Amino acid dipepetide frequency for Streptococcus satellite phage Javan322

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.921AlaAla: 0.921 ± 0.49
0.307AlaCys: 0.307 ± 0.287
3.07AlaAsp: 3.07 ± 1.033
4.912AlaGlu: 4.912 ± 1.237
3.377AlaPhe: 3.377 ± 0.747
2.149AlaGly: 2.149 ± 0.785
0.921AlaHis: 0.921 ± 0.524
4.298AlaIle: 4.298 ± 1.407
6.755AlaLys: 6.755 ± 1.651
4.298AlaLeu: 4.298 ± 1.152
1.228AlaMet: 1.228 ± 0.639
2.763AlaAsn: 2.763 ± 0.686
1.228AlaPro: 1.228 ± 0.528
1.842AlaGln: 1.842 ± 0.725
3.377AlaArg: 3.377 ± 0.913
1.535AlaSer: 1.535 ± 0.73
3.991AlaThr: 3.991 ± 1.05
1.535AlaVal: 1.535 ± 0.676
0.0AlaTrp: 0.0 ± 0.0
3.684AlaTyr: 3.684 ± 0.854
0.0AlaXaa: 0.0 ± 0.0
Cys
0.614CysAla: 0.614 ± 0.406
0.0CysCys: 0.0 ± 0.0
0.307CysAsp: 0.307 ± 0.287
0.614CysGlu: 0.614 ± 0.405
0.0CysPhe: 0.0 ± 0.0
0.614CysGly: 0.614 ± 0.441
0.0CysHis: 0.0 ± 0.0
0.307CysIle: 0.307 ± 0.281
0.921CysLys: 0.921 ± 0.464
0.921CysLeu: 0.921 ± 0.553
0.307CysMet: 0.307 ± 0.33
0.0CysAsn: 0.0 ± 0.0
0.307CysPro: 0.307 ± 0.287
0.0CysGln: 0.0 ± 0.0
0.614CysArg: 0.614 ± 0.361
0.307CysSer: 0.307 ± 0.287
0.307CysThr: 0.307 ± 0.262
0.307CysVal: 0.307 ± 0.287
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
1.535AspAla: 1.535 ± 0.75
0.614AspCys: 0.614 ± 0.392
3.684AspAsp: 3.684 ± 1.134
2.763AspGlu: 2.763 ± 0.921
4.605AspPhe: 4.605 ± 1.109
3.684AspGly: 3.684 ± 0.963
0.614AspHis: 0.614 ± 0.404
4.298AspIle: 4.298 ± 0.915
7.369AspLys: 7.369 ± 1.217
7.676AspLeu: 7.676 ± 1.284
0.921AspMet: 0.921 ± 0.472
4.605AspAsn: 4.605 ± 1.168
0.921AspPro: 0.921 ± 0.396
0.614AspGln: 0.614 ± 0.462
1.842AspArg: 1.842 ± 0.841
4.298AspSer: 4.298 ± 1.319
3.684AspThr: 3.684 ± 0.847
3.684AspVal: 3.684 ± 0.899
0.307AspTrp: 0.307 ± 0.287
2.149AspTyr: 2.149 ± 0.891
0.0AspXaa: 0.0 ± 0.0
Glu
3.377GluAla: 3.377 ± 0.983
1.228GluCys: 1.228 ± 0.435
3.991GluAsp: 3.991 ± 1.477
4.912GluGlu: 4.912 ± 1.315
3.07GluPhe: 3.07 ± 0.877
3.07GluGly: 3.07 ± 1.081
0.921GluHis: 0.921 ± 0.637
9.518GluIle: 9.518 ± 1.617
10.132GluLys: 10.132 ± 1.635
8.597GluLeu: 8.597 ± 1.726
1.535GluMet: 1.535 ± 0.765
4.298GluAsn: 4.298 ± 1.049
1.228GluPro: 1.228 ± 0.718
4.912GluGln: 4.912 ± 1.072
3.684GluArg: 3.684 ± 0.93
4.912GluSer: 4.912 ± 0.98
5.527GluThr: 5.527 ± 1.196
2.763GluVal: 2.763 ± 0.954
0.614GluTrp: 0.614 ± 0.341
4.298GluTyr: 4.298 ± 1.506
0.0GluXaa: 0.0 ± 0.0
Phe
0.921PheAla: 0.921 ± 0.407
0.307PheCys: 0.307 ± 0.287
3.07PheAsp: 3.07 ± 0.838
3.684PheGlu: 3.684 ± 0.7
2.149PhePhe: 2.149 ± 0.665
1.535PheGly: 1.535 ± 0.649
1.228PheHis: 1.228 ± 0.47
2.149PheIle: 2.149 ± 0.714
6.448PheLys: 6.448 ± 1.463
4.912PheLeu: 4.912 ± 1.158
0.614PheMet: 0.614 ± 0.393
1.535PheAsn: 1.535 ± 0.751
1.228PhePro: 1.228 ± 0.601
1.842PheGln: 1.842 ± 0.655
1.842PheArg: 1.842 ± 0.515
3.684PheSer: 3.684 ± 0.901
1.842PheThr: 1.842 ± 0.92
2.149PheVal: 2.149 ± 0.934
0.921PheTrp: 0.921 ± 0.481
1.535PheTyr: 1.535 ± 0.614
0.0PheXaa: 0.0 ± 0.0
Gly
2.149GlyAla: 2.149 ± 0.769
0.307GlyCys: 0.307 ± 0.262
1.535GlyAsp: 1.535 ± 0.762
3.07GlyGlu: 3.07 ± 1.044
3.07GlyPhe: 3.07 ± 0.796
2.149GlyGly: 2.149 ± 1.13
0.921GlyHis: 0.921 ± 0.516
2.456GlyIle: 2.456 ± 0.79
4.605GlyLys: 4.605 ± 1.019
4.298GlyLeu: 4.298 ± 0.683
1.535GlyMet: 1.535 ± 0.738
1.842GlyAsn: 1.842 ± 0.855
0.0GlyPro: 0.0 ± 0.0
1.535GlyGln: 1.535 ± 0.692
1.842GlyArg: 1.842 ± 0.711
2.456GlySer: 2.456 ± 0.978
2.763GlyThr: 2.763 ± 0.757
3.07GlyVal: 3.07 ± 0.836
0.614GlyTrp: 0.614 ± 0.382
3.684GlyTyr: 3.684 ± 1.045
0.0GlyXaa: 0.0 ± 0.0
His
3.07HisAla: 3.07 ± 1.14
0.0HisCys: 0.0 ± 0.0
0.614HisAsp: 0.614 ± 0.453
0.307HisGlu: 0.307 ± 0.28
0.614HisPhe: 0.614 ± 0.508
0.307HisGly: 0.307 ± 0.254
0.614HisHis: 0.614 ± 0.361
1.228HisIle: 1.228 ± 0.696
2.149HisLys: 2.149 ± 0.676
2.456HisLeu: 2.456 ± 0.986
0.307HisMet: 0.307 ± 0.354
1.228HisAsn: 1.228 ± 0.646
0.307HisPro: 0.307 ± 0.316
0.307HisGln: 0.307 ± 0.287
0.0HisArg: 0.0 ± 0.0
1.535HisSer: 1.535 ± 0.662
1.535HisThr: 1.535 ± 0.779
0.0HisVal: 0.0 ± 0.0
0.0HisTrp: 0.0 ± 0.0
1.228HisTyr: 1.228 ± 0.612
0.0HisXaa: 0.0 ± 0.0
Ile
3.07IleAla: 3.07 ± 0.98
0.307IleCys: 0.307 ± 0.316
5.527IleAsp: 5.527 ± 1.038
5.527IleGlu: 5.527 ± 1.728
2.456IlePhe: 2.456 ± 1.007
2.149IleGly: 2.149 ± 0.573
1.228IleHis: 1.228 ± 0.579
5.834IleIle: 5.834 ± 1.287
8.597IleLys: 8.597 ± 1.476
8.597IleLeu: 8.597 ± 1.143
0.307IleMet: 0.307 ± 0.287
4.912IleAsn: 4.912 ± 0.802
2.456IlePro: 2.456 ± 0.539
3.684IleGln: 3.684 ± 0.89
2.456IleArg: 2.456 ± 0.836
4.298IleSer: 4.298 ± 1.059
5.527IleThr: 5.527 ± 1.153
3.377IleVal: 3.377 ± 1.004
0.0IleTrp: 0.0 ± 0.0
2.149IleTyr: 2.149 ± 0.712
0.0IleXaa: 0.0 ± 0.0
Lys
5.22LysAla: 5.22 ± 1.572
0.614LysCys: 0.614 ± 0.425
6.755LysAsp: 6.755 ± 1.332
12.588LysGlu: 12.588 ± 2.58
3.991LysPhe: 3.991 ± 1.282
5.834LysGly: 5.834 ± 1.485
1.842LysHis: 1.842 ± 0.594
7.369LysIle: 7.369 ± 1.427
8.597LysLys: 8.597 ± 1.732
6.448LysLeu: 6.448 ± 1.141
2.456LysMet: 2.456 ± 0.868
6.448LysAsn: 6.448 ± 1.321
1.842LysPro: 1.842 ± 0.712
5.527LysGln: 5.527 ± 1.116
6.448LysArg: 6.448 ± 1.456
6.448LysSer: 6.448 ± 1.044
6.755LysThr: 6.755 ± 1.856
4.605LysVal: 4.605 ± 1.159
1.228LysTrp: 1.228 ± 0.471
3.07LysTyr: 3.07 ± 0.723
0.0LysXaa: 0.0 ± 0.0
Leu
7.369LeuAla: 7.369 ± 1.659
0.614LeuCys: 0.614 ± 0.443
7.983LeuAsp: 7.983 ± 1.38
10.746LeuGlu: 10.746 ± 1.985
3.684LeuPhe: 3.684 ± 0.652
5.527LeuGly: 5.527 ± 1.008
1.535LeuHis: 1.535 ± 0.795
4.298LeuIle: 4.298 ± 1.128
7.369LeuLys: 7.369 ± 1.58
8.904LeuLeu: 8.904 ± 1.788
3.07LeuMet: 3.07 ± 0.816
6.141LeuAsn: 6.141 ± 1.397
2.763LeuPro: 2.763 ± 0.785
3.377LeuGln: 3.377 ± 0.817
3.684LeuArg: 3.684 ± 0.795
6.448LeuSer: 6.448 ± 1.404
5.527LeuThr: 5.527 ± 1.186
5.834LeuVal: 5.834 ± 1.61
0.307LeuTrp: 0.307 ± 0.281
2.763LeuTyr: 2.763 ± 0.838
0.0LeuXaa: 0.0 ± 0.0
Met
1.228MetAla: 1.228 ± 0.548
0.0MetCys: 0.0 ± 0.0
2.149MetAsp: 2.149 ± 0.818
1.535MetGlu: 1.535 ± 0.561
0.0MetPhe: 0.0 ± 0.0
0.307MetGly: 0.307 ± 0.346
0.0MetHis: 0.0 ± 0.0
1.535MetIle: 1.535 ± 0.542
2.763MetLys: 2.763 ± 0.686
1.535MetLeu: 1.535 ± 0.447
0.0MetMet: 0.0 ± 0.0
1.842MetAsn: 1.842 ± 0.841
0.0MetPro: 0.0 ± 0.0
0.307MetGln: 0.307 ± 0.339
1.228MetArg: 1.228 ± 0.566
1.535MetSer: 1.535 ± 0.706
2.456MetThr: 2.456 ± 1.098
0.614MetVal: 0.614 ± 0.5
0.0MetTrp: 0.0 ± 0.0
0.614MetTyr: 0.614 ± 0.411
0.0MetXaa: 0.0 ± 0.0
Asn
4.298AsnAla: 4.298 ± 0.834
0.307AsnCys: 0.307 ± 0.262
1.535AsnAsp: 1.535 ± 0.604
2.456AsnGlu: 2.456 ± 0.903
3.07AsnPhe: 3.07 ± 0.827
3.377AsnGly: 3.377 ± 0.866
1.228AsnHis: 1.228 ± 0.447
3.991AsnIle: 3.991 ± 1.388
5.22AsnLys: 5.22 ± 1.371
5.834AsnLeu: 5.834 ± 1.017
0.921AsnMet: 0.921 ± 0.518
5.834AsnAsn: 5.834 ± 1.89
1.842AsnPro: 1.842 ± 0.867
3.684AsnGln: 3.684 ± 1.063
1.535AsnArg: 1.535 ± 0.716
2.763AsnSer: 2.763 ± 0.957
5.527AsnThr: 5.527 ± 1.274
2.456AsnVal: 2.456 ± 0.939
0.307AsnTrp: 0.307 ± 0.254
3.991AsnTyr: 3.991 ± 0.856
0.0AsnXaa: 0.0 ± 0.0
Pro
0.921ProAla: 0.921 ± 0.492
0.0ProCys: 0.0 ± 0.0
1.228ProAsp: 1.228 ± 0.532
3.377ProGlu: 3.377 ± 0.892
1.842ProPhe: 1.842 ± 0.793
0.0ProGly: 0.0 ± 0.0
0.614ProHis: 0.614 ± 0.39
0.921ProIle: 0.921 ± 0.462
3.377ProLys: 3.377 ± 1.053
0.614ProLeu: 0.614 ± 0.361
0.0ProMet: 0.0 ± 0.0
1.228ProAsn: 1.228 ± 0.486
0.307ProPro: 0.307 ± 0.28
0.921ProGln: 0.921 ± 0.624
1.228ProArg: 1.228 ± 0.593
1.228ProSer: 1.228 ± 0.57
1.228ProThr: 1.228 ± 0.607
1.228ProVal: 1.228 ± 0.477
0.0ProTrp: 0.0 ± 0.0
1.228ProTyr: 1.228 ± 0.451
0.0ProXaa: 0.0 ± 0.0
Gln
4.912GlnAla: 4.912 ± 1.327
0.921GlnCys: 0.921 ± 0.464
2.763GlnAsp: 2.763 ± 0.996
2.456GlnGlu: 2.456 ± 0.792
2.149GlnPhe: 2.149 ± 0.919
0.307GlnGly: 0.307 ± 0.33
1.842GlnHis: 1.842 ± 0.672
3.377GlnIle: 3.377 ± 0.854
3.991GlnLys: 3.991 ± 0.779
2.456GlnLeu: 2.456 ± 0.968
0.307GlnMet: 0.307 ± 0.287
2.149GlnAsn: 2.149 ± 0.946
0.614GlnPro: 0.614 ± 0.401
1.842GlnGln: 1.842 ± 0.687
1.228GlnArg: 1.228 ± 0.753
2.763GlnSer: 2.763 ± 0.906
2.456GlnThr: 2.456 ± 0.876
3.684GlnVal: 3.684 ± 0.957
0.614GlnTrp: 0.614 ± 0.465
1.535GlnTyr: 1.535 ± 0.552
0.0GlnXaa: 0.0 ± 0.0
Arg
1.535ArgAla: 1.535 ± 0.731
0.0ArgCys: 0.0 ± 0.0
2.763ArgAsp: 2.763 ± 0.853
3.684ArgGlu: 3.684 ± 0.838
2.149ArgPhe: 2.149 ± 0.933
2.456ArgGly: 2.456 ± 0.789
0.614ArgHis: 0.614 ± 0.338
3.377ArgIle: 3.377 ± 0.647
6.755ArgLys: 6.755 ± 1.323
4.298ArgLeu: 4.298 ± 1.114
1.228ArgMet: 1.228 ± 0.577
3.07ArgAsn: 3.07 ± 0.751
0.921ArgPro: 0.921 ± 0.399
2.149ArgGln: 2.149 ± 0.758
1.535ArgArg: 1.535 ± 0.683
1.535ArgSer: 1.535 ± 0.644
2.763ArgThr: 2.763 ± 0.743
1.228ArgVal: 1.228 ± 0.863
0.307ArgTrp: 0.307 ± 0.267
3.07ArgTyr: 3.07 ± 0.861
0.0ArgXaa: 0.0 ± 0.0
Ser
3.377SerAla: 3.377 ± 1.731
0.0SerCys: 0.0 ± 0.0
4.605SerAsp: 4.605 ± 0.863
6.755SerGlu: 6.755 ± 1.782
2.456SerPhe: 2.456 ± 1.13
2.149SerGly: 2.149 ± 0.667
1.228SerHis: 1.228 ± 0.606
5.22SerIle: 5.22 ± 1.326
5.834SerLys: 5.834 ± 1.261
5.834SerLeu: 5.834 ± 1.357
1.535SerMet: 1.535 ± 0.692
3.07SerAsn: 3.07 ± 1.147
2.149SerPro: 2.149 ± 0.695
1.228SerGln: 1.228 ± 0.645
1.842SerArg: 1.842 ± 0.627
4.605SerSer: 4.605 ± 1.063
4.605SerThr: 4.605 ± 1.145
3.07SerVal: 3.07 ± 0.83
0.307SerTrp: 0.307 ± 0.33
2.149SerTyr: 2.149 ± 0.701
0.0SerXaa: 0.0 ± 0.0
Thr
3.07ThrAla: 3.07 ± 1.052
0.307ThrCys: 0.307 ± 0.281
1.535ThrAsp: 1.535 ± 0.63
4.912ThrGlu: 4.912 ± 1.429
1.535ThrPhe: 1.535 ± 0.596
5.22ThrGly: 5.22 ± 1.062
1.842ThrHis: 1.842 ± 0.569
4.912ThrIle: 4.912 ± 1.063
4.912ThrLys: 4.912 ± 1.063
7.369ThrLeu: 7.369 ± 1.269
0.921ThrMet: 0.921 ± 0.461
3.07ThrAsn: 3.07 ± 0.827
1.228ThrPro: 1.228 ± 0.552
4.605ThrGln: 4.605 ± 1.2
4.298ThrArg: 4.298 ± 1.156
3.991ThrSer: 3.991 ± 0.962
4.298ThrThr: 4.298 ± 1.176
4.298ThrVal: 4.298 ± 1.21
0.921ThrTrp: 0.921 ± 0.527
3.07ThrTyr: 3.07 ± 1.237
0.0ThrXaa: 0.0 ± 0.0
Val
2.456ValAla: 2.456 ± 0.812
0.307ValCys: 0.307 ± 0.287
3.991ValAsp: 3.991 ± 0.869
3.07ValGlu: 3.07 ± 1.13
1.228ValPhe: 1.228 ± 0.512
1.842ValGly: 1.842 ± 0.723
0.0ValHis: 0.0 ± 0.0
3.377ValIle: 3.377 ± 1.087
3.991ValLys: 3.991 ± 1.232
5.527ValLeu: 5.527 ± 1.279
0.614ValMet: 0.614 ± 0.496
3.07ValAsn: 3.07 ± 0.846
1.535ValPro: 1.535 ± 0.626
1.535ValGln: 1.535 ± 0.768
2.456ValArg: 2.456 ± 0.835
3.684ValSer: 3.684 ± 0.932
3.991ValThr: 3.991 ± 1.125
3.377ValVal: 3.377 ± 1.206
0.307ValTrp: 0.307 ± 0.286
3.07ValTyr: 3.07 ± 0.881
0.0ValXaa: 0.0 ± 0.0
Trp
0.921TrpAla: 0.921 ± 0.466
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
1.842TrpGlu: 1.842 ± 0.719
0.0TrpPhe: 0.0 ± 0.0
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.614TrpIle: 0.614 ± 0.387
0.614TrpLys: 0.614 ± 0.384
0.614TrpLeu: 0.614 ± 0.429
0.0TrpMet: 0.0 ± 0.0
0.307TrpAsn: 0.307 ± 0.267
0.0TrpPro: 0.0 ± 0.0
0.307TrpGln: 0.307 ± 0.262
0.307TrpArg: 0.307 ± 0.286
0.307TrpSer: 0.307 ± 0.262
0.0TrpThr: 0.0 ± 0.0
0.921TrpVal: 0.921 ± 0.418
0.0TrpTrp: 0.0 ± 0.0
0.307TrpTyr: 0.307 ± 0.254
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.228TyrAla: 1.228 ± 0.467
0.307TyrCys: 0.307 ± 0.286
2.763TyrAsp: 2.763 ± 0.9
3.377TyrGlu: 3.377 ± 0.763
2.149TyrPhe: 2.149 ± 0.649
1.228TyrGly: 1.228 ± 0.454
0.614TyrHis: 0.614 ± 0.424
3.377TyrIle: 3.377 ± 1.089
3.684TyrLys: 3.684 ± 1.144
6.755TyrLeu: 6.755 ± 1.529
1.535TyrMet: 1.535 ± 0.674
2.763TyrAsn: 2.763 ± 1.089
0.614TyrPro: 0.614 ± 0.351
2.149TyrGln: 2.149 ± 0.824
3.991TyrArg: 3.991 ± 1.178
3.684TyrSer: 3.684 ± 1.064
1.535TyrThr: 1.535 ± 0.627
1.535TyrVal: 1.535 ± 0.63
0.307TyrTrp: 0.307 ± 0.287
1.535TyrTyr: 1.535 ± 0.811
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 21 proteins (3258 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski