Amino acid dipepetide frequency for Marininema mesophilum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.914AlaAla: 5.914 ± 0.098	0.682AlaCys: 0.682 ± 0.029	3.747AlaAsp: 3.747 ± 0.066	5.099AlaGlu: 5.099 ± 0.092	3.061AlaPhe: 3.061 ± 0.06	5.961AlaGly: 5.961 ± 0.105	1.52AlaHis: 1.52 ± 0.047	5.222AlaIle: 5.222 ± 0.085	4.282AlaLys: 4.282 ± 0.086	7.64AlaLeu: 7.64 ± 0.093	2.049AlaMet: 2.049 ± 0.056	2.375AlaAsn: 2.375 ± 0.052	2.709AlaPro: 2.709 ± 0.182	2.673AlaGln: 2.673 ± 0.061	3.831AlaArg: 3.831 ± 0.074	4.278AlaSer: 4.278 ± 0.075	4.163AlaThr: 4.163 ± 0.081	5.879AlaVal: 5.879 ± 0.097	0.919AlaTrp: 0.919 ± 0.034	2.248AlaTyr: 2.248 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.551CysAla: 0.551 ± 0.029	0.136CysCys: 0.136 ± 0.012	0.431CysAsp: 0.431 ± 0.021	0.469CysGlu: 0.469 ± 0.025	0.384CysPhe: 0.384 ± 0.021	0.787CysGly: 0.787 ± 0.03	0.218CysHis: 0.218 ± 0.016	0.569CysIle: 0.569 ± 0.022	0.328CysLys: 0.328 ± 0.02	0.789CysLeu: 0.789 ± 0.027	0.173CysMet: 0.173 ± 0.012	0.264CysAsn: 0.264 ± 0.016	0.439CysPro: 0.439 ± 0.023	0.281CysGln: 0.281 ± 0.017	0.483CysArg: 0.483 ± 0.026	0.557CysSer: 0.557 ± 0.025	0.477CysThr: 0.477 ± 0.023	0.502CysVal: 0.502 ± 0.022	0.121CysTrp: 0.121 ± 0.011	0.279CysTyr: 0.279 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	3.508AspAla: 3.508 ± 0.065	0.415AspCys: 0.415 ± 0.021	2.271AspAsp: 2.271 ± 0.072	3.809AspGlu: 3.809 ± 0.067	2.074AspPhe: 2.074 ± 0.058	3.828AspGly: 3.828 ± 0.071	1.387AspHis: 1.387 ± 0.039	3.275AspIle: 3.275 ± 0.068	2.564AspLys: 2.564 ± 0.058	5.329AspLeu: 5.329 ± 0.084	1.211AspMet: 1.211 ± 0.028	1.508AspAsn: 1.508 ± 0.055	2.694AspPro: 2.694 ± 0.064	2.221AspGln: 2.221 ± 0.051	3.182AspArg: 3.182 ± 0.061	2.708AspSer: 2.708 ± 0.061	2.492AspThr: 2.492 ± 0.058	3.696AspVal: 3.696 ± 0.07	0.826AspTrp: 0.826 ± 0.031	1.634AspTyr: 1.634 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	5.627GluAla: 5.627 ± 0.104	0.429GluCys: 0.429 ± 0.02	3.426GluAsp: 3.426 ± 0.061	6.908GluGlu: 6.908 ± 0.127	1.81GluPhe: 1.81 ± 0.05	5.12GluGly: 5.12 ± 0.078	1.334GluHis: 1.334 ± 0.043	4.43GluIle: 4.43 ± 0.086	5.474GluLys: 5.474 ± 0.09	6.515GluLeu: 6.515 ± 0.086	2.163GluMet: 2.163 ± 0.054	2.535GluAsn: 2.535 ± 0.051	2.19GluPro: 2.19 ± 0.045	3.064GluGln: 3.064 ± 0.066	4.455GluArg: 4.455 ± 0.083	3.507GluSer: 3.507 ± 0.061	3.495GluThr: 3.495 ± 0.067	5.215GluVal: 5.215 ± 0.086	1.106GluTrp: 1.106 ± 0.037	1.835GluTyr: 1.835 ± 0.05	0.0GluXaa: 0.0 ± 0.0
