.033HisLeu: 2.033 ± 0.034	0.522HisMet: 0.522 ± 0.016	0.472HisAsn: 0.472 ± 0.016	1.29HisPro: 1.29 ± 0.026	0.614HisGln: 0.614 ± 0.017	1.457HisArg: 1.457 ± 0.031	1.019HisSer: 1.019 ± 0.027	0.809HisThr: 0.809 ± 0.021	1.51HisVal: 1.51 ± 0.03	0.364HisTrp: 0.364 ± 0.015	0.555HisTyr: 0.555 ± 0.016	0.003HisXaa: 0.003 ± 0.001
Ile	7.759IleAla: 7.759 ± 0.076	0.508IleCys: 0.508 ± 0.016	3.789IleAsp: 3.789 ± 0.049	3.591IleGlu: 3.591 ± 0.048	1.947IlePhe: 1.947 ± 0.036	5.344IleGly: 5.344 ± 0.065	0.991IleHis: 0.991 ± 0.022	2.517IleIle: 2.517 ± 0.041	1.62IleLys: 1.62 ± 0.029	4.458IleLeu: 4.458 ± 0.054	1.121IleMet: 1.121 ± 0.021	1.462IleAsn: 1.462 ± 0.028	2.385IlePro: 2.385 ± 0.033	1.194IleGln: 1.194 ± 0.026	3.409IleArg: 3.409 ± 0.044	3.18IleSer: 3.18 ± 0.046	2.582IleThr: 2.582 ± 0.037	4.816IleVal: 4.816 ± 0.057	0.633IleTrp: 0.633 ± 0.021	1.2IleTyr: 1.2 ± 0.024	0.004IleXaa: 0.004 ± 0.001
Lys	4.804LysAla: 4.804 ± 0.06	0.176LysCys: 0.176 ± 0.009	1.88LysAsp: 1.88 ± 0.035	1.71LysGlu: 1.71 ± 0.035	1.035LysPhe: 1.035 ± 0.025	2.801LysGly: 2.801 ± 0.038	0.689LysHis: 0.689 ± 0.017	2.031LysIle: 2.031 ± 0.037	1.605LysLys: 1.605 ± 0.037	3.678LysLeu: 3.678 ± 0.05	0.935LysMet: 0.935 ± 0.023	0.977LysAsn: 0.977 ± 0.025	2.404LysPro: 2.404 ± 0.039	1.145LysGln: 1.145 ± 0.028	2.626LysArg: 2.626 ± 0.035	2.147LysSer: 2.147 ± 0.039	2.183LysThr: 2.183 ± 0.034	2.705LysVal: 2.705 ± 0.037	0.444LysTrp: 0.444 ± 0.015	0.706LysTyr: 0.706 ± 0.021	0.001LysXaa: 0.001 ± 0.001
Leu	13.475LeuAla: 13.475 ± 0.101	0.891LeuCys: 0.891 ± 0.022	5.954LeuAsp: 5.954 ± 0.062	5.047LeuGlu: 5.047 ± 0.061	3.744LeuPhe: 3.744 ± 0.056	8.214LeuGly: 8.214 ± 0.08	1.818LeuHis: 1.818 ± 0.034	5.116LeuIle: 5.116 ± 0.063	3.827LeuLys: 3.827 ± 0.044	9.347LeuLeu: 9.347 ± 0.083	2.305LeuMet: 2.305 ± 0.032	2.5LeuAsn: 2.5 ± 0.039	5.441LeuPro: 5.441 ± 0.052	2.755LeuGln: 2.755 ± 0.04	6.416LeuArg: 6.416 ± 0.063	6.585LeuSer: 6.585 ± 0.06	5.216LeuThr: 5.216 ± 0.057	7.596LeuVal: 7.596 ± 0.071	1.174LeuTrp: 1.174 ± 0.031	2.063LeuTyr: 2.063 ± 0.034	0.007LeuXaa: 0.007 ± 0.002
Met	3.283MetAla: 3.283 ± 0.042	0.163MetCys: 0.163 ± 0.01	1.121MetAsp: 1.121 ± 0.024	1.075MetGlu: 1.075 ± 0.027	0.77MetPhe: 0.77 ± 0.021	1.656MetGly: 1.656 ± 0.027	0.488MetHis: 0.488 ± 0.018	1.422MetIle: 1.422 ± 0.033	1.142MetLys: 1.142 ± 0.027	2.628MetLeu: 2.628 ± 0.041	0.704MetMet: 0.704 ± 0.021	0.839MetAsn: 0.839 ± 0.019	1.554MetPro: 1.554 ± 0.031	0.844MetGln: 0.844 ± 0.022	1.838MetArg: 1.838 ± 0.027	1.647MetSer: 1.647 ± 0.029	1.842MetThr: 1.842 ± 0.032	1.809MetVal: 1.809 ± 0.031	0.229MetTrp: 0.229 ± 0.011	0.293MetTyr: 0.293 ± 0.011	0.001MetXaa: 0.001 ± 0.001
Asn	3.213AsnAla: 3.213 ± 0.043	0.255AsnCys: 0.255 ± 0.012	1.441AsnAsp: 1.441 ± 0.026	1.31AsnGlu: 1.31 ± 0.028	1.112AsnPhe: 1.112 ± 0.021	2.459AsnGly: 2.459 ± 0.035	0.531AsnHis: 0.531 ± 0.016	1.444AsnIle: 1.444 ± 0.03	0.765AsnLys: 0.765 ± 0.023	2.521AsnLeu: 2.521 ± 0.036	0.641AsnMet: 0.641 ± 0.019	0.736AsnAsn: 0.736 ± 0.023	1.828AsnPro: 1.828 ± 0.032	0.759AsnGln: 0.759 ± 0.02	1.834AsnArg: 1.834 ± 0.03	1.391AsnSer: 1.391 ± 0.026	1.268AsnThr: 1.268 ± 0.025	1.967AsnVal: 1.967 ± 0.035	0.474AsnTrp: 0.474 ± 0.017	0.718AsnTyr: 0.718 ± 0.021	0.003AsnXaa: 0.003 ± 0.001
Pro	6.174ProAla: 6.174 ± 0.058	0.32ProCys: 0.32 ± 0.014	3.468ProAsp: 3.468 ± 0.049	3.424ProGlu: 3.424 ± 0.043	2.006ProPhe: 2.006 ± 0.029	4.398ProGly: 4.398 ± 0.057	1.04ProHis: 1.04 ± 0.024	2.363ProIle: 2.363 ± 0.035	1.921ProLys: 1.921 ± 0.038	4.719ProLeu: 4.719 ± 0.051	1.16ProMet: 1.16 ± 0.026	1.371ProAsn: 1.371 ± 0.029	2.405ProPro: 2.405 ± 0.043	1.653ProGln: 1.653 ± 0.028	2.757ProArg: 2.757 ± 0.041	2.831ProSer: 2.831 ± 0.041	2.368ProThr: 2.368 ± 0.039	4.098ProVal: 4.098 ± 0.05	0.741ProTrp: 0.741 ± 0.022	1.236ProTyr: 1.236 ± 0.026	0.005ProXaa: 0.005 ± 0.001
Gln	3.933GlnAla: 3.933 ± 0.049	0.211GlnCys: 0.211 ± 0.011	1.394GlnAsp: 1.394 ± 0.028	1.437GlnGlu: 1.437 ± 0.03	1.106GlnPhe: 1.106 ± 0.024	2.242GlnGly: 2.242 ± 0.038	0.656GlnHis: 0.656 ± 0.02	1.833GlnIle: 1.833 ± 0.035	1.222GlnLys: 1.222 ± 0.023	2.834GlnLeu: 2.834 ± 0.041	0.869GlnMet: 0.869 ± 0.022	0.895GlnAsn: 0.895 ± 0.023	1.673GlnPro: 1.673 ± 0.029	1.196GlnGln: 1.196 ± 0.031	2.462GlnArg: 2.462 ± 0.045	1.775GlnSer: 1.775 ± 0.027	1.666GlnThr: 1.666 ± 0.026	2.093GlnVal: 2.093 ± 0.029	0.433GlnTrp: 0.433 ± 0.015	0.58GlnTyr: 0.58 ± 0.019	0.003GlnXaa: 0.003 ± 0.001
Arg	7.379ArgAla: 7.379 ± 0.071	0.516ArgCys: 0.516 ± 0.017	3.968ArgAsp: 3.968 ± 0.048	3.914ArgGlu: 3.914 ± 0.05	2.927ArgPhe: 2.927 ± 0.04	4.62ArgGly: 4.62 ± 0.058	1.818ArgHis: 1.818 ± 0.033	4.035ArgIle: 4.035 ± 0.048	2.615ArgLys: 2.615 ± 0.039	7.797ArgLeu: 7.797 ± 0.075	1.841ArgMet: 1.841 ± 0.028	1.95ArgAsn: 1.95 ± 0.033	3.451ArgPro: 3.451 ± 0.044	2.697ArgGln: 2.697 ± 0.04	5.675ArgArg: 5.675 ± 0.07	3.977ArgSer: 3.977 ± 0.048	3.414ArgThr: 3.414 ± 0.045	4.356ArgVal: 4.356 ± 0.048	0.966ArgTrp: 0.966 ± 0.023	1.727ArgTyr: 1.727 ± 0.033	0.007ArgXaa: 0.007 ± 0.002
Ser	6.32SerAla: 6.32 ± 0.063	0.456SerCys: 0.456 ± 0.015	3.092SerAsp: 3.092 ± 0.036	2.866SerGlu: 2.866 ± 0.048	2.462SerPhe: 2.462 ± 0.034	5.796SerGly: 5.796 ± 0.055	1.159SerHis: 1.159 ± 0.028	3.019SerIle: 3.019 ± 0.047	1.832SerLys: 1.832 ± 0.032	5.534SerLeu: 5.534 ± 0.063	1.433SerMet: 1.433 ± 0.027	1.434SerAsn: 1.434 ± 0.028	2.862SerPro: 2.862 ± 0.042	1.639SerGln: 1.639 ± 0.031	3.825SerArg: 3.825 ± 0.044	3.17SerSer: 3.17 ± 0.049	2.788SerThr: 2.788 ± 0.046	4.215SerVal: 4.215 ± 0.046	0.797SerTrp: 0.797 ± 0.019	1.328SerTyr: 1.328 ± 0.028	0.007SerXaa: 0.007 ± 0.002
Thr	6.157ThrAla: 6.157 ± 0.064	0.41ThrCys: 0.41 ± 0.014	2.636ThrAsp: 2.636 ± 0.039	2.609ThrGlu: 2.609 ± 0.043	2.028ThrPhe: 2.028 ± 0.035	4.855ThrGly: 4.855 ± 0.052	0.993ThrHis: 0.993 ± 0.022	3.096ThrIle: 3.096 ± 0.046	1.664ThrLys: 1.664 ± 0.031	5.428ThrLeu: 5.428 ± 0.06	1.293ThrMet: 1.293 ± 0.026	1.261ThrAsn: 1.261 ± 0.028	2.885ThrPro: 2.885 ± 0.038	1.296ThrGln: 1.296 ± 0.022	3.122ThrArg: 3.122 ± 0.044	2.88ThrSer: 2.88 ± 0.041	2.709ThrThr: 2.709 ± 0.041	4.256ThrVal: 4.256 ± 0.054	0.656ThrTrp: 0.656 ± 0.019	1.144ThrTyr: 1.144 ± 0.025	0.007ThrXaa: 0.007 ± 0.002
Val	9.313ValAla: 9.313 ± 0.078	0.628ValCys: 0.628 ± 0.02	4.153ValAsp: 4.153 ± 0.051	4.549ValGlu: 4.549 ± 0.048	2.944ValPhe: 2.944 ± 0.04	5.663ValGly: 5.663 ± 0.062	1.39ValHis: 1.39 ± 0.026	3.985ValIle: 3.985 ± 0.049	2.474ValLys: 2.474 ± 0.037	7.54ValLeu: 7.54 ± 0.069	1.825ValMet: 1.825 ± 0.032	1.927ValAsn: 1.927 ± 0.033	3.757ValPro: 3.757 ± 0.048	1.948ValGln: 1.948 ± 0.029	4.888ValArg: 4.888 ± 0.046	4.533ValSer: 4.533 ± 0.058	4.303ValThr: 4.303 ± 0.048	6.024ValVal: 6.024 ± 0.069	0.941ValTrp: 0.941 ± 0.026	1.48ValTyr: 1.48 ± 0.03	0.004ValXaa: 0.004 ± 0.001
Trp	1.287TrpAla: 1.287 ± 0.029	0.149TrpCys: 0.149 ± 0.009	0.625TrpAsp: 0.625 ± 0.022	0.545TrpGlu: 0.545 ± 0.019	0.579TrpPhe: 0.579 ± 0.017	0.878TrpGly: 0.878 ± 0.02	0.35TrpHis: 0.35 ± 0.014	0.682TrpIle: 0.682 ± 0.018	0.508TrpLys: 0.508 ± 0.016	1.728TrpLeu: 1.728 ± 0.036	0.374TrpMet: 0.374 ± 0.014	0.515TrpAsn: 0.515 ± 0.019	0.723TrpPro: 0.723 ± 0.02	0.598TrpGln: 0.598 ± 0.02	1.159TrpArg: 1.159 ± 0.025	0.901TrpSer: 0.901 ± 0.025	0.794TrpThr: 0.794 ± 0.023	0.811TrpVal: 0.811 ± 0.021	0.255TrpTrp: 0.255 ± 0.013	0.309TrpTyr: 0.309 ± 0.014	0.001TrpXaa: 0.001 ± 0.0
Tyr	2.443TyrAla: 2.443 ± 0.038	0.244TyrCys: 0.244 ± 0.011	1.501TyrAsp: 1.501 ± 0.027	1.231TyrGlu: 1.231 ± 0.026	0.981TyrPhe: 0.981 ± 0.023	2.09TyrGly: 2.09 ± 0.04	0.479TyrHis: 0.479 ± 0.016	0.96TyrIle: 0.96 ± 0.025	0.659TyrLys: 0.659 ± 0.017	2.287TyrLeu: 2.287 ± 0.037	0.439TyrMet: 0.439 ± 0.014	0.603TyrAsn: 0.603 ± 0.018	1.107TyrPro: 1.107 ± 0.025	0.731TyrGln: 0.731 ± 0.02	1.763TyrArg: 1.763 ± 0.032	1.261TyrSer: 1.261 ± 0.026	1.07TyrThr: 1.07 ± 0.026	1.669TyrVal: 1.669 ± 0.03	0.358TyrTrp: 0.358 ± 0.013	0.59TyrTyr: 0.59 ± 0.019	0.001TyrXaa: 0.001 ± 0.0
Xaa	0.008XaaAla: 0.008 ± 0.002	0.0XaaCys: 0.0 ± 0.0	0.007XaaAsp: 0.007 ± 0.002	0.004XaaGlu: 0.004 ± 0.002	0.003XaaPhe: 0.003 ± 0.001	0.009XaaGly: 0.009 ± 0.002	0.002XaaHis: 0.002 ± 0.001	0.004XaaIle: 0.004 ± 0.002	0.002XaaLys: 0.002 ± 0.001	0.004XaaLeu: 0.004 ± 0.001	0.003XaaMet: 0.003 ± 0.001	0.002XaaAsn: 0.002 ± 0.001	0.006XaaPro: 0.006 ± 0.002	0.002XaaGln: 0.002 ± 0.001	0.005XaaArg: 0.005 ± 0.001	0.005XaaSer: 0.005 ± 0.001	0.004XaaThr: 0.004 ± 0.002	0.006XaaVal: 0.006 ± 0.002	0.002XaaTrp: 0.002 ± 0.001	0.001XaaTyr: 0.001 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7026 proteins (1930628 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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