Amino acid dipepetide frequency for Bacteroides sp. PHL 2737

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.589AlaAla: 5.589 ± 0.081	0.989AlaCys: 0.989 ± 0.026	4.157AlaAsp: 4.157 ± 0.05	4.62AlaGlu: 4.62 ± 0.06	3.159AlaPhe: 3.159 ± 0.04	5.285AlaGly: 5.285 ± 0.07	1.154AlaHis: 1.154 ± 0.027	4.653AlaIle: 4.653 ± 0.062	3.845AlaLys: 3.845 ± 0.053	6.643AlaLeu: 6.643 ± 0.068	1.933AlaMet: 1.933 ± 0.036	3.096AlaAsn: 3.096 ± 0.046	2.231AlaPro: 2.231 ± 0.042	2.548AlaGln: 2.548 ± 0.047	3.157AlaArg: 3.157 ± 0.051	4.215AlaSer: 4.215 ± 0.06	3.81AlaThr: 3.81 ± 0.05	4.853AlaVal: 4.853 ± 0.067	0.796AlaTrp: 0.796 ± 0.025	2.885AlaTyr: 2.885 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.756CysAla: 0.756 ± 0.025	0.241CysCys: 0.241 ± 0.012	0.624CysAsp: 0.624 ± 0.021	0.662CysGlu: 0.662 ± 0.022	0.686CysPhe: 0.686 ± 0.021	1.006CysGly: 1.006 ± 0.027	0.286CysHis: 0.286 ± 0.015	0.966CysIle: 0.966 ± 0.026	0.694CysLys: 0.694 ± 0.021	1.192CysLeu: 1.192 ± 0.027	0.347CysMet: 0.347 ± 0.016	0.58CysAsn: 0.58 ± 0.021	0.574CysPro: 0.574 ± 0.02	0.361CysGln: 0.361 ± 0.015	0.697CysArg: 0.697 ± 0.025	0.794CysSer: 0.794 ± 0.025	0.696CysThr: 0.696 ± 0.023	0.741CysVal: 0.741 ± 0.021	0.162CysTrp: 0.162 ± 0.01	0.564CysTyr: 0.564 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	3.717AspAla: 3.717 ± 0.051	0.624AspCys: 0.624 ± 0.019	2.509AspAsp: 2.509 ± 0.044	3.665AspGlu: 3.665 ± 0.054	2.932AspPhe: 2.932 ± 0.039	4.097AspGly: 4.097 ± 0.064	0.844AspHis: 0.844 ± 0.024	4.035AspIle: 4.035 ± 0.051	3.986AspLys: 3.986 ± 0.056	4.477AspLeu: 4.477 ± 0.057	1.551AspMet: 1.551 ± 0.03	2.691AspAsn: 2.691 ± 0.046	1.886AspPro: 1.886 ± 0.032	1.284AspGln: 1.284 ± 0.03	2.591AspArg: 2.591 ± 0.04	3.099AspSer: 3.099 ± 0.054	2.798AspThr: 2.798 ± 0.045	3.42AspVal: 3.42 ± 0.045	0.864AspTrp: 0.864 ± 0.025	2.877AspTyr: 2.877 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	4.799GluAla: 4.799 ± 0.065	0.659GluCys: 0.659 ± 0.02	3.07GluAsp: 3.07 ± 0.043	5.193GluGlu: 5.193 ± 0.073	2.392GluPhe: 2.392 ± 0.041	4.129GluGly: 4.129 ± 0.052	1.245GluHis: 1.245 ± 0.026	4.709GluIle: 4.709 ± 0.066	5.374GluLys: 5.374 ± 0.066	6.383GluLeu: 6.383 ± 0.065	2.025GluMet: 2.025 ± 0.038	3.45GluAsn: 3.45 ± 0.051	1.738GluPro: 1.738 ± 0.038	2.659GluGln: 2.659 ± 0.048	3.458GluArg: 3.458 ± 0.054	3.253GluSer: 3.253 ± 0.048	3.359GluThr: 3.359 ± 0.044	4.308GluVal: 4.308 ± 0.057	0.843GluTrp: 0.843 ± 0.023	2.82GluTyr: 2.82 ± 0.044	0.0GluXaa: 0.0 ± 0.0
Phe	3.014PheAla: 3.014 ± 0.041	0.714PheCys: 0.714 ± 0.021	2.731PheAsp: 2.731 ± 0.042	2.493PheGlu: 2.493 ± 0.046	2.262PhePhe: 2.262 ± 0.042	3.049PheGly: 3.049 ± 0.049	0.884PheHis: 0.884 ± 0.023	3.403PheIle: 3.403 ± 0.051	2.306PheLys: 2.306 ± 0.036	4.186PheLeu: 4.186 ± 0.059	1.33PheMet: 1.33 ± 0.028	2.336PheAsn: 2.336 ± 0.037	1.798PhePro: 1.798 ± 0.037	1.24PheGln: 1.24 ± 0.028	2.454PheArg: 2.454 ± 0.038	3.49PheSer: 3.49 ± 0.05	2.79PheThr: 2.79 ± 0.042	2.876PheVal: 2.876 ± 0.043	0.569PheTrp: 0.569 ± 0.022	2.088PheTyr: 2.088 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	4.294GlyAla: 4.294 ± 0.068	0.936GlyCys: 0.936 ± 0.027	3.535GlyAsp: 3.535 ± 0.046	4.273GlyGlu: 4.273 ± 0.056	3.137GlyPhe: 3.137 ± 0.048	4.812GlyGly: 4.812 ± 0.069	1.212GlyHis: 1.212 ± 0.032	5.238GlyIle: 5.238 ± 0.063	5.378GlyLys: 5.378 ± 0.064	5.826GlyLeu: 5.826 ± 0.059	2.157GlyMet: 2.157 ± 0.041	3.595GlyAsn: 3.595 ± 0.054	1.302GlyPro: 1.302 ± 0.031	2.182GlyGln: 2.182 ± 0.038	2.976GlyArg: 2.976 ± 0.049	4.094GlySer: 4.094 ± 0.066	4.26GlyThr: 4.26 ± 0.052	4.713GlyVal: 4.713 ± 0.064	1.018GlyTrp: 1.018 ± 0.028	3.414GlyTyr: 3.414 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	1.167HisAla: 1.167 ± 0.028	0.297HisCys: 0.297 ± 0.015	0.846HisAsp: 0.846 ± 0.023	0.991HisGlu: 0.991 ± 0.027	1.021HisPhe: 1.021 ± 0.024	1.151HisGly: 1.151 ± 0.028	0.442HisHis: 0.442 ± 0.019	1.357HisIle: 1.357 ± 0.031	1.017HisLys: 1.017 ± 0.032	1.788HisLeu: 1.788 ± 0.034	0.365HisMet: 0.365 ± 0.015	0.902HisAsn: 0.902 ± 0.023	1.027HisPro: 1.027 ± 0.026	0.605HisGln: 0.605 ± 0.022	0.954HisArg: 0.954 ± 0.026	1.114HisSer: 1.114 ± 0.028	1.098HisThr: 1.098 ± 0.024	1.03HisVal: 1.03 ± 0.028	0.274HisTrp: 0.274 ± 0.014	0.897HisTyr: 0.897 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	5.13IleAla: 5.13 ± 0.061	0.975IleCys: 0.975 ± 0.027	4.043IleAsp: 4.043 ± 0.052	4.435IleGlu: 4.435 ± 0.06	2.772IlePhe: 2.772 ± 0.049	4.758IleGly: 4.758 ± 0.06	1.374IleHis: 1.374 ± 0.027	4.67IleIle: 4.67 ± 0.062	3.968IleLys: 3.968 ± 0.057	6.086IleLeu: 6.086 ± 0.063	1.48IleMet: 1.48 ± 0.032	3.477IleAsn: 3.477 ± 0.056	3.202IlePro: 3.202 ± 0.045	2.195IleGln: 2.195 ± 0.04	3.787IleArg: 3.787 ± 0.049	4.724IleSer: 4.724 ± 0.064	4.009IleThr: 4.009 ± 0.058	4.288IleVal: 4.288 ± 0.049	0.684IleTrp: 0.684 ± 0.022	2.895IleTyr: 2.895 ± 0.043	0.0IleXaa: 0.0 ± 0.0
Lys	4.875LysAla: 4.875 ± 0.063	0.571LysCys: 0.571 ± 0.022	3.952LysAsp: 3.952 ± 0.049	5.971LysGlu: 5.971 ± 0.082	2.117LysPhe: 2.117 ± 0.04	4.52LysGly: 4.52 ± 0.052	1.158LysHis: 1.158 ± 0.026	4.183LysIle: 4.183 ± 0.059	5.11LysLys: 5.11 ± 0.054	5.452LysLeu: 5.452 ± 0.057	2.055LysMet: 2.055 ± 0.037	3.348LysAsn: 3.348 ± 0.052	2.165LysPro: 2.165 ± 0.039	2.651LysGln: 2.651 ± 0.044	3.296LysArg: 3.296 ± 0.046	3.4LysSer: 3.4 ± 0.05	3.554LysThr: 3.554 ± 0.053	4.346LysVal: 4.346 ± 0.055	0.751LysTrp: 0.751 ± 0.022	2.878LysTyr: 2.878 ± 0.044	0.0LysXaa: 0.0 ± 0.0
Leu	6.364LeuAla: 6.364 ± 0.081	1.395LeuCys: 1.395 ± 0.031	4.483LeuAsp: 4.483 ± 0.056	5.101LeuGlu: 5.101 ± 0.06	4.821LeuPhe: 4.821 ± 0.062	5.51LeuGly: 5.51 ± 0.065	1.73LeuHis: 1.73 ± 0.036	5.759LeuIle: 5.759 ± 0.067	6.482LeuLys: 6.482 ± 0.066	9.564LeuLeu: 9.564 ± 0.102	2.511LeuMet: 2.511 ± 0.042	4.762LeuAsn: 4.762 ± 0.067	4.328LeuPro: 4.328 ± 0.058	3.391LeuGln: 3.391 ± 0.048	4.377LeuArg: 4.377 ± 0.06	6.982LeuSer: 6.982 ± 0.07	5.33LeuThr: 5.33 ± 0.052	5.195LeuVal: 5.195 ± 0.057	1.032LeuTrp: 1.032 ± 0.024	3.755LeuTyr: 3.755 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	2.04MetAla: 2.04 ± 0.037	0.242MetCys: 0.242 ± 0.012	1.509MetAsp: 1.509 ± 0.032	1.935MetGlu: 1.935 ± 0.038	1.034MetPhe: 1.034 ± 0.024	1.874MetGly: 1.874 ± 0.039	0.415MetHis: 0.415 ± 0.016	1.705MetIle: 1.705 ± 0.032	2.696MetLys: 2.696 ± 0.041	2.43MetLeu: 2.43 ± 0.035	0.808MetMet: 0.808 ± 0.023	1.666MetAsn: 1.666 ± 0.034	1.126MetPro: 1.126 ± 0.029	1.068MetGln: 1.068 ± 0.027	1.297MetArg: 1.297 ± 0.027	1.327MetSer: 1.327 ± 0.031	1.486MetThr: 1.486 ± 0.032	1.537MetVal: 1.537 ± 0.033	0.243MetTrp: 0.243 ± 0.012	0.859MetTyr: 0.859 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	3.302AsnAla: 3.302 ± 0.052	0.517AsnCys: 0.517 ± 0.019	2.578AsnAsp: 2.578 ± 0.041	3.06AsnGlu: 3.06 ± 0.042	2.186AsnPhe: 2.186 ± 0.039	3.859AsnGly: 3.859 ± 0.061	0.948AsnHis: 0.948 ± 0.023	3.673AsnIle: 3.673 ± 0.055	3.2AsnLys: 3.2 ± 0.053	4.489AsnLeu: 4.489 ± 0.059	1.242AsnMet: 1.242 ± 0.029	2.533AsnAsn: 2.533 ± 0.051	2.434AsnPro: 2.434 ± 0.039	1.656AsnGln: 1.656 ± 0.039	2.6AsnArg: 2.6 ± 0.038	2.762AsnSer: 2.762 ± 0.041	2.751AsnThr: 2.751 ± 0.047	3.075AsnVal: 3.075 ± 0.049	0.651AsnTrp: 0.651 ± 0.021	2.395AsnTyr: 2.395 ± 0.04	0.0AsnXaa: 0.0 ± 0.0
Pro	2.887ProAla: 2.887 ± 0.044	0.403ProCys: 0.403 ± 0.017	2.588ProAsp: 2.588 ± 0.047	3.471ProGlu: 3.471 ± 0.05	1.889ProPhe: 1.889 ± 0.033	2.608ProGly: 2.608 ± 0.041	0.668ProHis: 0.668 ± 0.02	2.299ProIle: 2.299 ± 0.044	1.976ProLys: 1.976 ± 0.034	3.356ProLeu: 3.356 ± 0.041	0.946ProMet: 0.946 ± 0.026	1.659ProAsn: 1.659 ± 0.034	0.921ProPro: 0.921 ± 0.027	1.455ProGln: 1.455 ± 0.032	1.413ProArg: 1.413 ± 0.033	2.252ProSer: 2.252 ± 0.036	1.919ProThr: 1.919 ± 0.03	3.151ProVal: 3.151 ± 0.051	0.446ProTrp: 0.446 ± 0.018	1.718ProTyr: 1.718 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	2.491GlnAla: 2.491 ± 0.042	0.328GlnCys: 0.328 ± 0.013	1.562GlnAsp: 1.562 ± 0.027	2.48GlnGlu: 2.48 ± 0.041	1.307GlnPhe: 1.307 ± 0.027	2.105GlnGly: 2.105 ± 0.036	0.608GlnHis: 0.608 ± 0.02	2.348GlnIle: 2.348 ± 0.041	2.551GlnLys: 2.551 ± 0.047	3.308GlnLeu: 3.308 ± 0.05	1.005GlnMet: 1.005 ± 0.028	1.732GlnAsn: 1.732 ± 0.039	1.343GlnPro: 1.343 ± 0.027	1.569GlnGln: 1.569 ± 0.04	1.69GlnArg: 1.69 ± 0.033	2.021GlnSer: 2.021 ± 0.031	2.092GlnThr: 2.092 ± 0.04	2.176GlnVal: 2.176 ± 0.041	0.477GlnTrp: 0.477 ± 0.018	1.473GlnTyr: 1.473 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	2.769ArgAla: 2.769 ± 0.044	0.502ArgCys: 0.502 ± 0.017	2.224ArgAsp: 2.224 ± 0.04	3.313ArgGlu: 3.313 ± 0.057	2.461ArgPhe: 2.461 ± 0.043	2.536ArgGly: 2.536 ± 0.039	0.988ArgHis: 0.988 ± 0.025	3.793ArgIle: 3.793 ± 0.047	3.662ArgLys: 3.662 ± 0.049	4.741ArgLeu: 4.741 ± 0.062	1.681ArgMet: 1.681 ± 0.035	2.564ArgAsn: 2.564 ± 0.042	1.694ArgPro: 1.694 ± 0.034	2.02ArgGln: 2.02 ± 0.037	2.456ArgArg: 2.456 ± 0.046	2.6ArgSer: 2.6 ± 0.04	2.656ArgThr: 2.656 ± 0.044	2.705ArgVal: 2.705 ± 0.04	0.646ArgTrp: 0.646 ± 0.021	2.331ArgTyr: 2.331 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	4.184SerAla: 4.184 ± 0.059	0.909SerCys: 0.909 ± 0.024	3.277SerAsp: 3.277 ± 0.046	3.598SerGlu: 3.598 ± 0.05	3.359SerPhe: 3.359 ± 0.05	4.728SerGly: 4.728 ± 0.063	1.118SerHis: 1.118 ± 0.028	4.261SerIle: 4.261 ± 0.06	3.395SerLys: 3.395 ± 0.046	6.107SerLeu: 6.107 ± 0.07	1.463SerMet: 1.463 ± 0.035	2.615SerAsn: 2.615 ± 0.05	2.444SerPro: 2.444 ± 0.044	1.964SerGln: 1.964 ± 0.036	2.716SerArg: 2.716 ± 0.042	3.916SerSer: 3.916 ± 0.072	3.182SerThr: 3.182 ± 0.05	4.417SerVal: 4.417 ± 0.061	0.838SerTrp: 0.838 ± 0.024	2.796SerTyr: 2.796 ± 0.053	0.0SerXaa: 0.0 ± 0.0
Thr	4.048ThrAla: 4.048 ± 0.057	0.612ThrCys: 0.612 ± 0.024	3.528ThrAsp: 3.528 ± 0.051	3.471ThrGlu: 3.471 ± 0.055	2.757ThrPhe: 2.757 ± 0.044	4.503ThrGly: 4.503 ± 0.06	0.981ThrHis: 0.981 ± 0.025	3.85ThrIle: 3.85 ± 0.052	2.768ThrLys: 2.768 ± 0.043	5.575ThrLeu: 5.575 ± 0.067	1.212ThrMet: 1.212 ± 0.029	2.443ThrAsn: 2.443 ± 0.041	2.806ThrPro: 2.806 ± 0.045	1.781ThrGln: 1.781 ± 0.031	2.294ThrArg: 2.294 ± 0.037	3.219ThrSer: 3.219 ± 0.049	3.107ThrThr: 3.107 ± 0.048	4.121ThrVal: 4.121 ± 0.059	0.656ThrTrp: 0.656 ± 0.019	2.434ThrTyr: 2.434 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	4.602ValAla: 4.602 ± 0.053	0.979ValCys: 0.979 ± 0.027	3.52ValAsp: 3.52 ± 0.052	3.922ValGlu: 3.922 ± 0.053	2.99ValPhe: 2.99 ± 0.043	3.912ValGly: 3.912 ± 0.061	1.1ValHis: 1.1 ± 0.027	4.368ValIle: 4.368 ± 0.053	4.245ValLys: 4.245 ± 0.056	5.872ValLeu: 5.872 ± 0.067	1.657ValMet: 1.657 ± 0.037	3.286ValAsn: 3.286 ± 0.051	2.686ValPro: 2.686 ± 0.038	1.947ValGln: 1.947 ± 0.034	3.097ValArg: 3.097 ± 0.051	4.611ValSer: 4.611 ± 0.059	3.843ValThr: 3.843 ± 0.059	4.328ValVal: 4.328 ± 0.063	0.767ValTrp: 0.767 ± 0.023	2.673ValTyr: 2.673 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	0.737TrpAla: 0.737 ± 0.021	0.171TrpCys: 0.171 ± 0.009	0.686TrpAsp: 0.686 ± 0.023	0.822TrpGlu: 0.822 ± 0.024	0.555TrpPhe: 0.555 ± 0.021	0.944TrpGly: 0.944 ± 0.03	0.252TrpHis: 0.252 ± 0.012	0.861TrpIle: 0.861 ± 0.026	0.943TrpLys: 0.943 ± 0.027	1.157TrpLeu: 1.157 ± 0.026	0.433TrpMet: 0.433 ± 0.019	0.757TrpAsn: 0.757 ± 0.022	0.296TrpPro: 0.296 ± 0.016	0.525TrpGln: 0.525 ± 0.018	0.615TrpArg: 0.615 ± 0.02	0.687TrpSer: 0.687 ± 0.021	0.689TrpThr: 0.689 ± 0.021	0.688TrpVal: 0.688 ± 0.019	0.19TrpTrp: 0.19 ± 0.012	0.501TrpTyr: 0.501 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.853TyrAla: 2.853 ± 0.042	0.567TyrCys: 0.567 ± 0.021	2.526TyrAsp: 2.526 ± 0.04	2.392TyrGlu: 2.392 ± 0.041	2.172TyrPhe: 2.172 ± 0.04	2.965TyrGly: 2.965 ± 0.042	0.936TyrHis: 0.936 ± 0.023	2.82TyrIle: 2.82 ± 0.044	2.756TyrLys: 2.756 ± 0.047	4.24TyrLeu: 4.24 ± 0.06	1.098TyrMet: 1.098 ± 0.026	2.42TyrAsn: 2.42 ± 0.05	2.022TyrPro: 2.022 ± 0.035	1.564TyrGln: 1.564 ± 0.031	2.415TyrArg: 2.415 ± 0.047	2.728TyrSer: 2.728 ± 0.04	2.736TyrThr: 2.736 ± 0.046	2.439TyrVal: 2.439 ± 0.037	0.605TyrTrp: 0.605 ± 0.022	2.2TyrTyr: 2.2 ± 0.044	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4515 proteins (1598771 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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