Amino acid dipepetide frequency for Gila monster-associated gemycircularvirus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.589AlaAla: 3.589 ± 0.411
0.0AlaCys: 0.0 ± 0.0
5.981AlaAsp: 5.981 ± 1.487
4.785AlaGlu: 4.785 ± 2.418
3.589AlaPhe: 3.589 ± 0.411
1.196AlaGly: 1.196 ± 1.025
2.392AlaHis: 2.392 ± 1.209
2.392AlaIle: 2.392 ± 1.209
1.196AlaLys: 1.196 ± 0.892
1.196AlaLeu: 1.196 ± 1.025
0.0AlaMet: 0.0 ± 0.0
4.785AlaAsn: 4.785 ± 0.989
7.177AlaPro: 7.177 ± 0.822
3.589AlaGln: 3.589 ± 1.59
5.981AlaArg: 5.981 ± 0.403
5.981AlaSer: 5.981 ± 1.972
4.785AlaThr: 4.785 ± 0.989
3.589AlaVal: 3.589 ± 1.766
0.0AlaTrp: 0.0 ± 0.0
1.196AlaTyr: 1.196 ± 0.892
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
2.392CysCys: 2.392 ± 1.209
2.392CysAsp: 2.392 ± 1.209
0.0CysGlu: 0.0 ± 0.0
1.196CysPhe: 1.196 ± 1.025
0.0CysGly: 0.0 ± 0.0
0.0CysHis: 0.0 ± 0.0
1.196CysIle: 1.196 ± 0.892
1.196CysLys: 1.196 ± 0.892
0.0CysLeu: 0.0 ± 0.0
1.196CysMet: 1.196 ± 0.892
0.0CysAsn: 0.0 ± 0.0
1.196CysPro: 1.196 ± 1.025
0.0CysGln: 0.0 ± 0.0
7.177CysArg: 7.177 ± 3.627
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
1.196CysVal: 1.196 ± 0.892
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
2.392AspAla: 2.392 ± 2.05
3.589AspCys: 3.589 ± 1.766
8.373AspAsp: 8.373 ± 1.175
4.785AspGlu: 4.785 ± 2.559
2.392AspPhe: 2.392 ± 1.209
10.766AspGly: 10.766 ± 3.882
2.392AspHis: 2.392 ± 1.209
8.373AspIle: 8.373 ± 0.849
4.785AspLys: 4.785 ± 0.768
0.0AspLeu: 0.0 ± 0.0
0.0AspMet: 0.0 ± 0.0
2.392AspAsn: 2.392 ± 2.05
2.392AspPro: 2.392 ± 1.785
1.196AspGln: 1.196 ± 1.025
1.196AspArg: 1.196 ± 1.025
3.589AspSer: 3.589 ± 0.411
4.785AspThr: 4.785 ± 0.989
3.589AspVal: 3.589 ± 3.075
3.589AspTrp: 3.589 ± 1.766
7.177AspTyr: 7.177 ± 1.868
0.0AspXaa: 0.0 ± 0.0
Glu
5.981GluAla: 5.981 ± 1.487
0.0GluCys: 0.0 ± 0.0
2.392GluAsp: 2.392 ± 0.782
4.785GluGlu: 4.785 ± 0.989
1.196GluPhe: 1.196 ± 0.892
2.392GluGly: 2.392 ± 2.05
2.392GluHis: 2.392 ± 0.782
3.589GluIle: 3.589 ± 0.411
2.392GluLys: 2.392 ± 1.209
0.0GluLeu: 0.0 ± 0.0
0.0GluMet: 0.0 ± 0.0
4.785GluAsn: 4.785 ± 2.418
2.392GluPro: 2.392 ± 1.209
2.392GluGln: 2.392 ± 1.209
11.962GluArg: 11.962 ± 6.046
4.785GluSer: 4.785 ± 0.989
0.0GluThr: 0.0 ± 0.0
1.196GluVal: 1.196 ± 1.025
2.392GluTrp: 2.392 ± 1.209
4.785GluTyr: 4.785 ± 0.768
0.0GluXaa: 0.0 ± 0.0
Phe
2.392PheAla: 2.392 ± 0.782
0.0PheCys: 0.0 ± 0.0
13.158PheAsp: 13.158 ± 3.257
2.392PheGlu: 2.392 ± 0.782
0.0PhePhe: 0.0 ± 0.0
7.177PheGly: 7.177 ± 0.822
1.196PheHis: 1.196 ± 0.892
2.392PheIle: 2.392 ± 1.209
1.196PheLys: 1.196 ± 1.025
4.785PheLeu: 4.785 ± 2.418
2.392PheMet: 2.392 ± 2.05
2.392PheAsn: 2.392 ± 1.785
2.392PhePro: 2.392 ± 1.209
0.0PheGln: 0.0 ± 0.0
4.785PheArg: 4.785 ± 0.989
3.589PheSer: 3.589 ± 1.59
0.0PheThr: 0.0 ± 0.0
2.392PheVal: 2.392 ± 0.782
1.196PheTrp: 1.196 ± 1.025
0.0PheTyr: 0.0 ± 0.0
0.0PheXaa: 0.0 ± 0.0
Gly
7.177GlyAla: 7.177 ± 1.356
0.0GlyCys: 0.0 ± 0.0
4.785GlyAsp: 4.785 ± 2.418
3.589GlyGlu: 3.589 ± 1.766
4.785GlyPhe: 4.785 ± 0.768
4.785GlyGly: 4.785 ± 0.768
0.0GlyHis: 0.0 ± 0.0
1.196GlyIle: 1.196 ± 1.025
5.981GlyLys: 5.981 ± 1.613
0.0GlyLeu: 0.0 ± 0.0
0.0GlyMet: 0.0 ± 0.0
7.177GlyAsn: 7.177 ± 0.822
1.196GlyPro: 1.196 ± 0.892
2.392GlyGln: 2.392 ± 2.05
7.177GlyArg: 7.177 ± 2.983
2.392GlySer: 2.392 ± 2.05
8.373GlyThr: 8.373 ± 1.114
3.589GlyVal: 3.589 ± 1.766
2.392GlyTrp: 2.392 ± 0.782
1.196GlyTyr: 1.196 ± 1.025
0.0GlyXaa: 0.0 ± 0.0
His
3.589HisAla: 3.589 ± 1.766
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
1.196HisGlu: 1.196 ± 1.025
1.196HisPhe: 1.196 ± 0.892
4.785HisGly: 4.785 ± 2.418
0.0HisHis: 0.0 ± 0.0
0.0HisIle: 0.0 ± 0.0
2.392HisLys: 2.392 ± 1.209
0.0HisLeu: 0.0 ± 0.0
0.0HisMet: 0.0 ± 0.0
1.196HisAsn: 1.196 ± 0.892
1.196HisPro: 1.196 ± 1.025
0.0HisGln: 0.0 ± 0.0
2.392HisArg: 2.392 ± 2.05
1.196HisSer: 1.196 ± 0.892
0.0HisThr: 0.0 ± 0.0
3.589HisVal: 3.589 ± 0.411
0.0HisTrp: 0.0 ± 0.0
2.392HisTyr: 2.392 ± 1.209
0.0HisXaa: 0.0 ± 0.0
Ile
1.196IleAla: 1.196 ± 1.025
1.196IleCys: 1.196 ± 0.892
3.589IleAsp: 3.589 ± 1.59
1.196IleGlu: 1.196 ± 1.025
4.785IlePhe: 4.785 ± 4.1
2.392IleGly: 2.392 ± 1.209
1.196IleHis: 1.196 ± 1.025
4.785IleIle: 4.785 ± 2.418
3.589IleLys: 3.589 ± 0.411
3.589IleLeu: 3.589 ± 1.766
2.392IleMet: 2.392 ± 0.782
3.589IleAsn: 3.589 ± 0.411
0.0IlePro: 0.0 ± 0.0
1.196IleGln: 1.196 ± 0.892
2.392IleArg: 2.392 ± 1.209
4.785IleSer: 4.785 ± 2.418
7.177IleThr: 7.177 ± 1.868
4.785IleVal: 4.785 ± 2.523
0.0IleTrp: 0.0 ± 0.0
1.196IleTyr: 1.196 ± 0.892
0.0IleXaa: 0.0 ± 0.0
Lys
0.0LysAla: 0.0 ± 0.0
0.0LysCys: 0.0 ± 0.0
3.589LysAsp: 3.589 ± 0.411
2.392LysGlu: 2.392 ± 1.209
0.0LysPhe: 0.0 ± 0.0
3.589LysGly: 3.589 ± 1.329
0.0LysHis: 0.0 ± 0.0
2.392LysIle: 2.392 ± 1.209
2.392LysLys: 2.392 ± 0.782
1.196LysLeu: 1.196 ± 1.025
1.196LysMet: 1.196 ± 1.025
0.0LysAsn: 0.0 ± 0.0
3.589LysPro: 3.589 ± 1.766
2.392LysGln: 2.392 ± 0.782
2.392LysArg: 2.392 ± 0.782
3.589LysSer: 3.589 ± 1.766
2.392LysThr: 2.392 ± 0.782
4.785LysVal: 4.785 ± 0.989
2.392LysTrp: 2.392 ± 1.209
3.589LysTyr: 3.589 ± 1.329
0.0LysXaa: 0.0 ± 0.0
Leu
0.0LeuAla: 0.0 ± 0.0
2.392LeuCys: 2.392 ± 1.209
5.981LeuAsp: 5.981 ± 1.972
4.785LeuGlu: 4.785 ± 2.418
1.196LeuPhe: 1.196 ± 1.025
8.373LeuGly: 8.373 ± 2.522
0.0LeuHis: 0.0 ± 0.0
2.392LeuIle: 2.392 ± 0.782
0.0LeuLys: 0.0 ± 0.0
2.392LeuLeu: 2.392 ± 1.209
1.196LeuMet: 1.196 ± 0.892
0.0LeuAsn: 0.0 ± 0.0
0.0LeuPro: 0.0 ± 0.0
1.196LeuGln: 1.196 ± 0.892
0.0LeuArg: 0.0 ± 0.0
4.785LeuSer: 4.785 ± 2.418
1.196LeuThr: 1.196 ± 1.025
1.196LeuVal: 1.196 ± 1.025
1.196LeuTrp: 1.196 ± 1.025
7.177LeuTyr: 7.177 ± 0.97
0.0LeuXaa: 0.0 ± 0.0
Met
1.196MetAla: 1.196 ± 1.025
1.196MetCys: 1.196 ± 0.892
1.196MetAsp: 1.196 ± 0.892
0.0MetGlu: 0.0 ± 0.0
0.0MetPhe: 0.0 ± 0.0
0.0MetGly: 0.0 ± 0.0
1.196MetHis: 1.196 ± 0.892
0.0MetIle: 0.0 ± 0.0
0.0MetLys: 0.0 ± 0.0
0.0MetLeu: 0.0 ± 0.0
0.0MetMet: 0.0 ± 0.0
1.196MetAsn: 1.196 ± 0.892
3.589MetPro: 3.589 ± 0.411
0.0MetGln: 0.0 ± 0.0
1.196MetArg: 1.196 ± 1.025
0.0MetSer: 0.0 ± 0.0
1.196MetThr: 1.196 ± 1.025
1.196MetVal: 1.196 ± 1.025
1.196MetTrp: 1.196 ± 1.025
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
1.196AsnAla: 1.196 ± 1.025
1.196AsnCys: 1.196 ± 0.892
2.392AsnAsp: 2.392 ± 2.05
1.196AsnGlu: 1.196 ± 0.892
2.392AsnPhe: 2.392 ± 1.209
1.196AsnGly: 1.196 ± 1.025
0.0AsnHis: 0.0 ± 0.0
3.589AsnIle: 3.589 ± 0.411
3.589AsnLys: 3.589 ± 0.411
5.981AsnLeu: 5.981 ± 0.403
1.196AsnMet: 1.196 ± 0.892
0.0AsnAsn: 0.0 ± 0.0
3.589AsnPro: 3.589 ± 0.411
5.981AsnGln: 5.981 ± 1.487
2.392AsnArg: 2.392 ± 2.05
2.392AsnSer: 2.392 ± 1.209
0.0AsnThr: 0.0 ± 0.0
3.589AsnVal: 3.589 ± 1.766
0.0AsnTrp: 0.0 ± 0.0
3.589AsnTyr: 3.589 ± 3.075
0.0AsnXaa: 0.0 ± 0.0
Pro
2.392ProAla: 2.392 ± 1.209
0.0ProCys: 0.0 ± 0.0
2.392ProAsp: 2.392 ± 2.05
9.569ProGlu: 9.569 ± 1.816
3.589ProPhe: 3.589 ± 0.411
0.0ProGly: 0.0 ± 0.0
3.589ProHis: 3.589 ± 1.766
4.785ProIle: 4.785 ± 0.768
0.0ProLys: 0.0 ± 0.0
3.589ProLeu: 3.589 ± 0.411
0.0ProMet: 0.0 ± 0.0
2.392ProAsn: 2.392 ± 2.05
4.785ProPro: 4.785 ± 2.418
4.785ProGln: 4.785 ± 2.418
7.177ProArg: 7.177 ± 3.627
2.392ProSer: 2.392 ± 0.782
2.392ProThr: 2.392 ± 0.782
0.0ProVal: 0.0 ± 0.0
0.0ProTrp: 0.0 ± 0.0
0.0ProTyr: 0.0 ± 0.0
0.0ProXaa: 0.0 ± 0.0
Gln
5.981GlnAla: 5.981 ± 1.487
0.0GlnCys: 0.0 ± 0.0
0.0GlnAsp: 0.0 ± 0.0
1.196GlnGlu: 1.196 ± 1.025
3.589GlnPhe: 3.589 ± 1.329
1.196GlnGly: 1.196 ± 0.892
0.0GlnHis: 0.0 ± 0.0
0.0GlnIle: 0.0 ± 0.0
1.196GlnLys: 1.196 ± 0.892
0.0GlnLeu: 0.0 ± 0.0
0.0GlnMet: 0.0 ± 0.0
0.0GlnAsn: 0.0 ± 0.0
2.392GlnPro: 2.392 ± 1.209
0.0GlnGln: 0.0 ± 0.0
4.785GlnArg: 4.785 ± 0.989
1.196GlnSer: 1.196 ± 1.025
1.196GlnThr: 1.196 ± 1.025
3.589GlnVal: 3.589 ± 0.411
0.0GlnTrp: 0.0 ± 0.0
4.785GlnTyr: 4.785 ± 0.989
0.0GlnXaa: 0.0 ± 0.0
Arg
3.589ArgAla: 3.589 ± 0.411
2.392ArgCys: 2.392 ± 1.209
5.981ArgAsp: 5.981 ± 1.487
7.177ArgGlu: 7.177 ± 3.627
4.785ArgPhe: 4.785 ± 2.418
4.785ArgGly: 4.785 ± 4.1
2.392ArgHis: 2.392 ± 1.209
4.785ArgIle: 4.785 ± 0.989
5.981ArgLys: 5.981 ± 3.559
4.785ArgLeu: 4.785 ± 2.418
1.196ArgMet: 1.196 ± 0.954
3.589ArgAsn: 3.589 ± 0.411
3.589ArgPro: 3.589 ± 0.411
1.196ArgGln: 1.196 ± 1.025
19.139ArgArg: 19.139 ± 13.214
3.589ArgSer: 3.589 ± 1.59
9.569ArgThr: 9.569 ± 1.98
7.177ArgVal: 7.177 ± 1.356
1.196ArgTrp: 1.196 ± 1.025
3.589ArgTyr: 3.589 ± 0.411
0.0ArgXaa: 0.0 ± 0.0
Ser
7.177SerAla: 7.177 ± 0.822
2.392SerCys: 2.392 ± 1.209
3.589SerAsp: 3.589 ± 1.766
3.589SerGlu: 3.589 ± 0.411
3.589SerPhe: 3.589 ± 0.411
2.392SerGly: 2.392 ± 2.05
1.196SerHis: 1.196 ± 1.025
3.589SerIle: 3.589 ± 1.766
0.0SerLys: 0.0 ± 0.0
4.785SerLeu: 4.785 ± 1.565
1.196SerMet: 1.196 ± 0.748
7.177SerAsn: 7.177 ± 0.822
0.0SerPro: 0.0 ± 0.0
0.0SerGln: 0.0 ± 0.0
7.177SerArg: 7.177 ± 2.983
3.589SerSer: 3.589 ± 1.766
4.785SerThr: 4.785 ± 4.1
2.392SerVal: 2.392 ± 1.209
0.0SerTrp: 0.0 ± 0.0
3.589SerTyr: 3.589 ± 1.59
0.0SerXaa: 0.0 ± 0.0
Thr
3.589ThrAla: 3.589 ± 0.411
0.0ThrCys: 0.0 ± 0.0
4.785ThrAsp: 4.785 ± 0.768
0.0ThrGlu: 0.0 ± 0.0
3.589ThrPhe: 3.589 ± 0.411
5.981ThrGly: 5.981 ± 3.559
0.0ThrHis: 0.0 ± 0.0
3.589ThrIle: 3.589 ± 1.59
2.392ThrLys: 2.392 ± 1.209
2.392ThrLeu: 2.392 ± 0.782
0.0ThrMet: 0.0 ± 0.0
1.196ThrAsn: 1.196 ± 1.025
8.373ThrPro: 8.373 ± 1.114
0.0ThrGln: 0.0 ± 0.0
2.392ThrArg: 2.392 ± 0.782
7.177ThrSer: 7.177 ± 2.983
1.196ThrThr: 1.196 ± 1.025
3.589ThrVal: 3.589 ± 0.411
1.196ThrTrp: 1.196 ± 1.025
2.392ThrTyr: 2.392 ± 2.05
0.0ThrXaa: 0.0 ± 0.0
Val
3.589ValAla: 3.589 ± 0.411
1.196ValCys: 1.196 ± 1.025
1.196ValAsp: 1.196 ± 0.892
2.392ValGlu: 2.392 ± 1.209
5.981ValPhe: 5.981 ± 0.403
4.785ValGly: 4.785 ± 0.989
2.392ValHis: 2.392 ± 1.209
4.785ValIle: 4.785 ± 2.124
2.392ValLys: 2.392 ± 0.782
2.392ValLeu: 2.392 ± 2.05
0.0ValMet: 0.0 ± 0.0
2.392ValAsn: 2.392 ± 0.782
0.0ValPro: 0.0 ± 0.0
3.589ValGln: 3.589 ± 0.411
7.177ValArg: 7.177 ± 0.822
4.785ValSer: 4.785 ± 0.768
2.392ValThr: 2.392 ± 1.209
1.196ValVal: 1.196 ± 1.025
0.0ValTrp: 0.0 ± 0.0
3.589ValTyr: 3.589 ± 0.411
0.0ValXaa: 0.0 ± 0.0
Trp
2.392TrpAla: 2.392 ± 1.209
1.196TrpCys: 1.196 ± 1.025
1.196TrpAsp: 1.196 ± 1.025
2.392TrpGlu: 2.392 ± 1.209
0.0TrpPhe: 0.0 ± 0.0
1.196TrpGly: 1.196 ± 0.892
2.392TrpHis: 2.392 ± 2.05
0.0TrpIle: 0.0 ± 0.0
0.0TrpLys: 0.0 ± 0.0
4.785TrpLeu: 4.785 ± 2.523
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
1.196TrpArg: 1.196 ± 1.025
2.392TrpSer: 2.392 ± 2.05
0.0TrpThr: 0.0 ± 0.0
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
5.981TyrAla: 5.981 ± 1.613
0.0TyrCys: 0.0 ± 0.0
4.785TyrAsp: 4.785 ± 2.559
2.392TyrGlu: 2.392 ± 1.209
5.981TyrPhe: 5.981 ± 1.613
1.196TyrGly: 1.196 ± 0.892
2.392TyrHis: 2.392 ± 1.209
1.196TyrIle: 1.196 ± 1.025
1.196TyrLys: 1.196 ± 0.892
3.589TyrLeu: 3.589 ± 0.411
1.196TyrMet: 1.196 ± 1.025
1.196TyrAsn: 1.196 ± 1.025
5.981TyrPro: 5.981 ± 1.487
1.196TyrGln: 1.196 ± 1.025
2.392TyrArg: 2.392 ± 0.782
1.196TyrSer: 1.196 ± 1.025
2.392TyrThr: 2.392 ± 2.05
3.589TyrVal: 3.589 ± 0.411
2.392TyrTrp: 2.392 ± 0.782
3.589TyrTyr: 3.589 ± 0.411
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (837 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski