Amino acid dipepetide frequency for Mycobacterium virus Crimd

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
22.378AlaAla: 22.378 ± 2.099
1.02AlaCys: 1.02 ± 0.268
8.05AlaAsp: 8.05 ± 0.834
9.123AlaGlu: 9.123 ± 0.767
3.274AlaPhe: 3.274 ± 0.67
9.499AlaGly: 9.499 ± 0.817
2.952AlaHis: 2.952 ± 0.409
5.796AlaIle: 5.796 ± 0.512
4.186AlaLys: 4.186 ± 0.557
10.948AlaLeu: 10.948 ± 0.909
3.864AlaMet: 3.864 ± 0.422
3.435AlaAsn: 3.435 ± 0.427
6.762AlaPro: 6.762 ± 0.665
5.098AlaGln: 5.098 ± 0.544
8.747AlaArg: 8.747 ± 0.741
5.206AlaSer: 5.206 ± 0.605
7.513AlaThr: 7.513 ± 0.847
10.089AlaVal: 10.089 ± 0.796
2.093AlaTrp: 2.093 ± 0.312
2.683AlaTyr: 2.683 ± 0.394
0.0AlaXaa: 0.0 ± 0.0
Cys
1.073CysAla: 1.073 ± 0.295
0.107CysCys: 0.107 ± 0.078
0.912CysAsp: 0.912 ± 0.31
0.698CysGlu: 0.698 ± 0.224
0.268CysPhe: 0.268 ± 0.127
1.664CysGly: 1.664 ± 0.373
0.161CysHis: 0.161 ± 0.088
0.376CysIle: 0.376 ± 0.133
0.215CysLys: 0.215 ± 0.095
0.751CysLeu: 0.751 ± 0.214
0.161CysMet: 0.161 ± 0.095
0.215CysAsn: 0.215 ± 0.103
0.966CysPro: 0.966 ± 0.318
0.268CysGln: 0.268 ± 0.117
0.644CysArg: 0.644 ± 0.178
0.59CysSer: 0.59 ± 0.186
0.698CysThr: 0.698 ± 0.204
0.537CysVal: 0.537 ± 0.161
0.376CysTrp: 0.376 ± 0.138
0.161CysTyr: 0.161 ± 0.088
0.0CysXaa: 0.0 ± 0.0
Asp
7.835AspAla: 7.835 ± 0.737
0.59AspCys: 0.59 ± 0.223
5.903AspAsp: 5.903 ± 0.692
6.064AspGlu: 6.064 ± 0.611
1.234AspPhe: 1.234 ± 0.248
6.494AspGly: 6.494 ± 0.655
1.073AspHis: 1.073 ± 0.297
1.556AspIle: 1.556 ± 0.312
2.415AspLys: 2.415 ± 0.299
6.225AspLeu: 6.225 ± 0.617
1.556AspMet: 1.556 ± 0.266
1.932AspAsn: 1.932 ± 0.337
4.132AspPro: 4.132 ± 0.573
2.039AspGln: 2.039 ± 0.369
4.454AspArg: 4.454 ± 0.488
2.254AspSer: 2.254 ± 0.258
3.166AspThr: 3.166 ± 0.383
4.83AspVal: 4.83 ± 0.441
1.288AspTrp: 1.288 ± 0.305
1.664AspTyr: 1.664 ± 0.357
0.0AspXaa: 0.0 ± 0.0
Glu
8.801GluAla: 8.801 ± 0.835
1.073GluCys: 1.073 ± 0.255
2.361GluAsp: 2.361 ± 0.413
1.556GluGlu: 1.556 ± 0.331
2.308GluPhe: 2.308 ± 0.366
4.615GluGly: 4.615 ± 0.534
1.61GluHis: 1.61 ± 0.332
2.093GluIle: 2.093 ± 0.278
1.717GluLys: 1.717 ± 0.391
6.547GluLeu: 6.547 ± 0.734
1.61GluMet: 1.61 ± 0.299
1.02GluAsn: 1.02 ± 0.232
3.005GluPro: 3.005 ± 0.444
2.737GluGln: 2.737 ± 0.294
5.259GluArg: 5.259 ± 0.669
2.361GluSer: 2.361 ± 0.355
2.737GluThr: 2.737 ± 0.324
5.259GluVal: 5.259 ± 0.799
0.859GluTrp: 0.859 ± 0.206
1.878GluTyr: 1.878 ± 0.36
0.0GluXaa: 0.0 ± 0.0
Phe
2.576PheAla: 2.576 ± 0.385
0.376PheCys: 0.376 ± 0.16
3.274PheAsp: 3.274 ± 0.422
1.556PheGlu: 1.556 ± 0.264
0.644PhePhe: 0.644 ± 0.215
2.469PheGly: 2.469 ± 0.42
0.215PheHis: 0.215 ± 0.115
0.859PheIle: 0.859 ± 0.164
1.395PheLys: 1.395 ± 0.315
1.986PheLeu: 1.986 ± 0.389
0.644PheMet: 0.644 ± 0.174
1.288PheAsn: 1.288 ± 0.368
0.966PhePro: 0.966 ± 0.227
0.698PheGln: 0.698 ± 0.195
1.717PheArg: 1.717 ± 0.342
0.966PheSer: 0.966 ± 0.2
1.878PheThr: 1.878 ± 0.287
1.932PheVal: 1.932 ± 0.323
0.322PheTrp: 0.322 ± 0.121
0.376PheTyr: 0.376 ± 0.172
0.0PheXaa: 0.0 ± 0.0
Gly
10.84GlyAla: 10.84 ± 0.949
1.181GlyCys: 1.181 ± 0.267
5.528GlyAsp: 5.528 ± 0.504
5.098GlyGlu: 5.098 ± 0.467
1.878GlyPhe: 1.878 ± 0.271
10.411GlyGly: 10.411 ± 1.464
1.717GlyHis: 1.717 ± 0.341
2.737GlyIle: 2.737 ± 0.568
3.757GlyLys: 3.757 ± 0.625
6.601GlyLeu: 6.601 ± 0.82
1.449GlyMet: 1.449 ± 0.257
2.576GlyAsn: 2.576 ± 0.433
3.542GlyPro: 3.542 ± 0.606
2.254GlyGln: 2.254 ± 0.437
6.547GlyArg: 6.547 ± 0.59
5.635GlySer: 5.635 ± 0.639
5.742GlyThr: 5.742 ± 0.666
6.547GlyVal: 6.547 ± 0.551
2.254GlyTrp: 2.254 ± 0.299
2.147GlyTyr: 2.147 ± 0.446
0.0GlyXaa: 0.0 ± 0.0
His
2.254HisAla: 2.254 ± 0.404
0.268HisCys: 0.268 ± 0.118
1.288HisAsp: 1.288 ± 0.297
1.61HisGlu: 1.61 ± 0.318
0.322HisPhe: 0.322 ± 0.154
2.308HisGly: 2.308 ± 0.353
0.537HisHis: 0.537 ± 0.189
0.805HisIle: 0.805 ± 0.215
0.376HisLys: 0.376 ± 0.184
2.254HisLeu: 2.254 ± 0.389
0.161HisMet: 0.161 ± 0.08
0.59HisAsn: 0.59 ± 0.156
1.234HisPro: 1.234 ± 0.269
0.429HisGln: 0.429 ± 0.162
1.449HisArg: 1.449 ± 0.384
0.751HisSer: 0.751 ± 0.176
1.61HisThr: 1.61 ± 0.326
2.039HisVal: 2.039 ± 0.398
0.644HisTrp: 0.644 ± 0.205
0.698HisTyr: 0.698 ± 0.206
0.0HisXaa: 0.0 ± 0.0
Ile
5.42IleAla: 5.42 ± 0.59
0.161IleCys: 0.161 ± 0.092
3.649IleAsp: 3.649 ± 0.452
3.005IleGlu: 3.005 ± 0.442
0.805IlePhe: 0.805 ± 0.245
3.596IleGly: 3.596 ± 0.643
0.59IleHis: 0.59 ± 0.186
0.698IleIle: 0.698 ± 0.182
1.503IleLys: 1.503 ± 0.29
2.683IleLeu: 2.683 ± 0.399
0.215IleMet: 0.215 ± 0.089
1.503IleAsn: 1.503 ± 0.252
2.039IlePro: 2.039 ± 0.419
0.912IleGln: 0.912 ± 0.235
2.2IleArg: 2.2 ± 0.313
1.932IleSer: 1.932 ± 0.316
2.2IleThr: 2.2 ± 0.321
3.22IleVal: 3.22 ± 0.421
0.429IleTrp: 0.429 ± 0.182
0.429IleTyr: 0.429 ± 0.167
0.0IleXaa: 0.0 ± 0.0
Lys
4.776LysAla: 4.776 ± 0.654
0.483LysCys: 0.483 ± 0.159
1.181LysAsp: 1.181 ± 0.241
0.912LysGlu: 0.912 ± 0.182
1.395LysPhe: 1.395 ± 0.271
3.327LysGly: 3.327 ± 0.608
0.537LysHis: 0.537 ± 0.165
1.556LysIle: 1.556 ± 0.284
0.805LysLys: 0.805 ± 0.239
4.025LysLeu: 4.025 ± 0.398
0.805LysMet: 0.805 ± 0.182
0.483LysAsn: 0.483 ± 0.175
2.952LysPro: 2.952 ± 0.376
0.805LysGln: 0.805 ± 0.203
2.952LysArg: 2.952 ± 0.465
1.073LysSer: 1.073 ± 0.225
1.717LysThr: 1.717 ± 0.385
3.542LysVal: 3.542 ± 0.515
0.59LysTrp: 0.59 ± 0.154
0.698LysTyr: 0.698 ± 0.235
0.0LysXaa: 0.0 ± 0.0
Leu
12.397LeuAla: 12.397 ± 0.992
0.751LeuCys: 0.751 ± 0.254
7.781LeuAsp: 7.781 ± 0.735
2.844LeuGlu: 2.844 ± 0.396
2.039LeuPhe: 2.039 ± 0.318
6.44LeuGly: 6.44 ± 0.562
2.093LeuHis: 2.093 ± 0.401
3.327LeuIle: 3.327 ± 0.46
2.63LeuLys: 2.63 ± 0.41
5.313LeuLeu: 5.313 ± 0.588
1.878LeuMet: 1.878 ± 0.307
2.039LeuAsn: 2.039 ± 0.288
4.454LeuPro: 4.454 ± 0.59
2.844LeuGln: 2.844 ± 0.488
6.172LeuArg: 6.172 ± 0.657
5.259LeuSer: 5.259 ± 0.416
4.937LeuThr: 4.937 ± 0.554
6.064LeuVal: 6.064 ± 0.575
1.556LeuTrp: 1.556 ± 0.3
1.771LeuTyr: 1.771 ± 0.397
0.0LeuXaa: 0.0 ± 0.0
Met
2.791MetAla: 2.791 ± 0.391
0.0MetCys: 0.0 ± 0.0
0.698MetAsp: 0.698 ± 0.198
0.59MetGlu: 0.59 ± 0.181
0.859MetPhe: 0.859 ± 0.24
1.395MetGly: 1.395 ± 0.296
0.644MetHis: 0.644 ± 0.23
0.966MetIle: 0.966 ± 0.232
0.537MetLys: 0.537 ± 0.159
1.825MetLeu: 1.825 ± 0.327
0.268MetMet: 0.268 ± 0.117
0.429MetAsn: 0.429 ± 0.135
1.127MetPro: 1.127 ± 0.246
0.644MetGln: 0.644 ± 0.175
1.127MetArg: 1.127 ± 0.271
2.952MetSer: 2.952 ± 0.348
2.039MetThr: 2.039 ± 0.355
1.342MetVal: 1.342 ± 0.304
0.376MetTrp: 0.376 ± 0.145
0.322MetTyr: 0.322 ± 0.155
0.0MetXaa: 0.0 ± 0.0
Asn
4.079AsnAla: 4.079 ± 0.577
0.429AsnCys: 0.429 ± 0.175
1.342AsnAsp: 1.342 ± 0.282
1.073AsnGlu: 1.073 ± 0.298
0.644AsnPhe: 0.644 ± 0.154
3.22AsnGly: 3.22 ± 0.51
0.376AsnHis: 0.376 ± 0.144
0.966AsnIle: 0.966 ± 0.263
0.912AsnLys: 0.912 ± 0.228
1.932AsnLeu: 1.932 ± 0.319
0.59AsnMet: 0.59 ± 0.166
0.644AsnAsn: 0.644 ± 0.219
2.737AsnPro: 2.737 ± 0.338
0.537AsnGln: 0.537 ± 0.171
1.825AsnArg: 1.825 ± 0.325
1.181AsnSer: 1.181 ± 0.288
1.503AsnThr: 1.503 ± 0.305
2.093AsnVal: 2.093 ± 0.312
0.537AsnTrp: 0.537 ± 0.164
0.59AsnTyr: 0.59 ± 0.154
0.0AsnXaa: 0.0 ± 0.0
Pro
8.586ProAla: 8.586 ± 0.556
0.322ProCys: 0.322 ± 0.134
3.542ProAsp: 3.542 ± 0.513
4.24ProGlu: 4.24 ± 0.577
1.234ProPhe: 1.234 ± 0.245
5.957ProGly: 5.957 ± 0.58
1.02ProHis: 1.02 ± 0.297
1.717ProIle: 1.717 ± 0.245
2.469ProLys: 2.469 ± 0.41
3.864ProLeu: 3.864 ± 0.485
1.449ProMet: 1.449 ± 0.297
1.342ProAsn: 1.342 ± 0.318
3.059ProPro: 3.059 ± 0.466
1.395ProGln: 1.395 ± 0.295
3.596ProArg: 3.596 ± 0.62
3.327ProSer: 3.327 ± 0.491
3.005ProThr: 3.005 ± 0.444
4.401ProVal: 4.401 ± 0.475
1.181ProTrp: 1.181 ± 0.217
1.181ProTyr: 1.181 ± 0.289
0.0ProXaa: 0.0 ± 0.0
Gln
5.313GlnAla: 5.313 ± 0.633
0.376GlnCys: 0.376 ± 0.169
1.073GlnAsp: 1.073 ± 0.205
1.342GlnGlu: 1.342 ± 0.273
0.859GlnPhe: 0.859 ± 0.189
2.039GlnGly: 2.039 ± 0.36
1.288GlnHis: 1.288 ± 0.231
1.664GlnIle: 1.664 ± 0.296
1.127GlnLys: 1.127 ± 0.249
2.737GlnLeu: 2.737 ± 0.41
1.127GlnMet: 1.127 ± 0.223
0.644GlnAsn: 0.644 ± 0.226
2.039GlnPro: 2.039 ± 0.335
1.288GlnGln: 1.288 ± 0.189
2.469GlnArg: 2.469 ± 0.407
1.02GlnSer: 1.02 ± 0.313
1.61GlnThr: 1.61 ± 0.274
2.898GlnVal: 2.898 ± 0.464
0.751GlnTrp: 0.751 ± 0.189
1.073GlnTyr: 1.073 ± 0.236
0.0GlnXaa: 0.0 ± 0.0
Arg
6.655ArgAla: 6.655 ± 0.852
0.859ArgCys: 0.859 ± 0.25
4.776ArgAsp: 4.776 ± 0.558
5.313ArgGlu: 5.313 ± 0.702
1.932ArgPhe: 1.932 ± 0.386
4.723ArgGly: 4.723 ± 0.488
1.556ArgHis: 1.556 ± 0.386
3.327ArgIle: 3.327 ± 0.576
3.22ArgLys: 3.22 ± 0.428
6.064ArgLeu: 6.064 ± 0.725
1.932ArgMet: 1.932 ± 0.329
2.576ArgAsn: 2.576 ± 0.53
3.435ArgPro: 3.435 ± 0.564
3.435ArgGln: 3.435 ± 0.447
6.386ArgArg: 6.386 ± 0.971
3.488ArgSer: 3.488 ± 0.404
3.918ArgThr: 3.918 ± 0.456
4.24ArgVal: 4.24 ± 0.562
2.039ArgTrp: 2.039 ± 0.301
1.878ArgTyr: 1.878 ± 0.344
0.0ArgXaa: 0.0 ± 0.0
Ser
6.708SerAla: 6.708 ± 0.774
0.429SerCys: 0.429 ± 0.16
2.791SerAsp: 2.791 ± 0.315
3.059SerGlu: 3.059 ± 0.371
1.717SerPhe: 1.717 ± 0.297
4.186SerGly: 4.186 ± 0.46
1.127SerHis: 1.127 ± 0.357
1.932SerIle: 1.932 ± 0.363
1.02SerLys: 1.02 ± 0.199
4.347SerLeu: 4.347 ± 0.429
1.127SerMet: 1.127 ± 0.255
1.664SerAsn: 1.664 ± 0.312
4.132SerPro: 4.132 ± 0.469
1.556SerGln: 1.556 ± 0.264
2.898SerArg: 2.898 ± 0.384
2.737SerSer: 2.737 ± 0.436
2.952SerThr: 2.952 ± 0.437
4.132SerVal: 4.132 ± 0.489
1.127SerTrp: 1.127 ± 0.244
0.966SerTyr: 0.966 ± 0.204
0.0SerXaa: 0.0 ± 0.0
Thr
6.118ThrAla: 6.118 ± 0.768
0.859ThrCys: 0.859 ± 0.274
3.649ThrAsp: 3.649 ± 0.438
3.703ThrGlu: 3.703 ± 0.364
1.717ThrPhe: 1.717 ± 0.32
5.313ThrGly: 5.313 ± 0.75
1.234ThrHis: 1.234 ± 0.321
2.737ThrIle: 2.737 ± 0.434
2.308ThrLys: 2.308 ± 0.394
3.918ThrLeu: 3.918 ± 0.479
0.429ThrMet: 0.429 ± 0.2
1.395ThrAsn: 1.395 ± 0.335
4.186ThrPro: 4.186 ± 0.481
1.556ThrGln: 1.556 ± 0.349
3.703ThrArg: 3.703 ± 0.519
3.649ThrSer: 3.649 ± 0.55
2.952ThrThr: 2.952 ± 0.422
5.42ThrVal: 5.42 ± 0.485
1.073ThrTrp: 1.073 ± 0.224
1.717ThrTyr: 1.717 ± 0.323
0.0ThrXaa: 0.0 ± 0.0
Val
9.767ValAla: 9.767 ± 0.952
1.127ValCys: 1.127 ± 0.272
6.172ValAsp: 6.172 ± 0.526
5.903ValGlu: 5.903 ± 0.641
1.664ValPhe: 1.664 ± 0.319
6.923ValGly: 6.923 ± 0.787
2.093ValHis: 2.093 ± 0.543
2.898ValIle: 2.898 ± 0.376
2.844ValLys: 2.844 ± 0.404
5.85ValLeu: 5.85 ± 0.621
1.073ValMet: 1.073 ± 0.252
1.986ValAsn: 1.986 ± 0.343
4.562ValPro: 4.562 ± 0.485
2.039ValGln: 2.039 ± 0.352
5.313ValArg: 5.313 ± 0.628
3.971ValSer: 3.971 ± 0.424
4.508ValThr: 4.508 ± 0.44
5.742ValVal: 5.742 ± 0.686
2.469ValTrp: 2.469 ± 0.454
1.556ValTyr: 1.556 ± 0.309
0.0ValXaa: 0.0 ± 0.0
Trp
1.825TrpAla: 1.825 ± 0.294
0.268TrpCys: 0.268 ± 0.105
1.073TrpAsp: 1.073 ± 0.287
0.751TrpGlu: 0.751 ± 0.173
0.537TrpPhe: 0.537 ± 0.162
1.234TrpGly: 1.234 ± 0.218
0.483TrpHis: 0.483 ± 0.174
0.698TrpIle: 0.698 ± 0.205
0.376TrpLys: 0.376 ± 0.123
2.952TrpLeu: 2.952 ± 0.374
0.268TrpMet: 0.268 ± 0.119
0.59TrpAsn: 0.59 ± 0.174
0.912TrpPro: 0.912 ± 0.214
0.966TrpGln: 0.966 ± 0.194
2.683TrpArg: 2.683 ± 0.414
1.127TrpSer: 1.127 ± 0.266
1.288TrpThr: 1.288 ± 0.232
1.986TrpVal: 1.986 ± 0.337
0.429TrpTrp: 0.429 ± 0.157
0.376TrpTyr: 0.376 ± 0.119
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.522TyrAla: 2.522 ± 0.339
0.161TyrCys: 0.161 ± 0.094
1.664TyrAsp: 1.664 ± 0.312
0.966TyrGlu: 0.966 ± 0.253
0.805TyrPhe: 0.805 ± 0.198
2.63TyrGly: 2.63 ± 0.395
0.322TyrHis: 0.322 ± 0.132
0.483TyrIle: 0.483 ± 0.148
0.805TyrLys: 0.805 ± 0.22
1.771TyrLeu: 1.771 ± 0.288
0.268TyrMet: 0.268 ± 0.11
0.859TyrAsn: 0.859 ± 0.167
0.698TyrPro: 0.698 ± 0.164
1.234TyrGln: 1.234 ± 0.265
1.61TyrArg: 1.61 ± 0.251
1.127TyrSer: 1.127 ± 0.222
1.664TyrThr: 1.664 ± 0.392
2.147TyrVal: 2.147 ± 0.42
0.429TyrTrp: 0.429 ± 0.177
0.537TyrTyr: 0.537 ± 0.175
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 95 proteins (18635 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski