Amino acid dipepetide frequency for Murid herpesvirus 1 (MuHV-1) (Mouse cytomegalovirus)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.132AlaAla: 12.132 ± 0.791
1.505AlaCys: 1.505 ± 0.149
4.287AlaAsp: 4.287 ± 0.241
3.664AlaGlu: 3.664 ± 0.272
2.752AlaPhe: 2.752 ± 0.18
4.88AlaGly: 4.88 ± 0.367
1.581AlaHis: 1.581 ± 0.183
3.512AlaIle: 3.512 ± 0.248
2.341AlaLys: 2.341 ± 0.193
6.719AlaLeu: 6.719 ± 0.329
1.748AlaMet: 1.748 ± 0.151
2.296AlaAsn: 2.296 ± 0.222
3.968AlaPro: 3.968 ± 0.283
1.824AlaGln: 1.824 ± 0.177
5.549AlaArg: 5.549 ± 0.336
6.689AlaSer: 6.689 ± 0.354
5.975AlaThr: 5.975 ± 0.366
6.613AlaVal: 6.613 ± 0.429
0.76AlaTrp: 0.76 ± 0.125
1.611AlaTyr: 1.611 ± 0.151
0.0AlaXaa: 0.0 ± 0.0
Cys
1.551CysAla: 1.551 ± 0.17
0.562CysCys: 0.562 ± 0.119
1.52CysAsp: 1.52 ± 0.147
1.171CysGlu: 1.171 ± 0.142
0.836CysPhe: 0.836 ± 0.107
1.505CysGly: 1.505 ± 0.166
0.441CysHis: 0.441 ± 0.078
0.973CysIle: 0.973 ± 0.16
0.639CysLys: 0.639 ± 0.099
2.189CysLeu: 2.189 ± 0.204
0.486CysMet: 0.486 ± 0.09
0.745CysAsn: 0.745 ± 0.111
0.927CysPro: 0.927 ± 0.127
0.73CysGln: 0.73 ± 0.133
2.159CysArg: 2.159 ± 0.186
1.383CysSer: 1.383 ± 0.163
1.231CysThr: 1.231 ± 0.132
2.204CysVal: 2.204 ± 0.219
0.182CysTrp: 0.182 ± 0.061
0.684CysTyr: 0.684 ± 0.095
0.0CysXaa: 0.0 ± 0.0
Asp
4.91AspAla: 4.91 ± 0.363
0.684AspCys: 0.684 ± 0.082
5.716AspAsp: 5.716 ± 0.599
4.865AspGlu: 4.865 ± 0.391
2.022AspPhe: 2.022 ± 0.187
4.667AspGly: 4.667 ± 0.367
1.11AspHis: 1.11 ± 0.122
2.508AspIle: 2.508 ± 0.184
1.444AspLys: 1.444 ± 0.139
5.002AspLeu: 5.002 ± 0.338
1.383AspMet: 1.383 ± 0.154
1.976AspAsn: 1.976 ± 0.166
3.709AspPro: 3.709 ± 0.242
1.459AspGln: 1.459 ± 0.151
4.241AspArg: 4.241 ± 0.241
4.226AspSer: 4.226 ± 0.321
3.269AspThr: 3.269 ± 0.207
4.089AspVal: 4.089 ± 0.334
0.395AspTrp: 0.395 ± 0.071
1.383AspTyr: 1.383 ± 0.168
0.0AspXaa: 0.0 ± 0.0
Glu
3.375GluAla: 3.375 ± 0.283
1.216GluCys: 1.216 ± 0.138
4.074GluAsp: 4.074 ± 0.379
4.409GluGlu: 4.409 ± 0.444
1.839GluPhe: 1.839 ± 0.159
2.873GluGly: 2.873 ± 0.203
1.095GluHis: 1.095 ± 0.136
2.615GluIle: 2.615 ± 0.19
2.174GluLys: 2.174 ± 0.182
4.515GluLeu: 4.515 ± 0.31
1.307GluMet: 1.307 ± 0.161
2.113GluAsn: 2.113 ± 0.189
2.949GluPro: 2.949 ± 0.36
1.429GluGln: 1.429 ± 0.14
4.606GluArg: 4.606 ± 0.311
4.165GluSer: 4.165 ± 0.248
3.816GluThr: 3.816 ± 0.27
2.706GluVal: 2.706 ± 0.208
0.502GluTrp: 0.502 ± 0.081
1.627GluTyr: 1.627 ± 0.204
0.0GluXaa: 0.0 ± 0.0
Phe
2.812PheAla: 2.812 ± 0.21
1.049PheCys: 1.049 ± 0.116
2.22PheAsp: 2.22 ± 0.186
1.794PheGlu: 1.794 ± 0.188
2.007PhePhe: 2.007 ± 0.19
2.448PheGly: 2.448 ± 0.211
0.897PheHis: 0.897 ± 0.132
1.475PheIle: 1.475 ± 0.212
1.307PheLys: 1.307 ± 0.138
3.861PheLeu: 3.861 ± 0.266
0.836PheMet: 0.836 ± 0.12
1.186PheAsn: 1.186 ± 0.141
1.672PhePro: 1.672 ± 0.166
0.821PheGln: 0.821 ± 0.121
2.691PheArg: 2.691 ± 0.212
3.345PheSer: 3.345 ± 0.277
2.083PheThr: 2.083 ± 0.21
3.375PheVal: 3.375 ± 0.211
0.502PheTrp: 0.502 ± 0.075
1.627PheTyr: 1.627 ± 0.235
0.0PheXaa: 0.0 ± 0.0
Gly
5.214GlyAla: 5.214 ± 0.358
1.338GlyCys: 1.338 ± 0.161
3.907GlyAsp: 3.907 ± 0.315
3.512GlyGlu: 3.512 ± 0.224
2.448GlyPhe: 2.448 ± 0.232
8.194GlyGly: 8.194 ± 0.74
1.399GlyHis: 1.399 ± 0.16
2.402GlyIle: 2.402 ± 0.21
1.9GlyLys: 1.9 ± 0.174
4.758GlyLeu: 4.758 ± 0.313
1.231GlyMet: 1.231 ± 0.164
1.961GlyAsn: 1.961 ± 0.209
3.056GlyPro: 3.056 ± 0.243
1.657GlyGln: 1.657 ± 0.163
5.442GlyArg: 5.442 ± 0.332
5.838GlySer: 5.838 ± 0.58
4.515GlyThr: 4.515 ± 0.336
4.789GlyVal: 4.789 ± 0.331
0.867GlyTrp: 0.867 ± 0.135
2.022GlyTyr: 2.022 ± 0.19
0.0GlyXaa: 0.0 ± 0.0
His
1.581HisAla: 1.581 ± 0.167
0.334HisCys: 0.334 ± 0.073
1.323HisAsp: 1.323 ± 0.167
1.019HisGlu: 1.019 ± 0.121
0.699HisPhe: 0.699 ± 0.087
1.414HisGly: 1.414 ± 0.145
1.277HisHis: 1.277 ± 0.353
0.927HisIle: 0.927 ± 0.116
0.791HisLys: 0.791 ± 0.138
2.068HisLeu: 2.068 ± 0.179
0.395HisMet: 0.395 ± 0.078
0.76HisAsn: 0.76 ± 0.112
1.566HisPro: 1.566 ± 0.185
0.791HisGln: 0.791 ± 0.137
1.885HisArg: 1.885 ± 0.231
1.307HisSer: 1.307 ± 0.155
1.414HisThr: 1.414 ± 0.171
1.642HisVal: 1.642 ± 0.149
0.137HisTrp: 0.137 ± 0.044
0.699HisTyr: 0.699 ± 0.085
0.0HisXaa: 0.0 ± 0.0
Ile
3.162IleAla: 3.162 ± 0.24
1.11IleCys: 1.11 ± 0.15
2.22IleAsp: 2.22 ± 0.162
2.113IleGlu: 2.113 ± 0.186
1.946IlePhe: 1.946 ± 0.205
2.645IleGly: 2.645 ± 0.223
0.973IleHis: 0.973 ± 0.126
1.87IleIle: 1.87 ± 0.219
1.459IleLys: 1.459 ± 0.178
3.922IleLeu: 3.922 ± 0.203
1.11IleMet: 1.11 ± 0.123
2.007IleAsn: 2.007 ± 0.196
2.6IlePro: 2.6 ± 0.283
1.231IleGln: 1.231 ± 0.142
3.238IleArg: 3.238 ± 0.251
3.588IleSer: 3.588 ± 0.226
3.01IleThr: 3.01 ± 0.256
3.557IleVal: 3.557 ± 0.238
0.365IleTrp: 0.365 ± 0.079
1.885IleTyr: 1.885 ± 0.227
0.0IleXaa: 0.0 ± 0.0
Lys
1.961LysAla: 1.961 ± 0.186
0.715LysCys: 0.715 ± 0.108
1.733LysAsp: 1.733 ± 0.149
1.718LysGlu: 1.718 ± 0.171
1.064LysPhe: 1.064 ± 0.129
1.459LysGly: 1.459 ± 0.146
1.019LysHis: 1.019 ± 0.114
2.372LysIle: 2.372 ± 0.22
2.478LysLys: 2.478 ± 0.263
2.949LysLeu: 2.949 ± 0.214
1.064LysMet: 1.064 ± 0.125
1.596LysAsn: 1.596 ± 0.18
1.505LysPro: 1.505 ± 0.175
1.064LysGln: 1.064 ± 0.141
3.238LysArg: 3.238 ± 0.241
2.721LysSer: 2.721 ± 0.202
2.539LysThr: 2.539 ± 0.172
2.083LysVal: 2.083 ± 0.198
0.334LysTrp: 0.334 ± 0.066
1.034LysTyr: 1.034 ± 0.131
0.0LysXaa: 0.0 ± 0.0
Leu
6.491LeuAla: 6.491 ± 0.38
2.873LeuCys: 2.873 ± 0.233
4.5LeuAsp: 4.5 ± 0.32
4.044LeuGlu: 4.044 ± 0.341
3.588LeuPhe: 3.588 ± 0.278
4.834LeuGly: 4.834 ± 0.348
2.022LeuHis: 2.022 ± 0.178
3.785LeuIle: 3.785 ± 0.26
3.116LeuLys: 3.116 ± 0.294
8.179LeuLeu: 8.179 ± 0.426
1.748LeuMet: 1.748 ± 0.16
2.417LeuAsn: 2.417 ± 0.234
5.123LeuPro: 5.123 ± 0.348
2.478LeuGln: 2.478 ± 0.203
6.871LeuArg: 6.871 ± 0.447
7.449LeuSer: 7.449 ± 0.3
5.792LeuThr: 5.792 ± 0.356
5.975LeuVal: 5.975 ± 0.344
0.836LeuTrp: 0.836 ± 0.139
2.615LeuTyr: 2.615 ± 0.219
0.0LeuXaa: 0.0 ± 0.0
Met
1.718MetAla: 1.718 ± 0.167
0.441MetCys: 0.441 ± 0.088
1.201MetAsp: 1.201 ± 0.164
1.155MetGlu: 1.155 ± 0.14
0.973MetPhe: 0.973 ± 0.122
0.943MetGly: 0.943 ± 0.13
0.35MetHis: 0.35 ± 0.066
1.277MetIle: 1.277 ± 0.152
0.836MetLys: 0.836 ± 0.116
2.204MetLeu: 2.204 ± 0.195
0.699MetMet: 0.699 ± 0.121
0.927MetAsn: 0.927 ± 0.125
0.973MetPro: 0.973 ± 0.126
0.547MetGln: 0.547 ± 0.085
1.611MetArg: 1.611 ± 0.16
2.083MetSer: 2.083 ± 0.171
1.551MetThr: 1.551 ± 0.146
1.277MetVal: 1.277 ± 0.137
0.304MetTrp: 0.304 ± 0.085
0.806MetTyr: 0.806 ± 0.125
0.0MetXaa: 0.0 ± 0.0
Asn
2.949AsnAla: 2.949 ± 0.254
0.578AsnCys: 0.578 ± 0.099
1.748AsnAsp: 1.748 ± 0.194
1.733AsnGlu: 1.733 ± 0.173
1.019AsnPhe: 1.019 ± 0.12
2.463AsnGly: 2.463 ± 0.221
0.578AsnHis: 0.578 ± 0.094
1.581AsnIle: 1.581 ± 0.134
1.338AsnLys: 1.338 ± 0.154
2.843AsnLeu: 2.843 ± 0.18
0.836AsnMet: 0.836 ± 0.112
1.809AsnAsn: 1.809 ± 0.2
1.581AsnPro: 1.581 ± 0.136
0.836AsnGln: 0.836 ± 0.109
2.448AsnArg: 2.448 ± 0.191
2.524AsnSer: 2.524 ± 0.226
2.752AsnThr: 2.752 ± 0.24
2.721AsnVal: 2.721 ± 0.212
0.365AsnTrp: 0.365 ± 0.077
0.867AsnTyr: 0.867 ± 0.118
0.0AsnXaa: 0.0 ± 0.0
Pro
4.804ProAla: 4.804 ± 0.351
1.003ProCys: 1.003 ± 0.135
3.223ProAsp: 3.223 ± 0.261
3.375ProGlu: 3.375 ± 0.319
2.052ProPhe: 2.052 ± 0.186
3.512ProGly: 3.512 ± 0.273
1.201ProHis: 1.201 ± 0.17
2.204ProIle: 2.204 ± 0.23
1.916ProLys: 1.916 ± 0.178
4.713ProLeu: 4.713 ± 0.264
0.958ProMet: 0.958 ± 0.156
1.414ProAsn: 1.414 ± 0.162
6.643ProPro: 6.643 ± 0.653
1.946ProGln: 1.946 ± 0.192
4.591ProArg: 4.591 ± 0.353
5.23ProSer: 5.23 ± 0.422
3.725ProThr: 3.725 ± 0.423
4.241ProVal: 4.241 ± 0.314
0.517ProTrp: 0.517 ± 0.088
1.429ProTyr: 1.429 ± 0.177
0.0ProXaa: 0.0 ± 0.0
Gln
1.703GlnAla: 1.703 ± 0.208
0.562GlnCys: 0.562 ± 0.101
1.338GlnAsp: 1.338 ± 0.148
1.535GlnGlu: 1.535 ± 0.19
1.003GlnPhe: 1.003 ± 0.12
1.262GlnGly: 1.262 ± 0.135
0.791GlnHis: 0.791 ± 0.111
1.353GlnIle: 1.353 ± 0.125
1.323GlnLys: 1.323 ± 0.13
2.554GlnLeu: 2.554 ± 0.281
0.669GlnMet: 0.669 ± 0.104
1.14GlnAsn: 1.14 ± 0.133
1.672GlnPro: 1.672 ± 0.189
2.539GlnGln: 2.539 ± 0.516
2.752GlnArg: 2.752 ± 0.197
2.25GlnSer: 2.25 ± 0.178
2.144GlnThr: 2.144 ± 0.212
1.672GlnVal: 1.672 ± 0.141
0.213GlnTrp: 0.213 ± 0.056
0.715GlnTyr: 0.715 ± 0.109
0.0GlnXaa: 0.0 ± 0.0
Arg
5.397ArgAla: 5.397 ± 0.299
2.022ArgCys: 2.022 ± 0.199
5.062ArgAsp: 5.062 ± 0.292
3.983ArgGlu: 3.983 ± 0.256
2.949ArgPhe: 2.949 ± 0.231
5.473ArgGly: 5.473 ± 0.384
2.174ArgHis: 2.174 ± 0.193
3.056ArgIle: 3.056 ± 0.209
2.797ArgLys: 2.797 ± 0.226
6.887ArgLeu: 6.887 ± 0.386
1.87ArgMet: 1.87 ± 0.203
2.539ArgAsn: 2.539 ± 0.229
4.971ArgPro: 4.971 ± 0.402
2.584ArgGln: 2.584 ± 0.218
9.486ArgArg: 9.486 ± 0.604
6.567ArgSer: 6.567 ± 0.39
4.211ArgThr: 4.211 ± 0.269
5.427ArgVal: 5.427 ± 0.325
1.11ArgTrp: 1.11 ± 0.151
2.508ArgTyr: 2.508 ± 0.209
0.0ArgXaa: 0.0 ± 0.0
Ser
6.096SerAla: 6.096 ± 0.368
1.946SerCys: 1.946 ± 0.166
5.366SerAsp: 5.366 ± 0.455
4.698SerGlu: 4.698 ± 0.307
2.904SerPhe: 2.904 ± 0.245
6.339SerGly: 6.339 ± 0.504
1.596SerHis: 1.596 ± 0.158
3.451SerIle: 3.451 ± 0.247
2.463SerLys: 2.463 ± 0.219
6.142SerLeu: 6.142 ± 0.374
1.657SerMet: 1.657 ± 0.176
2.508SerAsn: 2.508 ± 0.188
5.078SerPro: 5.078 ± 0.375
2.235SerGln: 2.235 ± 0.213
6.841SerArg: 6.841 ± 0.421
11.295SerSer: 11.295 ± 1.214
5.99SerThr: 5.99 ± 0.451
6.4SerVal: 6.4 ± 0.463
0.867SerTrp: 0.867 ± 0.123
2.326SerTyr: 2.326 ± 0.178
0.0SerXaa: 0.0 ± 0.0
Thr
6.096ThrAla: 6.096 ± 0.359
1.14ThrCys: 1.14 ± 0.136
3.436ThrAsp: 3.436 ± 0.241
3.36ThrGlu: 3.36 ± 0.246
2.721ThrPhe: 2.721 ± 0.178
4.226ThrGly: 4.226 ± 0.334
1.186ThrHis: 1.186 ± 0.14
3.542ThrIle: 3.542 ± 0.304
2.372ThrLys: 2.372 ± 0.218
5.123ThrLeu: 5.123 ± 0.306
1.551ThrMet: 1.551 ± 0.156
2.159ThrAsn: 2.159 ± 0.199
4.409ThrPro: 4.409 ± 0.357
1.794ThrGln: 1.794 ± 0.176
4.089ThrArg: 4.089 ± 0.305
5.64ThrSer: 5.64 ± 0.408
6.917ThrThr: 6.917 ± 0.855
6.415ThrVal: 6.415 ± 0.347
0.897ThrTrp: 0.897 ± 0.132
1.824ThrTyr: 1.824 ± 0.185
0.0ThrXaa: 0.0 ± 0.0
Val
5.777ValAla: 5.777 ± 0.345
2.037ValCys: 2.037 ± 0.177
4.059ValAsp: 4.059 ± 0.227
3.253ValGlu: 3.253 ± 0.224
3.466ValPhe: 3.466 ± 0.271
4.956ValGly: 4.956 ± 0.33
1.399ValHis: 1.399 ± 0.142
3.329ValIle: 3.329 ± 0.251
2.387ValLys: 2.387 ± 0.215
6.507ValLeu: 6.507 ± 0.403
1.475ValMet: 1.475 ± 0.135
2.478ValAsn: 2.478 ± 0.241
4.485ValPro: 4.485 ± 0.374
2.068ValGln: 2.068 ± 0.181
5.351ValArg: 5.351 ± 0.324
6.917ValSer: 6.917 ± 0.341
5.093ValThr: 5.093 ± 0.353
6.476ValVal: 6.476 ± 0.373
0.912ValTrp: 0.912 ± 0.122
2.645ValTyr: 2.645 ± 0.228
0.0ValXaa: 0.0 ± 0.0
Trp
0.547TrpAla: 0.547 ± 0.101
0.319TrpCys: 0.319 ± 0.073
0.334TrpAsp: 0.334 ± 0.06
0.456TrpGlu: 0.456 ± 0.11
0.502TrpPhe: 0.502 ± 0.08
0.517TrpGly: 0.517 ± 0.07
0.243TrpHis: 0.243 ± 0.049
0.608TrpIle: 0.608 ± 0.097
0.486TrpLys: 0.486 ± 0.088
0.943TrpLeu: 0.943 ± 0.113
0.289TrpMet: 0.289 ± 0.091
0.334TrpAsn: 0.334 ± 0.077
0.593TrpPro: 0.593 ± 0.098
0.38TrpGln: 0.38 ± 0.102
1.049TrpArg: 1.049 ± 0.128
0.806TrpSer: 0.806 ± 0.096
0.897TrpThr: 0.897 ± 0.117
0.608TrpVal: 0.608 ± 0.109
0.319TrpTrp: 0.319 ± 0.079
0.471TrpTyr: 0.471 ± 0.087
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.128TyrAla: 2.128 ± 0.205
0.684TyrCys: 0.684 ± 0.111
1.794TyrAsp: 1.794 ± 0.139
1.551TyrGlu: 1.551 ± 0.155
1.216TyrPhe: 1.216 ± 0.114
1.839TyrGly: 1.839 ± 0.182
0.699TyrHis: 0.699 ± 0.115
1.171TyrIle: 1.171 ± 0.124
1.079TyrLys: 1.079 ± 0.13
2.676TyrLeu: 2.676 ± 0.211
0.547TyrMet: 0.547 ± 0.095
1.201TyrAsn: 1.201 ± 0.173
1.216TyrPro: 1.216 ± 0.133
0.775TyrGln: 0.775 ± 0.112
2.934TyrArg: 2.934 ± 0.239
2.174TyrSer: 2.174 ± 0.218
1.976TyrThr: 1.976 ± 0.215
2.797TyrVal: 2.797 ± 0.215
0.319TyrTrp: 0.319 ± 0.065
1.079TyrTyr: 1.079 ± 0.135
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 164 proteins (65780 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski