Amino acid dipepetide frequency for Sulfitobacter phage pCB2047-A

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.526AlaAla: 16.526 ± 1.648
0.787AlaCys: 0.787 ± 0.267
7.712AlaAsp: 7.712 ± 0.76
8.027AlaGlu: 8.027 ± 0.845
4.092AlaPhe: 4.092 ± 0.51
10.309AlaGly: 10.309 ± 1.202
1.731AlaHis: 1.731 ± 0.414
6.06AlaIle: 6.06 ± 0.657
5.037AlaLys: 5.037 ± 0.689
10.388AlaLeu: 10.388 ± 0.864
4.564AlaMet: 4.564 ± 0.612
4.328AlaAsn: 4.328 ± 0.646
5.037AlaPro: 5.037 ± 0.808
5.43AlaGln: 5.43 ± 0.743
8.027AlaArg: 8.027 ± 0.905
6.453AlaSer: 6.453 ± 0.66
6.611AlaThr: 6.611 ± 0.936
6.847AlaVal: 6.847 ± 0.713
2.204AlaTrp: 2.204 ± 0.483
2.204AlaTyr: 2.204 ± 0.44
0.0AlaXaa: 0.0 ± 0.0
Cys
0.944CysAla: 0.944 ± 0.304
0.079CysCys: 0.079 ± 0.08
1.023CysAsp: 1.023 ± 0.336
0.787CysGlu: 0.787 ± 0.243
0.157CysPhe: 0.157 ± 0.116
0.472CysGly: 0.472 ± 0.174
0.079CysHis: 0.079 ± 0.08
0.315CysIle: 0.315 ± 0.182
0.787CysLys: 0.787 ± 0.243
0.944CysLeu: 0.944 ± 0.247
0.236CysMet: 0.236 ± 0.166
0.472CysAsn: 0.472 ± 0.241
0.393CysPro: 0.393 ± 0.214
0.236CysGln: 0.236 ± 0.139
0.63CysArg: 0.63 ± 0.227
0.944CysSer: 0.944 ± 0.257
0.315CysThr: 0.315 ± 0.138
0.551CysVal: 0.551 ± 0.232
0.079CysTrp: 0.079 ± 0.071
0.157CysTyr: 0.157 ± 0.107
0.0CysXaa: 0.0 ± 0.0
Asp
9.68AspAla: 9.68 ± 0.817
0.63AspCys: 0.63 ± 0.241
3.935AspAsp: 3.935 ± 0.619
4.643AspGlu: 4.643 ± 0.71
2.125AspPhe: 2.125 ± 0.402
5.666AspGly: 5.666 ± 0.612
0.944AspHis: 0.944 ± 0.224
2.754AspIle: 2.754 ± 0.363
2.125AspLys: 2.125 ± 0.299
5.666AspLeu: 5.666 ± 0.563
2.676AspMet: 2.676 ± 0.454
3.069AspAsn: 3.069 ± 0.458
3.384AspPro: 3.384 ± 0.463
2.125AspGln: 2.125 ± 0.417
4.014AspArg: 4.014 ± 0.436
2.99AspSer: 2.99 ± 0.472
3.463AspThr: 3.463 ± 0.45
4.171AspVal: 4.171 ± 0.591
1.338AspTrp: 1.338 ± 0.32
1.81AspTyr: 1.81 ± 0.42
0.0AspXaa: 0.0 ± 0.0
Glu
7.791GluAla: 7.791 ± 1.062
0.63GluCys: 0.63 ± 0.22
3.856GluAsp: 3.856 ± 0.674
2.754GluGlu: 2.754 ± 0.529
1.967GluPhe: 1.967 ± 0.418
5.037GluGly: 5.037 ± 0.688
0.944GluHis: 0.944 ± 0.318
2.125GluIle: 2.125 ± 0.408
2.912GluLys: 2.912 ± 0.568
4.171GluLeu: 4.171 ± 0.466
2.282GluMet: 2.282 ± 0.438
2.046GluAsn: 2.046 ± 0.347
1.417GluPro: 1.417 ± 0.314
2.597GluGln: 2.597 ± 0.47
3.699GluArg: 3.699 ± 0.559
2.44GluSer: 2.44 ± 0.392
4.014GluThr: 4.014 ± 0.5
3.935GluVal: 3.935 ± 0.603
