Amino acid dipepetide frequency for Pyrenochaeta sp. DS3sAY3a

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.8AlaAla: 8.8 ± 0.049
1.161AlaCys: 1.161 ± 0.013
4.115AlaAsp: 4.115 ± 0.026
4.991AlaGlu: 4.991 ± 0.036
3.326AlaPhe: 3.326 ± 0.023
5.695AlaGly: 5.695 ± 0.034
1.91AlaHis: 1.91 ± 0.018
4.402AlaIle: 4.402 ± 0.027
4.143AlaLys: 4.143 ± 0.028
8.028AlaLeu: 8.028 ± 0.039
1.932AlaMet: 1.932 ± 0.019
3.069AlaAsn: 3.069 ± 0.021
4.995AlaPro: 4.995 ± 0.04
3.573AlaGln: 3.573 ± 0.029
4.938AlaArg: 4.938 ± 0.034
7.281AlaSer: 7.281 ± 0.041
5.346AlaThr: 5.346 ± 0.031
5.3AlaVal: 5.3 ± 0.029
1.27AlaTrp: 1.27 ± 0.015
2.305AlaTyr: 2.305 ± 0.022
0.0AlaXaa: 0.0 ± 0.0
Cys
1.075CysAla: 1.075 ± 0.014
0.304CysCys: 0.304 ± 0.008
0.693CysAsp: 0.693 ± 0.01
0.622CysGlu: 0.622 ± 0.01
0.578CysPhe: 0.578 ± 0.009
1.029CysGly: 1.029 ± 0.018
0.344CysHis: 0.344 ± 0.007
0.789CysIle: 0.789 ± 0.012
0.559CysLys: 0.559 ± 0.011
1.292CysLeu: 1.292 ± 0.016
0.302CysMet: 0.302 ± 0.006
0.466CysAsn: 0.466 ± 0.009
0.702CysPro: 0.702 ± 0.011
0.484CysGln: 0.484 ± 0.009
0.792CysArg: 0.792 ± 0.012
1.016CysSer: 1.016 ± 0.014
0.807CysThr: 0.807 ± 0.011
0.842CysVal: 0.842 ± 0.013
0.235CysTrp: 0.235 ± 0.006
0.394CysTyr: 0.394 ± 0.008
0.0CysXaa: 0.0 ± 0.0
Asp
4.83AspAla: 4.83 ± 0.034
0.652AspCys: 0.652 ± 0.011
4.001AspAsp: 4.001 ± 0.034
4.226AspGlu: 4.226 ± 0.036
2.287AspPhe: 2.287 ± 0.018
3.83AspGly: 3.83 ± 0.028
1.202AspHis: 1.202 ± 0.016
3.054AspIle: 3.054 ± 0.023
2.369AspLys: 2.369 ± 0.019
4.906AspLeu: 4.906 ± 0.03
1.251AspMet: 1.251 ± 0.014
1.794AspAsn: 1.794 ± 0.017
3.144AspPro: 3.144 ± 0.024
1.805AspGln: 1.805 ± 0.017
2.909AspArg: 2.909 ± 0.026
3.936AspSer: 3.936 ± 0.03
2.977AspThr: 2.977 ± 0.021
3.712AspVal: 3.712 ± 0.025
0.953AspTrp: 0.953 ± 0.012
1.588AspTyr: 1.588 ± 0.015
0.0AspXaa: 0.0 ± 0.0
Glu
5.188GluAla: 5.188 ± 0.036
0.656GluCys: 0.656 ± 0.01
4.116GluAsp: 4.116 ± 0.035
5.086GluGlu: 5.086 ± 0.046
1.907GluPhe: 1.907 ± 0.017
3.783GluGly: 3.783 ± 0.027
1.484GluHis: 1.484 ± 0.016
2.951GluIle: 2.951 ± 0.022
3.676GluLys: 3.676 ± 0.029
5.061GluLeu: 5.061 ± 0.034
1.397GluMet: 1.397 ± 0.015
2.202GluAsn: 2.202 ± 0.02
2.69GluPro: 2.69 ± 0.029
2.543GluGln: 2.543 ± 0.021
3.876GluArg: 3.876 ± 0.03
3.976GluSer: 3.976 ± 0.03
3.341GluThr: 3.341 ± 0.02
3.497GluVal: 3.497 ± 0.024
0.907GluTrp: 0.907 ± 0.013
1.702GluTyr: 1.702 ± 0.018
0.0GluXaa: 0.0 ± 0.0
Phe
3.304PheAla: 3.304 ± 0.022
0.595PheCys: 0.595 ± 0.009
2.314PheAsp: 2.314 ± 0.02
2.248PheGlu: 2.248 ± 0.018
1.694PhePhe: 1.694 ± 0.018
2.968PheGly: 2.968 ± 0.027
0.915PheHis: 0.915 ± 0.011
1.873PheIle: 1.873 ± 0.019
1.63PheLys: 1.63 ± 0.017
3.541PheLeu: 3.541 ± 0.026
0.776PheMet: 0.776 ± 0.01
1.486PheAsn: 1.486 ± 0.016
2.019PhePro: 2.019 ± 0.019
1.427PheGln: 1.427 ± 0.015
1.975PheArg: 1.975 ± 0.016
3.038PheSer: 3.038 ± 0.023
2.287PheThr: 2.287 ± 0.019
2.462PheVal: 2.462 ± 0.022
0.718PheTrp: 0.718 ± 0.011
1.112PheTyr: 1.112 ± 0.014
0.0PheXaa: 0.0 ± 0.0
Gly
5.32GlyAla: 5.32 ± 0.032
0.94GlyCys: 0.94 ± 0.013
3.421GlyAsp: 3.421 ± 0.028
3.612GlyGlu: 3.612 ± 0.027
2.897GlyPhe: 2.897 ± 0.024
5.553GlyGly: 5.553 ± 0.044
1.643GlyHis: 1.643 ± 0.017
3.594GlyIle: 3.594 ± 0.023
3.503GlyLys: 3.503 ± 0.026
6.004GlyLeu: 6.004 ± 0.034
1.613GlyMet: 1.613 ± 0.017
2.541GlyAsn: 2.541 ± 0.026
3.245GlyPro: 3.245 ± 0.026
2.485GlyGln: 2.485 ± 0.021
4.049GlyArg: 4.049 ± 0.03
5.382GlySer: 5.382 ± 0.033
4.038GlyThr: 4.038 ± 0.027
4.394GlyVal: 4.394 ± 0.027
1.236GlyTrp: 1.236 ± 0.014
2.128GlyTyr: 2.128 ± 0.018
0.0GlyXaa: 0.0 ± 0.0
His
1.972HisAla: 1.972 ± 0.019
0.377HisCys: 0.377 ± 0.009
1.349HisAsp: 1.349 ± 0.015
1.377HisGlu: 1.377 ± 0.015
0.994HisPhe: 0.994 ± 0.011
1.735HisGly: 1.735 ± 0.015
0.844HisHis: 0.844 ± 0.015
1.305HisIle: 1.305 ± 0.014
0.963HisLys: 0.963 ± 0.013
2.291HisLeu: 2.291 ± 0.019
0.519HisMet: 0.519 ± 0.009
0.866HisAsn: 0.866 ± 0.012
1.61HisPro: 1.61 ± 0.016
0.985HisGln: 0.985 ± 0.012
1.519HisArg: 1.519 ± 0.017
1.864HisSer: 1.864 ± 0.02
1.387HisThr: 1.387 ± 0.016
1.505HisVal: 1.505 ± 0.017
0.392HisTrp: 0.392 ± 0.008
0.71HisTyr: 0.71 ± 0.011
0.0HisXaa: 0.0 ± 0.0
Ile
4.509IleAla: 4.509 ± 0.029
0.792IleCys: 0.792 ± 0.012
2.863IleAsp: 2.863 ± 0.021
2.927IleGlu: 2.927 ± 0.025
2.061IlePhe: 2.061 ± 0.018
3.296IleGly: 3.296 ± 0.025
1.224IleHis: 1.224 ± 0.013
2.613IleIle: 2.613 ± 0.022
2.243IleLys: 2.243 ± 0.02
4.624IleLeu: 4.624 ± 0.033
1.029IleMet: 1.029 ± 0.012
1.789IleAsn: 1.789 ± 0.015
3.149IlePro: 3.149 ± 0.024
1.922IleGln: 1.922 ± 0.017
2.786IleArg: 2.786 ± 0.021
3.845IleSer: 3.845 ± 0.026
2.999IleThr: 2.999 ± 0.024
3.349IleVal: 3.349 ± 0.024
0.796IleTrp: 0.796 ± 0.011
1.466IleTyr: 1.466 ± 0.014
0.0IleXaa: 0.0 ± 0.0
Lys
4.288LysAla: 4.288 ± 0.031
0.559LysCys: 0.559 ± 0.009
2.923LysAsp: 2.923 ± 0.022
3.401LysGlu: 3.401 ± 0.027
1.514LysPhe: 1.514 ± 0.013
3.039LysGly: 3.039 ± 0.021
1.224LysHis: 1.224 ± 0.015
2.308LysIle: 2.308 ± 0.021
3.353LysLys: 3.353 ± 0.035
4.032LysLeu: 4.032 ± 0.028
0.998LysMet: 0.998 ± 0.012
1.808LysAsn: 1.808 ± 0.016
2.719LysPro: 2.719 ± 0.02
1.829LysGln: 1.829 ± 0.018
3.409LysArg: 3.409 ± 0.028
3.527LysSer: 3.527 ± 0.028
2.873LysThr: 2.873 ± 0.021
2.859LysVal: 2.859 ± 0.023
0.748LysTrp: 0.748 ± 0.011
1.425LysTyr: 1.425 ± 0.016
0.0LysXaa: 0.0 ± 0.0
Leu
7.87LeuAla: 7.87 ± 0.041
1.295LeuCys: 1.295 ± 0.016
5.078LeuAsp: 5.078 ± 0.031
5.438LeuGlu: 5.438 ± 0.039
3.414LeuPhe: 3.414 ± 0.025
5.88LeuGly: 5.88 ± 0.032
2.376LeuHis: 2.376 ± 0.022
4.0LeuIle: 4.0 ± 0.027
4.264LeuLys: 4.264 ± 0.034
8.411LeuLeu: 8.411 ± 0.051
1.756LeuMet: 1.756 ± 0.016
3.211LeuAsn: 3.211 ± 0.023
5.597LeuPro: 5.597 ± 0.029
3.892LeuGln: 3.892 ± 0.028
5.692LeuArg: 5.692 ± 0.031
7.224LeuSer: 7.224 ± 0.035
4.809LeuThr: 4.809 ± 0.029
5.391LeuVal: 5.391 ± 0.029
1.286LeuTrp: 1.286 ± 0.015
2.386LeuTyr: 2.386 ± 0.02
0.0LeuXaa: 0.0 ± 0.0
Met
2.101MetAla: 2.101 ± 0.017
0.272MetCys: 0.272 ± 0.007
1.198MetAsp: 1.198 ± 0.013
1.198MetGlu: 1.198 ± 0.014
0.789MetPhe: 0.789 ± 0.011
1.431MetGly: 1.431 ± 0.016
0.529MetHis: 0.529 ± 0.009
1.006MetIle: 1.006 ± 0.013
1.002MetLys: 1.002 ± 0.013
1.878MetLeu: 1.878 ± 0.019
0.556MetMet: 0.556 ± 0.009
0.803MetAsn: 0.803 ± 0.011
1.274MetPro: 1.274 ± 0.014
0.876MetGln: 0.876 ± 0.012
1.296MetArg: 1.296 ± 0.015
1.833MetSer: 1.833 ± 0.018
1.262MetThr: 1.262 ± 0.015
1.258MetVal: 1.258 ± 0.015
0.291MetTrp: 0.291 ± 0.007
0.566MetTyr: 0.566 ± 0.01
0.0MetXaa: 0.0 ± 0.0
Asn
3.282AsnAla: 3.282 ± 0.023
0.472AsnCys: 0.472 ± 0.009
1.973AsnAsp: 1.973 ± 0.017
2.019AsnGlu: 2.019 ± 0.018
1.438AsnPhe: 1.438 ± 0.015
3.012AsnGly: 3.012 ± 0.022
0.86AsnHis: 0.86 ± 0.011
2.141AsnIle: 2.141 ± 0.02
1.564AsnLys: 1.564 ± 0.014
3.284AsnLeu: 3.284 ± 0.023
0.853AsnMet: 0.853 ± 0.012
1.469AsnAsn: 1.469 ± 0.018
2.427AsnPro: 2.427 ± 0.024
1.347AsnGln: 1.347 ± 0.014
1.869AsnArg: 1.869 ± 0.02
2.686AsnSer: 2.686 ± 0.021
2.271AsnThr: 2.271 ± 0.019
2.397AsnVal: 2.397 ± 0.019
0.6AsnTrp: 0.6 ± 0.011
1.062AsnTyr: 1.062 ± 0.012
0.0AsnXaa: 0.0 ± 0.0
Pro
5.248ProAla: 5.248 ± 0.034
0.574ProCys: 0.574 ± 0.011
3.03ProAsp: 3.03 ± 0.019
3.626ProGlu: 3.626 ± 0.028
2.119ProPhe: 2.119 ± 0.021
3.779ProGly: 3.779 ± 0.031
1.387ProHis: 1.387 ± 0.014
2.648ProIle: 2.648 ± 0.022
2.758ProLys: 2.758 ± 0.022
4.777ProLeu: 4.777 ± 0.03
1.072ProMet: 1.072 ± 0.016
2.288ProAsn: 2.288 ± 0.019
5.011ProPro: 5.011 ± 0.059
2.559ProGln: 2.559 ± 0.028
3.399ProArg: 3.399 ± 0.028
5.915ProSer: 5.915 ± 0.038
4.167ProThr: 4.167 ± 0.032
3.443ProVal: 3.443 ± 0.027
0.789ProTrp: 0.789 ± 0.013
1.559ProTyr: 1.559 ± 0.017
0.0ProXaa: 0.0 ± 0.0
Gln
3.462GlnAla: 3.462 ± 0.026
0.505GlnCys: 0.505 ± 0.009
2.133GlnAsp: 2.133 ± 0.017
2.339GlnGlu: 2.339 ± 0.022
1.333GlnPhe: 1.333 ± 0.013
2.418GlnGly: 2.418 ± 0.023
1.195GlnHis: 1.195 ± 0.015
1.947GlnIle: 1.947 ± 0.02
1.983GlnLys: 1.983 ± 0.019
3.413GlnLeu: 3.413 ± 0.025
0.852GlnMet: 0.852 ± 0.012
1.622GlnAsn: 1.622 ± 0.018
2.524GlnPro: 2.524 ± 0.024
2.395GlnGln: 2.395 ± 0.041
2.708GlnArg: 2.708 ± 0.023
3.179GlnSer: 3.179 ± 0.026
2.346GlnThr: 2.346 ± 0.02
2.151GlnVal: 2.151 ± 0.017
0.611GlnTrp: 0.611 ± 0.009
1.228GlnTyr: 1.228 ± 0.013
0.0GlnXaa: 0.0 ± 0.0
Arg
4.716ArgAla: 4.716 ± 0.035
0.801ArgCys: 0.801 ± 0.012
3.213ArgAsp: 3.213 ± 0.028
3.607ArgGlu: 3.607 ± 0.027
2.159ArgPhe: 2.159 ± 0.016
3.709ArgGly: 3.709 ± 0.032
1.535ArgHis: 1.535 ± 0.017
2.981ArgIle: 2.981 ± 0.022
3.446ArgLys: 3.446 ± 0.025
5.365ArgLeu: 5.365 ± 0.031
1.328ArgMet: 1.328 ± 0.014
2.352ArgAsn: 2.352 ± 0.018
3.438ArgPro: 3.438 ± 0.024
2.527ArgGln: 2.527 ± 0.021
4.931ArgArg: 4.931 ± 0.041
4.701ArgSer: 4.701 ± 0.035
3.461ArgThr: 3.461 ± 0.024
3.345ArgVal: 3.345 ± 0.026
0.98ArgTrp: 0.98 ± 0.012
1.697ArgTyr: 1.697 ± 0.016
0.0ArgXaa: 0.0 ± 0.0
Ser
6.576SerAla: 6.576 ± 0.036
0.957SerCys: 0.957 ± 0.012
4.024SerAsp: 4.024 ± 0.024
3.985SerGlu: 3.985 ± 0.028
3.101SerPhe: 3.101 ± 0.02
5.26SerGly: 5.26 ± 0.028
1.888SerHis: 1.888 ± 0.018
4.154SerIle: 4.154 ± 0.027
3.767SerLys: 3.767 ± 0.026
7.088SerLeu: 7.088 ± 0.037
1.692SerMet: 1.692 ± 0.018
3.072SerAsn: 3.072 ± 0.024
5.375SerPro: 5.375 ± 0.047
3.177SerGln: 3.177 ± 0.027
4.892SerArg: 4.892 ± 0.033
8.421SerSer: 8.421 ± 0.073
5.696SerThr: 5.696 ± 0.032
4.481SerVal: 4.481 ± 0.026
1.19SerTrp: 1.19 ± 0.012
2.104SerTyr: 2.104 ± 0.018
0.0SerXaa: 0.0 ± 0.0
Thr
5.276ThrAla: 5.276 ± 0.029
0.854ThrCys: 0.854 ± 0.012
2.774ThrAsp: 2.774 ± 0.019
3.013ThrGlu: 3.013 ± 0.023
2.427ThrPhe: 2.427 ± 0.017
4.043ThrGly: 4.043 ± 0.029
1.368ThrHis: 1.368 ± 0.015
3.267ThrIle: 3.267 ± 0.022
2.717ThrLys: 2.717 ± 0.023
5.498ThrLeu: 5.498 ± 0.032
1.201ThrMet: 1.201 ± 0.014
2.175ThrAsn: 2.175 ± 0.021
4.425ThrPro: 4.425 ± 0.039
2.25ThrGln: 2.25 ± 0.022
3.228ThrArg: 3.228 ± 0.025
5.378ThrSer: 5.378 ± 0.034
4.362ThrThr: 4.362 ± 0.036
3.662ThrVal: 3.662 ± 0.024
0.969ThrTrp: 0.969 ± 0.011
1.711ThrTyr: 1.711 ± 0.015
0.0ThrXaa: 0.0 ± 0.0
Val
5.254ValAla: 5.254 ± 0.031
0.875ValCys: 0.875 ± 0.012
3.605ValAsp: 3.605 ± 0.026
3.835ValGlu: 3.835 ± 0.026
2.485ValPhe: 2.485 ± 0.023
4.058ValGly: 4.058 ± 0.026
1.476ValHis: 1.476 ± 0.012
2.931ValIle: 2.931 ± 0.022
2.882ValLys: 2.882 ± 0.022
5.681ValLeu: 5.681 ± 0.033
1.266ValMet: 1.266 ± 0.015
2.18ValAsn: 2.18 ± 0.019
3.562ValPro: 3.562 ± 0.026
2.504ValGln: 2.504 ± 0.02
3.39ValArg: 3.39 ± 0.024
4.504ValSer: 4.504 ± 0.025
3.447ValThr: 3.447 ± 0.025
4.289ValVal: 4.289 ± 0.029
0.943ValTrp: 0.943 ± 0.013
1.766ValTyr: 1.766 ± 0.018
0.0ValXaa: 0.0 ± 0.0
Trp
1.21TrpAla: 1.21 ± 0.016
0.234TrpCys: 0.234 ± 0.006
0.931TrpAsp: 0.931 ± 0.012
0.887TrpGlu: 0.887 ± 0.012
0.605TrpPhe: 0.605 ± 0.009
1.001TrpGly: 1.001 ± 0.015
0.399TrpHis: 0.399 ± 0.008
0.865TrpIle: 0.865 ± 0.012
0.857TrpLys: 0.857 ± 0.012
1.42TrpLeu: 1.42 ± 0.016
0.39TrpMet: 0.39 ± 0.008
0.694TrpAsn: 0.694 ± 0.01
0.679TrpPro: 0.679 ± 0.009
0.607TrpGln: 0.607 ± 0.01
1.022TrpArg: 1.022 ± 0.012
1.148TrpSer: 1.148 ± 0.012
1.002TrpThr: 1.002 ± 0.013
0.944TrpVal: 0.944 ± 0.011
0.303TrpTrp: 0.303 ± 0.008
0.493TrpTyr: 0.493 ± 0.008
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.299TyrAla: 2.299 ± 0.021
0.453TyrCys: 0.453 ± 0.009
1.671TyrAsp: 1.671 ± 0.016
1.601TyrGlu: 1.601 ± 0.017
1.254TyrPhe: 1.254 ± 0.014
2.078TyrGly: 2.078 ± 0.02
0.763TyrHis: 0.763 ± 0.011
1.451TyrIle: 1.451 ± 0.016
1.155TyrLys: 1.155 ± 0.014
2.674TyrLeu: 2.674 ± 0.021
0.636TyrMet: 0.636 ± 0.01
1.14TyrAsn: 1.14 ± 0.013
1.564TyrPro: 1.564 ± 0.017
1.156TyrGln: 1.156 ± 0.013
1.614TyrArg: 1.614 ± 0.017
2.046TyrSer: 2.046 ± 0.018
1.722TyrThr: 1.722 ± 0.017
1.655TyrVal: 1.655 ± 0.016
0.471TyrTrp: 0.471 ± 0.009
0.939TyrTyr: 0.939 ± 0.014
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 14984 proteins (6812781 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski