Amino acid dipepetide frequency for Hymenobacter sedentarius

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.579AlaAla: 14.579 ± 0.164	0.801AlaCys: 0.801 ± 0.026	5.819AlaAsp: 5.819 ± 0.071	5.911AlaGlu: 5.911 ± 0.081	3.888AlaPhe: 3.888 ± 0.058	9.089AlaGly: 9.089 ± 0.103	2.247AlaHis: 2.247 ± 0.052	4.112AlaIle: 4.112 ± 0.059	4.022AlaLys: 4.022 ± 0.057	11.415AlaLeu: 11.415 ± 0.128	1.982AlaMet: 1.982 ± 0.047	3.669AlaAsn: 3.669 ± 0.07	5.835AlaPro: 5.835 ± 0.084	5.568AlaGln: 5.568 ± 0.074	6.198AlaArg: 6.198 ± 0.082	5.75AlaSer: 5.75 ± 0.083	7.301AlaThr: 7.301 ± 0.203	7.611AlaVal: 7.611 ± 0.092	1.265AlaTrp: 1.265 ± 0.034	3.27AlaTyr: 3.27 ± 0.061	0.0AlaXaa: 0.0 ± 0.0
Cys	0.697CysAla: 0.697 ± 0.027	0.106CysCys: 0.106 ± 0.009	0.369CysAsp: 0.369 ± 0.019	0.357CysGlu: 0.357 ± 0.018	0.312CysPhe: 0.312 ± 0.021	0.625CysGly: 0.625 ± 0.025	0.198CysHis: 0.198 ± 0.013	0.33CysIle: 0.33 ± 0.016	0.199CysLys: 0.199 ± 0.014	0.741CysLeu: 0.741 ± 0.025	0.115CysMet: 0.115 ± 0.01	0.244CysAsn: 0.244 ± 0.012	0.408CysPro: 0.408 ± 0.023	0.318CysGln: 0.318 ± 0.017	0.411CysArg: 0.411 ± 0.016	0.423CysSer: 0.423 ± 0.017	0.459CysThr: 0.459 ± 0.034	0.42CysVal: 0.42 ± 0.02	0.094CysTrp: 0.094 ± 0.008	0.262CysTyr: 0.262 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	5.239AspAla: 5.239 ± 0.07	0.324AspCys: 0.324 ± 0.017	2.265AspAsp: 2.265 ± 0.051	2.959AspGlu: 2.959 ± 0.06	2.511AspPhe: 2.511 ± 0.045	3.826AspGly: 3.826 ± 0.067	0.945AspHis: 0.945 ± 0.027	2.356AspIle: 2.356 ± 0.047	2.265AspLys: 2.265 ± 0.043	5.066AspLeu: 5.066 ± 0.071	0.917AspMet: 0.917 ± 0.028	1.898AspAsn: 1.898 ± 0.037	2.451AspPro: 2.451 ± 0.046	1.888AspGln: 1.888 ± 0.037	2.437AspArg: 2.437 ± 0.048	2.494AspSer: 2.494 ± 0.054	2.516AspThr: 2.516 ± 0.043	3.733AspVal: 3.733 ± 0.057	0.711AspTrp: 0.711 ± 0.028	2.132AspTyr: 2.132 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	5.825GluAla: 5.825 ± 0.084	0.302GluCys: 0.302 ± 0.015	2.1GluAsp: 2.1 ± 0.045	2.954GluGlu: 2.954 ± 0.063	2.078GluPhe: 2.078 ± 0.044	3.288GluGly: 3.288 ± 0.054	1.178GluHis: 1.178 ± 0.029	2.577GluIle: 2.577 ± 0.047	2.692GluLys: 2.692 ± 0.057	6.097GluLeu: 6.097 ± 0.081	1.267GluMet: 1.267 ± 0.036	1.92GluAsn: 1.92 ± 0.039	2.206GluPro: 2.206 ± 0.047	2.605GluGln: 2.605 ± 0.052	3.083GluArg: 3.083 ± 0.058	2.192GluSer: 2.192 ± 0.045	2.825GluThr: 2.825 ± 0.049	3.853GluVal: 3.853 ± 0.06	0.611GluTrp: 0.611 ± 0.021	1.657GluTyr: 