0.866GluTrp: 0.866 ± 0.233
1.967GluTyr: 1.967 ± 0.431
0.0GluXaa: 0.0 ± 0.0
Phe
2.361PheAla: 2.361 ± 0.337
0.236PheCys: 0.236 ± 0.119
3.148PheAsp: 3.148 ± 0.571
1.731PheGlu: 1.731 ± 0.369
1.023PhePhe: 1.023 ± 0.299
4.171PheGly: 4.171 ± 0.618
0.866PheHis: 0.866 ± 0.265
0.708PheIle: 0.708 ± 0.211
1.731PheLys: 1.731 ± 0.346
1.967PheLeu: 1.967 ± 0.387
1.574PheMet: 1.574 ± 0.347
1.338PheAsn: 1.338 ± 0.315
1.18PhePro: 1.18 ± 0.268
0.866PheGln: 0.866 ± 0.291
2.204PheArg: 2.204 ± 0.387
1.889PheSer: 1.889 ± 0.414
1.338PheThr: 1.338 ± 0.39
2.046PheVal: 2.046 ± 0.394
0.63PheTrp: 0.63 ± 0.226
0.787PheTyr: 0.787 ± 0.242
0.0PheXaa: 0.0 ± 0.0
Gly
10.545GlyAla: 10.545 ± 1.822
0.866GlyCys: 0.866 ± 0.268
5.115GlyAsp: 5.115 ± 0.689
4.407GlyGlu: 4.407 ± 0.609
2.99GlyPhe: 2.99 ± 0.53
9.758GlyGly: 9.758 ± 1.567
1.417GlyHis: 1.417 ± 0.314
4.328GlyIle: 4.328 ± 0.542
3.699GlyLys: 3.699 ± 0.558
6.768GlyLeu: 6.768 ± 0.723
2.282GlyMet: 2.282 ± 0.342
3.148GlyAsn: 3.148 ± 0.408
2.676GlyPro: 2.676 ± 0.394
3.777GlyGln: 3.777 ± 0.73
4.328GlyArg: 4.328 ± 0.504
4.801GlySer: 4.801 ± 0.711
5.43GlyThr: 5.43 ± 0.924
6.296GlyVal: 6.296 ± 0.872
1.574GlyTrp: 1.574 ± 0.339
3.463GlyTyr: 3.463 ± 0.545
0.0GlyXaa: 0.0 ± 0.0
His
1.18HisAla: 1.18 ± 0.338
0.157HisCys: 0.157 ± 0.101
1.731HisAsp: 1.731 ± 0.407
1.259HisGlu: 1.259 ± 0.33
0.63HisPhe: 0.63 ± 0.242
1.81HisGly: 1.81 ± 0.399
0.551HisHis: 0.551 ± 0.221
1.495HisIle: 1.495 ± 0.343
0.551HisLys: 0.551 ± 0.205
1.18HisLeu: 1.18 ± 0.353
0.315HisMet: 0.315 ± 0.144
0.708HisAsn: 0.708 ± 0.344
1.259HisPro: 1.259 ± 0.304
0.866HisGln: 0.866 ± 0.307
0.866HisArg: 0.866 ± 0.259
0.787HisSer: 0.787 ± 0.256
1.259HisThr: 1.259 ± 0.311
1.574HisVal: 1.574 ± 0.347
0.472HisTrp: 0.472 ± 0.227
0.393HisTyr: 0.393 ± 0.177
0.0HisXaa: 0.0 ± 0.0
Ile
5.981IleAla: 5.981 ± 0.683
0.472IleCys: 0.472 ± 0.233
2.99IleAsp: 2.99 ± 0.505
3.227IleGlu: 3.227 ± 0.437
1.023IlePhe: 1.023 ± 0.28
4.328IleGly: 4.328 ± 0.535
1.102IleHis: 1.102 ± 0.275
2.204IleIle: 2.204 ± 0.362
2.518IleLys: 2.518 ± 0.495
2.282IleLeu: 2.282 ± 0.328
0.866IleMet: 0.866 ± 0.299
1.18IleAsn: 1.18 ± 0.336
1.653IlePro: 1.653 ± 0.307
1.653IleGln: 1.653 ± 0.245
2.597IleArg: 2.597 ± 0.562
3.463IleSer: 3.463 ± 0.536
2.754IleThr: 2.754 ± 0.444
2.754IleVal: 2.754 ± 0.588
1.18IleTrp: 1.18 ± 0.385
1.259IleTyr: 1.259 ± 0.299
0.0IleXaa: 0.0 ± 0.0
Lys
6.453LysAla: 6.453 ± 0.992
0.866LysCys: 0.866 ± 0.27
1.259LysAsp: 1.259 ± 0.316
2.44LysGlu: 2.44 ± 0.439
1.495LysPhe: 1.495 ± 0.302
3.227LysGly: 3.227 ± 0.62
0.944LysHis: 0.944 ± 0.262
2.204LysIle: 2.204 ± 0.425
2.046LysLys: 2.046 ± 0.519
3.541LysLeu: 3.541 ± 0.472
1.338LysMet: 1.338 ± 0.274
1.259LysAsn: 1.259 ± 0.343
2.204LysPro: 2.204 ± 0.501
1.653LysGln: 1.653 ± 0.422
3.305LysArg: 3.305 ± 0.568
2.754LysSer: 2.754 ± 0.552
2.518LysThr: 2.518 ± 0.38
2.597LysVal: 2.597 ± 0.531
0.944LysTrp: 0.944 ± 0.298
1.495LysTyr: 1.495 ± 0.334
0.0LysXaa: 0.0 ± 0.0
Leu
8.578LeuAla: 8.578 ± 0.781
1.338LeuCys: 1.338 ± 0.371
3.699LeuAsp: 3.699 ± 0.495
3.463LeuGlu: 3.463 ± 0.555
1.653LeuPhe: 1.653 ± 0.414
7.083LeuGly: 7.083 ± 0.706
1.653LeuHis: 1.653 ± 0.319
3.935LeuIle: 3.935 ± 0.546
2.44LeuLys: 2.44 ± 0.474
5.43LeuLeu: 5.43 ± 0.789
2.282LeuMet: 2.282 ± 0.428
2.912LeuAsn: 2.912 ± 0.59
3.148LeuPro: 3.148 ± 0.437
2.912LeuGln: 2.912 ± 0.585
5.981LeuArg: 5.981 ± 0.696
6.138LeuSer: 6.138 ± 0.774
4.25LeuThr: 4.25 ± 0.677
3.699LeuVal: 3.699 ± 0.529
0.63LeuTrp: 0.63 ± 0.189
2.518LeuTyr: 2.518 ± 0.43
0.0LeuXaa: 0.0 ± 0.0
Met
3.227MetAla: 3.227 ± 0.558
0.236MetCys: 0.236 ± 0.128
1.967MetAsp: 1.967 ± 0.384
1.259MetGlu: 1.259 ± 0.317
0.63MetPhe: 0.63 ± 0.206
2.754MetGly: 2.754 ± 0.438
0.315MetHis: 0.315 ± 0.157
1.023MetIle: 1.023 ± 0.264
1.102MetLys: 1.102 ± 0.328
1.338MetLeu: 1.338 ± 0.358
0.787MetMet: 0.787 ± 0.272
0.866MetAsn: 0.866 ± 0.231
1.731MetPro: 1.731 ± 0.309
2.361MetGln: 2.361 ± 0.446
1.889MetArg: 1.889 ± 0.399
2.125MetSer: 2.125 ± 0.448
2.361MetThr: 2.361 ± 0.38
1.889MetVal: 1.889 ± 0.498
0.551MetTrp: 0.551 ± 0.163
0.315MetTyr: 0.315 ± 0.134
0.0MetXaa: 0.0 ± 0.0
Asn
4.564AsnAla: 4.564 ± 0.636
0.551AsnCys: 0.551 ± 0.201
3.541AsnAsp: 3.541 ± 0.576
1.889AsnGlu: 1.889 ± 0.361
0.866AsnPhe: 0.866 ± 0.289
3.62AsnGly: 3.62 ± 0.521
0.708AsnHis: 0.708 ± 0.233
1.417AsnIle: 1.417 ± 0.342
1.338AsnLys: 1.338 ± 0.385
2.046AsnLeu: 2.046 ± 0.318
0.551AsnMet: 0.551 ± 0.198
1.102AsnAsn: 1.102 ± 0.269
2.518AsnPro: 2.518 ± 0.363
1.81AsnGln: 1.81 ± 0.416
2.361AsnArg: 2.361 ± 0.37
1.81AsnSer: 1.81 ± 0.386
1.889AsnThr: 1.889 ± 0.372
2.597AsnVal: 2.597 ± 0.482
0.944AsnTrp: 0.944 ± 0.219
0.708AsnTyr: 0.708 ± 0.181
0.0AsnXaa: 0.0 ± 0.0
Pro
5.115ProAla: 5.115 ± 0.686
0.315ProCys: 0.315 ± 0.206
4.879ProAsp: 4.879 ± 0.746
3.305ProGlu: 3.305 ± 0.457
1.495ProPhe: 1.495 ± 0.271
2.361ProGly: 2.361 ± 0.388
1.338ProHis: 1.338 ± 0.325
1.495ProIle: 1.495 ± 0.365
2.282ProLys: 2.282 ± 0.54
3.069ProLeu: 3.069 ± 0.42
0.944ProMet: 0.944 ± 0.257
2.204ProAsn: 2.204 ± 0.495
1.653ProPro: 1.653 ± 0.412
1.653ProGln: 1.653 ± 0.319
2.754ProArg: 2.754 ± 0.433
2.361ProSer: 2.361 ± 0.595
2.676ProThr: 2.676 ± 0.386
2.204ProVal: 2.204 ± 0.352
0.708ProTrp: 0.708 ± 0.256
1.18ProTyr: 1.18 ± 0.262
0.0ProXaa: 0.0 ± 0.0
Gln
5.273GlnAla: 5.273 ± 0.73
0.236GlnCys: 0.236 ± 0.159
1.731GlnAsp: 1.731 ± 0.39
2.44GlnGlu: 2.44 ± 0.543
1.495GlnPhe: 1.495 ± 0.314
3.62GlnGly: 3.62 ± 0.677
0.63GlnHis: 0.63 ± 0.214
1.81GlnIle: 1.81 ± 0.376
2.204GlnLys: 2.204 ± 0.362
2.912GlnLeu: 2.912 ± 0.532
1.574GlnMet: 1.574 ± 0.445
1.967GlnAsn: 1.967 ± 0.367
1.731GlnPro: 1.731 ± 0.349
2.282GlnGln: 2.282 ± 0.501
3.463GlnArg: 3.463 ± 0.511
2.99GlnSer: 2.99 ± 0.497
3.148GlnThr: 3.148 ± 0.587
1.889GlnVal: 1.889 ± 0.448
1.102GlnTrp: 1.102 ± 0.316
0.787GlnTyr: 0.787 ± 0.219
0.0GlnXaa: 0.0 ± 0.0
Arg
7.712ArgAla: 7.712 ± 0.837
0.708ArgCys: 0.708 ± 0.209
5.273ArgAsp: 5.273 ± 0.634
3.384ArgGlu: 3.384 ± 0.577
1.889ArgPhe: 1.889 ± 0.394
4.643ArgGly: 4.643 ± 0.565
1.417ArgHis: 1.417 ± 0.354
2.833ArgIle: 2.833 ± 0.455
4.092ArgLys: 4.092 ± 0.758
5.902ArgLeu: 5.902 ± 0.552
1.338ArgMet: 1.338 ± 0.269
2.282ArgAsn: 2.282 ± 0.401
2.046ArgPro: 2.046 ± 0.42
2.44ArgGln: 2.44 ± 0.512
5.115ArgArg: 5.115 ± 0.847
3.935ArgSer: 3.935 ± 0.633
2.361ArgThr: 2.361 ± 0.459
4.722ArgVal: 4.722 ± 0.597
1.18ArgTrp: 1.18 ± 0.329
1.81ArgTyr: 1.81 ± 0.301
0.0ArgXaa: 0.0 ± 0.0
Ser
7.87SerAla: 7.87 ± 0.682
0.393SerCys: 0.393 ± 0.161
3.856SerAsp: 3.856 ± 0.461
3.069SerGlu: 3.069 ± 0.591
1.574SerPhe: 1.574 ± 0.402
6.217SerGly: 6.217 ± 0.744
1.259SerHis: 1.259 ± 0.359
3.069SerIle: 3.069 ± 0.46
2.676SerLys: 2.676 ± 0.367
4.564SerLeu: 4.564 ± 0.61
1.653SerMet: 1.653 ± 0.323
2.597SerAsn: 2.597 ± 0.504
2.046SerPro: 2.046 ± 0.336
2.833SerGln: 2.833 ± 0.541
4.171SerArg: 4.171 ± 0.536
3.069SerSer: 3.069 ± 0.53
3.384SerThr: 3.384 ± 0.516
3.227SerVal: 3.227 ± 0.562
0.708SerTrp: 0.708 ± 0.228
1.18SerTyr: 1.18 ± 0.293
0.0SerXaa: 0.0 ± 0.0
Thr
6.374ThrAla: 6.374 ± 0.705
0.236ThrCys: 0.236 ± 0.12
3.777ThrAsp: 3.777 ± 0.731
2.99ThrGlu: 2.99 ± 0.525
3.069ThrPhe: 3.069 ± 0.499
6.06ThrGly: 6.06 ± 0.88
1.102ThrHis: 1.102 ± 0.286
2.518ThrIle: 2.518 ± 0.539
2.204ThrLys: 2.204 ± 0.512
4.014ThrLeu: 4.014 ± 0.611
0.708ThrMet: 0.708 ± 0.209
1.967ThrAsn: 1.967 ± 0.501
5.666ThrPro: 5.666 ± 0.812
2.912ThrGln: 2.912 ± 0.531
2.833ThrArg: 2.833 ± 0.465
2.518ThrSer: 2.518 ± 0.53
3.305ThrThr: 3.305 ± 0.527
4.643ThrVal: 4.643 ± 0.665
0.708ThrTrp: 0.708 ± 0.24
0.866ThrTyr: 0.866 ± 0.272
0.0ThrXaa: 0.0 ± 0.0
Val
7.161ValAla: 7.161 ± 0.983
0.393ValCys: 0.393 ± 0.169
4.171ValAsp: 4.171 ± 0.595
4.171ValGlu: 4.171 ± 0.571
2.125ValPhe: 2.125 ± 0.414
3.62ValGly: 3.62 ± 0.756
0.787ValHis: 0.787 ± 0.241
3.384ValIle: 3.384 ± 0.589
3.148ValLys: 3.148 ± 0.451
4.801ValLeu: 4.801 ± 0.734
2.046ValMet: 2.046 ± 0.351
2.361ValAsn: 2.361 ± 0.438
2.597ValPro: 2.597 ± 0.468
2.833ValGln: 2.833 ± 0.502
3.62ValArg: 3.62 ± 0.656
5.037ValSer: 5.037 ± 0.898
4.958ValThr: 4.958 ± 0.46
3.541ValVal: 3.541 ± 0.689
0.551ValTrp: 0.551 ± 0.224
1.731ValTyr: 1.731 ± 0.395
0.0ValXaa: 0.0 ± 0.0
Trp
2.204TrpAla: 2.204 ± 0.448
0.315TrpCys: 0.315 ± 0.151
1.417TrpAsp: 1.417 ± 0.473
0.944TrpGlu: 0.944 ± 0.222
0.393TrpPhe: 0.393 ± 0.19
1.023TrpGly: 1.023 ± 0.323
0.551TrpHis: 0.551 ± 0.202
0.787TrpIle: 0.787 ± 0.217
0.708TrpLys: 0.708 ± 0.259
1.259TrpLeu: 1.259 ± 0.383
0.157TrpMet: 0.157 ± 0.11
0.472TrpAsn: 0.472 ± 0.212
0.472TrpPro: 0.472 ± 0.183
0.708TrpGln: 0.708 ± 0.269
1.18TrpArg: 1.18 ± 0.25
1.259TrpSer: 1.259 ± 0.336
0.944TrpThr: 0.944 ± 0.281
1.417TrpVal: 1.417 ± 0.321
0.236TrpTrp: 0.236 ± 0.116
0.315TrpTyr: 0.315 ± 0.137
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.833TyrAla: 2.833 ± 0.478
0.157TyrCys: 0.157 ± 0.12
2.125TyrAsp: 2.125 ± 0.491
1.259TyrGlu: 1.259 ± 0.292
1.102TyrPhe: 1.102 ± 0.297
1.889TyrGly: 1.889 ± 0.437
0.708TyrHis: 0.708 ± 0.312
1.023TyrIle: 1.023 ± 0.242
1.023TyrLys: 1.023 ± 0.272
1.495TyrLeu: 1.495 ± 0.299
0.472TyrMet: 0.472 ± 0.179
0.551TyrAsn: 0.551 ± 0.199
1.18TyrPro: 1.18 ± 0.289
1.338TyrGln: 1.338 ± 0.368
2.046TyrArg: 2.046 ± 0.362
1.653TyrSer: 1.653 ± 0.311
1.495TyrThr: 1.495 ± 0.354
2.44TyrVal: 2.44 ± 0.493
0.157TyrTrp: 0.157 ± 0.104
0.551TyrTyr: 0.551 ± 0.251
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 72 proteins (12708 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski