Amino acid dipepetide frequency for Halomonas gudaonensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.602AlaAla: 13.602 ± 0.152	1.253AlaCys: 1.253 ± 0.038	6.294AlaAsp: 6.294 ± 0.09	8.484AlaGlu: 8.484 ± 0.115	4.125AlaPhe: 4.125 ± 0.062	9.823AlaGly: 9.823 ± 0.135	2.43AlaHis: 2.43 ± 0.044	5.431AlaIle: 5.431 ± 0.077	2.574AlaLys: 2.574 ± 0.056	14.633AlaLeu: 14.633 ± 0.161	3.465AlaMet: 3.465 ± 0.064	2.462AlaAsn: 2.462 ± 0.052	4.811AlaPro: 4.811 ± 0.074	3.849AlaGln: 3.849 ± 0.063	8.897AlaArg: 8.897 ± 0.102	6.369AlaSer: 6.369 ± 0.082	5.62AlaThr: 5.62 ± 0.082	8.195AlaVal: 8.195 ± 0.094	2.053AlaTrp: 2.053 ± 0.049	2.282AlaTyr: 2.282 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.867CysAla: 0.867 ± 0.027	0.113CysCys: 0.113 ± 0.01	0.55CysAsp: 0.55 ± 0.021	0.511CysGlu: 0.511 ± 0.021	0.318CysPhe: 0.318 ± 0.015	0.899CysGly: 0.899 ± 0.032	0.371CysHis: 0.371 ± 0.019	0.358CysIle: 0.358 ± 0.016	0.169CysLys: 0.169 ± 0.012	1.048CysLeu: 1.048 ± 0.032	0.193CysMet: 0.193 ± 0.013	0.203CysAsn: 0.203 ± 0.014	0.512CysPro: 0.512 ± 0.025	0.342CysGln: 0.342 ± 0.015	0.865CysArg: 0.865 ± 0.026	0.448CysSer: 0.448 ± 0.022	0.402CysThr: 0.402 ± 0.02	0.599CysVal: 0.599 ± 0.024	0.128CysTrp: 0.128 ± 0.01	0.229CysTyr: 0.229 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.085AspAla: 7.085 ± 0.1	0.476AspCys: 0.476 ± 0.022	4.284AspAsp: 4.284 ± 0.117	4.395AspGlu: 4.395 ± 0.071	2.089AspPhe: 2.089 ± 0.042	4.987AspGly: 4.987 ± 0.116	1.384AspHis: 1.384 ± 0.036	2.735AspIle: 2.735 ± 0.062	1.383AspLys: 1.383 ± 0.039	5.654AspLeu: 5.654 ± 0.078	1.256AspMet: 1.256 ± 0.034	1.372AspAsn: 1.372 ± 0.042	3.212AspPro: 3.212 ± 0.059	1.737AspGln: 1.737 ± 0.036	4.063AspArg: 4.063 ± 0.075	2.748AspSer: 2.748 ± 0.071	2.912AspThr: 2.912 ± 0.061	4.096AspVal: 4.096 ± 0.079	1.047AspTrp: 1.047 ± 0.03	1.714AspTyr: 1.714 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	9.241GluAla: 9.241 ± 0.114	0.498GluCys: 0.498 ± 0.021	2.866GluAsp: 2.866 ± 0.06	4.166GluGlu: 4.166 ± 0.075	1.674GluPhe: 1.674 ± 0.038	5.144GluGly: 5.144 ± 0.086	1.753GluHis: 1.753 ± 0.044	2.945GluIle: 2.945 ± 0.051	1.68GluLys: 1.68 ± 0.049	7.424GluLeu: 7.424 ± 0.097	1.524GluMet: 1.524 ± 0.042	1.468GluAsn: 1.468 ± 0.037	3.169GluPro: 3.169 ± 0.065	2.839GluGln: 2.839 ± 0.061	7.275GluArg: 7.275 ± 0.096	3.477GluSer: 3.477 ± 0.06	3.644GluThr: 3.644 ± 0.059	4.92GluVal: 4.92 ± 0.069	0.973GluTrp: 0.973 ± 0.026	1.182GluTyr: 1.182 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	3.761PheAla: 3.761 ± 0.058	0.358PheCys: 0.358 ± 0.018	2.537PheAsp: 2.537 ± 0.05	2.147PheGlu: 2.147 ± 0.044	1.247PhePhe: 1.247 ± 0.04	3.112PheGly: 3.112 ± 0.052	0.827PheHis: 0.827 ± 0.029	1.498PheIle: 1.498 ± 0.042	0.809PheLys: 0.809 ± 0.028	3.188PheLeu: 3.188 ± 0.055	0.761PheMet: 0.761 ± 0.029	0.928PheAsn: 0.928 ± 0.027	1.467PhePro: 1.467 ± 0.032	1.11PheGln: 1.11 ± 0.034	2.057PheArg: 2.057 ± 0.042	2.065PheSer: 2.065 ± 0.038	1.887PheThr: 1.887 ± 0.041	2.516PheVal: 2.516 ± 0.051	0.487PheTrp: 0.487 ± 0.021	0.85PheTyr: 0.85 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	7.659GlyAla: 7.659 ± 0.122	0.905GlyCys: 0.905 ± 0.031	4.812GlyAsp: 4.812 ± 0.154	6.33GlyGlu: 6.33 ± 0.083	3.095GlyPhe: 3.095 ± 0.056	6.933GlyGly: 6.933 ± 0.168	2.163GlyHis: 2.163 ± 0.041	4.342GlyIle: 4.342 ± 0.075	2.5GlyLys: 2.5 ± 0.052	9.471GlyLeu: 9.471 ± 0.106	2.496GlyMet: 2.496 ± 0.057	2.101GlyAsn: 2.101 ± 0.053	2.825GlyPro: 2.825 ± 0.052	3.102GlyGln: 3.102 ± 0.059	6.092GlyArg: 6.092 ± 0.08	4.39GlySer: 4.39 ± 0.099	3.838GlyThr: 3.838 ± 0.071	6.486GlyVal: 6.486 ± 0.079	1.426GlyTrp: 1.426 ± 0.036	2.342GlyTyr: 2.342 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.745HisAla: 2.745 ± 0.046	0.314HisCys: 0.314 ± 0.017	1.66HisAsp: 1.66 ± 0.043	1.502HisGlu: 1.502 ± 0.035	1.026HisPhe: 1.026 ± 0.028	2.342HisGly: 2.342 ± 0.043	0.815HisHis: 0.815 ± 0.027	0.847HisIle: 0.847 ± 0.028	0.472HisLys: 0.472 ± 0.019	2.658HisLeu: 2.658 ± 0.055	0.443HisMet: 0.443 ± 0.019	0.482HisAsn: 0.482 ± 0.019	1.612HisPro: 1.612 ± 0.046	0.855HisGln: 0.855 ± 0.026	2.111HisArg: 2.111 ± 0.046	1.133HisSer: 1.133 ± 0.031	0.959HisThr: 0.959 ± 0.03	1.527HisVal: 1.527 ± 0.035	0.427HisTrp: 0.427 ± 0.019	0.77HisTyr: 0.77 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.616IleAla: 5.616 ± 0.077	0.391IleCys: 0.391 ± 0.02	3.474IleAsp: 3.474 ± 0.055	3.484IleGlu: 3.484 ± 0.067	1.337IlePhe: 1.337 ± 0.039	4.237IleGly: 4.237 ± 0.058	1.057IleHis: 1.057 ± 0.029	1.633IleIle: 1.633 ± 0.043	1.129IleLys: 1.129 ± 0.031	3.763IleLeu: 3.763 ± 0.067	0.824IleMet: 0.824 ± 0.027	1.29IleAsn: 1.29 ± 0.036	2.125IlePro: 2.125 ± 0.044	1.349IleGln: 1.349 ± 0.034	2.963IleArg: 2.963 ± 0.046	2.224IleSer: 2.224 ± 0.048	2.311IleThr: 2.311 ± 0.045	3.343IleVal: 3.343 ± 0.05	0.437IleTrp: 0.437 ± 0.019	0.907IleTyr: 0.907 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	2.857LysAla: 2.857 ± 0.055	0.152LysCys: 0.152 ± 0.012	1.074LysAsp: 1.074 ± 0.035	1.359LysGlu: 1.359 ± 0.043	0.534LysPhe: 0.534 ± 0.02	1.979LysGly: 1.979 ± 0.047	0.568LysHis: 0.568 ± 0.023	1.007LysIle: 1.007 ± 0.031	0.836LysLys: 0.836 ± 0.033	2.537LysLeu: 2.537 ± 0.037	0.497LysMet: 0.497 ± 0.022	0.595LysAsn: 0.595 ± 0.025	1.405LysPro: 1.405 ± 0.035	0.933LysGln: 0.933 ± 0.029	2.144LysArg: 2.144 ± 0.053	1.272LysSer: 1.272 ± 0.031	1.268LysThr: 1.268 ± 0.037	1.886LysVal: 1.886 ± 0.043	0.241LysTrp: 0.241 ± 0.013	0.462LysTyr: 0.462 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	16.138LeuAla: 16.138 ± 0.182	1.054LeuCys: 1.054 ± 0.031	7.528LeuAsp: 7.528 ± 0.093	7.943LeuGlu: 7.943 ± 0.098	3.716LeuPhe: 3.716 ± 0.076	9.695LeuGly: 9.695 ± 0.108	2.478LeuHis: 2.478 ± 0.047	5.046LeuIle: 5.046 ± 0.073	2.869LeuLys: 2.869 ± 0.053	12.472LeuLeu: 12.472 ± 0.167	2.762LeuMet: 2.762 ± 0.055	2.513LeuAsn: 2.513 ± 0.046	6.263LeuPro: 6.263 ± 0.08	3.117LeuGln: 3.117 ± 0.051	7.233LeuArg: 7.233 ± 0.084	6.554LeuSer: 6.554 ± 0.081	6.06LeuThr: 6.06 ± 0.071	8.434LeuVal: 8.434 ± 0.105	1.49LeuTrp: 1.49 ± 0.041	2.39LeuTyr: 2.39 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	3.208MetAla: 3.208 ± 0.057	0.154MetCys: 0.154 ± 0.011	1.084MetAsp: 1.084 ± 0.032	1.22MetGlu: 1.22 ± 0.029	0.595MetPhe: 0.595 ± 0.023	1.88MetGly: 1.88 ± 0.051	0.5MetHis: 0.5 ± 0.021	1.127MetIle: 1.127 ± 0.035	0.722MetLys: 0.722 ± 0.026	2.587MetLeu: 2.587 ± 0.052	0.617MetMet: 0.617 ± 0.033	0.742MetAsn: 0.742 ± 0.025	1.454MetPro: 1.454 ± 0.033	0.887MetGln: 0.887 ± 0.029	1.591MetArg: 1.591 ± 0.041	1.677MetSer: 1.677 ± 0.034	1.747MetThr: 1.747 ± 0.041	1.691MetVal: 1.691 ± 0.041	0.19MetTrp: 0.19 ± 0.014	0.321MetTyr: 0.321 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	2.82AsnAla: 2.82 ± 0.053	0.195AsnCys: 0.195 ± 0.013	1.403AsnAsp: 1.403 ± 0.04	1.299AsnGlu: 1.299 ± 0.034	0.765AsnPhe: 0.765 ± 0.026	2.009AsnGly: 2.009 ± 0.051	0.514AsnHis: 0.514 ± 0.021	1.019AsnIle: 1.019 ± 0.03	0.46AsnLys: 0.46 ± 0.02	2.616AsnLeu: 2.616 ± 0.051	0.48AsnMet: 0.48 ± 0.02	0.581AsnAsn: 0.581 ± 0.024	1.571AsnPro: 1.571 ± 0.036	0.805AsnGln: 0.805 ± 0.028	1.885AsnArg: 1.885 ± 0.042	0.981AsnSer: 0.981 ± 0.033	1.054AsnThr: 1.054 ± 0.031	1.763AsnVal: 1.763 ± 0.044	0.362AsnTrp: 0.362 ± 0.017	0.565AsnTyr: 0.565 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	5.469ProAla: 5.469 ± 0.09	0.378ProCys: 0.378 ± 0.02	3.38ProAsp: 3.38 ± 0.055	4.163ProGlu: 4.163 ± 0.068	1.704ProPhe: 1.704 ± 0.042	4.48ProGly: 4.48 ± 0.068	1.18ProHis: 1.18 ± 0.029	1.896ProIle: 1.896 ± 0.045	1.045ProLys: 1.045 ± 0.028	5.769ProLeu: 5.769 ± 0.088	1.201ProMet: 1.201 ± 0.033	1.11ProAsn: 1.11 ± 0.029	2.375ProPro: 2.375 ± 0.052	1.667ProGln: 1.667 ± 0.039	3.271ProArg: 3.271 ± 0.053	2.673ProSer: 2.673 ± 0.054	2.244ProThr: 2.244 ± 0.041	3.827ProVal: 3.827 ± 0.057	0.883ProTrp: 0.883 ± 0.03	1.081ProTyr: 1.081 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	5.12GlnAla: 5.12 ± 0.085	0.262GlnCys: 0.262 ± 0.015	1.529GlnAsp: 1.529 ± 0.037	2.019GlnGlu: 2.019 ± 0.05	1.002GlnPhe: 1.002 ± 0.028	3.053GlnGly: 3.053 ± 0.051	0.844GlnHis: 0.844 ± 0.026	1.252GlnIle: 1.252 ± 0.03	0.768GlnLys: 0.768 ± 0.027	3.936GlnLeu: 3.936 ± 0.061	0.752GlnMet: 0.752 ± 0.025	0.677GlnAsn: 0.677 ± 0.026	1.875GlnPro: 1.875 ± 0.04	1.788GlnGln: 1.788 ± 0.054	3.776GlnArg: 3.776 ± 0.067	1.636GlnSer: 1.636 ± 0.034	1.482GlnThr: 1.482 ± 0.038	2.747GlnVal: 2.747 ± 0.053	0.534GlnTrp: 0.534 ± 0.021	0.637GlnTyr: 0.637 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	7.006ArgAla: 7.006 ± 0.077	0.702ArgCys: 0.702 ± 0.025	4.612ArgAsp: 4.612 ± 0.072	5.925ArgGlu: 5.925 ± 0.095	3.118ArgPhe: 3.118 ± 0.056	4.946ArgGly: 4.946 ± 0.077	2.613ArgHis: 2.613 ± 0.057	3.504ArgIle: 3.504 ± 0.056	1.712ArgLys: 1.712 ± 0.04	10.938ArgLeu: 10.938 ± 0.129	1.705ArgMet: 1.705 ± 0.032	1.645ArgAsn: 1.645 ± 0.035	3.307ArgPro: 3.307 ± 0.057	3.614ArgGln: 3.614 ± 0.074	6.788ArgArg: 6.788 ± 0.104	3.429ArgSer: 3.429 ± 0.054	3.129ArgThr: 3.129 ± 0.054	5.374ArgVal: 5.374 ± 0.061	1.27ArgTrp: 1.27 ± 0.036	2.168ArgTyr: 2.168 ± 0.049	0.0ArgXaa: 0.0 ± 0.0
Ser	5.457SerAla: 5.457 ± 0.074	0.399SerCys: 0.399 ± 0.021	2.95SerAsp: 2.95 ± 0.072	3.139SerGlu: 3.139 ± 0.054	1.756SerPhe: 1.756 ± 0.042	5.001SerGly: 5.001 ± 0.087	1.365SerHis: 1.365 ± 0.04	2.172SerIle: 2.172 ± 0.047	1.039SerLys: 1.039 ± 0.033	6.568SerLeu: 6.568 ± 0.079	1.326SerMet: 1.326 ± 0.033	1.184SerAsn: 1.184 ± 0.039	2.869SerPro: 2.869 ± 0.051	1.99SerGln: 1.99 ± 0.042	4.375SerArg: 4.375 ± 0.066	2.794SerSer: 2.794 ± 0.057	2.376SerThr: 2.376 ± 0.041	3.847SerVal: 3.847 ± 0.078	0.697SerTrp: 0.697 ± 0.025	1.096SerTyr: 1.096 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	5.548ThrAla: 5.548 ± 0.078	0.441ThrCys: 0.441 ± 0.021	2.447ThrAsp: 2.447 ± 0.046	2.624ThrGlu: 2.624 ± 0.055	1.748ThrPhe: 1.748 ± 0.037	4.346ThrGly: 4.346 ± 0.066	1.184ThrHis: 1.184 ± 0.031	1.965ThrIle: 1.965 ± 0.046	0.829ThrLys: 0.829 ± 0.026	7.364ThrLeu: 7.364 ± 0.099	0.973ThrMet: 0.973 ± 0.029	1.02ThrAsn: 1.02 ± 0.029	3.313ThrPro: 3.313 ± 0.057	1.697ThrGln: 1.697 ± 0.035	3.682ThrArg: 3.682 ± 0.057	2.385ThrSer: 2.385 ± 0.046	2.621ThrThr: 2.621 ± 0.059	3.608ThrVal: 3.608 ± 0.06	0.644ThrTrp: 0.644 ± 0.022	1.031ThrTyr: 1.031 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	8.904ValAla: 8.904 ± 0.097	0.649ValCys: 0.649 ± 0.023	4.307ValAsp: 4.307 ± 0.078	5.242ValGlu: 5.242 ± 0.073	2.475ValPhe: 2.475 ± 0.048	5.59ValGly: 5.59 ± 0.084	1.557ValHis: 1.557 ± 0.038	3.771ValIle: 3.771 ± 0.061	1.837ValLys: 1.837 ± 0.046	7.786ValLeu: 7.786 ± 0.089	1.945ValMet: 1.945 ± 0.044	1.877ValAsn: 1.877 ± 0.035	3.626ValPro: 3.626 ± 0.059	2.077ValGln: 2.077 ± 0.043	4.819ValArg: 4.819 ± 0.063	4.283ValSer: 4.283 ± 0.073	4.291ValThr: 4.291 ± 0.073	6.03ValVal: 6.03 ± 0.08	0.907ValTrp: 0.907 ± 0.027	1.523ValTyr: 1.523 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.187TrpAla: 1.187 ± 0.035	0.161TrpCys: 0.161 ± 0.013	0.547TrpAsp: 0.547 ± 0.024	0.774TrpGlu: 0.774 ± 0.026	0.482TrpPhe: 0.482 ± 0.023	0.902TrpGly: 0.902 ± 0.029	0.468TrpHis: 0.468 ± 0.02	0.622TrpIle: 0.622 ± 0.022	0.335TrpLys: 0.335 ± 0.014	2.549TrpLeu: 2.549 ± 0.05	0.37TrpMet: 0.37 ± 0.018	0.346TrpAsn: 0.346 ± 0.018	0.762TrpPro: 0.762 ± 0.03	0.994TrpGln: 0.994 ± 0.03	1.331TrpArg: 1.331 ± 0.038	0.745TrpSer: 0.745 ± 0.024	0.598TrpThr: 0.598 ± 0.023	1.032TrpVal: 1.032 ± 0.03	0.321TrpTrp: 0.321 ± 0.018	0.333TrpTyr: 0.333 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.363TyrAla: 2.363 ± 0.041	0.268TyrCys: 0.268 ± 0.014	1.29TyrAsp: 1.29 ± 0.036	1.135TyrGlu: 1.135 ± 0.032	0.803TyrPhe: 0.803 ± 0.027	1.95TyrGly: 1.95 ± 0.043	0.632TyrHis: 0.632 ± 0.022	0.726TyrIle: 0.726 ± 0.026	0.439TyrLys: 0.439 ± 0.018	2.796TyrLeu: 2.796 ± 0.053	0.403TyrMet: 0.403 ± 0.018	0.549TyrAsn: 0.549 ± 0.022	1.242TyrPro: 1.242 ± 0.036	0.935TyrGln: 0.935 ± 0.029	2.288TyrArg: 2.288 ± 0.045	1.116TyrSer: 1.116 ± 0.03	1.026TyrThr: 1.026 ± 0.028	1.579TyrVal: 1.579 ± 0.034	0.343TyrTrp: 0.343 ± 0.016	0.625TyrTyr: 0.625 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3869 proteins (1252047 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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