Amino acid dipepetide frequency for Bifidobacterium goeldii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.94AlaAla: 14.94 ± 0.224
1.101AlaCys: 1.101 ± 0.038
7.917AlaAsp: 7.917 ± 0.133
5.828AlaGlu: 5.828 ± 0.117
3.566AlaPhe: 3.566 ± 0.072
9.098AlaGly: 9.098 ± 0.131
2.488AlaHis: 2.488 ± 0.064
5.935AlaIle: 5.935 ± 0.093
4.855AlaLys: 4.855 ± 0.091
10.339AlaLeu: 10.339 ± 0.143
3.254AlaMet: 3.254 ± 0.073
3.929AlaAsn: 3.929 ± 0.089
4.181AlaPro: 4.181 ± 0.092
4.905AlaGln: 4.905 ± 0.105
6.082AlaArg: 6.082 ± 0.107
6.737AlaSer: 6.737 ± 0.115
6.329AlaThr: 6.329 ± 0.103
8.408AlaVal: 8.408 ± 0.109
1.546AlaTrp: 1.546 ± 0.052
2.818AlaTyr: 2.818 ± 0.065
0.0AlaXaa: 0.0 ± 0.0
Cys
1.131CysAla: 1.131 ± 0.041
0.125CysCys: 0.125 ± 0.011
0.564CysAsp: 0.564 ± 0.027
0.499CysGlu: 0.499 ± 0.032
0.322CysPhe: 0.322 ± 0.02
0.979CysGly: 0.979 ± 0.042
0.208CysHis: 0.208 ± 0.016
0.452CysIle: 0.452 ± 0.025
0.236CysLys: 0.236 ± 0.02
0.75CysLeu: 0.75 ± 0.03
0.243CysMet: 0.243 ± 0.017
0.275CysAsn: 0.275 ± 0.017
0.435CysPro: 0.435 ± 0.024
0.239CysGln: 0.239 ± 0.021
0.515CysArg: 0.515 ± 0.031
0.524CysSer: 0.524 ± 0.027
0.532CysThr: 0.532 ± 0.025
0.764CysVal: 0.764 ± 0.035
0.112CysTrp: 0.112 ± 0.012
0.244CysTyr: 0.244 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
7.592AspAla: 7.592 ± 0.132
0.573AspCys: 0.573 ± 0.03
5.002AspAsp: 5.002 ± 0.101
4.515AspGlu: 4.515 ± 0.099
2.265AspPhe: 2.265 ± 0.055
5.622AspGly: 5.622 ± 0.113
1.416AspHis: 1.416 ± 0.039
3.289AspIle: 3.289 ± 0.076
2.429AspLys: 2.429 ± 0.07
5.257AspLeu: 5.257 ± 0.09
1.68AspMet: 1.68 ± 0.049
2.116AspAsn: 2.116 ± 0.052
3.403AspPro: 3.403 ± 0.068
1.997AspGln: 1.997 ± 0.055
3.283AspArg: 3.283 ± 0.087
3.734AspSer: 3.734 ± 0.091
3.859AspThr: 3.859 ± 0.084
4.994AspVal: 4.994 ± 0.083
1.022AspTrp: 1.022 ± 0.037
2.012AspTyr: 2.012 ± 0.062
0.0AspXaa: 0.0 ± 0.0
Glu
5.778GluAla: 5.778 ± 0.104
0.43GluCys: 0.43 ± 0.023
2.948GluAsp: 2.948 ± 0.067
2.984GluGlu: 2.984 ± 0.087
1.747GluPhe: 1.747 ± 0.047
3.608GluGly: 3.608 ± 0.076
1.79GluHis: 1.79 ± 0.058
2.705GluIle: 2.705 ± 0.062
1.843GluLys: 1.843 ± 0.067
5.102GluLeu: 5.102 ± 0.091
1.303GluMet: 1.303 ± 0.043
1.823GluAsn: 1.823 ± 0.045
2.511GluPro: 2.511 ± 0.059
2.687GluGln: 2.687 ± 0.067
3.985GluArg: 3.985 ± 0.095
3.213GluSer: 3.213 ± 0.073
3.219GluThr: 3.219 ± 0.075
3.269GluVal: 3.269 ± 0.086
0.642GluTrp: 0.642 ± 0.028
1.853GluTyr: 1.853 ± 0.057
0.0GluXaa: 0.0 ± 0.0
Phe
4.189PheAla: 4.189 ± 0.083
0.373PheCys: 0.373 ± 0.024
2.735PheAsp: 2.735 ± 0.062
1.763PheGlu: 1.763 ± 0.052
1.189PhePhe: 1.189 ± 0.046
3.191PheGly: 3.191 ± 0.07
0.725PheHis: 0.725 ± 0.034
1.76PheIle: 1.76 ± 0.061
1.047PheLys: 1.047 ± 0.037
2.628PheLeu: 2.628 ± 0.069
0.775PheMet: 0.775 ± 0.031
1.274PheAsn: 1.274 ± 0.045
1.354PhePro: 1.354 ± 0.043
0.914PheGln: 0.914 ± 0.042
1.578PheArg: 1.578 ± 0.049
2.184PheSer: 2.184 ± 0.056
2.378PheThr: 2.378 ± 0.062
2.676PheVal: 2.676 ± 0.069
0.483PheTrp: 0.483 ± 0.025
0.984PheTyr: 0.984 ± 0.042
0.0PheXaa: 0.0 ± 0.0
Gly
7.461GlyAla: 7.461 ± 0.105
0.719GlyCys: 0.719 ± 0.03
4.701GlyAsp: 4.701 ± 0.079
4.381GlyGlu: 4.381 ± 0.088
3.191GlyPhe: 3.191 ± 0.071
5.904GlyGly: 5.904 ± 0.12
1.667GlyHis: 1.667 ± 0.054
4.507GlyIle: 4.507 ± 0.09
3.751GlyLys: 3.751 ± 0.077
6.754GlyLeu: 6.754 ± 0.099
2.153GlyMet: 2.153 ± 0.061
2.816GlyAsn: 2.816 ± 0.064
2.371GlyPro: 2.371 ± 0.055
2.539GlyGln: 2.539 ± 0.064
4.207GlyArg: 4.207 ± 0.08
5.237GlySer: 5.237 ± 0.116
5.19GlyThr: 5.19 ± 0.092
6.367GlyVal: 6.367 ± 0.082
1.315GlyTrp: 1.315 ± 0.048
2.676GlyTyr: 2.676 ± 0.067
0.0GlyXaa: 0.0 ± 0.0
His
2.448HisAla: 2.448 ± 0.06
0.246HisCys: 0.246 ± 0.022
1.706HisAsp: 1.706 ± 0.051
1.244HisGlu: 1.244 ± 0.043
0.637HisPhe: 0.637 ± 0.031
1.951HisGly: 1.951 ± 0.061
0.629HisHis: 0.629 ± 0.029
1.223HisIle: 1.223 ± 0.043
0.598HisLys: 0.598 ± 0.025
1.625HisLeu: 1.625 ± 0.049
0.621HisMet: 0.621 ± 0.03
0.736HisAsn: 0.736 ± 0.033
1.25HisPro: 1.25 ± 0.042
0.624HisGln: 0.624 ± 0.026
1.35HisArg: 1.35 ± 0.04
1.149HisSer: 1.149 ± 0.04
1.366HisThr: 1.366 ± 0.048
1.83HisVal: 1.83 ± 0.056
0.359HisTrp: 0.359 ± 0.023
0.686HisTyr: 0.686 ± 0.032
0.0HisXaa: 0.0 ± 0.0
Ile
7.337IleAla: 7.337 ± 0.104
0.585IleCys: 0.585 ± 0.028
4.185IleAsp: 4.185 ± 0.084
3.154IleGlu: 3.154 ± 0.068
1.508IlePhe: 1.508 ± 0.048
4.743IleGly: 4.743 ± 0.094
1.019IleHis: 1.019 ± 0.037
3.196IleIle: 3.196 ± 0.084
1.687IleLys: 1.687 ± 0.052
3.837IleLeu: 3.837 ± 0.091
1.26IleMet: 1.26 ± 0.045
1.966IleAsn: 1.966 ± 0.053
2.665IlePro: 2.665 ± 0.059
1.328IleGln: 1.328 ± 0.042
2.906IleArg: 2.906 ± 0.069
3.087IleSer: 3.087 ± 0.064
3.702IleThr: 3.702 ± 0.075
4.945IleVal: 4.945 ± 0.079
0.587IleTrp: 0.587 ± 0.027
1.195IleTyr: 1.195 ± 0.04
0.0IleXaa: 0.0 ± 0.0
Lys
4.722LysAla: 4.722 ± 0.097
0.159LysCys: 0.159 ± 0.014
2.314LysAsp: 2.314 ± 0.071
1.928LysGlu: 1.928 ± 0.059
0.977LysPhe: 0.977 ± 0.037
2.54LysGly: 2.54 ± 0.065
0.896LysHis: 0.896 ± 0.033
1.914LysIle: 1.914 ± 0.06
1.773LysLys: 1.773 ± 0.065
3.208LysLeu: 3.208 ± 0.076
0.851LysMet: 0.851 ± 0.038
1.457LysAsn: 1.457 ± 0.048
2.238LysPro: 2.238 ± 0.058
1.511LysGln: 1.511 ± 0.047
2.333LysArg: 2.333 ± 0.057
2.224LysSer: 2.224 ± 0.062
2.702LysThr: 2.702 ± 0.07
2.628LysVal: 2.628 ± 0.081
0.436LysTrp: 0.436 ± 0.027
1.057LysTyr: 1.057 ± 0.038
0.0LysXaa: 0.0 ± 0.0
Leu
10.284LeuAla: 10.284 ± 0.115
0.944LeuCys: 0.944 ± 0.035
5.878LeuAsp: 5.878 ± 0.09
4.278LeuGlu: 4.278 ± 0.089
3.129LeuPhe: 3.129 ± 0.074
6.72LeuGly: 6.72 ± 0.091
1.911LeuHis: 1.911 ± 0.048
5.053LeuIle: 5.053 ± 0.105
3.423LeuLys: 3.423 ± 0.063
7.675LeuLeu: 7.675 ± 0.136
2.149LeuMet: 2.149 ± 0.063
3.133LeuAsn: 3.133 ± 0.067
4.396LeuPro: 4.396 ± 0.078
2.367LeuGln: 2.367 ± 0.048
4.978LeuArg: 4.978 ± 0.088
5.375LeuSer: 5.375 ± 0.096
5.827LeuThr: 5.827 ± 0.107
5.971LeuVal: 5.971 ± 0.107
1.044LeuTrp: 1.044 ± 0.042
2.104LeuTyr: 2.104 ± 0.057
0.0LeuXaa: 0.0 ± 0.0
Met
2.705MetAla: 2.705 ± 0.066
0.244MetCys: 0.244 ± 0.019
1.279MetAsp: 1.279 ± 0.047
0.992MetGlu: 0.992 ± 0.032
0.904MetPhe: 0.904 ± 0.041
1.689MetGly: 1.689 ± 0.042
0.55MetHis: 0.55 ± 0.023
1.562MetIle: 1.562 ± 0.047
0.922MetLys: 0.922 ± 0.037
2.628MetLeu: 2.628 ± 0.068
0.711MetMet: 0.711 ± 0.034
0.979MetAsn: 0.979 ± 0.037
1.576MetPro: 1.576 ± 0.051
0.807MetGln: 0.807 ± 0.033
1.688MetArg: 1.688 ± 0.049
1.881MetSer: 1.881 ± 0.053
2.035MetThr: 2.035 ± 0.049
1.755MetVal: 1.755 ± 0.052
0.331MetTrp: 0.331 ± 0.021
0.574MetTyr: 0.574 ± 0.027
0.0MetXaa: 0.0 ± 0.0
Asn
4.201AsnAla: 4.201 ± 0.084
0.243AsnCys: 0.243 ± 0.018
2.418AsnAsp: 2.418 ± 0.054
1.849AsnGlu: 1.849 ± 0.06
0.956AsnPhe: 0.956 ± 0.036
3.43AsnGly: 3.43 ± 0.091
0.682AsnHis: 0.682 ± 0.028
1.75AsnIle: 1.75 ± 0.048
1.316AsnLys: 1.316 ± 0.049
2.656AsnLeu: 2.656 ± 0.07
0.807AsnMet: 0.807 ± 0.032
1.448AsnAsn: 1.448 ± 0.055
2.368AsnPro: 2.368 ± 0.06
1.092AsnGln: 1.092 ± 0.044
1.93AsnArg: 1.93 ± 0.045
1.932AsnSer: 1.932 ± 0.068
2.515AsnThr: 2.515 ± 0.079
2.652AsnVal: 2.652 ± 0.061
0.498AsnTrp: 0.498 ± 0.026
0.954AsnTyr: 0.954 ± 0.037
0.0AsnXaa: 0.0 ± 0.0
Pro
5.19ProAla: 5.19 ± 0.1
0.318ProCys: 0.318 ± 0.018
3.394ProAsp: 3.394 ± 0.076
2.973ProGlu: 2.973 ± 0.073
1.66ProPhe: 1.66 ± 0.05
3.405ProGly: 3.405 ± 0.074
0.973ProHis: 0.973 ± 0.038
2.36ProIle: 2.36 ± 0.062
1.742ProLys: 1.742 ± 0.049
3.69ProLeu: 3.69 ± 0.084
1.143ProMet: 1.143 ± 0.041
1.748ProAsn: 1.748 ± 0.051
1.229ProPro: 1.229 ± 0.042
1.924ProGln: 1.924 ± 0.057
2.12ProArg: 2.12 ± 0.054
2.946ProSer: 2.946 ± 0.064
3.045ProThr: 3.045 ± 0.065
3.787ProVal: 3.787 ± 0.068
0.649ProTrp: 0.649 ± 0.031
1.448ProTyr: 1.448 ± 0.053
0.0ProXaa: 0.0 ± 0.0
Gln
3.989GlnAla: 3.989 ± 0.083
0.298GlnCys: 0.298 ± 0.021
1.563GlnAsp: 1.563 ± 0.046
1.576GlnGlu: 1.576 ± 0.05
1.144GlnPhe: 1.144 ± 0.04
2.253GlnGly: 2.253 ± 0.059
0.868GlnHis: 0.868 ± 0.033
1.891GlnIle: 1.891 ± 0.052
1.101GlnLys: 1.101 ± 0.053
3.544GlnLeu: 3.544 ± 0.067
0.952GlnMet: 0.952 ± 0.037
1.088GlnAsn: 1.088 ± 0.041
1.96GlnPro: 1.96 ± 0.085
1.874GlnGln: 1.874 ± 0.064
2.363GlnArg: 2.363 ± 0.064
2.346GlnSer: 2.346 ± 0.067
2.065GlnThr: 2.065 ± 0.058
2.393GlnVal: 2.393 ± 0.06
0.648GlnTrp: 0.648 ± 0.03
1.211GlnTyr: 1.211 ± 0.049
0.0GlnXaa: 0.0 ± 0.0
Arg
5.437ArgAla: 5.437 ± 0.097
0.487ArgCys: 0.487 ± 0.026
3.577ArgAsp: 3.577 ± 0.083
3.532ArgGlu: 3.532 ± 0.083
2.215ArgPhe: 2.215 ± 0.064
3.579ArgGly: 3.579 ± 0.068
1.458ArgHis: 1.458 ± 0.048
3.562ArgIle: 3.562 ± 0.079
2.299ArgLys: 2.299 ± 0.064
5.183ArgLeu: 5.183 ± 0.1
1.736ArgMet: 1.736 ± 0.052
1.934ArgAsn: 1.934 ± 0.057
2.212ArgPro: 2.212 ± 0.061
2.048ArgGln: 2.048 ± 0.054
4.365ArgArg: 4.365 ± 0.106
3.11ArgSer: 3.11 ± 0.076
3.213ArgThr: 3.213 ± 0.073
4.111ArgVal: 4.111 ± 0.076
0.933ArgTrp: 0.933 ± 0.037
1.809ArgTyr: 1.809 ± 0.049
0.0ArgXaa: 0.0 ± 0.0
Ser
6.997SerAla: 6.997 ± 0.126
0.452SerCys: 0.452 ± 0.026
4.059SerAsp: 4.059 ± 0.084
3.079SerGlu: 3.079 ± 0.062
2.116SerPhe: 2.116 ± 0.058
5.449SerGly: 5.449 ± 0.111
1.289SerHis: 1.289 ± 0.039
3.218SerIle: 3.218 ± 0.074
2.233SerLys: 2.233 ± 0.066
5.144SerLeu: 5.144 ± 0.093
1.691SerMet: 1.691 ± 0.042
2.182SerAsn: 2.182 ± 0.065
2.401SerPro: 2.401 ± 0.06
2.187SerGln: 2.187 ± 0.06
3.146SerArg: 3.146 ± 0.074
4.536SerSer: 4.536 ± 0.144
4.123SerThr: 4.123 ± 0.085
4.567SerVal: 4.567 ± 0.087
0.883SerTrp: 0.883 ± 0.037
1.658SerTyr: 1.658 ± 0.053
0.0SerXaa: 0.0 ± 0.0
Thr
7.266ThrAla: 7.266 ± 0.13
0.469ThrCys: 0.469 ± 0.026
4.061ThrAsp: 4.061 ± 0.085
2.728ThrGlu: 2.728 ± 0.068
2.242ThrPhe: 2.242 ± 0.057
5.292ThrGly: 5.292 ± 0.086
1.264ThrHis: 1.264 ± 0.04
3.874ThrIle: 3.874 ± 0.072
2.255ThrLys: 2.255 ± 0.067
5.941ThrLeu: 5.941 ± 0.091
1.541ThrMet: 1.541 ± 0.05
2.226ThrAsn: 2.226 ± 0.061
3.682ThrPro: 3.682 ± 0.079
2.108ThrGln: 2.108 ± 0.057
3.049ThrArg: 3.049 ± 0.07
3.772ThrSer: 3.772 ± 0.087
4.193ThrThr: 4.193 ± 0.097
5.969ThrVal: 5.969 ± 0.106
0.852ThrTrp: 0.852 ± 0.039
1.685ThrTyr: 1.685 ± 0.05
0.0ThrXaa: 0.0 ± 0.0
Val
8.278ValAla: 8.278 ± 0.115
0.885ValCys: 0.885 ± 0.035
4.96ValAsp: 4.96 ± 0.085
3.962ValGlu: 3.962 ± 0.083
2.875ValPhe: 2.875 ± 0.074
4.903ValGly: 4.903 ± 0.08
1.559ValHis: 1.559 ± 0.051
4.646ValIle: 4.646 ± 0.083
2.846ValLys: 2.846 ± 0.075
6.895ValLeu: 6.895 ± 0.113
1.909ValMet: 1.909 ± 0.05
2.837ValAsn: 2.837 ± 0.064
3.699ValPro: 3.699 ± 0.071
2.175ValGln: 2.175 ± 0.058
4.169ValArg: 4.169 ± 0.077
5.009ValSer: 5.009 ± 0.089
5.517ValThr: 5.517 ± 0.116
5.887ValVal: 5.887 ± 0.117
0.971ValTrp: 0.971 ± 0.033
1.981ValTyr: 1.981 ± 0.056
0.0ValXaa: 0.0 ± 0.0
Trp
1.193TrpAla: 1.193 ± 0.043
0.155TrpCys: 0.155 ± 0.015
0.831TrpAsp: 0.831 ± 0.037
0.575TrpGlu: 0.575 ± 0.031
0.552TrpPhe: 0.552 ± 0.031
0.947TrpGly: 0.947 ± 0.037
0.361TrpHis: 0.361 ± 0.022
0.75TrpIle: 0.75 ± 0.036
0.633TrpLys: 0.633 ± 0.03
1.419TrpLeu: 1.419 ± 0.05
0.437TrpMet: 0.437 ± 0.026
0.694TrpAsn: 0.694 ± 0.03
0.528TrpPro: 0.528 ± 0.031
0.737TrpGln: 0.737 ± 0.03
0.925TrpArg: 0.925 ± 0.038
0.889TrpSer: 0.889 ± 0.035
0.81TrpThr: 0.81 ± 0.037
0.881TrpVal: 0.881 ± 0.029
0.281TrpTrp: 0.281 ± 0.02
0.439TrpTyr: 0.439 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.114TyrAla: 3.114 ± 0.069
0.343TyrCys: 0.343 ± 0.022
1.966TyrAsp: 1.966 ± 0.062
1.604TyrGlu: 1.604 ± 0.048
1.005TyrPhe: 1.005 ± 0.038
2.603TyrGly: 2.603 ± 0.067
0.524TyrHis: 0.524 ± 0.024
1.245TyrIle: 1.245 ± 0.039
0.88TyrLys: 0.88 ± 0.041
2.367TyrLeu: 2.367 ± 0.063
0.595TyrMet: 0.595 ± 0.027
1.036TyrAsn: 1.036 ± 0.049
1.282TyrPro: 1.282 ± 0.045
1.065TyrGln: 1.065 ± 0.035
1.83TyrArg: 1.83 ± 0.057
1.521TyrSer: 1.521 ± 0.054
1.852TyrThr: 1.852 ± 0.058
2.107TyrVal: 2.107 ± 0.052
0.447TyrTrp: 0.447 ± 0.031
0.868TyrTyr: 0.868 ± 0.035
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2046 proteins (761304 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski