Amino acid dipepetide frequency for Roseiarcus fermentans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.21AlaAla: 23.21 ± 0.213	1.236AlaCys: 1.236 ± 0.032	7.563AlaAsp: 7.563 ± 0.063	7.907AlaGlu: 7.907 ± 0.08	5.401AlaPhe: 5.401 ± 0.069	12.487AlaGly: 12.487 ± 0.101	2.521AlaHis: 2.521 ± 0.035	7.117AlaIle: 7.117 ± 0.07	3.854AlaLys: 3.854 ± 0.051	16.141AlaLeu: 16.141 ± 0.128	3.485AlaMet: 3.485 ± 0.051	3.082AlaAsn: 3.082 ± 0.051	7.879AlaPro: 7.879 ± 0.086	3.781AlaGln: 3.781 ± 0.054	11.476AlaArg: 11.476 ± 0.108	7.465AlaSer: 7.465 ± 0.076	6.82AlaThr: 6.82 ± 0.078	9.858AlaVal: 9.858 ± 0.093	1.8AlaTrp: 1.8 ± 0.032	2.759AlaTyr: 2.759 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	1.2CysAla: 1.2 ± 0.029	0.115CysCys: 0.115 ± 0.008	0.546CysAsp: 0.546 ± 0.02	0.427CysGlu: 0.427 ± 0.017	0.326CysPhe: 0.326 ± 0.013	0.987CysGly: 0.987 ± 0.026	0.203CysHis: 0.203 ± 0.012	0.306CysIle: 0.306 ± 0.014	0.206CysLys: 0.206 ± 0.011	0.815CysLeu: 0.815 ± 0.024	0.138CysMet: 0.138 ± 0.009	0.212CysAsn: 0.212 ± 0.011	0.47CysPro: 0.47 ± 0.02	0.19CysGln: 0.19 ± 0.01	0.659CysArg: 0.659 ± 0.017	0.394CysSer: 0.394 ± 0.017	0.305CysThr: 0.305 ± 0.014	0.705CysVal: 0.705 ± 0.022	0.114CysTrp: 0.114 ± 0.008	0.163CysTyr: 0.163 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.778AspAla: 7.778 ± 0.077	0.524AspCys: 0.524 ± 0.02	3.183AspAsp: 3.183 ± 0.045	3.339AspGlu: 3.339 ± 0.043	2.155AspPhe: 2.155 ± 0.031	5.32AspGly: 5.32 ± 0.057	1.078AspHis: 1.078 ± 0.025	2.546AspIle: 2.546 ± 0.033	1.469AspLys: 1.469 ± 0.032	6.059AspLeu: 6.059 ± 0.065	1.074AspMet: 1.074 ± 0.025	1.181AspAsn: 1.181 ± 0.025	3.891AspPro: 3.891 ± 0.049	1.412AspGln: 1.412 ± 0.029	4.668AspArg: 4.668 ± 0.053	2.359AspSer: 2.359 ± 0.04	2.149AspThr: 2.149 ± 0.043	4.343AspVal: 4.343 ± 0.055	0.986AspTrp: 0.986 ± 0.024	1.363AspTyr: 1.363 ± 0.028	0.0AspXaa: 0.0 ± 0.0
Glu	8.709GluAla: 8.709 ± 0.088	0.33GluCys: 0.33 ± 0.013	2.459GluAsp: 2.459 ± 0.038	2.552GluGlu: 2.552 ± 0.041	1.662GluPhe: 1.662 ± 0.032	4.131GluGly: 4.131 ± 0.053	0.946GluHis: 0.946 ± 0.024	3.048GluIle: 3.048 ± 0.04	1.773GluLys: 1.773 ± 0.032	4.488GluLeu: 4.488 ± 0.057	1.132GluMet: 1.132 ± 0.024	1.13GluAsn: 1.13 ± 0.025	2.917GluPro: 2.917 ± 0.044	1.571GluGln: 1.571 ± 0.025	5.481GluArg: 5.481 ± 0.071	2.372GluSer: 2.372 ± 0.038	3.543GluThr: 3.543 ± 0.048	3.378GluVal: 3.378 ± 0.04	0.665GluTrp: 0.665 ± 0.021	0.79GluTyr: 0.79 ± 0.023	0.0GluXaa: 0.0 ± 0.0
Phe	5.437PheAla: 5.437 ± 0.065	0.384PheCys: 0.384 ± 0.014	2.715PheAsp: 2.715 ± 0.04	2.028PheGlu: 2.028 ± 0.029	1.345PhePhe: 1.345 ± 0.029	3.849PheGly: 3.849 ± 0.051	0.719PheHis: 0.719 ± 0.019	1.319PheIle: 1.319 ± 0.03	0.84PheLys: 0.84 ± 0.023	3.45PheLeu: 3.45 ± 0.046	0.675PheMet: 0.675 ± 0.017	0.98PheAsn: 0.98 ± 0.027	1.666PhePro: 1.666 ± 0.032	0.935PheGln: 0.935 ± 0.023	2.354PheArg: 2.354 ± 0.038	2.195PheSer: 2.195 ± 0.038	1.783PheThr: 1.783 ± 0.035	3.26PheVal: 3.26 ± 0.048	0.559PheTrp: 0.559 ± 0.017	0.848PheTyr: 0.848 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	12.795GlyAla: 12.795 ± 0.138	0.862GlyCys: 0.862 ± 0.026	4.884GlyAsp: 4.884 ± 0.056	4.764GlyGlu: 4.764 ± 0.059	3.802GlyPhe: 3.802 ± 0.05	8.589GlyGly: 8.589 ± 0.147	1.676GlyHis: 1.676 ± 0.032	3.084GlyIle: 3.084 ± 0.049	2.869GlyLys: 2.869 ± 0.047	9.213GlyLeu: 9.213 ± 0.073	2.021GlyMet: 2.021 ± 0.035	1.715GlyAsn: 1.715 ± 0.044	4.209GlyPro: 4.209 ± 0.05	2.498GlyGln: 2.498 ± 0.039	7.253GlyArg: 7.253 ± 0.074	4.688GlySer: 4.688 ± 0.069	3.661GlyThr: 3.661 ± 0.086	7.727GlyVal: 7.727 ± 0.063	1.369GlyTrp: 1.369 ± 0.031	2.246GlyTyr: 2.246 ± 0.039	0.0GlyXaa: 0.0 ± 0.0
His	2.406HisAla: 2.406 ± 0.039	0.227HisCys: 0.227 ± 0.012	1.105HisAsp: 1.105 ± 0.026	0.957HisGlu: 0.957 ± 0.021	0.764HisPhe: 0.764 ± 0.021	1.874HisGly: 1.874 ± 0.031	0.483HisHis: 0.483 ± 0.025	0.748HisIle: 0.748 ± 0.022	0.409HisLys: 0.409 ± 0.015	1.677HisLeu: 1.677 ± 0.03	0.377HisMet: 0.377 ± 0.015	0.415HisAsn: 0.415 ± 0.017	1.255HisPro: 1.255 ± 0.027	0.44HisGln: 0.44 ± 0.014	1.345HisArg: 1.345 ± 0.029	0.776HisSer: 0.776 ± 0.02	0.681HisThr: 0.681 ± 0.02	1.471HisVal: 1.471 ± 0.027	0.303HisTrp: 0.303 ± 0.013	0.489HisTyr: 0.489 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	7.413IleAla: 7.413 ± 0.062	0.392IleCys: 0.392 ± 0.014	3.279IleAsp: 3.279 ± 0.044	3.293IleGlu: 3.293 ± 0.043	1.378IlePhe: 1.378 ± 0.03	4.764IleGly: 4.764 ± 0.057	0.844IleHis: 0.844 ± 0.022	1.428IleIle: 1.428 ± 0.032	1.109IleLys: 1.109 ± 0.027	3.995IleLeu: 3.995 ± 0.048	0.729IleMet: 0.729 ± 0.02	1.109IleAsn: 1.109 ± 0.026	2.079IlePro: 2.079 ± 0.033	0.98IleGln: 0.98 ± 0.021	2.871IleArg: 2.871 ± 0.044	2.149IleSer: 2.149 ± 0.04	1.866IleThr: 1.866 ± 0.04	4.682IleVal: 4.682 ± 0.055	0.498IleTrp: 0.498 ± 0.016	0.904IleTyr: 0.904 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	4.103LysAla: 4.103 ± 0.053	0.15LysCys: 0.15 ± 0.009	1.438LysAsp: 1.438 ± 0.034	1.182LysGlu: 1.182 ± 0.029	0.816LysPhe: 0.816 ± 0.022	2.356LysGly: 2.356 ± 0.043	0.468LysHis: 0.468 ± 0.016	1.462LysIle: 1.462 ± 0.033	0.911LysLys: 0.911 ± 0.029	2.805LysLeu: 2.805 ± 0.041	0.607LysMet: 0.607 ± 0.02	0.603LysAsn: 0.603 ± 0.02	1.972LysPro: 1.972 ± 0.032	0.731LysGln: 0.731 ± 0.02	2.192LysArg: 2.192 ± 0.039	1.587LysSer: 1.587 ± 0.028	1.757LysThr: 1.757 ± 0.035	1.958LysVal: 1.958 ± 0.035	0.336LysTrp: 0.336 ± 0.015	0.527LysTyr: 0.527 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	16.014LeuAla: 16.014 ± 0.11	0.887LeuCys: 0.887 ± 0.023	6.232LeuAsp: 6.232 ± 0.062	4.87LeuGlu: 4.87 ± 0.06	3.507LeuPhe: 3.507 ± 0.048	8.8LeuGly: 8.8 ± 0.076	1.687LeuHis: 1.687 ± 0.031	4.606LeuIle: 4.606 ± 0.054	2.975LeuLys: 2.975 ± 0.039	8.363LeuLeu: 8.363 ± 0.079	2.101LeuMet: 2.101 ± 0.036	2.205LeuAsn: 2.205 ± 0.035	5.21LeuPro: 5.21 ± 0.055	2.227LeuGln: 2.227 ± 0.035	7.146LeuArg: 7.146 ± 0.079	5.905LeuSer: 5.905 ± 0.059	5.464LeuThr: 5.464 ± 0.071	7.651LeuVal: 7.651 ± 0.073	1.181LeuTrp: 1.181 ± 0.024	1.974LeuTyr: 1.974 ± 0.034	0.0LeuXaa: 0.0 ± 0.0
Met	2.848MetAla: 2.848 ± 0.042	0.136MetCys: 0.136 ± 0.009	0.937MetAsp: 0.937 ± 0.025	0.849MetGlu: 0.849 ± 0.023	0.643MetPhe: 0.643 ± 0.021	1.557MetGly: 1.557 ± 0.03	0.335MetHis: 0.335 ± 0.01	1.237MetIle: 1.237 ± 0.028	0.821MetLys: 0.821 ± 0.022	2.0MetLeu: 2.0 ± 0.037	0.535MetMet: 0.535 ± 0.02	0.684MetAsn: 0.684 ± 0.024	1.197MetPro: 1.197 ± 0.028	0.622MetGln: 0.622 ± 0.015	1.813MetArg: 1.813 ± 0.034	1.518MetSer: 1.518 ± 0.028	1.891MetThr: 1.891 ± 0.033	1.292MetVal: 1.292 ± 0.028	0.181MetTrp: 0.181 ± 0.01	0.246MetTyr: 0.246 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.251AsnAla: 3.251 ± 0.052	0.231AsnCys: 0.231 ± 0.012	1.251AsnAsp: 1.251 ± 0.027	0.966AsnGlu: 0.966 ± 0.024	0.908AsnPhe: 0.908 ± 0.026	2.367AsnGly: 2.367 ± 0.051	0.411AsnHis: 0.411 ± 0.013	1.036AsnIle: 1.036 ± 0.024	0.496AsnLys: 0.496 ± 0.017	2.323AsnLeu: 2.323 ± 0.037	0.436AsnMet: 0.436 ± 0.017	0.578AsnAsn: 0.578 ± 0.021	1.789AsnPro: 1.789 ± 0.03	0.61AsnGln: 0.61 ± 0.019	1.495AsnArg: 1.495 ± 0.029	1.106AsnSer: 1.106 ± 0.032	1.028AsnThr: 1.028 ± 0.031	1.842AsnVal: 1.842 ± 0.034	0.366AsnTrp: 0.366 ± 0.013	0.573AsnTyr: 0.573 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	7.682ProAla: 7.682 ± 0.086	0.376ProCys: 0.376 ± 0.014	3.859ProAsp: 3.859 ± 0.05	3.508ProGlu: 3.508 ± 0.05	2.103ProPhe: 2.103 ± 0.028	5.161ProGly: 5.161 ± 0.061	1.026ProHis: 1.026 ± 0.023	2.381ProIle: 2.381 ± 0.041	1.684ProLys: 1.684 ± 0.034	4.835ProLeu: 4.835 ± 0.056	1.197ProMet: 1.197 ± 0.026	1.403ProAsn: 1.403 ± 0.028	3.595ProPro: 3.595 ± 0.073	1.507ProGln: 1.507 ± 0.026	3.559ProArg: 3.559 ± 0.05	3.074ProSer: 3.074 ± 0.046	2.817ProThr: 2.817 ± 0.039	3.931ProVal: 3.931 ± 0.048	0.824ProTrp: 0.824 ± 0.022	1.19ProTyr: 1.19 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	3.76GlnAla: 3.76 ± 0.054	0.193GlnCys: 0.193 ± 0.01	1.204GlnAsp: 1.204 ± 0.025	1.128GlnGlu: 1.128 ± 0.024	0.955GlnPhe: 0.955 ± 0.021	2.103GlnGly: 2.103 ± 0.035	0.445GlnHis: 0.445 ± 0.015	1.498GlnIle: 1.498 ± 0.029	0.862GlnLys: 0.862 ± 0.022	2.173GlnLeu: 2.173 ± 0.039	0.669GlnMet: 0.669 ± 0.018	0.689GlnAsn: 0.689 ± 0.018	1.501GlnPro: 1.501 ± 0.03	0.863GlnGln: 0.863 ± 0.022	2.037GlnArg: 2.037 ± 0.034	1.556GlnSer: 1.556 ± 0.028	1.631GlnThr: 1.631 ± 0.031	1.796GlnVal: 1.796 ± 0.037	0.398GlnTrp: 0.398 ± 0.017	0.51GlnTyr: 0.51 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	10.362ArgAla: 10.362 ± 0.104	0.565ArgCys: 0.565 ± 0.02	4.394ArgAsp: 4.394 ± 0.06	4.334ArgGlu: 4.334 ± 0.063	3.145ArgPhe: 3.145 ± 0.04	5.454ArgGly: 5.454 ± 0.056	1.531ArgHis: 1.531 ± 0.033	3.816ArgIle: 3.816 ± 0.048	2.197ArgLys: 2.197 ± 0.04	8.851ArgLeu: 8.851 ± 0.09	1.739ArgMet: 1.739 ± 0.032	1.633ArgAsn: 1.633 ± 0.028	4.375ArgPro: 4.375 ± 0.061	2.18ArgGln: 2.18 ± 0.03	7.477ArgArg: 7.477 ± 0.095	3.923ArgSer: 3.923 ± 0.055	3.392ArgThr: 3.392 ± 0.045	5.205ArgVal: 5.205 ± 0.055	1.15ArgTrp: 1.15 ± 0.027	1.612ArgTyr: 1.612 ± 0.029	0.0ArgXaa: 0.0 ± 0.0
Ser	7.14SerAla: 7.14 ± 0.08	0.412SerCys: 0.412 ± 0.015	2.907SerAsp: 2.907 ± 0.038	2.549SerGlu: 2.549 ± 0.037	2.102SerPhe: 2.102 ± 0.033	5.858SerGly: 5.858 ± 0.107	0.958SerHis: 0.958 ± 0.023	2.426SerIle: 2.426 ± 0.039	1.26SerLys: 1.26 ± 0.029	5.306SerLeu: 5.306 ± 0.06	1.094SerMet: 1.094 ± 0.024	1.299SerAsn: 1.299 ± 0.033	3.199SerPro: 3.199 ± 0.04	1.406SerGln: 1.406 ± 0.029	3.735SerArg: 3.735 ± 0.045	2.868SerSer: 2.868 ± 0.047	2.532SerThr: 2.532 ± 0.045	4.004SerVal: 4.004 ± 0.051	0.706SerTrp: 0.706 ± 0.018	1.128SerTyr: 1.128 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	6.27ThrAla: 6.27 ± 0.076	0.38ThrCys: 0.38 ± 0.014	2.414ThrAsp: 2.414 ± 0.03	2.161ThrGlu: 2.161 ± 0.031	2.021ThrPhe: 2.021 ± 0.036	4.748ThrGly: 4.748 ± 0.068	0.917ThrHis: 0.917 ± 0.021	2.879ThrIle: 2.879 ± 0.05	1.224ThrLys: 1.224 ± 0.031	5.91ThrLeu: 5.91 ± 0.075	1.037ThrMet: 1.037 ± 0.023	1.184ThrAsn: 1.184 ± 0.032	3.386ThrPro: 3.386 ± 0.042	1.242ThrGln: 1.242 ± 0.022	3.274ThrArg: 3.274 ± 0.047	2.592ThrSer: 2.592 ± 0.056	2.837ThrThr: 2.837 ± 0.07	4.155ThrVal: 4.155 ± 0.066	0.613ThrTrp: 0.613 ± 0.018	1.066ThrTyr: 1.066 ± 0.027	0.0ThrXaa: 0.0 ± 0.0
Val	11.327ValAla: 11.327 ± 0.094	0.707ValCys: 0.707 ± 0.022	4.524ValAsp: 4.524 ± 0.048	4.663ValGlu: 4.663 ± 0.05	2.955ValPhe: 2.955 ± 0.04	6.49ValGly: 6.49 ± 0.063	1.321ValHis: 1.321 ± 0.028	3.433ValIle: 3.433 ± 0.047	2.12ValLys: 2.12 ± 0.034	6.779ValLeu: 6.779 ± 0.065	1.634ValMet: 1.634 ± 0.033	1.998ValAsn: 1.998 ± 0.038	3.256ValPro: 3.256 ± 0.045	1.793ValGln: 1.793 ± 0.028	5.271ValArg: 5.271 ± 0.061	4.398ValSer: 4.398 ± 0.066	4.327ValThr: 4.327 ± 0.051	6.81ValVal: 6.81 ± 0.075	0.98ValTrp: 0.98 ± 0.024	1.678ValTyr: 1.678 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.419TrpAla: 1.419 ± 0.027	0.119TrpCys: 0.119 ± 0.008	0.634TrpAsp: 0.634 ± 0.02	0.537TrpGlu: 0.537 ± 0.018	0.527TrpPhe: 0.527 ± 0.016	0.985TrpGly: 0.985 ± 0.025	0.222TrpHis: 0.222 ± 0.01	0.688TrpIle: 0.688 ± 0.02	0.421TrpLys: 0.421 ± 0.015	1.683TrpLeu: 1.683 ± 0.032	0.308TrpMet: 0.308 ± 0.013	0.408TrpAsn: 0.408 ± 0.015	0.778TrpPro: 0.778 ± 0.021	0.354TrpGln: 0.354 ± 0.015	1.505TrpArg: 1.505 ± 0.027	0.877TrpSer: 0.877 ± 0.022	0.9TrpThr: 0.9 ± 0.022	0.766TrpVal: 0.766 ± 0.021	0.211TrpTrp: 0.211 ± 0.011	0.249TrpTyr: 0.249 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.718TyrAla: 2.718 ± 0.042	0.255TyrCys: 0.255 ± 0.012	1.345TyrAsp: 1.345 ± 0.026	1.065TyrGlu: 1.065 ± 0.024	0.828TyrPhe: 0.828 ± 0.02	2.045TyrGly: 2.045 ± 0.039	0.411TyrHis: 0.411 ± 0.015	0.706TyrIle: 0.706 ± 0.023	0.459TyrLys: 0.459 ± 0.017	2.14TyrLeu: 2.14 ± 0.038	0.353TyrMet: 0.353 ± 0.016	0.555TyrAsn: 0.555 ± 0.017	1.087TyrPro: 1.087 ± 0.022	0.632TyrGln: 0.632 ± 0.019	1.722TyrArg: 1.722 ± 0.035	1.089TyrSer: 1.089 ± 0.025	0.926TyrThr: 0.926 ± 0.023	1.628TyrVal: 1.628 ± 0.031	0.351TyrTrp: 0.351 ± 0.014	0.547TyrTyr: 0.547 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6190 proteins (1936078 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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