Amino acid dipepetide frequency for Anaerovibrio sp. JC8

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.295AlaAla: 8.295 ± 0.136	0.952AlaCys: 0.952 ± 0.035	5.066AlaAsp: 5.066 ± 0.077	6.033AlaGlu: 6.033 ± 0.111	3.099AlaPhe: 3.099 ± 0.068	6.733AlaGly: 6.733 ± 0.093	1.395AlaHis: 1.395 ± 0.038	5.666AlaIle: 5.666 ± 0.085	5.331AlaLys: 5.331 ± 0.081	7.232AlaLeu: 7.232 ± 0.103	2.837AlaMet: 2.837 ± 0.072	3.268AlaAsn: 3.268 ± 0.078	2.439AlaPro: 2.439 ± 0.069	2.769AlaGln: 2.769 ± 0.074	3.435AlaArg: 3.435 ± 0.07	4.295AlaSer: 4.295 ± 0.081	4.047AlaThr: 4.047 ± 0.087	6.711AlaVal: 6.711 ± 0.105	0.59AlaTrp: 0.59 ± 0.029	2.619AlaTyr: 2.619 ± 0.06	0.0AlaXaa: 0.0 ± 0.0
Cys	0.848CysAla: 0.848 ± 0.034	0.221CysCys: 0.221 ± 0.019	0.692CysAsp: 0.692 ± 0.03	0.666CysGlu: 0.666 ± 0.031	0.504CysPhe: 0.504 ± 0.026	1.227CysGly: 1.227 ± 0.05	0.288CysHis: 0.288 ± 0.022	0.836CysIle: 0.836 ± 0.034	0.612CysLys: 0.612 ± 0.034	1.058CysLeu: 1.058 ± 0.034	0.366CysMet: 0.366 ± 0.02	0.498CysAsn: 0.498 ± 0.029	0.615CysPro: 0.615 ± 0.034	0.436CysGln: 0.436 ± 0.023	0.621CysArg: 0.621 ± 0.03	0.729CysSer: 0.729 ± 0.032	0.552CysThr: 0.552 ± 0.024	0.773CysVal: 0.773 ± 0.033	0.104CysTrp: 0.104 ± 0.01	0.47CysTyr: 0.47 ± 0.026	0.0CysXaa: 0.0 ± 0.0
Asp	4.435AspAla: 4.435 ± 0.079	0.639AspCys: 0.639 ± 0.03	3.422AspAsp: 3.422 ± 0.076	4.494AspGlu: 4.494 ± 0.084	2.85AspPhe: 2.85 ± 0.067	4.561AspGly: 4.561 ± 0.094	0.906AspHis: 0.906 ± 0.051	5.054AspIle: 5.054 ± 0.079	4.367AspLys: 4.367 ± 0.077	4.44AspLeu: 4.44 ± 0.078	2.216AspMet: 2.216 ± 0.051	3.005AspAsn: 3.005 ± 0.065	1.687AspPro: 1.687 ± 0.054	1.431AspGln: 1.431 ± 0.048	2.553AspArg: 2.553 ± 0.061	3.165AspSer: 3.165 ± 0.064	3.094AspThr: 3.094 ± 0.061	4.35AspVal: 4.35 ± 0.079	0.553AspTrp: 0.553 ± 0.03	2.752AspTyr: 2.752 ± 0.067	0.0AspXaa: 0.0 ± 0.0
Glu	6.475GluAla: 6.475 ± 0.113	0.691GluCys: 0.691 ± 0.033	3.802GluAsp: 3.802 ± 0.075	5.618GluGlu: 5.618 ± 0.117	2.578GluPhe: 2.578 ± 0.062	4.224GluGly: 4.224 ± 0.078	1.307GluHis: 1.307 ± 0.04	5.226GluIle: 5.226 ± 0.104	5.624GluLys: 5.624 ± 0.094	6.833GluLeu: 6.833 ± 0.113	2.305GluMet: 2.305 ± 0.064	3.42GluAsn: 3.42 ± 0.071	1.943GluPro: 1.943 ± 0.069	2.655GluGln: 2.655 ± 0.075	3.018GluArg: 3.018 ± 0.066	3.101GluSer: 3.101 ± 0.067	2.94GluThr: 2.94 ± 0.055	4.504GluVal: 4.504 ± 0.093	0.608GluTrp: 0.608 ± 0.029	2.724GluTyr: 2.724 ± 0.062	0.0GluXaa: 0.0 ± 0.0
Phe	3.117PheAla: 3.117 ± 0.07	0.601PheCys: 0.601 ± 0.031	2.599PheAsp: 2.599 ± 0.057	2.154PheGlu: 2.154 ± 0.05	1.795PhePhe: 1.795 ± 0.054	3.072PheGly: 3.072 ± 0.065	0.705PheHis: 0.705 ± 0.032	2.735PheIle: 2.735 ± 0.071	2.192PheLys: 2.192 ± 0.05	3.336PheLeu: 3.336 ± 0.088	1.287PheMet: 1.287 ± 0.046	1.782PheAsn: 1.782 ± 0.053	1.249PhePro: 1.249 ± 0.045	1.091PheGln: 1.091 ± 0.033	1.47PheArg: 1.47 ± 0.045	2.661PheSer: 2.661 ± 0.059	2.327PheThr: 2.327 ± 0.054	2.743PheVal: 2.743 ± 0.065	0.392PheTrp: 0.392 ± 0.025	1.484PheTyr: 1.484 ± 0.042	0.0PheXaa: 0.0 ± 0.0
Gly	5.909GlyAla: 5.909 ± 0.113	1.118GlyCys: 1.118 ± 0.04	4.11GlyAsp: 4.11 ± 0.078	4.552GlyGlu: 4.552 ± 0.077	3.028GlyPhe: 3.028 ± 0.06	5.969GlyGly: 5.969 ± 0.203	1.471GlyHis: 1.471 ± 0.049	5.989GlyIle: 5.989 ± 0.111	5.291GlyLys: 5.291 ± 0.102	6.264GlyLeu: 6.264 ± 0.104	2.576GlyMet: 2.576 ± 0.069	3.352GlyAsn: 3.352 ± 0.09	1.628GlyPro: 1.628 ± 0.041	2.431GlyGln: 2.431 ± 0.07	3.304GlyArg: 3.304 ± 0.075	4.507GlySer: 4.507 ± 0.106	4.624GlyThr: 4.624 ± 0.127	5.446GlyVal: 5.446 ± 0.095	0.809GlyTrp: 0.809 ± 0.036	3.078GlyTyr: 3.078 ± 0.068	0.0GlyXaa: 0.0 ± 0.0
His	1.139HisAla: 1.139 ± 0.042	0.277HisCys: 0.277 ± 0.019	1.095HisAsp: 1.095 ± 0.045	1.137HisGlu: 1.137 ± 0.04	0.837HisPhe: 0.837 ± 0.04	1.435HisGly: 1.435 ± 0.045	0.493HisHis: 0.493 ± 0.044	1.512HisIle: 1.512 ± 0.045	1.024HisLys: 1.024 ± 0.036	1.483HisLeu: 1.483 ± 0.049	0.515HisMet: 0.515 ± 0.026	0.896HisAsn: 0.896 ± 0.035	0.928HisPro: 0.928 ± 0.036	0.578HisGln: 0.578 ± 0.028	0.908HisArg: 0.908 ± 0.039	1.058HisSer: 1.058 ± 0.038	0.956HisThr: 0.956 ± 0.034	1.223HisVal: 1.223 ± 0.037	0.193HisTrp: 0.193 ± 0.016	0.662HisTyr: 0.662 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	5.684IleAla: 5.684 ± 0.097	0.981IleCys: 0.981 ± 0.038	4.396IleAsp: 4.396 ± 0.091	4.448IleGlu: 4.448 ± 0.086	2.716IlePhe: 2.716 ± 0.061	5.314IleGly: 5.314 ± 0.095	1.267IleHis: 1.267 ± 0.042	5.305IleIle: 5.305 ± 0.101	4.779IleLys: 4.779 ± 0.08	5.988IleLeu: 5.988 ± 0.098	2.325IleMet: 2.325 ± 0.058	3.527IleAsn: 3.527 ± 0.08	2.919IlePro: 2.919 ± 0.066	2.11IleGln: 2.11 ± 0.055	3.239IleArg: 3.239 ± 0.072	4.541IleSer: 4.541 ± 0.074	4.072IleThr: 4.072 ± 0.077	4.896IleVal: 4.896 ± 0.089	0.51IleTrp: 0.51 ± 0.029	2.341IleTyr: 2.341 ± 0.063	0.0IleXaa: 0.0 ± 0.0
Lys	5.991LysAla: 5.991 ± 0.102	0.628LysCys: 0.628 ± 0.036	4.09LysAsp: 4.09 ± 0.073	5.366LysGlu: 5.366 ± 0.092	1.993LysPhe: 1.993 ± 0.057	4.345LysGly: 4.345 ± 0.069	1.163LysHis: 1.163 ± 0.039	4.431LysIle: 4.431 ± 0.088	5.298LysLys: 5.298 ± 0.098	5.779LysLeu: 5.779 ± 0.083	2.204LysMet: 2.204 ± 0.053	3.414LysAsn: 3.414 ± 0.085	2.214LysPro: 2.214 ± 0.061	2.135LysGln: 2.135 ± 0.052	2.864LysArg: 2.864 ± 0.065	3.25LysSer: 3.25 ± 0.065	3.232LysThr: 3.232 ± 0.068	4.631LysVal: 4.631 ± 0.087	0.641LysTrp: 0.641 ± 0.029	2.64LysTyr: 2.64 ± 0.067	0.0LysXaa: 0.0 ± 0.0
Leu	7.552LeuAla: 7.552 ± 0.124	1.118LeuCys: 1.118 ± 0.04	5.299LeuAsp: 5.299 ± 0.091	5.892LeuGlu: 5.892 ± 0.107	3.313LeuPhe: 3.313 ± 0.068	6.392LeuGly: 6.392 ± 0.115	1.554LeuHis: 1.554 ± 0.05	5.282LeuIle: 5.282 ± 0.092	6.088LeuLys: 6.088 ± 0.089	7.888LeuLeu: 7.888 ± 0.125	2.651LeuMet: 2.651 ± 0.057	3.918LeuAsn: 3.918 ± 0.068	3.723LeuPro: 3.723 ± 0.082	2.933LeuGln: 2.933 ± 0.073	3.818LeuArg: 3.818 ± 0.084	5.662LeuSer: 5.662 ± 0.089	4.929LeuThr: 4.929 ± 0.092	5.806LeuVal: 5.806 ± 0.096	0.675LeuTrp: 0.675 ± 0.029	2.837LeuTyr: 2.837 ± 0.067	0.0LeuXaa: 0.0 ± 0.0
Met	3.174MetAla: 3.174 ± 0.07	0.338MetCys: 0.338 ± 0.022	2.198MetAsp: 2.198 ± 0.059	2.412MetGlu: 2.412 ± 0.06	1.067MetPhe: 1.067 ± 0.042	2.52MetGly: 2.52 ± 0.057	0.475MetHis: 0.475 ± 0.023	1.857MetIle: 1.857 ± 0.05	2.135MetLys: 2.135 ± 0.046	3.001MetLeu: 3.001 ± 0.062	0.964MetMet: 0.964 ± 0.033	1.503MetAsn: 1.503 ± 0.05	1.34MetPro: 1.34 ± 0.049	1.06MetGln: 1.06 ± 0.036	1.34MetArg: 1.34 ± 0.052	1.91MetSer: 1.91 ± 0.057	1.888MetThr: 1.888 ± 0.051	2.272MetVal: 2.272 ± 0.054	0.225MetTrp: 0.225 ± 0.016	0.85MetTyr: 0.85 ± 0.034	0.0MetXaa: 0.0 ± 0.0
Asn	3.414AsnAla: 3.414 ± 0.069	0.553AsnCys: 0.553 ± 0.026	2.625AsnAsp: 2.625 ± 0.065	2.776AsnGlu: 2.776 ± 0.062	1.698AsnPhe: 1.698 ± 0.045	3.726AsnGly: 3.726 ± 0.112	0.868AsnHis: 0.868 ± 0.031	3.936AsnIle: 3.936 ± 0.065	2.987AsnLys: 2.987 ± 0.075	3.742AsnLeu: 3.742 ± 0.072	1.554AsnMet: 1.554 ± 0.052	2.452AsnAsn: 2.452 ± 0.077	2.068AsnPro: 2.068 ± 0.059	1.359AsnGln: 1.359 ± 0.045	1.94AsnArg: 1.94 ± 0.056	2.651AsnSer: 2.651 ± 0.066	2.488AsnThr: 2.488 ± 0.085	3.543AsnVal: 3.543 ± 0.088	0.462AsnTrp: 0.462 ± 0.025	1.746AsnTyr: 1.746 ± 0.053	0.0AsnXaa: 0.0 ± 0.0
Pro	2.783ProAla: 2.783 ± 0.074	0.389ProCys: 0.389 ± 0.023	2.426ProAsp: 2.426 ± 0.063	3.473ProGlu: 3.473 ± 0.081	1.417ProPhe: 1.417 ± 0.039	2.465ProGly: 2.465 ± 0.071	0.679ProHis: 0.679 ± 0.028	2.172ProIle: 2.172 ± 0.061	1.937ProLys: 1.937 ± 0.057	2.843ProLeu: 2.843 ± 0.061	1.099ProMet: 1.099 ± 0.036	1.377ProAsn: 1.377 ± 0.045	1.015ProPro: 1.015 ± 0.041	1.201ProGln: 1.201 ± 0.043	1.213ProArg: 1.213 ± 0.043	1.712ProSer: 1.712 ± 0.047	1.667ProThr: 1.667 ± 0.049	3.181ProVal: 3.181 ± 0.07	0.379ProTrp: 0.379 ± 0.024	1.368ProTyr: 1.368 ± 0.045	0.0ProXaa: 0.0 ± 0.0
Gln	2.936GlnAla: 2.936 ± 0.073	0.347GlnCys: 0.347 ± 0.024	1.715GlnAsp: 1.715 ± 0.056	2.633GlnGlu: 2.633 ± 0.064	1.041GlnPhe: 1.041 ± 0.036	2.209GlnGly: 2.209 ± 0.058	0.651GlnHis: 0.651 ± 0.029	2.142GlnIle: 2.142 ± 0.056	2.155GlnLys: 2.155 ± 0.059	3.133GlnLeu: 3.133 ± 0.072	1.027GlnMet: 1.027 ± 0.037	1.49GlnAsn: 1.49 ± 0.04	1.098GlnPro: 1.098 ± 0.04	1.574GlnGln: 1.574 ± 0.062	1.596GlnArg: 1.596 ± 0.05	1.68GlnSer: 1.68 ± 0.053	1.552GlnThr: 1.552 ± 0.051	2.169GlnVal: 2.169 ± 0.055	0.303GlnTrp: 0.303 ± 0.019	1.27GlnTyr: 1.27 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	2.983ArgAla: 2.983 ± 0.065	0.51ArgCys: 0.51 ± 0.028	2.44ArgAsp: 2.44 ± 0.063	3.35ArgGlu: 3.35 ± 0.065	1.707ArgPhe: 1.707 ± 0.049	2.737ArgGly: 2.737 ± 0.063	0.936ArgHis: 0.936 ± 0.034	3.29ArgIle: 3.29 ± 0.06	2.897ArgLys: 2.897 ± 0.065	4.167ArgLeu: 4.167 ± 0.079	1.462ArgMet: 1.462 ± 0.048	2.069ArgAsn: 2.069 ± 0.054	1.477ArgPro: 1.477 ± 0.045	1.889ArgGln: 1.889 ± 0.058	2.284ArgArg: 2.284 ± 0.059	2.128ArgSer: 2.128 ± 0.058	2.008ArgThr: 2.008 ± 0.058	2.937ArgVal: 2.937 ± 0.061	0.409ArgTrp: 0.409 ± 0.023	1.631ArgTyr: 1.631 ± 0.051	0.0ArgXaa: 0.0 ± 0.0
Ser	4.334SerAla: 4.334 ± 0.082	0.651SerCys: 0.651 ± 0.031	3.215SerAsp: 3.215 ± 0.066	3.334SerGlu: 3.334 ± 0.076	2.486SerPhe: 2.486 ± 0.061	4.765SerGly: 4.765 ± 0.122	1.121SerHis: 1.121 ± 0.033	4.123SerIle: 4.123 ± 0.076	3.325SerLys: 3.325 ± 0.077	5.143SerLeu: 5.143 ± 0.084	1.959SerMet: 1.959 ± 0.053	2.538SerAsn: 2.538 ± 0.071	1.911SerPro: 1.911 ± 0.049	1.897SerGln: 1.897 ± 0.054	2.673SerArg: 2.673 ± 0.062	3.571SerSer: 3.571 ± 0.075	2.898SerThr: 2.898 ± 0.07	4.235SerVal: 4.235 ± 0.08	0.581SerTrp: 0.581 ± 0.027	2.195SerTyr: 2.195 ± 0.063	0.0SerXaa: 0.0 ± 0.0
Thr	4.702ThrAla: 4.702 ± 0.091	0.535ThrCys: 0.535 ± 0.024	3.244ThrAsp: 3.244 ± 0.067	3.285ThrGlu: 3.285 ± 0.063	1.934ThrPhe: 1.934 ± 0.056	4.868ThrGly: 4.868 ± 0.135	0.901ThrHis: 0.901 ± 0.037	3.826ThrIle: 3.826 ± 0.074	2.982ThrLys: 2.982 ± 0.063	4.541ThrLeu: 4.541 ± 0.086	1.646ThrMet: 1.646 ± 0.048	2.185ThrAsn: 2.185 ± 0.073	2.192ThrPro: 2.192 ± 0.055	1.489ThrGln: 1.489 ± 0.05	2.053ThrArg: 2.053 ± 0.047	2.918ThrSer: 2.918 ± 0.067	2.996ThrThr: 2.996 ± 0.082	4.45ThrVal: 4.45 ± 0.109	0.431ThrTrp: 0.431 ± 0.028	1.719ThrTyr: 1.719 ± 0.054	0.0ThrXaa: 0.0 ± 0.0
Val	6.024ValAla: 6.024 ± 0.101	0.895ValCys: 0.895 ± 0.037	4.608ValAsp: 4.608 ± 0.079	5.069ValGlu: 5.069 ± 0.08	2.821ValPhe: 2.821 ± 0.066	5.068ValGly: 5.068 ± 0.095	1.19ValHis: 1.19 ± 0.036	4.954ValIle: 4.954 ± 0.092	4.612ValLys: 4.612 ± 0.087	6.337ValLeu: 6.337 ± 0.102	2.248ValMet: 2.248 ± 0.055	3.381ValAsn: 3.381 ± 0.085	2.779ValPro: 2.779 ± 0.065	2.114ValGln: 2.114 ± 0.059	2.895ValArg: 2.895 ± 0.066	4.574ValSer: 4.574 ± 0.088	4.178ValThr: 4.178 ± 0.092	5.649ValVal: 5.649 ± 0.104	0.546ValTrp: 0.546 ± 0.028	2.485ValTyr: 2.485 ± 0.063	0.0ValXaa: 0.0 ± 0.0
Trp	0.558TrpAla: 0.558 ± 0.029	0.139TrpCys: 0.139 ± 0.014	0.519TrpAsp: 0.519 ± 0.027	0.558TrpGlu: 0.558 ± 0.028	0.339TrpPhe: 0.339 ± 0.02	0.66TrpGly: 0.66 ± 0.03	0.22TrpHis: 0.22 ± 0.019	0.497TrpIle: 0.497 ± 0.025	0.566TrpLys: 0.566 ± 0.025	0.941TrpLeu: 0.941 ± 0.041	0.291TrpMet: 0.291 ± 0.018	0.515TrpAsn: 0.515 ± 0.028	0.275TrpPro: 0.275 ± 0.018	0.444TrpGln: 0.444 ± 0.025	0.417TrpArg: 0.417 ± 0.024	0.513TrpSer: 0.513 ± 0.026	0.449TrpThr: 0.449 ± 0.026	0.507TrpVal: 0.507 ± 0.027	0.116TrpTrp: 0.116 ± 0.014	0.358TrpTyr: 0.358 ± 0.025	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.462TyrAla: 2.462 ± 0.056	0.535TyrCys: 0.535 ± 0.026	2.412TyrAsp: 2.412 ± 0.054	2.344TyrGlu: 2.344 ± 0.052	1.567TyrPhe: 1.567 ± 0.048	3.167TyrGly: 3.167 ± 0.079	0.76TyrHis: 0.76 ± 0.031	2.525TyrIle: 2.525 ± 0.062	2.106TyrLys: 2.106 ± 0.059	3.18TyrLeu: 3.18 ± 0.076	0.996TyrMet: 0.996 ± 0.037	1.999TyrAsn: 1.999 ± 0.057	1.298TyrPro: 1.298 ± 0.04	1.122TyrGln: 1.122 ± 0.04	1.675TyrArg: 1.675 ± 0.046	2.327TyrSer: 2.327 ± 0.06	2.0TyrThr: 2.0 ± 0.055	2.399TyrVal: 2.399 ± 0.055	0.356TyrTrp: 0.356 ± 0.02	1.58TyrTyr: 1.58 ± 0.053	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2405 proteins (779044 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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