Amino acid dipepetide frequency for Rouxiella badensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.441AlaAla: 10.441 ± 0.117
1.082AlaCys: 1.082 ± 0.028
5.038AlaAsp: 5.038 ± 0.064
6.064AlaGlu: 6.064 ± 0.076
3.666AlaPhe: 3.666 ± 0.054
7.524AlaGly: 7.524 ± 0.078
1.875AlaHis: 1.875 ± 0.038
5.755AlaIle: 5.755 ± 0.071
4.067AlaLys: 4.067 ± 0.07
11.94AlaLeu: 11.94 ± 0.097
2.88AlaMet: 2.88 ± 0.045
3.205AlaAsn: 3.205 ± 0.051
3.671AlaPro: 3.671 ± 0.056
4.373AlaGln: 4.373 ± 0.064
5.15AlaArg: 5.15 ± 0.068
5.825AlaSer: 5.825 ± 0.072
4.834AlaThr: 4.834 ± 0.073
6.965AlaVal: 6.965 ± 0.077
1.321AlaTrp: 1.321 ± 0.033
2.317AlaTyr: 2.317 ± 0.036
0.0AlaXaa: 0.0 ± 0.0
Cys
0.885CysAla: 0.885 ± 0.026
0.167CysCys: 0.167 ± 0.012
0.512CysAsp: 0.512 ± 0.021
0.538CysGlu: 0.538 ± 0.019
0.436CysPhe: 0.436 ± 0.017
1.032CysGly: 1.032 ± 0.029
0.335CysHis: 0.335 ± 0.018
0.527CysIle: 0.527 ± 0.02
0.306CysLys: 0.306 ± 0.015
1.029CysLeu: 1.029 ± 0.024
0.206CysMet: 0.206 ± 0.013
0.294CysAsn: 0.294 ± 0.014
0.454CysPro: 0.454 ± 0.018
0.432CysGln: 0.432 ± 0.019
0.559CysArg: 0.559 ± 0.019
0.638CysSer: 0.638 ± 0.022
0.454CysThr: 0.454 ± 0.018
0.722CysVal: 0.722 ± 0.02
0.148CysTrp: 0.148 ± 0.011
0.304CysTyr: 0.304 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
5.118AspAla: 5.118 ± 0.07
0.493AspCys: 0.493 ± 0.02
2.671AspAsp: 2.671 ± 0.05
3.225AspGlu: 3.225 ± 0.047
2.228AspPhe: 2.228 ± 0.041
3.634AspGly: 3.634 ± 0.057
0.948AspHis: 0.948 ± 0.027
3.341AspIle: 3.341 ± 0.051
2.503AspLys: 2.503 ± 0.048
4.667AspLeu: 4.667 ± 0.071
1.297AspMet: 1.297 ± 0.033
2.091AspAsn: 2.091 ± 0.045
2.299AspPro: 2.299 ± 0.039
1.643AspGln: 1.643 ± 0.039
2.608AspArg: 2.608 ± 0.042
2.996AspSer: 2.996 ± 0.052
2.438AspThr: 2.438 ± 0.049
3.764AspVal: 3.764 ± 0.053
0.855AspTrp: 0.855 ± 0.024
1.808AspTyr: 1.808 ± 0.042
0.0AspXaa: 0.0 ± 0.0
Glu
5.238GluAla: 5.238 ± 0.064
0.406GluCys: 0.406 ± 0.017
2.458GluAsp: 2.458 ± 0.048
3.188GluGlu: 3.188 ± 0.055
1.969GluPhe: 1.969 ± 0.039
3.64GluGly: 3.64 ± 0.055
1.362GluHis: 1.362 ± 0.03
3.354GluIle: 3.354 ± 0.051
3.148GluLys: 3.148 ± 0.06
5.849GluLeu: 5.849 ± 0.068
1.641GluMet: 1.641 ± 0.035
2.312GluAsn: 2.312 ± 0.044
2.062GluPro: 2.062 ± 0.036
3.331GluGln: 3.331 ± 0.053
3.483GluArg: 3.483 ± 0.061
3.189GluSer: 3.189 ± 0.052
2.811GluThr: 2.811 ± 0.048
3.917GluVal: 3.917 ± 0.052
0.734GluTrp: 0.734 ± 0.026
1.375GluTyr: 1.375 ± 0.029
0.0GluXaa: 0.0 ± 0.0
Phe
3.771PheAla: 3.771 ± 0.057
0.54PheCys: 0.54 ± 0.019
2.289PheAsp: 2.289 ± 0.045
1.888PheGlu: 1.888 ± 0.043
1.691PhePhe: 1.691 ± 0.042
3.36PheGly: 3.36 ± 0.056
0.826PheHis: 0.826 ± 0.029
2.612PheIle: 2.612 ± 0.046
1.405PheLys: 1.405 ± 0.032
3.369PheLeu: 3.369 ± 0.059
1.02PheMet: 1.02 ± 0.026
1.782PheAsn: 1.782 ± 0.03
1.655PhePro: 1.655 ± 0.038
1.162PheGln: 1.162 ± 0.025
1.797PheArg: 1.797 ± 0.038
3.308PheSer: 3.308 ± 0.052
2.396PheThr: 2.396 ± 0.042
2.507PheVal: 2.507 ± 0.044
0.569PheTrp: 0.569 ± 0.02
1.267PheTyr: 1.267 ± 0.03
0.0PheXaa: 0.0 ± 0.0
Gly
6.305GlyAla: 6.305 ± 0.073
0.961GlyCys: 0.961 ± 0.027
3.49GlyAsp: 3.49 ± 0.058
4.453GlyGlu: 4.453 ± 0.053
3.332GlyPhe: 3.332 ± 0.056
5.528GlyGly: 5.528 ± 0.08
1.694GlyHis: 1.694 ± 0.041
5.076GlyIle: 5.076 ± 0.065
4.039GlyLys: 4.039 ± 0.061
7.883GlyLeu: 7.883 ± 0.091
2.31GlyMet: 2.31 ± 0.04
2.687GlyAsn: 2.687 ± 0.047
2.25GlyPro: 2.25 ± 0.045
3.083GlyGln: 3.083 ± 0.053
3.796GlyArg: 3.796 ± 0.057
4.402GlySer: 4.402 ± 0.059
3.824GlyThr: 3.824 ± 0.053
5.823GlyVal: 5.823 ± 0.072
1.266GlyTrp: 1.266 ± 0.03
2.622GlyTyr: 2.622 ± 0.051
0.0GlyXaa: 0.0 ± 0.0
His
2.009HisAla: 2.009 ± 0.036
0.32HisCys: 0.32 ± 0.013
1.14HisAsp: 1.14 ± 0.027
1.078HisGlu: 1.078 ± 0.027
1.053HisPhe: 1.053 ± 0.027
1.728HisGly: 1.728 ± 0.036
0.736HisHis: 0.736 ± 0.025
1.235HisIle: 1.235 ± 0.027
0.799HisLys: 0.799 ± 0.024
2.265HisLeu: 2.265 ± 0.044
0.519HisMet: 0.519 ± 0.017
0.8HisAsn: 0.8 ± 0.022
1.406HisPro: 1.406 ± 0.036
1.248HisGln: 1.248 ± 0.036
1.302HisArg: 1.302 ± 0.031
1.323HisSer: 1.323 ± 0.03
1.018HisThr: 1.018 ± 0.029
1.258HisVal: 1.258 ± 0.03
0.44HisTrp: 0.44 ± 0.017
0.845HisTyr: 0.845 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
6.586IleAla: 6.586 ± 0.082
0.592IleCys: 0.592 ± 0.023
3.633IleAsp: 3.633 ± 0.057
3.5IleGlu: 3.5 ± 0.058
2.15IlePhe: 2.15 ± 0.047
4.825IleGly: 4.825 ± 0.075
1.129IleHis: 1.129 ± 0.021
3.342IleIle: 3.342 ± 0.058
2.455IleLys: 2.455 ± 0.046
5.085IleLeu: 5.085 ± 0.075
1.246IleMet: 1.246 ± 0.032
2.526IleAsn: 2.526 ± 0.046
2.681IlePro: 2.681 ± 0.043
1.857IleGln: 1.857 ± 0.03
2.821IleArg: 2.821 ± 0.05
3.992IleSer: 3.992 ± 0.056
3.417IleThr: 3.417 ± 0.051
4.013IleVal: 4.013 ± 0.064
0.603IleTrp: 0.603 ± 0.022
1.52IleTyr: 1.52 ± 0.036
0.0IleXaa: 0.0 ± 0.0
Lys
4.211LysAla: 4.211 ± 0.063
0.219LysCys: 0.219 ± 0.014
2.171LysAsp: 2.171 ± 0.044
2.364LysGlu: 2.364 ± 0.052
1.206LysPhe: 1.206 ± 0.031
2.961LysGly: 2.961 ± 0.048
0.916LysHis: 0.916 ± 0.025
2.57LysIle: 2.57 ± 0.047
2.289LysLys: 2.289 ± 0.047
4.375LysLeu: 4.375 ± 0.056
1.3LysMet: 1.3 ± 0.03
1.787LysAsn: 1.787 ± 0.046
2.146LysPro: 2.146 ± 0.045
2.076LysGln: 2.076 ± 0.042
2.506LysArg: 2.506 ± 0.042
2.538LysSer: 2.538 ± 0.044
2.64LysThr: 2.64 ± 0.041
3.114LysVal: 3.114 ± 0.052
0.439LysTrp: 0.439 ± 0.018
1.067LysTyr: 1.067 ± 0.028
0.0LysXaa: 0.0 ± 0.0
Leu
11.457LeuAla: 11.457 ± 0.098
1.256LeuCys: 1.256 ± 0.031
5.571LeuAsp: 5.571 ± 0.061
5.522LeuGlu: 5.522 ± 0.075
4.298LeuPhe: 4.298 ± 0.065
7.963LeuGly: 7.963 ± 0.096
2.321LeuHis: 2.321 ± 0.042
5.983LeuIle: 5.983 ± 0.079
4.642LeuLys: 4.642 ± 0.068
12.199LeuLeu: 12.199 ± 0.14
2.945LeuMet: 2.945 ± 0.055
4.229LeuAsn: 4.229 ± 0.051
5.829LeuPro: 5.829 ± 0.078
4.339LeuGln: 4.339 ± 0.064
6.015LeuArg: 6.015 ± 0.07
8.113LeuSer: 8.113 ± 0.09
6.427LeuThr: 6.427 ± 0.075
7.321LeuVal: 7.321 ± 0.089
1.287LeuTrp: 1.287 ± 0.032
2.672LeuTyr: 2.672 ± 0.04
0.0LeuXaa: 0.0 ± 0.0
Met
2.85MetAla: 2.85 ± 0.044
0.19MetCys: 0.19 ± 0.013
1.124MetAsp: 1.124 ± 0.032
1.09MetGlu: 1.09 ± 0.03
0.885MetPhe: 0.885 ± 0.025
1.865MetGly: 1.865 ± 0.037
0.52MetHis: 0.52 ± 0.021
1.471MetIle: 1.471 ± 0.034
1.346MetLys: 1.346 ± 0.029
3.088MetLeu: 3.088 ± 0.051
0.817MetMet: 0.817 ± 0.026
1.046MetAsn: 1.046 ± 0.027
1.375MetPro: 1.375 ± 0.033
1.201MetGln: 1.201 ± 0.036
1.414MetArg: 1.414 ± 0.031
2.008MetSer: 2.008 ± 0.042
1.741MetThr: 1.741 ± 0.034
1.844MetVal: 1.844 ± 0.035
0.25MetTrp: 0.25 ± 0.013
0.479MetTyr: 0.479 ± 0.02
0.0MetXaa: 0.0 ± 0.0
Asn
3.58AsnAla: 3.58 ± 0.054
0.3AsnCys: 0.3 ± 0.015
1.914AsnAsp: 1.914 ± 0.037
1.804AsnGlu: 1.804 ± 0.04
1.393AsnPhe: 1.393 ± 0.032
2.894AsnGly: 2.894 ± 0.05
0.827AsnHis: 0.827 ± 0.025
2.37AsnIle: 2.37 ± 0.046
1.588AsnLys: 1.588 ± 0.038
3.757AsnLeu: 3.757 ± 0.057
0.859AsnMet: 0.859 ± 0.026
1.599AsnAsn: 1.599 ± 0.034
2.156AsnPro: 2.156 ± 0.038
1.738AsnGln: 1.738 ± 0.041
1.868AsnArg: 1.868 ± 0.04
1.996AsnSer: 1.996 ± 0.046
1.934AsnThr: 1.934 ± 0.042
2.523AsnVal: 2.523 ± 0.04
0.548AsnTrp: 0.548 ± 0.022
1.148AsnTyr: 1.148 ± 0.032
0.0AsnXaa: 0.0 ± 0.0
Pro
4.607ProAla: 4.607 ± 0.054
0.343ProCys: 0.343 ± 0.018
2.652ProAsp: 2.652 ± 0.047
3.342ProGlu: 3.342 ± 0.05
1.852ProPhe: 1.852 ± 0.042
3.274ProGly: 3.274 ± 0.053
1.048ProHis: 1.048 ± 0.024
2.131ProIle: 2.131 ± 0.041
1.725ProLys: 1.725 ± 0.037
5.281ProLeu: 5.281 ± 0.06
1.154ProMet: 1.154 ± 0.029
1.431ProAsn: 1.431 ± 0.03
1.661ProPro: 1.661 ± 0.04
2.387ProGln: 2.387 ± 0.039
2.01ProArg: 2.01 ± 0.04
2.594ProSer: 2.594 ± 0.045
2.301ProThr: 2.301 ± 0.037
3.789ProVal: 3.789 ± 0.051
0.685ProTrp: 0.685 ± 0.024
1.32ProTyr: 1.32 ± 0.031
0.0ProXaa: 0.0 ± 0.0
Gln
4.619GlnAla: 4.619 ± 0.068
0.336GlnCys: 0.336 ± 0.018
1.916GlnAsp: 1.916 ± 0.038
2.084GlnGlu: 2.084 ± 0.044
1.519GlnPhe: 1.519 ± 0.029
3.308GlnGly: 3.308 ± 0.053
1.261GlnHis: 1.261 ± 0.032
2.37GlnIle: 2.37 ± 0.042
1.842GlnLys: 1.842 ± 0.039
5.093GlnLeu: 5.093 ± 0.066
1.133GlnMet: 1.133 ± 0.025
1.469GlnAsn: 1.469 ± 0.036
2.292GlnPro: 2.292 ± 0.042
3.319GlnGln: 3.319 ± 0.084
3.061GlnArg: 3.061 ± 0.05
2.598GlnSer: 2.598 ± 0.043
2.197GlnThr: 2.197 ± 0.037
3.217GlnVal: 3.217 ± 0.051
0.69GlnTrp: 0.69 ± 0.026
1.155GlnTyr: 1.155 ± 0.027
0.0GlnXaa: 0.0 ± 0.0
Arg
4.572ArgAla: 4.572 ± 0.055
0.52ArgCys: 0.52 ± 0.019
2.733ArgAsp: 2.733 ± 0.05
3.533ArgGlu: 3.533 ± 0.051
2.434ArgPhe: 2.434 ± 0.039
3.339ArgGly: 3.339 ± 0.041
1.46ArgHis: 1.46 ± 0.031
3.293ArgIle: 3.293 ± 0.045
2.266ArgLys: 2.266 ± 0.039
6.526ArgLeu: 6.526 ± 0.09
1.428ArgMet: 1.428 ± 0.032
1.862ArgAsn: 1.862 ± 0.037
2.189ArgPro: 2.189 ± 0.042
3.011ArgGln: 3.011 ± 0.052
3.489ArgArg: 3.489 ± 0.054
2.891ArgSer: 2.891 ± 0.046
2.366ArgThr: 2.366 ± 0.044
3.835ArgVal: 3.835 ± 0.051
0.874ArgTrp: 0.874 ± 0.025
2.002ArgTyr: 2.002 ± 0.043
0.0ArgXaa: 0.0 ± 0.0
Ser
6.114SerAla: 6.114 ± 0.066
0.548SerCys: 0.548 ± 0.02
3.036SerAsp: 3.036 ± 0.053
3.306SerGlu: 3.306 ± 0.046
2.514SerPhe: 2.514 ± 0.04
5.547SerGly: 5.547 ± 0.063
1.527SerHis: 1.527 ± 0.034
3.316SerIle: 3.316 ± 0.052
2.289SerLys: 2.289 ± 0.045
7.557SerLeu: 7.557 ± 0.082
1.694SerMet: 1.694 ± 0.031
2.063SerAsn: 2.063 ± 0.042
2.878SerPro: 2.878 ± 0.048
2.77SerGln: 2.77 ± 0.05
3.477SerArg: 3.477 ± 0.048
4.154SerSer: 4.154 ± 0.063
3.208SerThr: 3.208 ± 0.054
4.51SerVal: 4.51 ± 0.061
0.929SerTrp: 0.929 ± 0.024
1.735SerTyr: 1.735 ± 0.034
0.0SerXaa: 0.0 ± 0.0
Thr
5.081ThrAla: 5.081 ± 0.059
0.431ThrCys: 0.431 ± 0.017
2.596ThrAsp: 2.596 ± 0.041
2.651ThrGlu: 2.651 ± 0.043
2.067ThrPhe: 2.067 ± 0.039
4.298ThrGly: 4.298 ± 0.048
1.319ThrHis: 1.319 ± 0.026
2.495ThrIle: 2.495 ± 0.046
1.5ThrLys: 1.5 ± 0.036
7.566ThrLeu: 7.566 ± 0.083
1.023ThrMet: 1.023 ± 0.026
1.427ThrAsn: 1.427 ± 0.036
3.391ThrPro: 3.391 ± 0.049
2.363ThrGln: 2.363 ± 0.042
2.972ThrArg: 2.972 ± 0.053
3.113ThrSer: 3.113 ± 0.055
2.761ThrThr: 2.761 ± 0.056
3.786ThrVal: 3.786 ± 0.053
0.644ThrTrp: 0.644 ± 0.023
1.327ThrTyr: 1.327 ± 0.034
0.0ThrXaa: 0.0 ± 0.0
Val
7.097ValAla: 7.097 ± 0.084
0.754ValCys: 0.754 ± 0.024
3.642ValAsp: 3.642 ± 0.05
4.091ValGlu: 4.091 ± 0.063
2.703ValPhe: 2.703 ± 0.048
5.019ValGly: 5.019 ± 0.064
1.272ValHis: 1.272 ± 0.029
4.674ValIle: 4.674 ± 0.072
3.228ValLys: 3.228 ± 0.058
7.471ValLeu: 7.471 ± 0.089
2.129ValMet: 2.129 ± 0.048
2.788ValAsn: 2.788 ± 0.042
3.083ValPro: 3.083 ± 0.049
2.459ValGln: 2.459 ± 0.046
3.506ValArg: 3.506 ± 0.047
4.911ValSer: 4.911 ± 0.046
4.176ValThr: 4.176 ± 0.056
5.673ValVal: 5.673 ± 0.07
0.891ValTrp: 0.891 ± 0.027
1.723ValTyr: 1.723 ± 0.038
0.0ValXaa: 0.0 ± 0.0
Trp
0.988TrpAla: 0.988 ± 0.025
0.162TrpCys: 0.162 ± 0.011
0.579TrpAsp: 0.579 ± 0.02
0.561TrpGlu: 0.561 ± 0.02
0.59TrpPhe: 0.59 ± 0.021
0.896TrpGly: 0.896 ± 0.028
0.421TrpHis: 0.421 ± 0.019
0.729TrpIle: 0.729 ± 0.025
0.53TrpLys: 0.53 ± 0.021
2.098TrpLeu: 2.098 ± 0.048
0.404TrpMet: 0.404 ± 0.018
0.451TrpAsn: 0.451 ± 0.019
0.61TrpPro: 0.61 ± 0.022
1.027TrpGln: 1.027 ± 0.027
0.92TrpArg: 0.92 ± 0.028
0.765TrpSer: 0.765 ± 0.025
0.531TrpThr: 0.531 ± 0.02
0.978TrpVal: 0.978 ± 0.027
0.205TrpTrp: 0.205 ± 0.013
0.38TrpTyr: 0.38 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.464TyrAla: 2.464 ± 0.044
0.356TyrCys: 0.356 ± 0.018
1.462TyrAsp: 1.462 ± 0.037
1.186TyrGlu: 1.186 ± 0.028
1.227TyrPhe: 1.227 ± 0.033
2.191TyrGly: 2.191 ± 0.045
0.724TyrHis: 0.724 ± 0.024
1.331TyrIle: 1.331 ± 0.029
0.929TyrLys: 0.929 ± 0.027
3.288TyrLeu: 3.288 ± 0.046
0.6TyrMet: 0.6 ± 0.019
0.945TyrAsn: 0.945 ± 0.027
1.499TyrPro: 1.499 ± 0.032
1.66TyrGln: 1.66 ± 0.04
1.867TyrArg: 1.867 ± 0.036
1.816TyrSer: 1.816 ± 0.041
1.336TyrThr: 1.336 ± 0.036
1.734TyrVal: 1.734 ± 0.032
0.449TyrTrp: 0.449 ± 0.02
0.882TyrTyr: 0.882 ± 0.029
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4260 proteins (1385808 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski