Amino acid dipepetide frequency for Gallus gallus (Chicken)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.7AlaAla: 7.7 ± 0.048	1.38AlaCys: 1.38 ± 0.014	3.134AlaAsp: 3.134 ± 0.014	5.201AlaGlu: 5.201 ± 0.023	2.492AlaPhe: 2.492 ± 0.014	4.83AlaGly: 4.83 ± 0.034	1.448AlaHis: 1.448 ± 0.008	2.824AlaIle: 2.824 ± 0.015	3.558AlaLys: 3.558 ± 0.018	6.909AlaLeu: 6.909 ± 0.041	1.557AlaMet: 1.557 ± 0.013	2.208AlaAsn: 2.208 ± 0.014	3.894AlaPro: 3.894 ± 0.029	3.053AlaGln: 3.053 ± 0.02	3.542AlaArg: 3.542 ± 0.018	5.535AlaSer: 5.535 ± 0.027	3.467AlaThr: 3.467 ± 0.02	5.345AlaVal: 5.345 ± 0.026	0.764AlaTrp: 0.764 ± 0.007	1.526AlaTyr: 1.526 ± 0.012	0.0AlaXaa: 0.0 ± 0.0
Cys	1.327CysAla: 1.327 ± 0.012	0.652CysCys: 0.652 ± 0.01	1.045CysAsp: 1.045 ± 0.014	1.304CysGlu: 1.304 ± 0.014	0.835CysPhe: 0.835 ± 0.008	1.562CysGly: 1.562 ± 0.015	0.674CysHis: 0.674 ± 0.01	1.049CysIle: 1.049 ± 0.011	1.243CysLys: 1.243 ± 0.015	2.101CysLeu: 2.101 ± 0.015	0.456CysMet: 0.456 ± 0.005	0.865CysAsn: 0.865 ± 0.012	1.421CysPro: 1.421 ± 0.021	1.052CysGln: 1.052 ± 0.013	1.358CysArg: 1.358 ± 0.013	2.132CysSer: 2.132 ± 0.016	1.18CysThr: 1.18 ± 0.011	1.375CysVal: 1.375 ± 0.014	0.304CysTrp: 0.304 ± 0.005	0.61CysTyr: 0.61 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	3.046AspAla: 3.046 ± 0.015	1.089AspCys: 1.089 ± 0.01	2.743AspAsp: 2.743 ± 0.017	3.616AspGlu: 3.616 ± 0.019	2.089AspPhe: 2.089 ± 0.013	3.562AspGly: 3.562 ± 0.023	1.101AspHis: 1.101 ± 0.008	2.715AspIle: 2.715 ± 0.016	2.596AspLys: 2.596 ± 0.014	4.788AspLeu: 4.788 ± 0.019	1.126AspMet: 1.126 ± 0.009	1.831AspAsn: 1.831 ± 0.014	2.719AspPro: 2.719 ± 0.016	1.748AspGln: 1.748 ± 0.01	2.331AspArg: 2.331 ± 0.015	4.232AspSer: 4.232 ± 0.019	2.489AspThr: 2.489 ± 0.013	3.217AspVal: 3.217 ± 0.018	0.61AspTrp: 0.61 ± 0.007	1.496AspTyr: 1.496 ± 0.01	0.0AspXaa: 0.0 ± 0.0
Glu	4.886GluAla: 4.886 ± 0.021	1.288GluCys: 1.288 ± 0.015	4.436GluAsp: 4.436 ± 0.022	7.99GluGlu: 7.99 ± 0.045	2.007GluPhe: 2.007 ± 0.012	4.114GluGly: 4.114 ± 0.017	1.555GluHis: 1.555 ± 0.01	3.268GluIle: 3.268 ± 0.015	5.453GluLys: 5.453 ± 0.034	6.495GluLeu: 6.495 ± 0.032	1.808GluMet: 1.808 ± 0.013	3.252GluAsn: 3.252 ± 0.02	2.938GluPro: 2.938 ± 0.018	3.326GluGln: 3.326 ± 0.022	4.139GluArg: 4.139 ± 0.025	4.564GluSer: 4.564 ± 0.022	3.485GluThr: 3.485 ± 0.02	4.229GluVal: 4.229 ± 0.019	0.719GluTrp: 0.719 ± 0.008	1.693GluTyr: 1.693 ± 0.011	0.0GluXaa: 0.0 ± 0.0
Phe	2.014PheAla: 2.014 ± 0.012	0.906PheCys: 0.906 ± 0.009	1.668PheAsp: 1.668 ± 0.011	1.955PheGlu: 1.955 ± 0.014	1.528PhePhe: 1.528 ± 0.015	2.145PheGly: 2.145 ± 0.013	0.989PheHis: 0.989 ± 0.008	1.815PheIle: 1.815 ± 0.014	1.786PheLys: 1.786 ± 0.012	3.771PheLeu: 3.771 ± 0.024	0.738PheMet: 0.738 ± 0.007	1.35PheAsn: 1.35 ± 0.01	1.937PhePro: 1.937 ± 0.016	1.67PheGln: 1.67 ± 0.01	1.84PheArg: 1.84 ± 0.012	3.251PheSer: 3.251 ± 0.015	2.011PheThr: 2.011 ± 0.013	2.122PheVal: 2.122 ± 0.013	0.487PheTrp: 0.487 ± 0.006	1.155PheTyr: 1.155 ± 0.009	0.0PheXaa: 0.0 ± 0.0
Gly	4.581GlyAla: 4.581 ± 0.039	1.406GlyCys: 1.406 ± 0.012	3.191GlyAsp: 3.191 ± 0.018	3.986GlyGlu: 3.986 ± 0.02	2.339GlyPhe: 2.339 ± 0.015	5.299GlyGly: 5.299 ± 0.047	1.648GlyHis: 1.648 ± 0.017	2.816GlyIle: 2.816 ± 0.015	3.757GlyLys: 3.757 ± 0.019	5.381GlyLeu: 5.381 ± 0.036	1.413GlyMet: 1.413 ± 0.011	2.491GlyAsn: 2.491 ± 0.015	3.39GlyPro: 3.39 ± 0.035	2.623GlyGln: 2.623 ± 0.016	3.92GlyArg: 3.92 ± 0.026	5.911GlySer: 5.911 ± 0.04	3.774GlyThr: 3.774 ± 0.024	3.716GlyVal: 3.716 ± 0.031	0.873GlyTrp: 0.873 ± 0.011	1.79GlyTyr: 1.79 ± 0.016	0.001GlyXaa: 0.001 ± 0.0
His	1.391HisAla: 1.391 ± 0.01	0.756HisCys: 0.756 ± 0.01	0.9HisAsp: 0.9 ± 0.008	1.313HisGlu: 1.313 ± 0.009	1.011HisPhe: 1.011 ± 0.009	1.611HisGly: 1.611 ± 0.011	0.893HisHis: 0.893 ± 0.01	1.288HisIle: 1.288 ± 0.012	1.272HisLys: 1.272 ± 0.011	2.703HisLeu: 2.703 ± 0.015	0.572HisMet: 0.572 ± 0.007	0.932HisAsn: 0.932 ± 0.008	1.711HisPro: 1.711 ± 0.02	1.171HisGln: 1.171 ± 0.009	1.565HisArg: 1.565 ± 0.012	2.299HisSer: 2.299 ± 0.015	1.34HisThr: 1.34 ± 0.013	1.486HisVal: 1.486 ± 0.012	0.341HisTrp: 0.341 ± 0.006	0.826HisTyr: 0.826 ± 0.008	0.0HisXaa: 0.0 ± 0.0
Ile	2.842IleAla: 2.842 ± 0.015	1.091IleCys: 1.091 ± 0.01	2.153IleAsp: 2.153 ± 0.014	2.715IleGlu: 2.715 ± 0.016	1.824IlePhe: 1.824 ± 0.014	2.354IleGly: 2.354 ± 0.021	1.263IleHis: 1.263 ± 0.011	2.396IleIle: 2.396 ± 0.014	2.708IleLys: 2.708 ± 0.016	4.395IleLeu: 4.395 ± 0.021	0.983IleMet: 0.983 ± 0.008	1.958IleAsn: 1.958 ± 0.013	2.763IlePro: 2.763 ± 0.017	2.328IleGln: 2.328 ± 0.015	2.403IleArg: 2.403 ± 0.012	3.87IleSer: 3.87 ± 0.018	2.709IleThr: 2.709 ± 0.015	2.613IleVal: 2.613 ± 0.015	0.54IleTrp: 0.54 ± 0.008	1.393IleTyr: 1.393 ± 0.01	0.0IleXaa: 0.0 ± 0.0
Lys	4.031LysAla: 4.031 ± 0.021	1.141LysCys: 1.141 ± 0.012	3.265LysAsp: 3.265 ± 0.019	5.376LysGlu: 5.376 ± 0.035	1.675LysPhe: 1.675 ± 0.013	3.277LysGly: 3.277 ± 0.019	1.468LysHis: 1.468 ± 0.011	2.814LysIle: 2.814 ± 0.016	4.889LysLys: 4.889 ± 0.03	5.272LysLeu: 5.272 ± 0.026	1.493LysMet: 1.493 ± 0.01	2.498LysAsn: 2.498 ± 0.013	2.943LysPro: 2.943 ± 0.019	2.848LysGln: 2.848 ± 0.019	3.377LysArg: 3.377 ± 0.017	4.079LysSer: 4.079 ± 0.023	3.118LysThr: 3.118 ± 0.016	3.47LysVal: 3.47 ± 0.018	0.622LysTrp: 0.622 ± 0.007	1.648LysTyr: 1.648 ± 0.01	0.0LysXaa: 0.0 ± 0.0
Leu	6.239LeuAla: 6.239 ± 0.028	2.224LeuCys: 2.224 ± 0.017	4.564LeuAsp: 4.564 ± 0.021	6.958LeuGlu: 6.958 ± 0.038	3.242LeuPhe: 3.242 ± 0.023	5.31LeuGly: 5.31 ± 0.023	2.697LeuHis: 2.697 ± 0.017	3.823LeuIle: 3.823 ± 0.022	5.889LeuLys: 5.889 ± 0.029	10.116LeuLeu: 10.116 ± 0.049	1.973LeuMet: 1.973 ± 0.011	3.574LeuAsn: 3.574 ± 0.017	5.75LeuPro: 5.75 ± 0.027	5.72LeuGln: 5.72 ± 0.028	5.567LeuArg: 5.567 ± 0.024	7.819LeuSer: 7.819 ± 0.028	4.775LeuThr: 4.775 ± 0.02	5.082LeuVal: 5.082 ± 0.02	1.252LeuTrp: 1.252 ± 0.032	2.582LeuTyr: 2.582 ± 0.025	0.0LeuXaa: 0.0 ± 0.0
Met	1.87MetAla: 1.87 ± 0.012	0.421MetCys: 0.421 ± 0.007	1.27MetAsp: 1.27 ± 0.009	1.947MetGlu: 1.947 ± 0.013	0.74MetPhe: 0.74 ± 0.008	1.529MetGly: 1.529 ± 0.036	0.493MetHis: 0.493 ± 0.006	0.854MetIle: 0.854 ± 0.008	1.52MetLys: 1.52 ± 0.009	1.979MetLeu: 1.979 ± 0.011	0.583MetMet: 0.583 ± 0.006	0.916MetAsn: 0.916 ± 0.008	1.073MetPro: 1.073 ± 0.01	1.042MetGln: 1.042 ± 0.009	1.072MetArg: 1.072 ± 0.008	1.618MetSer: 1.618 ± 0.01	1.092MetThr: 1.092 ± 0.01	1.373MetVal: 1.373 ± 0.009	0.247MetTrp: 0.247 ± 0.004	0.586MetTyr: 0.586 ± 0.007	0.0MetXaa: 0.0 ± 0.0
Asn	2.331AsnAla: 2.331 ± 0.014	0.892AsnCys: 0.892 ± 0.01	1.619AsnAsp: 1.619 ± 0.012	2.404AsnGlu: 2.404 ± 0.016	1.428AsnPhe: 1.428 ± 0.011	2.786AsnGly: 2.786 ± 0.02	0.939AsnHis: 0.939 ± 0.008	2.215AsnIle: 2.215 ± 0.012	2.354AsnLys: 2.354 ± 0.014	3.676AsnLeu: 3.676 ± 0.019	0.961AsnMet: 0.961 ± 0.009	1.676AsnAsn: 1.676 ± 0.015	2.156AsnPro: 2.156 ± 0.015	1.623AsnGln: 1.623 ± 0.011	1.915AsnArg: 1.915 ± 0.013	3.322AsnSer: 3.322 ± 0.018	2.118AsnThr: 2.118 ± 0.012	2.415AsnVal: 2.415 ± 0.017	0.456AsnTrp: 0.456 ± 0.005	1.141AsnTyr: 1.141 ± 0.008	0.0AsnXaa: 0.0 ± 0.0
Pro	4.72ProAla: 4.72 ± 0.034	1.194ProCys: 1.194 ± 0.015	2.611ProAsp: 2.611 ± 0.015	3.959ProGlu: 3.959 ± 0.019	1.844ProPhe: 1.844 ± 0.016	4.488ProGly: 4.488 ± 0.044	1.543ProHis: 1.543 ± 0.019	2.069ProIle: 2.069 ± 0.018	2.703ProLys: 2.703 ± 0.02	4.958ProLeu: 4.958 ± 0.023	1.064ProMet: 1.064 ± 0.014	1.923ProAsn: 1.923 ± 0.019	5.774ProPro: 5.774 ± 0.049	2.644ProGln: 2.644 ± 0.022	3.162ProArg: 3.162 ± 0.023	5.601ProSer: 5.601 ± 0.035	3.037ProThr: 3.037 ± 0.023	3.806ProVal: 3.806 ± 0.022	0.609ProTrp: 0.609 ± 0.007	1.453ProTyr: 1.453 ± 0.015	0.0ProXaa: 0.0 ± 0.0
Gln	3.179GlnAla: 3.179 ± 0.016	1.054GlnCys: 1.054 ± 0.022	2.207GlnAsp: 2.207 ± 0.013	3.713GlnGlu: 3.713 ± 0.023	1.367GlnPhe: 1.367 ± 0.01	2.592GlnGly: 2.592 ± 0.015	1.397GlnHis: 1.397 ± 0.013	2.064GlnIle: 2.064 ± 0.013	3.038GlnLys: 3.038 ± 0.019	4.635GlnLeu: 4.635 ± 0.028	1.133GlnMet: 1.133 ± 0.011	1.936GlnAsn: 1.936 ± 0.012	2.672GlnPro: 2.672 ± 0.021	3.233GlnGln: 3.233 ± 0.028	2.89GlnArg: 2.89 ± 0.013	3.3GlnSer: 3.3 ± 0.018	2.313GlnThr: 2.313 ± 0.014	2.668GlnVal: 2.668 ± 0.014	0.577GlnTrp: 0.577 ± 0.008	1.218GlnTyr: 1.218 ± 0.009	0.0GlnXaa: 0.0 ± 0.0
Arg	3.881ArgAla: 3.881 ± 0.018	1.354ArgCys: 1.354 ± 0.015	2.728ArgAsp: 2.728 ± 0.014	3.867ArgGlu: 3.867 ± 0.02	1.798ArgPhe: 1.798 ± 0.011	3.658ArgGly: 3.658 ± 0.027	1.458ArgHis: 1.458 ± 0.011	2.435ArgIle: 2.435 ± 0.014	3.606ArgLys: 3.606 ± 0.02	5.08ArgLeu: 5.08 ± 0.024	1.216ArgMet: 1.216 ± 0.009	2.186ArgAsn: 2.186 ± 0.013	3.009ArgPro: 3.009 ± 0.02	2.586ArgGln: 2.586 ± 0.016	4.52ArgArg: 4.52 ± 0.026	4.432ArgSer: 4.432 ± 0.024	2.768ArgThr: 2.768 ± 0.013	3.057ArgVal: 3.057 ± 0.015	0.731ArgTrp: 0.731 ± 0.009	1.551ArgTyr: 1.551 ± 0.011	0.0ArgXaa: 0.0 ± 0.0
Ser	5.781SerAla: 5.781 ± 0.025	1.926SerCys: 1.926 ± 0.017	4.032SerAsp: 4.032 ± 0.021	5.225SerGlu: 5.225 ± 0.022	2.964SerPhe: 2.964 ± 0.016	5.391SerGly: 5.391 ± 0.027	2.056SerHis: 2.056 ± 0.013	3.465SerIle: 3.465 ± 0.018	4.288SerLys: 4.288 ± 0.021	7.944SerLeu: 7.944 ± 0.032	1.742SerMet: 1.742 ± 0.024	2.886SerAsn: 2.886 ± 0.016	5.992SerPro: 5.992 ± 0.04	3.75SerGln: 3.75 ± 0.022	4.43SerArg: 4.43 ± 0.024	9.686SerSer: 9.686 ± 0.055	4.735SerThr: 4.735 ± 0.024	5.141SerVal: 5.141 ± 0.025	0.993SerTrp: 0.993 ± 0.008	2.103SerTyr: 2.103 ± 0.013	0.0SerXaa: 0.0 ± 0.0
Thr	4.2ThrAla: 4.2 ± 0.021	1.284ThrCys: 1.284 ± 0.016	2.689ThrAsp: 2.689 ± 0.014	3.751ThrGlu: 3.751 ± 0.02	1.984ThrPhe: 1.984 ± 0.013	3.457ThrGly: 3.457 ± 0.019	1.183ThrHis: 1.183 ± 0.01	2.388ThrIle: 2.388 ± 0.012	2.744ThrLys: 2.744 ± 0.016	4.942ThrLeu: 4.942 ± 0.018	1.12ThrMet: 1.12 ± 0.009	1.854ThrAsn: 1.854 ± 0.014	3.431ThrPro: 3.431 ± 0.025	2.178ThrGln: 2.178 ± 0.015	2.379ThrArg: 2.379 ± 0.012	4.714ThrSer: 4.714 ± 0.03	3.059ThrThr: 3.059 ± 0.037	3.962ThrVal: 3.962 ± 0.021	0.695ThrTrp: 0.695 ± 0.009	1.469ThrTyr: 1.469 ± 0.013	0.0ThrXaa: 0.0 ± 0.0
Val	4.162ValAla: 4.162 ± 0.021	1.53ValCys: 1.53 ± 0.013	2.884ValAsp: 2.884 ± 0.015	3.879ValGlu: 3.879 ± 0.02	2.357ValPhe: 2.357 ± 0.017	3.48ValGly: 3.48 ± 0.021	1.515ValHis: 1.515 ± 0.011	2.986ValIle: 2.986 ± 0.018	3.558ValLys: 3.558 ± 0.016	6.232ValLeu: 6.232 ± 0.027	1.344ValMet: 1.344 ± 0.01	2.393ValAsn: 2.393 ± 0.013	3.861ValPro: 3.861 ± 0.029	2.851ValGln: 2.851 ± 0.016	3.119ValArg: 3.119 ± 0.017	5.013ValSer: 5.013 ± 0.025	3.87ValThr: 3.87 ± 0.028	4.072ValVal: 4.072 ± 0.022	0.731ValTrp: 0.731 ± 0.008	1.639ValTyr: 1.639 ± 0.013	0.0ValXaa: 0.0 ± 0.0
Trp	0.747TrpAla: 0.747 ± 0.008	0.261TrpCys: 0.261 ± 0.005	0.66TrpAsp: 0.66 ± 0.009	0.784TrpGlu: 0.784 ± 0.008	0.427TrpPhe: 0.427 ± 0.006	0.97TrpGly: 0.97 ± 0.034	0.31TrpHis: 0.31 ± 0.005	0.573TrpIle: 0.573 ± 0.006	0.816TrpLys: 0.816 ± 0.007	1.196TrpLeu: 1.196 ± 0.01	0.331TrpMet: 0.331 ± 0.004	0.529TrpAsn: 0.529 ± 0.006	0.471TrpPro: 0.471 ± 0.007	0.546TrpGln: 0.546 ± 0.006	0.732TrpArg: 0.732 ± 0.008	0.87TrpSer: 0.87 ± 0.009	0.637TrpThr: 0.637 ± 0.008	0.727TrpVal: 0.727 ± 0.01	0.195TrpTrp: 0.195 ± 0.004	0.333TrpTyr: 0.333 ± 0.005	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.442TyrAla: 1.442 ± 0.011	0.693TyrCys: 0.693 ± 0.007	1.344TyrAsp: 1.344 ± 0.011	1.698TyrGlu: 1.698 ± 0.01	1.19TyrPhe: 1.19 ± 0.01	1.893TyrGly: 1.893 ± 0.031	0.749TyrHis: 0.749 ± 0.007	1.443TyrIle: 1.443 ± 0.011	1.527TyrLys: 1.527 ± 0.012	2.584TyrLeu: 2.584 ± 0.014	0.612TyrMet: 0.612 ± 0.006	1.164TyrAsn: 1.164 ± 0.009	1.256TyrPro: 1.256 ± 0.01	1.197TyrGln: 1.197 ± 0.008	1.66TyrArg: 1.66 ± 0.011	2.282TyrSer: 2.282 ± 0.015	1.51TyrThr: 1.51 ± 0.01	1.6TyrVal: 1.6 ± 0.011	0.368TyrTrp: 0.368 ± 0.008	0.954TyrTyr: 0.954 ± 0.009	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.019XaaXaa: 0.019 ± 0.006

Statistics based on 27791 proteins (17623393 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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