1.657 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	3.955PheAla: 3.955 ± 0.058	0.352PheCys: 0.352 ± 0.018	2.396PheAsp: 2.396 ± 0.046	2.199PheGlu: 2.199 ± 0.046	1.838PhePhe: 1.838 ± 0.041	3.5PheGly: 3.5 ± 0.054	0.794PheHis: 0.794 ± 0.023	1.77PheIle: 1.77 ± 0.042	1.478PheLys: 1.478 ± 0.037	3.751PheLeu: 3.751 ± 0.057	0.755PheMet: 0.755 ± 0.026	1.751PheAsn: 1.751 ± 0.04	1.771PhePro: 1.771 ± 0.034	1.579PheGln: 1.579 ± 0.03	2.441PheArg: 2.441 ± 0.043	2.692PheSer: 2.692 ± 0.049	2.867PheThr: 2.867 ± 0.062	2.917PheVal: 2.917 ± 0.049	0.557PheTrp: 0.557 ± 0.026	1.528PheTyr: 1.528 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	7.088GlyAla: 7.088 ± 0.088	0.701GlyCys: 0.701 ± 0.035	3.207GlyAsp: 3.207 ± 0.053	3.562GlyGlu: 3.562 ± 0.063	3.393GlyPhe: 3.393 ± 0.057	6.189GlyGly: 6.189 ± 0.105	1.824GlyHis: 1.824 ± 0.043	3.863GlyIle: 3.863 ± 0.063	3.656GlyLys: 3.656 ± 0.064	8.525GlyLeu: 8.525 ± 0.099	1.588GlyMet: 1.588 ± 0.041	2.851GlyAsn: 2.851 ± 0.063	3.357GlyPro: 3.357 ± 0.061	3.868GlyGln: 3.868 ± 0.055	4.652GlyArg: 4.652 ± 0.069	4.662GlySer: 4.662 ± 0.083	5.58GlyThr: 5.58 ± 0.129	5.457GlyVal: 5.457 ± 0.071	1.095GlyTrp: 1.095 ± 0.033	3.021GlyTyr: 3.021 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	1.923HisAla: 1.923 ± 0.041	0.202HisCys: 0.202 ± 0.013	1.151HisAsp: 1.151 ± 0.031	1.153HisGlu: 1.153 ± 0.031	1.068HisPhe: 1.068 ± 0.028	1.705HisGly: 1.705 ± 0.045	0.627HisHis: 0.627 ± 0.027	0.946HisIle: 0.946 ± 0.029	0.652HisLys: 0.652 ± 0.025	2.438HisLeu: 2.438 ± 0.051	0.379HisMet: 0.379 ± 0.016	0.748HisAsn: 0.748 ± 0.03	1.344HisPro: 1.344 ± 0.035	0.895HisGln: 0.895 ± 0.026	1.297HisArg: 1.297 ± 0.032	1.062HisSer: 1.062 ± 0.029	1.178HisThr: 1.178 ± 0.027	1.378HisVal: 1.378 ± 0.04	0.317HisTrp: 0.317 ± 0.015	0.909HisTyr: 0.909 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	4.327IleAla: 4.327 ± 0.065	0.386IleCys: 0.386 ± 0.018	2.444IleAsp: 2.444 ± 0.048	2.38IleGlu: 2.38 ± 0.055	1.656IlePhe: 1.656 ± 0.046	3.581IleGly: 3.581 ± 0.06	0.779IleHis: 0.779 ± 0.025	2.197IleIle: 2.197 ± 0.054	1.908IleLys: 1.908 ± 0.042	3.621IleLeu: 3.621 ± 0.064	0.81IleMet: 0.81 ± 0.026	1.832IleAsn: 1.832 ± 0.041	2.086IlePro: 2.086 ± 0.038	1.571IleGln: 1.571 ± 0.036	2.552IleArg: 2.552 ± 0.048	2.723IleSer: 2.723 ± 0.044	3.001IleThr: 3.001 ± 0.06	2.972IleVal: 2.972 ± 0.049	0.465IleTrp: 0.465 ± 0.017	1.351IleTyr: 1.351 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	4.292LysAla: 4.292 ± 0.068	0.181LysCys: 0.181 ± 0.014	2.066LysAsp: 2.066 ± 0.044	2.185LysGlu: 2.185 ± 0.052	1.461LysPhe: 1.461 ± 0.038	2.915LysGly: 2.915 ± 0.054	0.806LysHis: 0.806 ± 0.03	1.931LysIle: 1.931 ± 0.044	2.295LysLys: 2.295 ± 0.058	4.227LysLeu: 4.227 ± 0.066	1.127LysMet: 1.127 ± 0.034	1.686LysAsn: 1.686 ± 0.042	2.256LysPro: 2.256 ± 0.05	1.82LysGln: 1.82 ± 0.039	2.116LysArg: 2.116 ± 0.042	2.114LysSer: 2.114 ± 0.05	2.577LysThr: 2.577 ± 0.045	2.858LysVal: 2.858 ± 0.054	0.466LysTrp: 0.466 ± 0.023	1.406LysTyr: 1.406 ± 0.035	0.0LysXaa: 0.0 ± 0.0
Leu	12.699LeuAla: 12.699 ± 0.132	0.72LeuCys: 0.72 ± 0.026	5.224LeuAsp: 5.224 ± 0.07	4.827LeuGlu: 4.827 ± 0.073	3.932LeuPhe: 3.932 ± 0.065	8.215LeuGly: 8.215 ± 0.102	2.499LeuHis: 2.499 ± 0.05	3.892LeuIle: 3.892 ± 0.056	4.205LeuLys: 4.205 ± 0.071	12.897LeuLeu: 12.897 ± 0.178	1.973LeuMet: 1.973 ± 0.043	4.248LeuAsn: 4.248 ± 0.067	6.365LeuPro: 6.365 ± 0.079	4.092LeuGln: 4.092 ± 0.063	7.426LeuArg: 7.426 ± 0.092	6.18LeuSer: 6.18 ± 0.082	6.963LeuThr: 6.963 ± 0.085	7.537LeuVal: 7.537 ± 0.109	1.08LeuTrp: 1.08 ± 0.033	3.035LeuTyr: 3.035 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	2.164MetAla: 2.164 ± 0.047	0.121MetCys: 0.121 ± 0.01	0.838MetAsp: 0.838 ± 0.026	0.931MetGlu: 0.931 ± 0.027	0.596MetPhe: 0.596 ± 0.022	1.418MetGly: 1.418 ± 0.039	0.403MetHis: 0.403 ± 0.019	0.674MetIle: 0.674 ± 0.024	1.123MetLys: 1.123 ± 0.034	2.147MetLeu: 2.147 ± 0.041	0.423MetMet: 0.423 ± 0.02	0.759MetAsn: 0.759 ± 0.025	1.244MetPro: 1.244 ± 0.034	0.875MetGln: 0.875 ± 0.028	1.215MetArg: 1.215 ± 0.031	1.103MetSer: 1.103 ± 0.025	1.074MetThr: 1.074 ± 0.029	1.273MetVal: 1.273 ± 0.033	0.187MetTrp: 0.187 ± 0.011	0.462MetTyr: 0.462 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.711AsnAla: 3.711 ± 0.069	0.293AsnCys: 0.293 ± 0.016	1.83AsnAsp: 1.83 ± 0.042	1.799AsnGlu: 1.799 ± 0.039	1.747AsnPhe: 1.747 ± 0.04	3.335AsnGly: 3.335 ± 0.061	0.684AsnHis: 0.684 ± 0.023	1.788AsnIle: 1.788 ± 0.039	1.424AsnLys: 1.424 ± 0.036	3.828AsnLeu: 3.828 ± 0.061	0.677AsnMet: 0.677 ± 0.024	1.653AsnAsn: 1.653 ± 0.05	2.549AsnPro: 2.549 ± 0.047	1.635AsnGln: 1.635 ± 0.034	2.066AsnArg: 2.066 ± 0.044	2.086AsnSer: 2.086 ± 0.052	2.344AsnThr: 2.344 ± 0.056	2.649AsnVal: 2.649 ± 0.059	0.548AsnTrp: 0.548 ± 0.022	1.537AsnTyr: 1.537 ± 0.042	0.0AsnXaa: 0.0 ± 0.0
Pro	7.651ProAla: 7.651 ± 0.093	0.252ProCys: 0.252 ± 0.014	3.161ProAsp: 3.161 ± 0.057	3.422ProGlu: 3.422 ± 0.062	1.969ProPhe: 1.969 ± 0.04	4.411ProGly: 4.411 ± 0.066	1.058ProHis: 1.058 ± 0.031	2.016ProIle: 2.016 ± 0.044	1.952ProLys: 1.952 ± 0.049	5.133ProLeu: 5.133 ± 0.071	0.829ProMet: 0.829 ± 0.026	2.219ProAsn: 2.219 ± 0.049	2.142ProPro: 2.142 ± 0.054	1.908ProGln: 1.908 ± 0.041	2.557ProArg: 2.557 ± 0.05	2.562ProSer: 2.562 ± 0.054	3.624ProThr: 3.624 ± 0.059	4.213ProVal: 4.213 ± 0.066	0.589ProTrp: 0.589 ± 0.024	1.614ProTyr: 1.614 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	5.067GlnAla: 5.067 ± 0.072	0.187GlnCys: 0.187 ± 0.012	1.764GlnAsp: 1.764 ± 0.037	2.227GlnGlu: 2.227 ± 0.049	1.672GlnPhe: 1.672 ± 0.038	2.846GlnGly: 2.846 ± 0.045	1.17GlnHis: 1.17 ± 0.03	1.694GlnIle: 1.694 ± 0.043	1.741GlnLys: 1.741 ± 0.043	5.396GlnLeu: 5.396 ± 0.065	0.883GlnMet: 0.883 ± 0.025	1.588GlnAsn: 1.588 ± 0.038	2.873GlnPro: 2.873 ± 0.051	2.795GlnGln: 2.795 ± 0.057	3.094GlnArg: 3.094 ± 0.052	1.818GlnSer: 1.818 ± 0.043	2.36GlnThr: 2.36 ± 0.05	3.279GlnVal: 3.279 ± 0.055	0.53GlnTrp: 0.53 ± 0.021	1.418GlnTyr: 1.418 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	5.7ArgAla: 5.7 ± 0.088	0.371ArgCys: 0.371 ± 0.017	2.747ArgAsp: 2.747 ± 0.05	3.231ArgGlu: 3.231 ± 0.058	2.527ArgPhe: 2.527 ± 0.049	3.745ArgGly: 3.745 ± 0.058	1.45ArgHis: 1.45 ± 0.038	2.759ArgIle: 2.759 ± 0.049	2.209ArgLys: 2.209 ± 0.047	7.032ArgLeu: 7.032 ± 0.1	1.229ArgMet: 1.229 ± 0.03	2.117ArgAsn: 2.117 ± 0.045	3.215ArgPro: 3.215 ± 0.054	3.282ArgGln: 3.282 ± 0.056	4.286ArgArg: 4.286 ± 0.08	2.644ArgSer: 2.644 ± 0.052	3.461ArgThr: 3.461 ± 0.053	4.328ArgVal: 4.328 ± 0.058	0.843ArgTrp: 0.843 ± 0.029	2.48ArgTyr: 2.48 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	5.504SerAla: 5.504 ± 0.091	0.46SerCys: 0.46 ± 0.02	2.404SerAsp: 2.404 ± 0.04	2.438SerGlu: 2.438 ± 0.041	2.569SerPhe: 2.569 ± 0.051	4.797SerGly: 4.797 ± 0.077	1.036SerHis: 1.036 ± 0.032	2.558SerIle: 2.558 ± 0.048	2.081SerLys: 2.081 ± 0.045	5.624SerLeu: 5.624 ± 0.064	1.071SerMet: 1.071 ± 0.032	2.013SerAsn: 2.013 ± 0.046	3.055SerPro: 3.055 ± 0.053	2.081SerGln: 2.081 ± 0.055	3.026SerArg: 3.026 ± 0.046	3.339SerSer: 3.339 ± 0.065	3.552SerThr: 3.552 ± 0.065	3.775SerVal: 3.775 ± 0.068	0.671SerTrp: 0.671 ± 0.024	2.015SerTyr: 2.015 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	7.322ThrAla: 7.322 ± 0.18	0.387ThrCys: 0.387 ± 0.026	3.259ThrAsp: 3.259 ± 0.048	2.876ThrGlu: 2.876 ± 0.048	2.591ThrPhe: 2.591 ± 0.058	5.712ThrGly: 5.712 ± 0.15	1.179ThrHis: 1.179 ± 0.03	2.689ThrIle: 2.689 ± 0.049	2.293ThrLys: 2.293 ± 0.047	6.54ThrLeu: 6.54 ± 0.101	0.918ThrMet: 0.918 ± 0.027	2.358ThrAsn: 2.358 ± 0.058	3.943ThrPro: 3.943 ± 0.06	2.212ThrGln: 2.212 ± 0.046	3.094ThrArg: 3.094 ± 0.05	3.461ThrSer: 3.461 ± 0.067	4.193ThrThr: 4.193 ± 0.103	4.97ThrVal: 4.97 ± 0.096	0.75ThrTrp: 0.75 ± 0.026	2.266ThrTyr: 2.266 ± 0.065	0.0ThrXaa: 0.0 ± 0.0
Val	8.126ValAla: 8.126 ± 0.093	0.557ValCys: 0.557 ± 0.024	3.369ValAsp: 3.369 ± 0.056	3.648ValGlu: 3.648 ± 0.064	2.855ValPhe: 2.855 ± 0.047	5.499ValGly: 5.499 ± 0.071	1.332ValHis: 1.332 ± 0.034	2.93ValIle: 2.93 ± 0.057	2.801ValLys: 2.801 ± 0.063	8.242ValLeu: 8.242 ± 0.088	1.293ValMet: 1.293 ± 0.038	2.655ValAsn: 2.655 ± 0.056	4.027ValPro: 4.027 ± 0.064	2.916ValGln: 2.916 ± 0.048	4.482ValArg: 4.482 ± 0.061	4.128ValSer: 4.128 ± 0.066	4.384ValThr: 4.384 ± 0.116	5.914ValVal: 5.914 ± 0.074	0.802ValTrp: 0.802 ± 0.023	2.218ValTyr: 2.218 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	1.203TrpAla: 1.203 ± 0.034	0.095TrpCys: 0.095 ± 0.008	0.552TrpAsp: 0.552 ± 0.02	0.6TrpGlu: 0.6 ± 0.022	0.542TrpPhe: 0.542 ± 0.02	0.82TrpGly: 0.82 ± 0.029	0.346TrpHis: 0.346 ± 0.017	0.365TrpIle: 0.365 ± 0.015	0.493TrpLys: 0.493 ± 0.02	1.617TrpLeu: 1.617 ± 0.041	0.288TrpMet: 0.288 ± 0.016	0.495TrpAsn: 0.495 ± 0.022	0.531TrpPro: 0.531 ± 0.023	0.782TrpGln: 0.782 ± 0.027	0.838TrpArg: 0.838 ± 0.028	0.603TrpSer: 0.603 ± 0.022	0.597TrpThr: 0.597 ± 0.026	0.865TrpVal: 0.865 ± 0.028	0.2TrpTrp: 0.2 ± 0.012	0.382TrpTyr: 0.382 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.259TyrAla: 3.259 ± 0.05	0.288TyrCys: 0.288 ± 0.016	1.967TyrAsp: 1.967 ± 0.04	1.646TyrGlu: 1.646 ± 0.036	1.688TyrPhe: 1.688 ± 0.034	2.623TyrGly: 2.623 ± 0.052	0.82TyrHis: 0.82 ± 0.027	1.197TyrIle: 1.197 ± 0.034	1.293TyrLys: 1.293 ± 0.036	3.675TyrLeu: 3.675 ± 0.046	0.504TyrMet: 0.504 ± 0.021	1.48TyrAsn: 1.48 ± 0.038	1.624TyrPro: 1.624 ± 0.037	1.711TyrGln: 1.711 ± 0.041	2.385TyrArg: 2.385 ± 0.047	2.035TyrSer: 2.035 ± 0.059	2.156TyrThr: 2.156 ± 0.09	2.175TyrVal: 2.175 ± 0.044	0.436TyrTrp: 0.436 ± 0.018	1.513TyrTyr: 1.513 ± 0.042	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3828 proteins (1334700 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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