Amino acid dipepetide frequency for Streptococcus phage Javan151

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.364AlaAla: 4.364 ± 0.802
0.371AlaCys: 0.371 ± 0.194
4.549AlaAsp: 4.549 ± 0.578
5.199AlaGlu: 5.199 ± 0.633
2.6AlaPhe: 2.6 ± 0.489
4.549AlaGly: 4.549 ± 0.946
0.836AlaHis: 0.836 ± 0.318
4.828AlaIle: 4.828 ± 0.82
7.335AlaLys: 7.335 ± 0.768
6.499AlaLeu: 6.499 ± 0.772
2.6AlaMet: 2.6 ± 0.525
3.064AlaAsn: 3.064 ± 0.669
1.021AlaPro: 1.021 ± 0.391
2.878AlaGln: 2.878 ± 0.521
2.414AlaArg: 2.414 ± 0.452
4.178AlaSer: 4.178 ± 0.724
3.714AlaThr: 3.714 ± 0.626
4.178AlaVal: 4.178 ± 0.816
0.743AlaTrp: 0.743 ± 0.314
2.228AlaTyr: 2.228 ± 0.443
0.0AlaXaa: 0.0 ± 0.0
Cys
0.279CysAla: 0.279 ± 0.167
0.093CysCys: 0.093 ± 0.087
0.464CysAsp: 0.464 ± 0.261
0.371CysGlu: 0.371 ± 0.174
0.186CysPhe: 0.186 ± 0.119
0.65CysGly: 0.65 ± 0.281
0.093CysHis: 0.093 ± 0.1
0.279CysIle: 0.279 ± 0.125
0.557CysLys: 0.557 ± 0.235
0.0CysLeu: 0.0 ± 0.0
0.186CysMet: 0.186 ± 0.115
0.279CysAsn: 0.279 ± 0.156
0.279CysPro: 0.279 ± 0.161
0.186CysGln: 0.186 ± 0.121
0.279CysArg: 0.279 ± 0.16
0.279CysSer: 0.279 ± 0.152
0.186CysThr: 0.186 ± 0.122
0.279CysVal: 0.279 ± 0.158
0.186CysTrp: 0.186 ± 0.113
0.279CysTyr: 0.279 ± 0.135
0.0CysXaa: 0.0 ± 0.0
Asp
3.342AspAla: 3.342 ± 0.557
0.186AspCys: 0.186 ± 0.135
4.364AspAsp: 4.364 ± 0.761
5.106AspGlu: 5.106 ± 0.712
3.992AspPhe: 3.992 ± 0.609
5.106AspGly: 5.106 ± 0.943
0.371AspHis: 0.371 ± 0.161
5.478AspIle: 5.478 ± 0.855
5.199AspLys: 5.199 ± 0.757
6.128AspLeu: 6.128 ± 0.885
1.95AspMet: 1.95 ± 0.373
2.321AspAsn: 2.321 ± 0.586
1.485AspPro: 1.485 ± 0.555
1.207AspGln: 1.207 ± 0.386
2.135AspArg: 2.135 ± 0.552
4.364AspSer: 4.364 ± 0.653
3.064AspThr: 3.064 ± 0.575
4.085AspVal: 4.085 ± 0.632
0.65AspTrp: 0.65 ± 0.237
2.971AspTyr: 2.971 ± 0.54
0.0AspXaa: 0.0 ± 0.0
Glu
4.549GluAla: 4.549 ± 0.751
0.464GluCys: 0.464 ± 0.203
3.249GluAsp: 3.249 ± 0.634
7.149GluGlu: 7.149 ± 0.899
2.507GluPhe: 2.507 ± 0.471
3.621GluGly: 3.621 ± 0.402
0.928GluHis: 0.928 ± 0.286
5.849GluIle: 5.849 ± 0.623
5.849GluLys: 5.849 ± 0.661
8.541GluLeu: 8.541 ± 1.013
2.135GluMet: 2.135 ± 0.538
4.921GluAsn: 4.921 ± 0.773
1.671GluPro: 1.671 ± 0.339
3.342GluGln: 3.342 ± 0.497
3.714GluArg: 3.714 ± 0.606
4.271GluSer: 4.271 ± 0.828
3.157GluThr: 3.157 ± 0.511
5.942GluVal: 5.942 ± 0.793
1.021GluTrp: 1.021 ± 0.335
2.785GluTyr: 2.785 ± 0.463
0.0GluXaa: 0.0 ± 0.0
Phe
2.507PheAla: 2.507 ± 0.526
0.186PheCys: 0.186 ± 0.114
3.528PheAsp: 3.528 ± 0.652
3.249PheGlu: 3.249 ± 0.572
1.671PhePhe: 1.671 ± 0.505
2.785PheGly: 2.785 ± 0.457
0.371PheHis: 0.371 ± 0.163
2.414PheIle: 2.414 ± 0.553
4.642PheLys: 4.642 ± 0.709
2.135PheLeu: 2.135 ± 0.318
1.393PheMet: 1.393 ± 0.392
2.692PheAsn: 2.692 ± 0.514
0.928PhePro: 0.928 ± 0.311
1.3PheGln: 1.3 ± 0.434
2.043PheArg: 2.043 ± 0.436
2.321PheSer: 2.321 ± 0.479
1.857PheThr: 1.857 ± 0.4
1.485PheVal: 1.485 ± 0.346
0.371PheTrp: 0.371 ± 0.171
1.393PheTyr: 1.393 ± 0.407
0.0PheXaa: 0.0 ± 0.0
Gly
3.528GlyAla: 3.528 ± 0.771
0.279GlyCys: 0.279 ± 0.165
3.899GlyAsp: 3.899 ± 0.969
4.364GlyGlu: 4.364 ± 0.602
2.878GlyPhe: 2.878 ± 0.384
3.342GlyGly: 3.342 ± 0.547
0.836GlyHis: 0.836 ± 0.235
6.035GlyIle: 6.035 ± 1.014
4.828GlyLys: 4.828 ± 0.639
5.571GlyLeu: 5.571 ± 0.571
1.857GlyMet: 1.857 ± 0.412
3.899GlyAsn: 3.899 ± 0.643
0.836GlyPro: 0.836 ± 0.215
2.6GlyGln: 2.6 ± 0.48
2.043GlyArg: 2.043 ± 0.441
3.714GlySer: 3.714 ± 0.609
3.714GlyThr: 3.714 ± 0.618
2.878GlyVal: 2.878 ± 0.541
0.743GlyTrp: 0.743 ± 0.291
3.064GlyTyr: 3.064 ± 0.611
0.0GlyXaa: 0.0 ± 0.0
His
0.928HisAla: 0.928 ± 0.228
0.0HisCys: 0.0 ± 0.0
0.743HisAsp: 0.743 ± 0.334
0.928HisGlu: 0.928 ± 0.347
1.114HisPhe: 1.114 ± 0.286
1.021HisGly: 1.021 ± 0.257
0.743HisHis: 0.743 ± 0.286
1.393HisIle: 1.393 ± 0.477
0.836HisLys: 0.836 ± 0.303
1.114HisLeu: 1.114 ± 0.272
0.279HisMet: 0.279 ± 0.134
0.743HisAsn: 0.743 ± 0.253
0.743HisPro: 0.743 ± 0.228
0.557HisGln: 0.557 ± 0.192
0.557HisArg: 0.557 ± 0.189
0.743HisSer: 0.743 ± 0.369
1.207HisThr: 1.207 ± 0.323
0.836HisVal: 0.836 ± 0.34
0.279HisTrp: 0.279 ± 0.119
0.743HisTyr: 0.743 ± 0.273
0.0HisXaa: 0.0 ± 0.0
Ile
5.199IleAla: 5.199 ± 0.84
0.464IleCys: 0.464 ± 0.195
6.035IleAsp: 6.035 ± 0.828
6.685IleGlu: 6.685 ± 0.722
1.95IlePhe: 1.95 ± 0.442
4.271IleGly: 4.271 ± 0.589
1.485IleHis: 1.485 ± 0.367
5.849IleIle: 5.849 ± 0.608
8.541IleLys: 8.541 ± 1.095
4.178IleLeu: 4.178 ± 0.555
1.857IleMet: 1.857 ± 0.371
6.313IleAsn: 6.313 ± 0.841
2.414IlePro: 2.414 ± 0.469
2.043IleGln: 2.043 ± 0.434
2.971IleArg: 2.971 ± 0.438
6.313IleSer: 6.313 ± 0.766
4.642IleThr: 4.642 ± 0.565
4.178IleVal: 4.178 ± 0.703
1.021IleTrp: 1.021 ± 0.398
2.507IleTyr: 2.507 ± 0.527