Phe	3.126PheAla: 3.126 ± 0.062	0.385PheCys: 0.385 ± 0.023	2.083PheAsp: 2.083 ± 0.053	1.942PheGlu: 1.942 ± 0.051	2.076PhePhe: 2.076 ± 0.058	3.054PheGly: 3.054 ± 0.057	1.027PheHis: 1.027 ± 0.035	2.764PheIle: 2.764 ± 0.077	1.566PheLys: 1.566 ± 0.041	4.198PheLeu: 4.198 ± 0.089	0.867PheMet: 0.867 ± 0.035	1.504PheAsn: 1.504 ± 0.046	1.817PhePro: 1.817 ± 0.048	1.522PheGln: 1.522 ± 0.045	2.065PheArg: 2.065 ± 0.051	2.917PheSer: 2.917 ± 0.07	2.431PheThr: 2.431 ± 0.053	2.566PheVal: 2.566 ± 0.058	0.453PheTrp: 0.453 ± 0.021	1.307PheTyr: 1.307 ± 0.04	0.0PheXaa: 0.0 ± 0.0
Gly	5.405GlyAla: 5.405 ± 0.096	0.777GlyCys: 0.777 ± 0.031	3.643GlyAsp: 3.643 ± 0.076	5.308GlyGlu: 5.308 ± 0.091	3.189GlyPhe: 3.189 ± 0.058	5.792GlyGly: 5.792 ± 0.105	1.508GlyHis: 1.508 ± 0.041	5.762GlyIle: 5.762 ± 0.098	5.061GlyLys: 5.061 ± 0.097	7.394GlyLeu: 7.394 ± 0.106	2.483GlyMet: 2.483 ± 0.061	2.563GlyAsn: 2.563 ± 0.062	2.162GlyPro: 2.162 ± 0.05	2.449GlyGln: 2.449 ± 0.056	4.0GlyArg: 4.0 ± 0.083	4.422GlySer: 4.422 ± 0.07	4.481GlyThr: 4.481 ± 0.082	6.172GlyVal: 6.172 ± 0.097	1.252GlyTrp: 1.252 ± 0.042	2.618GlyTyr: 2.618 ± 0.061	0.0GlyXaa: 0.0 ± 0.0
His	1.429HisAla: 1.429 ± 0.038	0.256HisCys: 0.256 ± 0.017	0.936HisAsp: 0.936 ± 0.037	1.247HisGlu: 1.247 ± 0.039	1.063HisPhe: 1.063 ± 0.038	1.614HisGly: 1.614 ± 0.042	0.828HisHis: 0.828 ± 0.046	1.441HisIle: 1.441 ± 0.055	0.836HisLys: 0.836 ± 0.03	2.694HisLeu: 2.694 ± 0.086	0.531HisMet: 0.531 ± 0.024	0.598HisAsn: 0.598 ± 0.024	1.558HisPro: 1.558 ± 0.044	1.108HisGln: 1.108 ± 0.036	1.526HisArg: 1.526 ± 0.046	1.367HisSer: 1.367 ± 0.044	1.156HisThr: 1.156 ± 0.036	1.518HisVal: 1.518 ± 0.038	0.337HisTrp: 0.337 ± 0.019	0.752HisTyr: 0.752 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.491IleAla: 5.491 ± 0.078	0.645IleCys: 0.645 ± 0.029	3.566IleAsp: 3.566 ± 0.071	4.14IleGlu: 4.14 ± 0.075	2.432IlePhe: 2.432 ± 0.059	5.467IleGly: 5.467 ± 0.093	1.956IleHis: 1.956 ± 0.049	3.987IleIle: 3.987 ± 0.085	2.904IleLys: 2.904 ± 0.064	6.631IleLeu: 6.631 ± 0.109	1.296IleMet: 1.296 ± 0.034	2.327IleAsn: 2.327 ± 0.054	3.425IlePro: 3.425 ± 0.064	2.972IleGln: 2.972 ± 0.064	3.965IleArg: 3.965 ± 0.078	4.181IleSer: 4.181 ± 0.077	3.795IleThr: 3.795 ± 0.072	4.466IleVal: 4.466 ± 0.071	0.721IleTrp: 0.721 ± 0.027	1.905IleTyr: 1.905 ± 0.05	0.0IleXaa: 0.0 ± 0.0
Lys	4.145LysAla: 4.145 ± 0.079	0.226LysCys: 0.226 ± 0.017	3.158LysAsp: 3.158 ± 0.065	5.587LysGlu: 5.587 ± 0.087	1.243LysPhe: 1.243 ± 0.037	4.641LysGly: 4.641 ± 0.087	1.039LysHis: 1.039 ± 0.035	3.117LysIle: 3.117 ± 0.056	5.019LysLys: 5.019 ± 0.107	4.53LysLeu: 4.53 ± 0.073	1.675LysMet: 1.675 ± 0.045	2.325LysAsn: 2.325 ± 0.056	2.171LysPro: 2.171 ± 0.057	2.336LysGln: 2.336 ± 0.053	3.524LysArg: 3.524 ± 0.058	2.983LysSer: 2.983 ± 0.055	2.877LysThr: 2.877 ± 0.063	4.436LysVal: 4.436 ± 0.083	0.827LysTrp: 0.827 ± 0.03	1.493LysTyr: 1.493 ± 0.038	0.0LysXaa: 0.0 ± 0.0
Leu	8.532LeuAla: 8.532 ± 0.119	0.903LeuCys: 0.903 ± 0.029	5.135LeuAsp: 5.135 ± 0.083	6.38LeuGlu: 6.38 ± 0.086	4.553LeuPhe: 4.553 ± 0.094	7.194LeuGly: 7.194 ± 0.095	2.312LeuHis: 2.312 ± 0.057	6.577LeuIle: 6.577 ± 0.103	5.392LeuLys: 5.392 ± 0.073	10.761LeuLeu: 10.761 ± 0.147	2.491LeuMet: 2.491 ± 0.061	3.408LeuAsn: 3.408 ± 0.07	4.778LeuPro: 4.778 ± 0.074	3.672LeuGln: 3.672 ± 0.068	5.155LeuArg: 5.155 ± 0.079	7.154LeuSer: 7.154 ± 0.097	6.12LeuThr: 6.12 ± 0.091	6.64LeuVal: 6.64 ± 0.094	1.021LeuTrp: 1.021 ± 0.039	2.97LeuTyr: 2.97 ± 0.062	0.0LeuXaa: 0.0 ± 0.0
Met	2.239MetAla: 2.239 ± 0.053	0.162MetCys: 0.162 ± 0.014	1.617MetAsp: 1.617 ± 0.039	2.007MetGlu: 2.007 ± 0.052	0.843MetPhe: 0.843 ± 0.031	2.201MetGly: 2.201 ± 0.053	0.387MetHis: 0.387 ± 0.019	1.927MetIle: 1.927 ± 0.051	2.04MetLys: 2.04 ± 0.048	2.271MetLeu: 2.271 ± 0.054	0.899MetMet: 0.899 ± 0.039	1.173MetAsn: 1.173 ± 0.035	1.003MetPro: 1.003 ± 0.038	0.869MetGln: 0.869 ± 0.03	1.306MetArg: 1.306 ± 0.036	1.552MetSer: 1.552 ± 0.037	1.529MetThr: 1.529 ± 0.04	2.118MetVal: 2.118 ± 0.048	0.224MetTrp: 0.224 ± 0.016	0.604MetTyr: 0.604 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	2.197AsnAla: 2.197 ± 0.055	0.271AsnCys: 0.271 ± 0.017	1.667AsnAsp: 1.667 ± 0.045	2.186AsnGlu: 2.186 ± 0.048	1.184AsnPhe: 1.184 ± 0.038	2.538AsnGly: 2.538 ± 0.065	0.947AsnHis: 0.947 ± 0.034	2.142AsnIle: 2.142 ± 0.057	1.938AsnLys: 1.938 ± 0.051	3.389AsnLeu: 3.389 ± 0.063	0.926AsnMet: 0.926 ± 0.028	1.36AsnAsn: 1.36 ± 0.048	2.141AsnPro: 2.141 ± 0.055	1.78AsnGln: 1.78 ± 0.05	2.333AsnArg: 2.333 ± 0.053	1.822AsnSer: 1.822 ± 0.055	1.774AsnThr: 1.774 ± 0.052	2.287AsnVal: 2.287 ± 0.049	0.496AsnTrp: 0.496 ± 0.026	1.136AsnTyr: 1.136 ± 0.041	0.0AsnXaa: 0.0 ± 0.0
Pro	2.762ProAla: 2.762 ± 0.057	0.29ProCys: 0.29 ± 0.018	2.615ProAsp: 2.615 ± 0.052	3.305ProGlu: 3.305 ± 0.061	2.026ProPhe: 2.026 ± 0.045	3.22ProGly: 3.22 ± 0.067	1.076ProHis: 1.076 ± 0.036	2.826ProIle: 2.826 ± 0.056	2.181ProLys: 2.181 ± 0.057	4.342ProLeu: 4.342 ± 0.071	1.06ProMet: 1.06 ± 0.036	1.378ProAsn: 1.378 ± 0.039	1.58ProPro: 1.58 ± 0.057	1.605ProGln: 1.605 ± 0.043	1.934ProArg: 1.934 ± 0.041	2.743ProSer: 2.743 ± 0.063	2.463ProThr: 2.463 ± 0.052	3.505ProVal: 3.505 ± 0.204	0.6ProTrp: 0.6 ± 0.026	1.436ProTyr: 1.436 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	3.072GlnAla: 3.072 ± 0.062	0.265GlnCys: 0.265 ± 0.019	1.694GlnAsp: 1.694 ± 0.047	3.118GlnGlu: 3.118 ± 0.072	1.345GlnPhe: 1.345 ± 0.041	3.083GlnGly: 3.083 ± 0.06	0.787GlnHis: 0.787 ± 0.028	2.29GlnIle: 2.29 ± 0.054	2.362GlnLys: 2.362 ± 0.056	4.163GlnLeu: 4.163 ± 0.08	1.185GlnMet: 1.185 ± 0.035	1.197GlnAsn: 1.197 ± 0.041	1.625GlnPro: 1.625 ± 0.049	1.871GlnGln: 1.871 ± 0.061	2.287GlnArg: 2.287 ± 0.048	2.224GlnSer: 2.224 ± 0.058	1.927GlnThr: 1.927 ± 0.042	3.218GlnVal: 3.218 ± 0.06	0.553GlnTrp: 0.553 ± 0.026	1.118GlnTyr: 1.118 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	3.296ArgAla: 3.296 ± 0.069	0.431ArgCys: 0.431 ± 0.024	2.749ArgAsp: 2.749 ± 0.06	4.571ArgGlu: 4.571 ± 0.077	2.455ArgPhe: 2.455 ± 0.05	3.62ArgGly: 3.62 ± 0.068	1.186ArgHis: 1.186 ± 0.038	3.926ArgIle: 3.926 ± 0.068	3.327ArgLys: 3.327 ± 0.063	6.085ArgLeu: 6.085 ± 0.092	1.776ArgMet: 1.776 ± 0.043	1.881ArgAsn: 1.881 ± 0.046	1.995ArgPro: 1.995 ± 0.053	2.305ArgGln: 2.305 ± 0.048	3.5ArgArg: 3.5 ± 0.09	3.155ArgSer: 3.155 ± 0.056	2.701ArgThr: 2.701 ± 0.055	4.158ArgVal: 4.158 ± 0.072	0.93ArgTrp: 0.93 ± 0.037	1.962ArgTyr: 1.962 ± 0.049	0.0ArgXaa: 0.0 ± 0.0
Ser	3.857SerAla: 3.857 ± 0.076	0.466SerCys: 0.466 ± 0.022	2.832SerAsp: 2.832 ± 0.058	3.527SerGlu: 3.527 ± 0.068	2.974SerPhe: 2.974 ± 0.061	4.801SerGly: 4.801 ± 0.076	1.381SerHis: 1.381 ± 0.036	4.262SerIle: 4.262 ± 0.095	3.05SerLys: 3.05 ± 0.063	6.777SerLeu: 6.777 ± 0.107	1.674SerMet: 1.674 ± 0.042	2.063SerAsn: 2.063 ± 0.049	2.822SerPro: 2.822 ± 0.051	2.284SerGln: 2.284 ± 0.052	3.279SerArg: 3.279 ± 0.057	4.024SerSer: 4.024 ± 0.084	3.364SerThr: 3.364 ± 0.073	4.127SerVal: 4.127 ± 0.081	0.855SerTrp: 0.855 ± 0.03	1.921SerTyr: 1.921 ± 0.047	0.0SerXaa: 0.0 ± 0.0
Thr	4.161ThrAla: 4.161 ± 0.071	0.463ThrCys: 0.463 ± 0.027	2.653ThrAsp: 2.653 ± 0.066	3.3ThrGlu: 3.3 ± 0.056	2.376ThrPhe: 2.376 ± 0.059	4.693ThrGly: 4.693 ± 0.089	1.286ThrHis: 1.286 ± 0.034	3.737ThrIle: 3.737 ± 0.067	2.649ThrLys: 2.649 ± 0.06	5.826ThrLeu: 5.826 ± 0.082	1.357ThrMet: 1.357 ± 0.035	1.868ThrAsn: 1.868 ± 0.045	2.822ThrPro: 2.822 ± 0.068	1.873ThrGln: 1.873 ± 0.048	2.566ThrArg: 2.566 ± 0.058	3.492ThrSer: 3.492 ± 0.063	3.128ThrThr: 3.128 ± 0.064	4.333ThrVal: 4.333 ± 0.073	0.675ThrTrp: 0.675 ± 0.03	1.799ThrTyr: 1.799 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	6.226ValAla: 6.226 ± 0.198	0.625ValCys: 0.625 ± 0.025	4.138ValAsp: 4.138 ± 0.064	5.017ValGlu: 5.017 ± 0.094	2.657ValPhe: 2.657 ± 0.056	5.517ValGly: 5.517 ± 0.09	1.555ValHis: 1.555 ± 0.04	5.18ValIle: 5.18 ± 0.076	4.146ValLys: 4.146 ± 0.077	6.913ValLeu: 6.913 ± 0.081	1.939ValMet: 1.939 ± 0.046	2.593ValAsn: 2.593 ± 0.059	3.064ValPro: 3.064 ± 0.058	2.545ValGln: 2.545 ± 0.056	3.774ValArg: 3.774 ± 0.072	4.66ValSer: 4.66 ± 0.066	4.393ValThr: 4.393 ± 0.083	5.48ValVal: 5.48 ± 0.079	0.841ValTrp: 0.841 ± 0.032	2.05ValTyr: 2.05 ± 0.052	0.0ValXaa: 0.0 ± 0.0
Trp	0.748TrpAla: 0.748 ± 0.032	0.118TrpCys: 0.118 ± 0.01	0.627TrpAsp: 0.627 ± 0.029	0.892TrpGlu: 0.892 ± 0.035	0.639TrpPhe: 0.639 ± 0.024	0.905TrpGly: 0.905 ± 0.035	0.226TrpHis: 0.226 ± 0.015	1.011TrpIle: 1.011 ± 0.032	0.852TrpLys: 0.852 ± 0.034	1.571TrpLeu: 1.571 ± 0.041	0.506TrpMet: 0.506 ± 0.024	0.566TrpAsn: 0.566 ± 0.027	0.393TrpPro: 0.393 ± 0.021	0.522TrpGln: 0.522 ± 0.025	0.666TrpArg: 0.666 ± 0.026	0.843TrpSer: 0.843 ± 0.031	0.663TrpThr: 0.663 ± 0.025	1.031TrpVal: 1.031 ± 0.038	0.246TrpTrp: 0.246 ± 0.018	0.391TrpTyr: 0.391 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.964TyrAla: 1.964 ± 0.047	0.293TyrCys: 0.293 ± 0.018	1.646TyrAsp: 1.646 ± 0.05	1.828TyrGlu: 1.828 ± 0.047	1.286TyrPhe: 1.286 ± 0.036	2.407TyrGly: 2.407 ± 0.055	0.833TyrHis: 0.833 ± 0.03	1.831TyrIle: 1.831 ± 0.046	1.379TyrLys: 1.379 ± 0.045	3.33TyrLeu: 3.33 ± 0.065	0.707TyrMet: 0.707 ± 0.028	1.028TyrAsn: 1.028 ± 0.039	1.559TyrPro: 1.559 ± 0.044	1.43TyrGln: 1.43 ± 0.04	2.176TyrArg: 2.176 ± 0.047	1.75TyrSer: 1.75 ± 0.046	1.628TyrThr: 1.628 ± 0.046	1.967TyrVal: 1.967 ± 0.046	0.415TyrTrp: 0.415 ± 0.024	1.157TyrTyr: 1.157 ± 0.043	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3137 proteins (942030 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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