Amino acid dipepetide frequency for Streptococcus satellite phage Javan432

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.917AlaAla: 0.917 ± 0.669
0.0AlaCys: 0.0 ± 0.0
3.972AlaAsp: 3.972 ± 0.949
6.722AlaGlu: 6.722 ± 2.051
2.75AlaPhe: 2.75 ± 1.027
3.666AlaGly: 3.666 ± 1.119
0.611AlaHis: 0.611 ± 0.459
4.583AlaIle: 4.583 ± 1.312
5.194AlaLys: 5.194 ± 1.197
4.277AlaLeu: 4.277 ± 1.175
1.528AlaMet: 1.528 ± 0.82
3.055AlaAsn: 3.055 ± 0.922
1.222AlaPro: 1.222 ± 0.454
3.055AlaGln: 3.055 ± 0.922
2.444AlaArg: 2.444 ± 0.587
3.055AlaSer: 3.055 ± 0.839
5.805AlaThr: 5.805 ± 1.184
2.75AlaVal: 2.75 ± 0.718
0.917AlaTrp: 0.917 ± 0.368
1.833AlaTyr: 1.833 ± 0.547
0.0AlaXaa: 0.0 ± 0.0
Cys
0.306CysAla: 0.306 ± 0.277
0.0CysCys: 0.0 ± 0.0
1.222CysAsp: 1.222 ± 0.458
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
0.0CysGly: 0.0 ± 0.0
0.0CysHis: 0.0 ± 0.0
0.306CysIle: 0.306 ± 0.3
0.306CysLys: 0.306 ± 0.361
0.306CysLeu: 0.306 ± 0.304
0.306CysMet: 0.306 ± 0.261
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.306CysArg: 0.306 ± 0.248
0.306CysSer: 0.306 ± 0.248
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
0.611AspAla: 0.611 ± 0.348
0.306AspCys: 0.306 ± 0.3
3.972AspAsp: 3.972 ± 1.004
3.972AspGlu: 3.972 ± 1.025
4.583AspPhe: 4.583 ± 1.124
2.75AspGly: 2.75 ± 0.871
0.306AspHis: 0.306 ± 0.288
6.722AspIle: 6.722 ± 1.319
4.888AspLys: 4.888 ± 1.019
5.5AspLeu: 5.5 ± 0.944
2.139AspMet: 2.139 ± 0.627
3.972AspAsn: 3.972 ± 1.096
0.306AspPro: 0.306 ± 0.288
1.222AspGln: 1.222 ± 0.861
3.055AspArg: 3.055 ± 0.917
4.277AspSer: 4.277 ± 1.15
3.666AspThr: 3.666 ± 0.97
3.666AspVal: 3.666 ± 1.056
0.306AspTrp: 0.306 ± 0.304
4.888AspTyr: 4.888 ± 1.566
0.0AspXaa: 0.0 ± 0.0
Glu
4.277GluAla: 4.277 ± 1.009
0.306GluCys: 0.306 ± 0.277
3.972GluAsp: 3.972 ± 1.041
7.333GluGlu: 7.333 ± 1.58
2.139GluPhe: 2.139 ± 0.702
2.75GluGly: 2.75 ± 1.008
0.917GluHis: 0.917 ± 0.445
7.027GluIle: 7.027 ± 1.885
6.416GluLys: 6.416 ± 0.915
8.86GluLeu: 8.86 ± 0.792
1.833GluMet: 1.833 ± 0.736
5.194GluAsn: 5.194 ± 1.139
3.666GluPro: 3.666 ± 1.219
2.75GluGln: 2.75 ± 1.144
7.027GluArg: 7.027 ± 1.751
3.972GluSer: 3.972 ± 1.274
4.583GluThr: 4.583 ± 1.107
6.416GluVal: 6.416 ± 1.766
0.0GluTrp: 0.0 ± 0.0
4.583GluTyr: 4.583 ± 1.077
0.0GluXaa: 0.0 ± 0.0
Phe
1.833PheAla: 1.833 ± 0.946
0.0PheCys: 0.0 ± 0.0
3.972PheAsp: 3.972 ± 0.924
4.277PheGlu: 4.277 ± 1.137
1.833PhePhe: 1.833 ± 0.726
3.055PheGly: 3.055 ± 0.915
0.611PheHis: 0.611 ± 0.341
2.139PheIle: 2.139 ± 0.617
3.361PheLys: 3.361 ± 0.965
5.5PheLeu: 5.5 ± 1.056
0.917PheMet: 0.917 ± 0.501
1.222PheAsn: 1.222 ± 0.62
0.611PhePro: 0.611 ± 0.447
1.833PheGln: 1.833 ± 0.618
2.75PheArg: 2.75 ± 0.802
2.444PheSer: 2.444 ± 0.682
2.139PheThr: 2.139 ± 0.89
1.222PheVal: 1.222 ± 0.597
0.611PheTrp: 0.611 ± 0.482
2.444PheTyr: 2.444 ± 0.71
0.0PheXaa: 0.0 ± 0.0
Gly
2.444GlyAla: 2.444 ± 1.07
0.306GlyCys: 0.306 ± 0.248
3.666GlyAsp: 3.666 ± 1.227
4.277GlyGlu: 4.277 ± 1.064
4.277GlyPhe: 4.277 ± 0.973
1.833GlyGly: 1.833 ± 0.588
0.917GlyHis: 0.917 ± 0.449
3.055GlyIle: 3.055 ± 0.775
3.666GlyLys: 3.666 ± 0.969
5.194GlyLeu: 5.194 ± 1.422
2.139GlyMet: 2.139 ± 0.772
1.833GlyAsn: 1.833 ± 0.666
0.0GlyPro: 0.0 ± 0.0
3.055GlyGln: 3.055 ± 0.961
1.833GlyArg: 1.833 ± 0.559
1.528GlySer: 1.528 ± 0.6
2.75GlyThr: 2.75 ± 1.029
3.361GlyVal: 3.361 ± 0.883
0.306GlyTrp: 0.306 ± 0.274
2.75GlyTyr: 2.75 ± 0.796
0.0GlyXaa: 0.0 ± 0.0
His
1.222HisAla: 1.222 ± 0.619
0.0HisCys: 0.0 ± 0.0
0.306HisAsp: 0.306 ± 0.277
0.611HisGlu: 0.611 ± 0.315
0.917HisPhe: 0.917 ± 0.553
1.833HisGly: 1.833 ± 0.759
0.306HisHis: 0.306 ± 0.274
0.917HisIle: 0.917 ± 0.553
1.528HisLys: 1.528 ± 0.818
1.528HisLeu: 1.528 ± 0.418
0.0HisMet: 0.0 ± 0.0
0.306HisAsn: 0.306 ± 0.296
0.306HisPro: 0.306 ± 0.342
0.306HisGln: 0.306 ± 0.304
1.528HisArg: 1.528 ± 0.611
1.528HisSer: 1.528 ± 0.647
0.611HisThr: 0.611 ± 0.341
0.306HisVal: 0.306 ± 0.274
0.306HisTrp: 0.306 ± 0.274
0.917HisTyr: 0.917 ± 0.435
0.0HisXaa: 0.0 ± 0.0
Ile
4.583IleAla: 4.583 ± 1.099
0.611IleCys: 0.611 ± 0.41
6.111IleAsp: 6.111 ± 1.262
5.805IleGlu: 5.805 ± 1.575
2.444IlePhe: 2.444 ± 0.849
3.055IleGly: 3.055 ± 0.803
0.917IleHis: 0.917 ± 0.497
3.361IleIle: 3.361 ± 0.964
7.333IleLys: 7.333 ± 1.096
5.805IleLeu: 5.805 ± 0.787
1.528IleMet: 1.528 ± 0.635
2.75IleAsn: 2.75 ± 1.042
2.139IlePro: 2.139 ± 0.749
3.361IleGln: 3.361 ± 0.851
2.444IleArg: 2.444 ± 0.952
5.805IleSer: 5.805 ± 1.448
5.5IleThr: 5.5 ± 1.119
1.833IleVal: 1.833 ± 0.783
1.528IleTrp: 1.528 ± 0.667
3.055IleTyr: 3.055 ± 0.745
0.0IleXaa: 0.0 ± 0.0
Lys
8.86LysAla: 8.86 ± 1.945
0.0LysCys: 0.0 ± 0.0
5.5LysAsp: 5.5 ± 1.28
7.944LysGlu: 7.944 ± 1.237
2.444LysPhe: 2.444 ± 0.671
4.888LysGly: 4.888 ± 1.537
3.666LysHis: 3.666 ± 1.087
8.86LysIle: 8.86 ± 1.787
7.333LysLys: 7.333 ± 1.547
5.805LysLeu: 5.805 ± 1.974
1.222LysMet: 1.222 ± 0.532
3.666LysAsn: 3.666 ± 1.078
3.666LysPro: 3.666 ± 1.107
4.888LysGln: 4.888 ± 0.862
7.333LysArg: 7.333 ± 1.265
4.583LysSer: 4.583 ± 1.428
6.111LysThr: 6.111 ± 1.242
5.805LysVal: 5.805 ± 1.183
0.917LysTrp: 0.917 ± 0.542
1.222LysTyr: 1.222 ± 0.63
0.0LysXaa: 0.0 ± 0.0
Leu
7.944LeuAla: 7.944 ± 1.281
0.306LeuCys: 0.306 ± 0.296
8.249LeuAsp: 8.249 ± 2.458
10.694LeuGlu: 10.694 ± 1.4
3.972LeuPhe: 3.972 ± 0.939
2.444LeuGly: 2.444 ± 1.015
0.917LeuHis: 0.917 ± 0.368
4.277LeuIle: 4.277 ± 0.975
10.082LeuLys: 10.082 ± 1.849
9.777LeuLeu: 9.777 ± 2.082
0.917LeuMet: 0.917 ± 0.567
6.111LeuAsn: 6.111 ± 1.526
3.972LeuPro: 3.972 ± 1.468
3.666LeuGln: 3.666 ± 0.963
2.75LeuArg: 2.75 ± 0.871
3.972LeuSer: 3.972 ± 0.945
7.027LeuThr: 7.027 ± 1.521
4.583LeuVal: 4.583 ± 1.19
0.611LeuTrp: 0.611 ± 0.514
3.666LeuTyr: 3.666 ± 1.078
0.0LeuXaa: 0.0 ± 0.0
Met
2.444MetAla: 2.444 ± 0.719
0.0MetCys: 0.0 ± 0.0
2.139MetAsp: 2.139 ± 0.629
1.833MetGlu: 1.833 ± 0.666
0.917MetPhe: 0.917 ± 0.576
1.833MetGly: 1.833 ± 0.561
0.0MetHis: 0.0 ± 0.0
2.75MetIle: 2.75 ± 1.117
1.833MetLys: 1.833 ± 0.841
1.222MetLeu: 1.222 ± 0.5
0.306MetMet: 0.306 ± 0.344
2.75MetAsn: 2.75 ± 0.716
0.0MetPro: 0.0 ± 0.0
1.528MetGln: 1.528 ± 0.622
0.917MetArg: 0.917 ± 0.455
0.917MetSer: 0.917 ± 0.525
3.972MetThr: 3.972 ± 1.12
0.917MetVal: 0.917 ± 0.51
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
2.444AsnAla: 2.444 ± 0.675
0.0AsnCys: 0.0 ± 0.0
2.139AsnAsp: 2.139 ± 0.88
2.75AsnGlu: 2.75 ± 0.556
1.833AsnPhe: 1.833 ± 0.845
3.055AsnGly: 3.055 ± 1.158
0.917AsnHis: 0.917 ± 0.42
1.528AsnIle: 1.528 ± 0.654
3.972AsnLys: 3.972 ± 0.766
5.5AsnLeu: 5.5 ± 1.295
2.75AsnMet: 2.75 ± 1.177
2.139AsnAsn: 2.139 ± 1.063
3.361AsnPro: 3.361 ± 1.129
1.528AsnGln: 1.528 ± 0.697
1.833AsnArg: 1.833 ± 0.611
3.972AsnSer: 3.972 ± 1.264
2.139AsnThr: 2.139 ± 0.803
2.75AsnVal: 2.75 ± 0.772
0.611AsnTrp: 0.611 ± 0.399
2.75AsnTyr: 2.75 ± 0.778
0.0AsnXaa: 0.0 ± 0.0
Pro
2.139ProAla: 2.139 ± 0.565
0.306ProCys: 0.306 ± 0.248
1.833ProAsp: 1.833 ± 0.625
3.666ProGlu: 3.666 ± 1.348
1.528ProPhe: 1.528 ± 0.972
0.306ProGly: 0.306 ± 0.274
0.306ProHis: 0.306 ± 0.296
1.833ProIle: 1.833 ± 0.627
2.444ProLys: 2.444 ± 0.724
2.75ProLeu: 2.75 ± 0.799
1.222ProMet: 1.222 ± 0.625
2.444ProAsn: 2.444 ± 0.723
0.611ProPro: 0.611 ± 0.434
1.222ProGln: 1.222 ± 0.704
1.833ProArg: 1.833 ± 0.763
1.528ProSer: 1.528 ± 0.601
1.222ProThr: 1.222 ± 0.825
1.833ProVal: 1.833 ± 0.938
0.0ProTrp: 0.0 ± 0.0
2.444ProTyr: 2.444 ± 0.818
0.0ProXaa: 0.0 ± 0.0
Gln
3.361GlnAla: 3.361 ± 0.765
0.0GlnCys: 0.0 ± 0.0
1.222GlnAsp: 1.222 ± 0.539
2.75GlnGlu: 2.75 ± 1.033
1.833GlnPhe: 1.833 ± 0.728
2.444GlnGly: 2.444 ± 0.896
0.917GlnHis: 0.917 ± 0.368
3.055GlnIle: 3.055 ± 1.089
6.722GlnLys: 6.722 ± 1.677
4.277GlnLeu: 4.277 ± 1.046
0.917GlnMet: 0.917 ± 0.481
1.528GlnAsn: 1.528 ± 0.986
0.306GlnPro: 0.306 ± 0.307
2.75GlnGln: 2.75 ± 0.929
1.833GlnArg: 1.833 ± 0.762
3.055GlnSer: 3.055 ± 0.81
2.139GlnThr: 2.139 ± 0.799
1.833GlnVal: 1.833 ± 0.803
0.611GlnTrp: 0.611 ± 0.45
1.833GlnTyr: 1.833 ± 0.636
0.0GlnXaa: 0.0 ± 0.0
Arg
2.75ArgAla: 2.75 ± 0.705
0.0ArgCys: 0.0 ± 0.0
2.75ArgAsp: 2.75 ± 0.78
5.5ArgGlu: 5.5 ± 1.261
3.361ArgPhe: 3.361 ± 1.133
3.361ArgGly: 3.361 ± 0.848
1.222ArgHis: 1.222 ± 0.726
2.75ArgIle: 2.75 ± 0.645
4.888ArgLys: 4.888 ± 1.235
5.194ArgLeu: 5.194 ± 1.375
1.528ArgMet: 1.528 ± 0.719
3.055ArgAsn: 3.055 ± 1.28
1.528ArgPro: 1.528 ± 0.727
2.139ArgGln: 2.139 ± 0.745
2.75ArgArg: 2.75 ± 1.035
1.222ArgSer: 1.222 ± 0.6
1.528ArgThr: 1.528 ± 0.838
3.055ArgVal: 3.055 ± 1.135
0.0ArgTrp: 0.0 ± 0.0
2.75ArgTyr: 2.75 ± 1.185
0.0ArgXaa: 0.0 ± 0.0
Ser
2.139SerAla: 2.139 ± 0.735
0.306SerCys: 0.306 ± 0.304
3.361SerAsp: 3.361 ± 0.994
3.666SerGlu: 3.666 ± 0.851
1.833SerPhe: 1.833 ± 0.64
1.528SerGly: 1.528 ± 0.709
0.306SerHis: 0.306 ± 0.248
6.111SerIle: 6.111 ± 1.324
6.111SerLys: 6.111 ± 1.008
6.416SerLeu: 6.416 ± 1.46
1.528SerMet: 1.528 ± 0.698
1.528SerAsn: 1.528 ± 0.622
1.528SerPro: 1.528 ± 0.431
2.139SerGln: 2.139 ± 0.772
1.528SerArg: 1.528 ± 0.742
3.055SerSer: 3.055 ± 0.985
3.055SerThr: 3.055 ± 0.96
3.361SerVal: 3.361 ± 1.157
0.611SerTrp: 0.611 ± 0.43
3.055SerTyr: 3.055 ± 0.888
0.0SerXaa: 0.0 ± 0.0
Thr
4.583ThrAla: 4.583 ± 0.981
0.306ThrCys: 0.306 ± 0.261
3.055ThrAsp: 3.055 ± 0.853
3.361ThrGlu: 3.361 ± 0.675
3.055ThrPhe: 3.055 ± 1.334
4.888ThrGly: 4.888 ± 1.398
0.917ThrHis: 0.917 ± 0.624
2.444ThrIle: 2.444 ± 0.68
6.416ThrLys: 6.416 ± 1.253
7.027ThrLeu: 7.027 ± 1.194
1.833ThrMet: 1.833 ± 0.598
0.917ThrAsn: 0.917 ± 0.447
3.972ThrPro: 3.972 ± 0.977
3.666ThrGln: 3.666 ± 1.163
3.055ThrArg: 3.055 ± 0.599
3.055ThrSer: 3.055 ± 0.996
3.361ThrThr: 3.361 ± 1.39
3.361ThrVal: 3.361 ± 0.917
0.611ThrTrp: 0.611 ± 0.401
2.139ThrTyr: 2.139 ± 0.679
0.0ThrXaa: 0.0 ± 0.0
Val
3.666ValAla: 3.666 ± 0.916
0.306ValCys: 0.306 ± 0.361
1.528ValAsp: 1.528 ± 0.59
4.277ValGlu: 4.277 ± 1.404
0.611ValPhe: 0.611 ± 0.43
3.055ValGly: 3.055 ± 1.111
0.611ValHis: 0.611 ± 0.443
4.583ValIle: 4.583 ± 1.466
5.5ValLys: 5.5 ± 1.326
4.888ValLeu: 4.888 ± 1.674
1.528ValMet: 1.528 ± 0.805
2.139ValAsn: 2.139 ± 1.011
1.833ValPro: 1.833 ± 0.731
1.833ValGln: 1.833 ± 0.667
2.139ValArg: 2.139 ± 0.655
3.055ValSer: 3.055 ± 1.228
3.666ValThr: 3.666 ± 1.019
3.666ValVal: 3.666 ± 1.084
0.611ValTrp: 0.611 ± 0.412
3.361ValTyr: 3.361 ± 0.933
0.0ValXaa: 0.0 ± 0.0
Trp
0.306TrpAla: 0.306 ± 0.288
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
0.917TrpGlu: 0.917 ± 0.536
0.306TrpPhe: 0.306 ± 0.304
0.306TrpGly: 0.306 ± 0.344
0.0TrpHis: 0.0 ± 0.0
0.306TrpIle: 0.306 ± 0.304
1.528TrpLys: 1.528 ± 0.623
2.139TrpLeu: 2.139 ± 0.854
0.0TrpMet: 0.0 ± 0.0
0.306TrpAsn: 0.306 ± 0.296
0.306TrpPro: 0.306 ± 0.274
0.611TrpGln: 0.611 ± 0.562
0.0TrpArg: 0.0 ± 0.0
0.611TrpSer: 0.611 ± 0.348
0.611TrpThr: 0.611 ± 0.391
0.306TrpVal: 0.306 ± 0.3
0.306TrpTrp: 0.306 ± 0.304
0.306TrpTyr: 0.306 ± 0.304
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.528TyrAla: 1.528 ± 0.663
0.306TyrCys: 0.306 ± 0.3
2.444TyrAsp: 2.444 ± 1.277
3.666TyrGlu: 3.666 ± 1.509
2.139TyrPhe: 2.139 ± 0.881
2.139TyrGly: 2.139 ± 0.968
0.917TyrHis: 0.917 ± 0.576
3.361TyrIle: 3.361 ± 1.178
5.194TyrLys: 5.194 ± 1.452
3.972TyrLeu: 3.972 ± 1.017
1.833TyrMet: 1.833 ± 0.817
3.055TyrAsn: 3.055 ± 1.021
2.139TyrPro: 2.139 ± 0.872
1.833TyrGln: 1.833 ± 0.65
3.972TyrArg: 3.972 ± 1.528
1.222TyrSer: 1.222 ± 0.539
2.139TyrThr: 2.139 ± 0.562
1.833TyrVal: 1.833 ± 0.668
0.306TyrTrp: 0.306 ± 0.344
3.666TyrTyr: 3.666 ± 0.95
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 20 proteins (3274 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski