Amino acid dipepetide frequency for Duganella sp. CF402

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.398AlaAla: 18.398 ± 0.186
1.082AlaCys: 1.082 ± 0.028
6.754AlaAsp: 6.754 ± 0.063
6.321AlaGlu: 6.321 ± 0.076
3.706AlaPhe: 3.706 ± 0.043
10.25AlaGly: 10.25 ± 0.108
2.383AlaHis: 2.383 ± 0.038
5.808AlaIle: 5.808 ± 0.063
4.406AlaLys: 4.406 ± 0.061
13.891AlaLeu: 13.891 ± 0.2
3.297AlaMet: 3.297 ± 0.047
3.659AlaAsn: 3.659 ± 0.053
5.988AlaPro: 5.988 ± 0.083
5.725AlaGln: 5.725 ± 0.102
7.265AlaArg: 7.265 ± 0.068
7.066AlaSer: 7.066 ± 0.076
6.177AlaThr: 6.177 ± 0.064
8.371AlaVal: 8.371 ± 0.068
1.617AlaTrp: 1.617 ± 0.039
2.87AlaTyr: 2.87 ± 0.046
0.0AlaXaa: 0.0 ± 0.0
Cys
1.034CysAla: 1.034 ± 0.025
0.105CysCys: 0.105 ± 0.008
0.459CysAsp: 0.459 ± 0.018
0.403CysGlu: 0.403 ± 0.015
0.267CysPhe: 0.267 ± 0.011
0.846CysGly: 0.846 ± 0.023
0.242CysHis: 0.242 ± 0.013
0.35CysIle: 0.35 ± 0.014
0.262CysLys: 0.262 ± 0.011
0.705CysLeu: 0.705 ± 0.021
0.194CysMet: 0.194 ± 0.011
0.23CysAsn: 0.23 ± 0.012
0.341CysPro: 0.341 ± 0.016
0.23CysGln: 0.23 ± 0.011
0.454CysArg: 0.454 ± 0.018
0.456CysSer: 0.456 ± 0.016
0.43CysThr: 0.43 ± 0.016
0.6CysVal: 0.6 ± 0.019
0.109CysTrp: 0.109 ± 0.008
0.222CysTyr: 0.222 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
6.721AspAla: 6.721 ± 0.067
0.408AspCys: 0.408 ± 0.016
2.928AspAsp: 2.928 ± 0.052
2.99AspGlu: 2.99 ± 0.046
2.125AspPhe: 2.125 ± 0.029
5.134AspGly: 5.134 ± 0.082
1.083AspHis: 1.083 ± 0.026
2.795AspIle: 2.795 ± 0.034
2.306AspLys: 2.306 ± 0.038
5.2AspLeu: 5.2 ± 0.058
1.294AspMet: 1.294 ± 0.024
1.73AspAsn: 1.73 ± 0.035
2.647AspPro: 2.647 ± 0.042
2.094AspGln: 2.094 ± 0.075
2.741AspArg: 2.741 ± 0.041
2.71AspSer: 2.71 ± 0.044
2.834AspThr: 2.834 ± 0.076
3.806AspVal: 3.806 ± 0.054
0.917AspTrp: 0.917 ± 0.019
1.732AspTyr: 1.732 ± 0.03
0.0AspXaa: 0.0 ± 0.0
Glu
6.003GluAla: 6.003 ± 0.067
0.315GluCys: 0.315 ± 0.013
2.244GluAsp: 2.244 ± 0.033
2.703GluGlu: 2.703 ± 0.046
1.828GluPhe: 1.828 ± 0.031
3.359GluGly: 3.359 ± 0.048
1.294GluHis: 1.294 ± 0.027
2.809GluIle: 2.809 ± 0.046
2.186GluLys: 2.186 ± 0.04
5.868GluLeu: 5.868 ± 0.07
1.331GluMet: 1.331 ± 0.027
1.523GluAsn: 1.523 ± 0.029
2.052GluPro: 2.052 ± 0.032
3.053GluGln: 3.053 ± 0.049
3.947GluArg: 3.947 ± 0.052
2.378GluSer: 2.378 ± 0.044
2.539GluThr: 2.539 ± 0.041
3.656GluVal: 3.656 ± 0.044
0.734GluTrp: 0.734 ± 0.022
1.204GluTyr: 1.204 ± 0.026
0.0GluXaa: 0.0 ± 0.0
Phe
3.911PheAla: 3.911 ± 0.052
0.347PheCys: 0.347 ± 0.014
2.42PheAsp: 2.42 ± 0.037
1.843PheGlu: 1.843 ± 0.033
1.339PhePhe: 1.339 ± 0.036
3.313PheGly: 3.313 ± 0.049
0.727PheHis: 0.727 ± 0.019
1.681PheIle: 1.681 ± 0.031
1.454PheLys: 1.454 ± 0.027
2.935PheLeu: 2.935 ± 0.046
0.853PheMet: 0.853 ± 0.019
1.474PheAsn: 1.474 ± 0.03
1.408PhePro: 1.408 ± 0.03
1.127PheGln: 1.127 ± 0.025
1.833PheArg: 1.833 ± 0.03
2.421PheSer: 2.421 ± 0.037
2.06PheThr: 2.06 ± 0.035
2.502PheVal: 2.502 ± 0.038
0.468PheTrp: 0.468 ± 0.017
1.068PheTyr: 1.068 ± 0.024
0.0PheXaa: 0.0 ± 0.0
Gly
9.131GlyAla: 9.131 ± 0.104
0.707GlyCys: 0.707 ± 0.024
4.103GlyAsp: 4.103 ± 0.072
3.961GlyGlu: 3.961 ± 0.047
3.144GlyPhe: 3.144 ± 0.046
6.954GlyGly: 6.954 ± 0.145
1.737GlyHis: 1.737 ± 0.031
4.013GlyIle: 4.013 ± 0.052
4.094GlyLys: 4.094 ± 0.056
7.981GlyLeu: 7.981 ± 0.075
2.381GlyMet: 2.381 ± 0.046
2.721GlyAsn: 2.721 ± 0.102
2.622GlyPro: 2.622 ± 0.039
3.117GlyGln: 3.117 ± 0.042
4.425GlyArg: 4.425 ± 0.042
4.734GlySer: 4.734 ± 0.069
4.38GlyThr: 4.38 ± 0.073
6.465GlyVal: 6.465 ± 0.068
1.318GlyTrp: 1.318 ± 0.03
2.639GlyTyr: 2.639 ± 0.038
0.0GlyXaa: 0.0 ± 0.0
His
2.638HisAla: 2.638 ± 0.039
0.224HisCys: 0.224 ± 0.011
1.213HisAsp: 1.213 ± 0.026
1.079HisGlu: 1.079 ± 0.025
0.916HisPhe: 0.916 ± 0.026
1.969HisGly: 1.969 ± 0.036
0.632HisHis: 0.632 ± 0.023
1.016HisIle: 1.016 ± 0.023
0.701HisLys: 0.701 ± 0.02
2.084HisLeu: 2.084 ± 0.036
0.516HisMet: 0.516 ± 0.018
0.62HisAsn: 0.62 ± 0.021
1.264HisPro: 1.264 ± 0.03
0.799HisGln: 0.799 ± 0.021
1.215HisArg: 1.215 ± 0.026
1.092HisSer: 1.092 ± 0.024
1.052HisThr: 1.052 ± 0.025
1.393HisVal: 1.393 ± 0.028
0.362HisTrp: 0.362 ± 0.013
0.721HisTyr: 0.721 ± 0.019
0.0HisXaa: 0.0 ± 0.0
Ile
6.667IleAla: 6.667 ± 0.079
0.406IleCys: 0.406 ± 0.015
3.356IleAsp: 3.356 ± 0.047
2.998IleGlu: 2.998 ± 0.043
1.468IlePhe: 1.468 ± 0.028
4.485IleGly: 4.485 ± 0.051
0.906IleHis: 0.906 ± 0.023
2.096IleIle: 2.096 ± 0.043
2.025IleLys: 2.025 ± 0.037
3.76IleLeu: 3.76 ± 0.047
0.932IleMet: 0.932 ± 0.026
1.893IleAsn: 1.893 ± 0.038
2.105IlePro: 2.105 ± 0.038
1.337IleGln: 1.337 ± 0.028
2.503IleArg: 2.503 ± 0.042
3.068IleSer: 3.068 ± 0.047
2.893IleThr: 2.893 ± 0.041
3.64IleVal: 3.64 ± 0.05
0.504IleTrp: 0.504 ± 0.017
1.241IleTyr: 1.241 ± 0.026
0.0IleXaa: 0.0 ± 0.0
Lys
4.432LysAla: 4.432 ± 0.054
0.175LysCys: 0.175 ± 0.01
2.056LysAsp: 2.056 ± 0.037
1.984LysGlu: 1.984 ± 0.04
1.207LysPhe: 1.207 ± 0.024
2.61LysGly: 2.61 ± 0.043
0.814LysHis: 0.814 ± 0.021
2.042LysIle: 2.042 ± 0.033
1.766LysLys: 1.766 ± 0.039
4.576LysLeu: 4.576 ± 0.057
1.077LysMet: 1.077 ± 0.027
1.361LysAsn: 1.361 ± 0.031
2.369LysPro: 2.369 ± 0.039
1.846LysGln: 1.846 ± 0.032
2.358LysArg: 2.358 ± 0.035
2.021LysSer: 2.021 ± 0.035
2.179LysThr: 2.179 ± 0.04
2.896LysVal: 2.896 ± 0.042
0.441LysTrp: 0.441 ± 0.017
0.921LysTyr: 0.921 ± 0.025
0.0LysXaa: 0.0 ± 0.0
Leu
13.902LeuAla: 13.902 ± 0.127
0.955LeuCys: 0.955 ± 0.025
5.762LeuAsp: 5.762 ± 0.057
5.13LeuGlu: 5.13 ± 0.061
3.397LeuPhe: 3.397 ± 0.049
7.778LeuGly: 7.778 ± 0.071
2.293LeuHis: 2.293 ± 0.034
4.566LeuIle: 4.566 ± 0.052
4.106LeuLys: 4.106 ± 0.045
10.956LeuLeu: 10.956 ± 0.116
2.418LeuMet: 2.418 ± 0.039
3.51LeuAsn: 3.51 ± 0.046
5.744LeuPro: 5.744 ± 0.07
4.239LeuGln: 4.239 ± 0.051
6.843LeuArg: 6.843 ± 0.076
6.842LeuSer: 6.842 ± 0.109
5.868LeuThr: 5.868 ± 0.1
6.913LeuVal: 6.913 ± 0.066
1.159LeuTrp: 1.159 ± 0.031
2.321LeuTyr: 2.321 ± 0.032
0.0LeuXaa: 0.0 ± 0.0
Met
2.851MetAla: 2.851 ± 0.043
0.163MetCys: 0.163 ± 0.008
1.202MetAsp: 1.202 ± 0.028
1.15MetGlu: 1.15 ± 0.026
0.753MetPhe: 0.753 ± 0.02
1.649MetGly: 1.649 ± 0.037
0.539MetHis: 0.539 ± 0.016
1.088MetIle: 1.088 ± 0.025
1.21MetLys: 1.21 ± 0.022
2.806MetLeu: 2.806 ± 0.044
0.705MetMet: 0.705 ± 0.021
0.999MetAsn: 0.999 ± 0.024
1.394MetPro: 1.394 ± 0.03
1.205MetGln: 1.205 ± 0.028
1.596MetArg: 1.596 ± 0.029
1.683MetSer: 1.683 ± 0.028
1.576MetThr: 1.576 ± 0.031
1.67MetVal: 1.67 ± 0.034
0.238MetTrp: 0.238 ± 0.011
0.484MetTyr: 0.484 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
4.009AsnAla: 4.009 ± 0.059
0.258AsnCys: 0.258 ± 0.012
1.815AsnAsp: 1.815 ± 0.063
1.464AsnGlu: 1.464 ± 0.028
1.275AsnPhe: 1.275 ± 0.026
3.057AsnGly: 3.057 ± 0.055
0.646AsnHis: 0.646 ± 0.017
1.725AsnIle: 1.725 ± 0.035
1.235AsnLys: 1.235 ± 0.024
3.223AsnLeu: 3.223 ± 0.049
0.738AsnMet: 0.738 ± 0.02
1.237AsnAsn: 1.237 ± 0.036
1.842AsnPro: 1.842 ± 0.035
1.245AsnGln: 1.245 ± 0.025
1.78AsnArg: 1.78 ± 0.033
1.74AsnSer: 1.74 ± 0.034
1.889AsnThr: 1.889 ± 0.043
2.392AsnVal: 2.392 ± 0.043
0.496AsnTrp: 0.496 ± 0.016
1.025AsnTyr: 1.025 ± 0.026
0.0AsnXaa: 0.0 ± 0.0
Pro
6.615ProAla: 6.615 ± 0.085
0.286ProCys: 0.286 ± 0.013
2.942ProAsp: 2.942 ± 0.044
3.047ProGlu: 3.047 ± 0.045
1.672ProPhe: 1.672 ± 0.031
3.886ProGly: 3.886 ± 0.049
1.025ProHis: 1.025 ± 0.025
1.847ProIle: 1.847 ± 0.032
1.59ProLys: 1.59 ± 0.033
4.992ProLeu: 4.992 ± 0.055
1.092ProMet: 1.092 ± 0.027
1.451ProAsn: 1.451 ± 0.03
2.346ProPro: 2.346 ± 0.044
2.156ProGln: 2.156 ± 0.037
2.296ProArg: 2.296 ± 0.033
2.716ProSer: 2.716 ± 0.039
2.319ProThr: 2.319 ± 0.039
3.897ProVal: 3.897 ± 0.054
0.588ProTrp: 0.588 ± 0.019
1.191ProTyr: 1.191 ± 0.026
0.0ProXaa: 0.0 ± 0.0
Gln
5.456GlnAla: 5.456 ± 0.071
0.256GlnCys: 0.256 ± 0.012
1.684GlnAsp: 1.684 ± 0.033
1.857GlnGlu: 1.857 ± 0.036
1.502GlnPhe: 1.502 ± 0.032
2.811GlnGly: 2.811 ± 0.044
1.102GlnHis: 1.102 ± 0.027
2.167GlnIle: 2.167 ± 0.081
1.418GlnLys: 1.418 ± 0.031
4.936GlnLeu: 4.936 ± 0.095
1.1GlnMet: 1.1 ± 0.025
1.145GlnAsn: 1.145 ± 0.026
2.185GlnPro: 2.185 ± 0.038
2.513GlnGln: 2.513 ± 0.045
3.159GlnArg: 3.159 ± 0.049
2.099GlnSer: 2.099 ± 0.035
2.073GlnThr: 2.073 ± 0.031
3.084GlnVal: 3.084 ± 0.062
0.579GlnTrp: 0.579 ± 0.019
1.044GlnTyr: 1.044 ± 0.022
0.0GlnXaa: 0.0 ± 0.0
Arg
6.671ArgAla: 6.671 ± 0.066
0.44ArgCys: 0.44 ± 0.014
3.326ArgAsp: 3.326 ± 0.04
3.404ArgGlu: 3.404 ± 0.047
2.396ArgPhe: 2.396 ± 0.04
3.807ArgGly: 3.807 ± 0.048
1.546ArgHis: 1.546 ± 0.031
3.323ArgIle: 3.323 ± 0.045
2.335ArgLys: 2.335 ± 0.039
6.315ArgLeu: 6.315 ± 0.072
1.69ArgMet: 1.69 ± 0.036
2.086ArgAsn: 2.086 ± 0.031
2.405ArgPro: 2.405 ± 0.036
2.639ArgGln: 2.639 ± 0.045
3.874ArgArg: 3.874 ± 0.052
3.269ArgSer: 3.269 ± 0.048
2.916ArgThr: 2.916 ± 0.039
4.145ArgVal: 4.145 ± 0.044
0.936ArgTrp: 0.936 ± 0.022
2.028ArgTyr: 2.028 ± 0.039
0.0ArgXaa: 0.0 ± 0.0
Ser
7.147SerAla: 7.147 ± 0.079
0.434SerCys: 0.434 ± 0.016
3.034SerAsp: 3.034 ± 0.049
2.611SerGlu: 2.611 ± 0.04
2.21SerPhe: 2.21 ± 0.039
5.632SerGly: 5.632 ± 0.078
1.178SerHis: 1.178 ± 0.027
2.825SerIle: 2.825 ± 0.041
2.103SerLys: 2.103 ± 0.038
5.887SerLeu: 5.887 ± 0.066
1.38SerMet: 1.38 ± 0.026
1.874SerAsn: 1.874 ± 0.04
2.602SerPro: 2.602 ± 0.043
2.059SerGln: 2.059 ± 0.047
3.137SerArg: 3.137 ± 0.039
3.665SerSer: 3.665 ± 0.055
3.347SerThr: 3.347 ± 0.068
4.232SerVal: 4.232 ± 0.045
0.785SerTrp: 0.785 ± 0.023
1.764SerTyr: 1.764 ± 0.035
0.0SerXaa: 0.0 ± 0.0
Thr
6.366ThrAla: 6.366 ± 0.097
0.365ThrCys: 0.365 ± 0.016
2.789ThrAsp: 2.789 ± 0.065
2.443ThrGlu: 2.443 ± 0.038
1.778ThrPhe: 1.778 ± 0.03
4.742ThrGly: 4.742 ± 0.083
1.033ThrHis: 1.033 ± 0.027
2.78ThrIle: 2.78 ± 0.043
1.636ThrLys: 1.636 ± 0.032
6.313ThrLeu: 6.313 ± 0.076
1.2ThrMet: 1.2 ± 0.026
1.64ThrAsn: 1.64 ± 0.034
3.43ThrPro: 3.43 ± 0.047
1.985ThrGln: 1.985 ± 0.042
2.911ThrArg: 2.911 ± 0.039
3.116ThrSer: 3.116 ± 0.055
3.099ThrThr: 3.099 ± 0.072
4.42ThrVal: 4.42 ± 0.062
0.68ThrTrp: 0.68 ± 0.022
1.424ThrTyr: 1.424 ± 0.035
0.0ThrXaa: 0.0 ± 0.0
Val
8.949ValAla: 8.949 ± 0.088
0.616ValCys: 0.616 ± 0.019
3.869ValAsp: 3.869 ± 0.053
3.838ValGlu: 3.838 ± 0.046
2.536ValPhe: 2.536 ± 0.038
5.172ValGly: 5.172 ± 0.064
1.375ValHis: 1.375 ± 0.026
3.631ValIle: 3.631 ± 0.047
2.773ValLys: 2.773 ± 0.041
7.805ValLeu: 7.805 ± 0.071
1.823ValMet: 1.823 ± 0.038
2.473ValAsn: 2.473 ± 0.044
3.347ValPro: 3.347 ± 0.043
2.837ValGln: 2.837 ± 0.037
4.409ValArg: 4.409 ± 0.055
4.406ValSer: 4.406 ± 0.053
4.238ValThr: 4.238 ± 0.056
5.559ValVal: 5.559 ± 0.067
0.886ValTrp: 0.886 ± 0.023
1.762ValTyr: 1.762 ± 0.031
0.0ValXaa: 0.0 ± 0.0
Trp
1.149TrpAla: 1.149 ± 0.027
0.14TrpCys: 0.14 ± 0.009
0.68TrpAsp: 0.68 ± 0.021
0.555TrpGlu: 0.555 ± 0.017
0.522TrpPhe: 0.522 ± 0.018
0.888TrpGly: 0.888 ± 0.023
0.34TrpHis: 0.34 ± 0.013
0.656TrpIle: 0.656 ± 0.022
0.536TrpLys: 0.536 ± 0.018
1.75TrpLeu: 1.75 ± 0.04
0.414TrpMet: 0.414 ± 0.016
0.515TrpAsn: 0.515 ± 0.017
0.579TrpPro: 0.579 ± 0.018
0.776TrpGln: 0.776 ± 0.021
1.029TrpArg: 1.029 ± 0.025
0.8TrpSer: 0.8 ± 0.023
0.715TrpThr: 0.715 ± 0.019
0.812TrpVal: 0.812 ± 0.025
0.238TrpTrp: 0.238 ± 0.012
0.35TrpTyr: 0.35 ± 0.014
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.984TyrAla: 2.984 ± 0.041
0.258TyrCys: 0.258 ± 0.012
1.559TyrAsp: 1.559 ± 0.031
1.243TyrGlu: 1.243 ± 0.029
1.142TyrPhe: 1.142 ± 0.026
2.288TyrGly: 2.288 ± 0.037
0.612TyrHis: 0.612 ± 0.018
1.064TyrIle: 1.064 ± 0.026
0.989TyrLys: 0.989 ± 0.023
2.718TyrLeu: 2.718 ± 0.033
0.526TyrMet: 0.526 ± 0.018
0.951TyrAsn: 0.951 ± 0.024
1.282TyrPro: 1.282 ± 0.028
1.192TyrGln: 1.192 ± 0.026
1.774TyrArg: 1.774 ± 0.035
1.623TyrSer: 1.623 ± 0.033
1.566TyrThr: 1.566 ± 0.035
1.85TyrVal: 1.85 ± 0.033
0.39TyrTrp: 0.39 ± 0.017
0.834TyrTyr: 0.834 ± 0.024
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5435 proteins (1935185 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski