Amino acid dipepetide frequency for Streptomyces nodosus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.747AlaAla: 19.747 ± 0.149	1.02AlaCys: 1.02 ± 0.025	7.881AlaAsp: 7.881 ± 0.076	8.719AlaGlu: 8.719 ± 0.101	3.507AlaPhe: 3.507 ± 0.042	12.687AlaGly: 12.687 ± 0.102	2.898AlaHis: 2.898 ± 0.038	3.346AlaIle: 3.346 ± 0.045	2.711AlaLys: 2.711 ± 0.041	14.561AlaLeu: 14.561 ± 0.115	2.455AlaMet: 2.455 ± 0.035	1.809AlaAsn: 1.809 ± 0.035	6.832AlaPro: 6.832 ± 0.064	3.716AlaGln: 3.716 ± 0.044	10.291AlaArg: 10.291 ± 0.098	5.894AlaSer: 5.894 ± 0.067	6.689AlaThr: 6.689 ± 0.067	12.271AlaVal: 12.271 ± 0.104	1.81AlaTrp: 1.81 ± 0.033	2.743AlaTyr: 2.743 ± 0.042	0.001AlaXaa: 0.001 ± 0.001
Cys	1.034CysAla: 1.034 ± 0.024	0.09CysCys: 0.09 ± 0.007	0.478CysAsp: 0.478 ± 0.016	0.394CysGlu: 0.394 ± 0.015	0.205CysPhe: 0.205 ± 0.011	0.957CysGly: 0.957 ± 0.02	0.193CysHis: 0.193 ± 0.01	0.176CysIle: 0.176 ± 0.009	0.113CysLys: 0.113 ± 0.007	0.748CysLeu: 0.748 ± 0.021	0.113CysMet: 0.113 ± 0.009	0.132CysAsn: 0.132 ± 0.007	0.494CysPro: 0.494 ± 0.019	0.158CysGln: 0.158 ± 0.01	0.621CysArg: 0.621 ± 0.02	0.441CysSer: 0.441 ± 0.016	0.54CysThr: 0.54 ± 0.017	0.652CysVal: 0.652 ± 0.02	0.122CysTrp: 0.122 ± 0.008	0.16CysTyr: 0.16 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.385AspAla: 7.385 ± 0.087	0.412AspCys: 0.412 ± 0.013	3.539AspAsp: 3.539 ± 0.051	3.923AspGlu: 3.923 ± 0.057	1.693AspPhe: 1.693 ± 0.035	6.254AspGly: 6.254 ± 0.073	1.439AspHis: 1.439 ± 0.028	2.014AspIle: 2.014 ± 0.034	1.21AspLys: 1.21 ± 0.031	6.202AspLeu: 6.202 ± 0.068	0.828AspMet: 0.828 ± 0.022	0.934AspAsn: 0.934 ± 0.022	4.539AspPro: 4.539 ± 0.056	1.576AspGln: 1.576 ± 0.034	5.056AspArg: 5.056 ± 0.054	2.507AspSer: 2.507 ± 0.041	3.302AspThr: 3.302 ± 0.047	4.492AspVal: 4.492 ± 0.047	1.044AspTrp: 1.044 ± 0.026	1.113AspTyr: 1.113 ± 0.025	0.0AspXaa: 0.0 ± 0.0
Glu	7.414GluAla: 7.414 ± 0.084	0.366GluCys: 0.366 ± 0.014	2.907GluAsp: 2.907 ± 0.041	3.78GluGlu: 3.78 ± 0.063	1.469GluPhe: 1.469 ± 0.028	4.517GluGly: 4.517 ± 0.057	1.564GluHis: 1.564 ± 0.03	2.381GluIle: 2.381 ± 0.037	1.429GluLys: 1.429 ± 0.034	6.885GluLeu: 6.885 ± 0.084	0.918GluMet: 0.918 ± 0.025	1.1GluAsn: 1.1 ± 0.026	3.359GluPro: 3.359 ± 0.055	2.368GluGln: 2.368 ± 0.037	5.573GluArg: 5.573 ± 0.066	2.612GluSer: 2.612 ± 0.038	2.954GluThr: 2.954 ± 0.045	4.636GluVal: 4.636 ± 0.052	0.714GluTrp: 0.714 ± 0.019	1.116GluTyr: 1.116 ± 0.025	0.001GluXaa: 0.001 ± 0.001
Phe	3.589PheAla: 3.589 ± 0.05	0.262PheCys: 0.262 ± 0.012	1.952PheAsp: 1.952 ± 0.037	1.464PheGlu: 1.464 ± 0.026	0.878PhePhe: 0.878 ± 0.026	3.015PheGly: 3.015 ± 0.041	0.643PheHis: 0.643 ± 0.018	0.713PheIle: 0.713 ± 0.017	0.532PheLys: 0.532 ± 0.019	2.693PheLeu: 2.693 ± 0.045	0.411PheMet: 0.411 ± 0.015	0.545PheAsn: 0.545 ± 0.018	1.435PhePro: 1.435 ± 0.029	0.748PheGln: 0.748 ± 0.021	1.887PheArg: 1.887 ± 0.032	1.508PheSer: 1.508 ± 0.029	2.036PheThr: 2.036 ± 0.034	2.284PheVal: 2.284 ± 0.038	0.426PheTrp: 0.426 ± 0.015	0.582PheTyr: 0.582 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	10.935GlyAla: 10.935 ± 0.083	0.864GlyCys: 0.864 ± 0.027	5.088GlyAsp: 5.088 ± 0.061	5.078GlyGlu: 5.078 ± 0.053	2.945GlyPhe: 2.945 ± 0.042	8.668GlyGly: 8.668 ± 0.1	2.41GlyHis: 2.41 ± 0.038	3.575GlyIle: 3.575 ± 0.051	2.412GlyLys: 2.412 ± 0.044	9.621GlyLeu: 9.621 ± 0.075	2.01GlyMet: 2.01 ± 0.036	1.743GlyAsn: 1.743 ± 0.039	5.044GlyPro: 5.044 ± 0.061	2.607GlyGln: 2.607 ± 0.042	7.944GlyArg: 7.944 ± 0.064	5.417GlySer: 5.417 ± 0.062	6.512GlyThr: 6.512 ± 0.067	7.698GlyVal: 7.698 ± 0.081	1.682GlyTrp: 1.682 ± 0.037	2.225GlyTyr: 2.225 ± 0.036	0.001GlyXaa: 0.001 ± 0.001
His	2.573HisAla: 2.573 ± 0.04	0.215HisCys: 0.215 ± 0.011	1.4HisAsp: 1.4 ± 0.029	1.244HisGlu: 1.244 ± 0.026	0.678HisPhe: 0.678 ± 0.019	2.537HisGly: 2.537 ± 0.038	0.731HisHis: 0.731 ± 0.022	0.749HisIle: 0.749 ± 0.022	0.377HisLys: 0.377 ± 0.017	2.449HisLeu: 2.449 ± 0.043	0.351HisMet: 0.351 ± 0.013	0.373HisAsn: 0.373 ± 0.015	1.879HisPro: 1.879 ± 0.027	0.69HisGln: 0.69 ± 0.019	2.195HisArg: 2.195 ± 0.037	1.099HisSer: 1.099 ± 0.025	1.4HisThr: 1.4 ± 0.033	1.622HisVal: 1.622 ± 0.03	0.387HisTrp: 0.387 ± 0.014	0.497HisTyr: 0.497 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	4.896IleAla: 4.896 ± 0.05	0.293IleCys: 0.293 ± 0.012	2.282IleAsp: 2.282 ± 0.041	2.027IleGlu: 2.027 ± 0.035	0.72IlePhe: 0.72 ± 0.021	3.684IleGly: 3.684 ± 0.048	0.62IleHis: 0.62 ± 0.02	0.883IleIle: 0.883 ± 0.021	0.796IleLys: 0.796 ± 0.023	2.413IleLeu: 2.413 ± 0.043	0.464IleMet: 0.464 ± 0.019	0.696IleAsn: 0.696 ± 0.022	1.828IlePro: 1.828 ± 0.033	0.713IleGln: 0.713 ± 0.021	2.316IleArg: 2.316 ± 0.042	1.681IleSer: 1.681 ± 0.031	2.311IleThr: 2.311 ± 0.042	2.868IleVal: 2.868 ± 0.044	0.38IleTrp: 0.38 ± 0.016	0.536IleTyr: 0.536 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	2.94LysAla: 2.94 ± 0.053	0.106LysCys: 0.106 ± 0.007	1.442LysAsp: 1.442 ± 0.035	1.242LysGlu: 1.242 ± 0.03	0.452LysPhe: 0.452 ± 0.019	1.872LysGly: 1.872 ± 0.036	0.4LysHis: 0.4 ± 0.016	0.91LysIle: 0.91 ± 0.026	0.913LysLys: 0.913 ± 0.033	1.975LysLeu: 1.975 ± 0.036	0.396LysMet: 0.396 ± 0.016	0.573LysAsn: 0.573 ± 0.022	1.272LysPro: 1.272 ± 0.028	0.691LysGln: 0.691 ± 0.024	1.37LysArg: 1.37 ± 0.033	1.132LysSer: 1.132 ± 0.025	1.28LysThr: 1.28 ± 0.029	1.926LysVal: 1.926 ± 0.036	0.247LysTrp: 0.247 ± 0.013	0.46LysTyr: 0.46 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	14.705LeuAla: 14.705 ± 0.109	0.843LeuCys: 0.843 ± 0.022	6.847LeuAsp: 6.847 ± 0.069	5.014LeuGlu: 5.014 ± 0.066	2.68LeuPhe: 2.68 ± 0.048	9.433LeuGly: 9.433 ± 0.082	2.387LeuHis: 2.387 ± 0.036	3.423LeuIle: 3.423 ± 0.05	2.1LeuLys: 2.1 ± 0.04	11.67LeuLeu: 11.67 ± 0.106	1.735LeuMet: 1.735 ± 0.032	1.673LeuAsn: 1.673 ± 0.033	6.528LeuPro: 6.528 ± 0.077	2.247LeuGln: 2.247 ± 0.033	8.782LeuArg: 8.782 ± 0.085	5.558LeuSer: 5.558 ± 0.056	7.022LeuThr: 7.022 ± 0.067	9.039LeuVal: 9.039 ± 0.081	1.286LeuTrp: 1.286 ± 0.028	1.864LeuTyr: 1.864 ± 0.03	0.001LeuXaa: 0.001 ± 0.001
Met	2.317MetAla: 2.317 ± 0.039	0.134MetCys: 0.134 ± 0.008	0.91MetAsp: 0.91 ± 0.02	0.751MetGlu: 0.751 ± 0.021	0.439MetPhe: 0.439 ± 0.015	1.35MetGly: 1.35 ± 0.028	0.356MetHis: 0.356 ± 0.012	0.696MetIle: 0.696 ± 0.019	0.451MetLys: 0.451 ± 0.015	1.705MetLeu: 1.705 ± 0.03	0.306MetMet: 0.306 ± 0.014	0.46MetAsn: 0.46 ± 0.015	1.106MetPro: 1.106 ± 0.025	0.458MetGln: 0.458 ± 0.015	1.453MetArg: 1.453 ± 0.028	1.359MetSer: 1.359 ± 0.024	1.554MetThr: 1.554 ± 0.026	1.332MetVal: 1.332 ± 0.028	0.201MetTrp: 0.201 ± 0.012	0.352MetTyr: 0.352 ± 0.013	0.001MetXaa: 0.001 ± 0.0
Asn	2.139AsnAla: 2.139 ± 0.035	0.166AsnCys: 0.166 ± 0.008	0.945AsnAsp: 0.945 ± 0.024	0.805AsnGlu: 0.805 ± 0.022	0.479AsnPhe: 0.479 ± 0.018	1.91AsnGly: 1.91 ± 0.044	0.394AsnHis: 0.394 ± 0.016	0.674AsnIle: 0.674 ± 0.022	0.423AsnLys: 0.423 ± 0.017	1.64AsnLeu: 1.64 ± 0.029	0.312AsnMet: 0.312 ± 0.013	0.417AsnAsn: 0.417 ± 0.015	1.332AsnPro: 1.332 ± 0.025	0.514AsnGln: 0.514 ± 0.016	1.233AsnArg: 1.233 ± 0.025	0.916AsnSer: 0.916 ± 0.021	1.131AsnThr: 1.131 ± 0.035	1.362AsnVal: 1.362 ± 0.034	0.301AsnTrp: 0.301 ± 0.015	0.423AsnTyr: 0.423 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	8.108ProAla: 8.108 ± 0.084	0.33ProCys: 0.33 ± 0.015	4.359ProAsp: 4.359 ± 0.059	4.521ProGlu: 4.521 ± 0.061	1.544ProPhe: 1.544 ± 0.023	6.671ProGly: 6.671 ± 0.062	1.41ProHis: 1.41 ± 0.033	1.247ProIle: 1.247 ± 0.028	1.12ProLys: 1.12 ± 0.027	5.435ProLeu: 5.435 ± 0.057	1.004ProMet: 1.004 ± 0.026	0.873ProAsn: 0.873 ± 0.021	3.3ProPro: 3.3 ± 0.064	1.688ProGln: 1.688 ± 0.028	4.039ProArg: 4.039 ± 0.059	3.306ProSer: 3.306 ± 0.046	3.035ProThr: 3.035 ± 0.05	5.533ProVal: 5.533 ± 0.053	0.885ProTrp: 0.885 ± 0.022	1.422ProTyr: 1.422 ± 0.028	0.003ProXaa: 0.003 ± 0.001
Gln	3.601GlnAla: 3.601 ± 0.055	0.166GlnCys: 0.166 ± 0.01	1.523GlnAsp: 1.523 ± 0.029	1.52GlnGlu: 1.52 ± 0.028	0.675GlnPhe: 0.675 ± 0.018	2.381GlnGly: 2.381 ± 0.04	0.679GlnHis: 0.679 ± 0.017	1.158GlnIle: 1.158 ± 0.024	0.643GlnLys: 0.643 ± 0.019	3.065GlnLeu: 3.065 ± 0.048	0.506GlnMet: 0.506 ± 0.015	0.539GlnAsn: 0.539 ± 0.018	1.591GlnPro: 1.591 ± 0.032	1.28GlnGln: 1.28 ± 0.025	2.319GlnArg: 2.319 ± 0.037	1.325GlnSer: 1.325 ± 0.026	1.318GlnThr: 1.318 ± 0.025	2.416GlnVal: 2.416 ± 0.037	0.449GlnTrp: 0.449 ± 0.016	0.607GlnTyr: 0.607 ± 0.018	0.001GlnXaa: 0.001 ± 0.001
Arg	9.837ArgAla: 9.837 ± 0.089	0.595ArgCys: 0.595 ± 0.019	4.262ArgAsp: 4.262 ± 0.051	4.8ArgGlu: 4.8 ± 0.06	2.372ArgPhe: 2.372 ± 0.04	5.886ArgGly: 5.886 ± 0.061	2.196ArgHis: 2.196 ± 0.034	3.359ArgIle: 3.359 ± 0.044	1.633ArgLys: 1.633 ± 0.033	9.13ArgLeu: 9.13 ± 0.081	1.791ArgMet: 1.791 ± 0.034	1.365ArgAsn: 1.365 ± 0.032	4.975ArgPro: 4.975 ± 0.056	2.365ArgGln: 2.365 ± 0.041	8.081ArgArg: 8.081 ± 0.089	4.172ArgSer: 4.172 ± 0.05	5.528ArgThr: 5.528 ± 0.065	5.992ArgVal: 5.992 ± 0.066	1.376ArgTrp: 1.376 ± 0.031	1.743ArgTyr: 1.743 ± 0.035	0.001ArgXaa: 0.001 ± 0.001
Ser	6.639SerAla: 6.639 ± 0.074	0.409SerCys: 0.409 ± 0.014	2.708SerAsp: 2.708 ± 0.04	2.508SerGlu: 2.508 ± 0.035	1.57SerPhe: 1.57 ± 0.035	6.126SerGly: 6.126 ± 0.075	1.048SerHis: 1.048 ± 0.027	1.45SerIle: 1.45 ± 0.027	1.075SerLys: 1.075 ± 0.031	5.039SerLeu: 5.039 ± 0.064	1.088SerMet: 1.088 ± 0.024	0.867SerAsn: 0.867 ± 0.024	3.149SerPro: 3.149 ± 0.042	1.238SerGln: 1.238 ± 0.027	3.806SerArg: 3.806 ± 0.049	2.991SerSer: 2.991 ± 0.052	3.083SerThr: 3.083 ± 0.047	4.407SerVal: 4.407 ± 0.053	0.947SerTrp: 0.947 ± 0.025	1.276SerTyr: 1.276 ± 0.029	0.001SerXaa: 0.001 ± 0.001
Thr	8.926ThrAla: 8.926 ± 0.086	0.424ThrCys: 0.424 ± 0.015	3.667ThrAsp: 3.667 ± 0.047	3.412ThrGlu: 3.412 ± 0.046	1.588ThrPhe: 1.588 ± 0.029	6.746ThrGly: 6.746 ± 0.069	1.261ThrHis: 1.261 ± 0.027	1.639ThrIle: 1.639 ± 0.034	1.127ThrLys: 1.127 ± 0.029	5.915ThrLeu: 5.915 ± 0.054	0.939ThrMet: 0.939 ± 0.024	0.955ThrAsn: 0.955 ± 0.027	4.035ThrPro: 4.035 ± 0.053	1.307ThrGln: 1.307 ± 0.028	3.992ThrArg: 3.992 ± 0.042	3.133ThrSer: 3.133 ± 0.043	3.818ThrThr: 3.818 ± 0.05	6.408ThrVal: 6.408 ± 0.072	0.877ThrTrp: 0.877 ± 0.023	1.32ThrTyr: 1.32 ± 0.025	0.0ThrXaa: 0.0 ± 0.0
Val	10.421ValAla: 10.421 ± 0.094	0.791ValCys: 0.791 ± 0.021	4.943ValAsp: 4.943 ± 0.052	4.888ValGlu: 4.888 ± 0.056	2.51ValPhe: 2.51 ± 0.038	6.427ValGly: 6.427 ± 0.071	2.027ValHis: 2.027 ± 0.031	2.934ValIle: 2.934 ± 0.044	1.801ValLys: 1.801 ± 0.036	9.853ValLeu: 9.853 ± 0.095	1.51ValMet: 1.51 ± 0.03	1.639ValAsn: 1.639 ± 0.033	5.288ValPro: 5.288 ± 0.067	2.167ValGln: 2.167 ± 0.035	7.358ValArg: 7.358 ± 0.071	4.468ValSer: 4.468 ± 0.056	5.728ValThr: 5.728 ± 0.063	8.141ValVal: 8.141 ± 0.085	1.146ValTrp: 1.146 ± 0.025	1.592ValTyr: 1.592 ± 0.027	0.001ValXaa: 0.001 ± 0.001
Trp	1.586TrpAla: 1.586 ± 0.034	0.158TrpCys: 0.158 ± 0.009	0.822TrpAsp: 0.822 ± 0.02	0.719TrpGlu: 0.719 ± 0.02	0.537TrpPhe: 0.537 ± 0.018	1.091TrpGly: 1.091 ± 0.024	0.38TrpHis: 0.38 ± 0.013	0.555TrpIle: 0.555 ± 0.017	0.355TrpLys: 0.355 ± 0.014	1.735TrpLeu: 1.735 ± 0.035	0.274TrpMet: 0.274 ± 0.013	0.424TrpAsn: 0.424 ± 0.016	0.772TrpPro: 0.772 ± 0.023	0.605TrpGln: 0.605 ± 0.018	1.324TrpArg: 1.324 ± 0.027	0.938TrpSer: 0.938 ± 0.026	1.043TrpThr: 1.043 ± 0.027	0.947TrpVal: 0.947 ± 0.024	0.334TrpTrp: 0.334 ± 0.015	0.376TrpTyr: 0.376 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.798TyrAla: 2.798 ± 0.037	0.177TyrCys: 0.177 ± 0.011	1.51TyrAsp: 1.51 ± 0.033	1.25TyrGlu: 1.25 ± 0.026	0.66TyrPhe: 0.66 ± 0.021	2.265TyrGly: 2.265 ± 0.037	0.408TyrHis: 0.408 ± 0.014	0.523TyrIle: 0.523 ± 0.019	0.378TyrLys: 0.378 ± 0.015	2.107TyrLeu: 2.107 ± 0.039	0.275TyrMet: 0.275 ± 0.012	0.4TyrAsn: 0.4 ± 0.017	1.075TyrPro: 1.075 ± 0.023	0.627TyrGln: 0.627 ± 0.02	1.814TyrArg: 1.814 ± 0.035	0.971TyrSer: 0.971 ± 0.025	1.203TyrThr: 1.203 ± 0.028	1.609TyrVal: 1.609 ± 0.031	0.358TyrTrp: 0.358 ± 0.016	0.445TyrTyr: 0.445 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.001	0.001XaaGlu: 0.001 ± 0.001	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.001XaaMet: 0.001 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.003XaaPro: 0.003 ± 0.002	0.001XaaGln: 0.001 ± 0.001	0.002XaaArg: 0.002 ± 0.001	0.001XaaSer: 0.001 ± 0.001	0.001XaaThr: 0.001 ± 0.001	0.0XaaVal: 0.0 ± 0.0	0.001XaaTrp: 0.001 ± 0.001	0.0XaaTyr: 0.0 ± 0.0	0.05XaaXaa: 0.05 ± 0.015

Statistics based on 5863 proteins (1903485 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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