0.0IleXaa: 0.0 ± 0.0
Lys
6.128LysAla: 6.128 ± 0.55
0.371LysCys: 0.371 ± 0.159
5.385LysAsp: 5.385 ± 0.826
7.892LysGlu: 7.892 ± 0.91
2.692LysPhe: 2.692 ± 0.453
5.106LysGly: 5.106 ± 0.965
1.393LysHis: 1.393 ± 0.388
7.335LysIle: 7.335 ± 0.877
7.706LysLys: 7.706 ± 1.259
8.913LysLeu: 8.913 ± 0.942
2.135LysMet: 2.135 ± 0.478
6.499LysAsn: 6.499 ± 0.544
2.414LysPro: 2.414 ± 0.528
3.435LysGln: 3.435 ± 0.672
3.528LysArg: 3.528 ± 0.648
4.642LysSer: 4.642 ± 0.546
4.735LysThr: 4.735 ± 0.685
5.571LysVal: 5.571 ± 0.752
0.65LysTrp: 0.65 ± 0.237
2.228LysTyr: 2.228 ± 0.608
0.0LysXaa: 0.0 ± 0.0
Leu
7.427LeuAla: 7.427 ± 0.831
0.65LeuCys: 0.65 ± 0.294
6.128LeuAsp: 6.128 ± 0.829
5.849LeuGlu: 5.849 ± 0.784
3.064LeuPhe: 3.064 ± 0.5
5.663LeuGly: 5.663 ± 0.724
1.3LeuHis: 1.3 ± 0.285
5.013LeuIle: 5.013 ± 0.748
7.52LeuLys: 7.52 ± 0.904
5.385LeuLeu: 5.385 ± 0.59
1.671LeuMet: 1.671 ± 0.378
4.735LeuAsn: 4.735 ± 0.54
3.249LeuPro: 3.249 ± 0.546
2.971LeuGln: 2.971 ± 0.539
4.271LeuArg: 4.271 ± 0.532
6.963LeuSer: 6.963 ± 0.964
6.22LeuThr: 6.22 ± 0.728
4.364LeuVal: 4.364 ± 0.547
0.836LeuTrp: 0.836 ± 0.226
2.507LeuTyr: 2.507 ± 0.459
0.0LeuXaa: 0.0 ± 0.0
Met
1.764MetAla: 1.764 ± 0.33
0.0MetCys: 0.0 ± 0.0
1.485MetAsp: 1.485 ± 0.362
2.043MetGlu: 2.043 ± 0.444
0.928MetPhe: 0.928 ± 0.247
0.743MetGly: 0.743 ± 0.247
0.093MetHis: 0.093 ± 0.106
2.321MetIle: 2.321 ± 0.387
1.393MetLys: 1.393 ± 0.437
2.228MetLeu: 2.228 ± 0.566
0.743MetMet: 0.743 ± 0.253
1.671MetAsn: 1.671 ± 0.334
0.836MetPro: 0.836 ± 0.229
0.928MetGln: 0.928 ± 0.288
1.114MetArg: 1.114 ± 0.41
2.692MetSer: 2.692 ± 0.507
1.857MetThr: 1.857 ± 0.434
1.114MetVal: 1.114 ± 0.318
0.464MetTrp: 0.464 ± 0.194
0.371MetTyr: 0.371 ± 0.17
0.0MetXaa: 0.0 ± 0.0
Asn
4.456AsnAla: 4.456 ± 0.845
0.186AsnCys: 0.186 ± 0.133
3.435AsnAsp: 3.435 ± 0.417
2.6AsnGlu: 2.6 ± 0.414
2.692AsnPhe: 2.692 ± 0.636
4.828AsnGly: 4.828 ± 0.55
0.65AsnHis: 0.65 ± 0.238
3.992AsnIle: 3.992 ± 0.627
4.828AsnLys: 4.828 ± 0.532
5.013AsnLeu: 5.013 ± 0.797
1.207AsnMet: 1.207 ± 0.313
3.992AsnAsn: 3.992 ± 0.746
2.414AsnPro: 2.414 ± 0.463
1.764AsnGln: 1.764 ± 0.436
2.043AsnArg: 2.043 ± 0.476
3.528AsnSer: 3.528 ± 0.78
3.249AsnThr: 3.249 ± 0.49
4.271AsnVal: 4.271 ± 0.713
0.836AsnTrp: 0.836 ± 0.329
3.064AsnTyr: 3.064 ± 0.605
0.0AsnXaa: 0.0 ± 0.0
Pro
1.207ProAla: 1.207 ± 0.311
0.093ProCys: 0.093 ± 0.086
0.836ProAsp: 0.836 ± 0.26
2.321ProGlu: 2.321 ± 0.474
1.3ProPhe: 1.3 ± 0.351
0.464ProGly: 0.464 ± 0.223
0.65ProHis: 0.65 ± 0.24
2.785ProIle: 2.785 ± 0.564
3.064ProLys: 3.064 ± 0.519
2.043ProLeu: 2.043 ± 0.452
0.371ProMet: 0.371 ± 0.158
1.671ProAsn: 1.671 ± 0.328
0.557ProPro: 0.557 ± 0.213
1.207ProGln: 1.207 ± 0.249
0.836ProArg: 0.836 ± 0.326
1.393ProSer: 1.393 ± 0.41
1.393ProThr: 1.393 ± 0.332
2.135ProVal: 2.135 ± 0.383
0.186ProTrp: 0.186 ± 0.144
0.928ProTyr: 0.928 ± 0.322
0.0ProXaa: 0.0 ± 0.0
Gln
3.064GlnAla: 3.064 ± 0.44
0.279GlnCys: 0.279 ± 0.159
2.228GlnAsp: 2.228 ± 0.369
2.321GlnGlu: 2.321 ± 0.392
1.207GlnPhe: 1.207 ± 0.404
1.764GlnGly: 1.764 ± 0.316
0.743GlnHis: 0.743 ± 0.241
3.714GlnIle: 3.714 ± 0.493
3.157GlnLys: 3.157 ± 0.495
4.549GlnLeu: 4.549 ± 0.612
0.65GlnMet: 0.65 ± 0.233
1.671GlnAsn: 1.671 ± 0.433
0.279GlnPro: 0.279 ± 0.155
1.764GlnGln: 1.764 ± 0.471
1.578GlnArg: 1.578 ± 0.273
2.414GlnSer: 2.414 ± 0.462
2.692GlnThr: 2.692 ± 0.48
1.485GlnVal: 1.485 ± 0.286
0.186GlnTrp: 0.186 ± 0.117
1.114GlnTyr: 1.114 ± 0.307
0.0GlnXaa: 0.0 ± 0.0
Arg
3.064ArgAla: 3.064 ± 0.493
0.279ArgCys: 0.279 ± 0.148
2.785ArgAsp: 2.785 ± 0.498
2.785ArgGlu: 2.785 ± 0.479
1.021ArgPhe: 1.021 ± 0.305
1.857ArgGly: 1.857 ± 0.356
0.836ArgHis: 0.836 ± 0.324
3.064ArgIle: 3.064 ± 0.608
2.878ArgLys: 2.878 ± 0.519
3.528ArgLeu: 3.528 ± 0.539
1.578ArgMet: 1.578 ± 0.273
2.228ArgAsn: 2.228 ± 0.422
1.393ArgPro: 1.393 ± 0.323
2.043ArgGln: 2.043 ± 0.533
1.95ArgArg: 1.95 ± 0.419
2.135ArgSer: 2.135 ± 0.54
2.692ArgThr: 2.692 ± 0.434
2.135ArgVal: 2.135 ± 0.528
0.279ArgTrp: 0.279 ± 0.145
1.671ArgTyr: 1.671 ± 0.448
0.0ArgXaa: 0.0 ± 0.0
Ser
5.013SerAla: 5.013 ± 0.848
0.186SerCys: 0.186 ± 0.132
4.085SerAsp: 4.085 ± 0.496
4.735SerGlu: 4.735 ± 0.772
1.764SerPhe: 1.764 ± 0.376
4.178SerGly: 4.178 ± 0.953
0.743SerHis: 0.743 ± 0.302
4.642SerIle: 4.642 ± 0.912
5.849SerLys: 5.849 ± 0.802
5.942SerLeu: 5.942 ± 0.807
0.928SerMet: 0.928 ± 0.292
4.178SerAsn: 4.178 ± 0.618
0.928SerPro: 0.928 ± 0.352
2.6SerGln: 2.6 ± 0.542
2.228SerArg: 2.228 ± 0.535
4.549SerSer: 4.549 ± 0.795
3.342SerThr: 3.342 ± 0.968
4.178SerVal: 4.178 ± 0.609
0.464SerTrp: 0.464 ± 0.198
2.785SerTyr: 2.785 ± 0.485
0.0SerXaa: 0.0 ± 0.0
Thr
4.085ThrAla: 4.085 ± 0.741
0.464ThrCys: 0.464 ± 0.24
3.528ThrAsp: 3.528 ± 0.459
3.807ThrGlu: 3.807 ± 0.576
3.249ThrPhe: 3.249 ± 0.733
4.271ThrGly: 4.271 ± 0.627
1.393ThrHis: 1.393 ± 0.285
5.756ThrIle: 5.756 ± 0.77
5.199ThrLys: 5.199 ± 0.575
4.085ThrLeu: 4.085 ± 0.651
1.114ThrMet: 1.114 ± 0.276
2.321ThrAsn: 2.321 ± 0.454
1.393ThrPro: 1.393 ± 0.426
2.414ThrGln: 2.414 ± 0.368
1.95ThrArg: 1.95 ± 0.441
3.342ThrSer: 3.342 ± 0.535
5.199ThrThr: 5.199 ± 0.867
3.992ThrVal: 3.992 ± 0.651
0.743ThrTrp: 0.743 ± 0.308
1.95ThrTyr: 1.95 ± 0.441
0.0ThrXaa: 0.0 ± 0.0
Val
5.013ValAla: 5.013 ± 0.838
0.279ValCys: 0.279 ± 0.16
3.249ValAsp: 3.249 ± 0.71
4.828ValGlu: 4.828 ± 0.72
2.785ValPhe: 2.785 ± 0.465
3.249ValGly: 3.249 ± 0.447
0.836ValHis: 0.836 ± 0.27
5.756ValIle: 5.756 ± 0.911
4.828ValLys: 4.828 ± 0.694
5.013ValLeu: 5.013 ± 0.791
1.3ValMet: 1.3 ± 0.304
2.6ValAsn: 2.6 ± 0.398
1.207ValPro: 1.207 ± 0.322
1.393ValGln: 1.393 ± 0.349
2.507ValArg: 2.507 ± 0.414
3.435ValSer: 3.435 ± 0.512
5.013ValThr: 5.013 ± 0.655
3.528ValVal: 3.528 ± 0.568
0.743ValTrp: 0.743 ± 0.277
2.228ValTyr: 2.228 ± 0.611
0.0ValXaa: 0.0 ± 0.0
Trp
0.186TrpAla: 0.186 ± 0.115
0.279TrpCys: 0.279 ± 0.161
0.836TrpAsp: 0.836 ± 0.223
0.743TrpGlu: 0.743 ± 0.27
0.557TrpPhe: 0.557 ± 0.183
0.186TrpGly: 0.186 ± 0.112
0.279TrpHis: 0.279 ± 0.163
0.65TrpIle: 0.65 ± 0.238
1.114TrpLys: 1.114 ± 0.31
1.021TrpLeu: 1.021 ± 0.317
0.186TrpMet: 0.186 ± 0.121
1.3TrpAsn: 1.3 ± 0.654
0.186TrpPro: 0.186 ± 0.126
0.557TrpGln: 0.557 ± 0.209
0.279TrpArg: 0.279 ± 0.153
0.836TrpSer: 0.836 ± 0.235
0.464TrpThr: 0.464 ± 0.248
0.371TrpVal: 0.371 ± 0.159
0.093TrpTrp: 0.093 ± 0.087
0.743TrpTyr: 0.743 ± 0.224
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.043TyrAla: 2.043 ± 0.386
0.279TyrCys: 0.279 ± 0.17
2.692TyrAsp: 2.692 ± 0.702
2.692TyrGlu: 2.692 ± 0.41
1.114TyrPhe: 1.114 ± 0.384
3.249TyrGly: 3.249 ± 0.412
0.928TyrHis: 0.928 ± 0.267
1.764TyrIle: 1.764 ± 0.62
3.528TyrLys: 3.528 ± 0.985
3.899TyrLeu: 3.899 ± 0.76
0.557TyrMet: 0.557 ± 0.214
1.95TyrAsn: 1.95 ± 0.562
1.207TyrPro: 1.207 ± 0.387
1.671TyrGln: 1.671 ± 0.357
1.764TyrArg: 1.764 ± 0.39
1.207TyrSer: 1.207 ± 0.432
1.857TyrThr: 1.857 ± 0.476
2.785TyrVal: 2.785 ± 0.55
0.371TyrTrp: 0.371 ± 0.162
2.043TyrTyr: 2.043 ± 0.43
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 50 proteins (10772 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski