Amino acid dipepetide frequency for Spheniscid alphaherpesvirus 1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.472AlaAla: 8.472 ± 0.883
1.847AlaCys: 1.847 ± 0.209
5.24AlaAsp: 5.24 ± 0.446
4.478AlaGlu: 4.478 ± 0.385
2.77AlaPhe: 2.77 ± 0.218
4.409AlaGly: 4.409 ± 0.387
1.108AlaHis: 1.108 ± 0.157
4.109AlaIle: 4.109 ± 0.322
3.024AlaLys: 3.024 ± 0.262
7.364AlaLeu: 7.364 ± 0.432
2.516AlaMet: 2.516 ± 0.257
3.001AlaAsn: 3.001 ± 0.243
2.909AlaPro: 2.909 ± 0.311
1.547AlaGln: 1.547 ± 0.219
4.825AlaArg: 4.825 ± 0.317
7.11AlaSer: 7.11 ± 0.549
4.501AlaThr: 4.501 ± 0.279
6.233AlaVal: 6.233 ± 0.374
0.785AlaTrp: 0.785 ± 0.163
2.839AlaTyr: 2.839 ± 0.216
0.0AlaXaa: 0.0 ± 0.0
Cys
1.408CysAla: 1.408 ± 0.205
0.6CysCys: 0.6 ± 0.1
1.408CysAsp: 1.408 ± 0.174
1.293CysGlu: 1.293 ± 0.176
0.993CysPhe: 0.993 ± 0.152
1.362CysGly: 1.362 ± 0.239
0.554CysHis: 0.554 ± 0.137
1.223CysIle: 1.223 ± 0.183
0.808CysLys: 0.808 ± 0.121
2.101CysLeu: 2.101 ± 0.236
0.577CysMet: 0.577 ± 0.1
0.9CysAsn: 0.9 ± 0.161
1.085CysPro: 1.085 ± 0.182
0.623CysGln: 0.623 ± 0.103
2.008CysArg: 2.008 ± 0.218
1.916CysSer: 1.916 ± 0.23
1.57CysThr: 1.57 ± 0.287
1.639CysVal: 1.639 ± 0.176
0.277CysTrp: 0.277 ± 0.083
0.831CysTyr: 0.831 ± 0.142
0.0CysXaa: 0.0 ± 0.0
Asp
4.709AspAla: 4.709 ± 0.315
1.039AspCys: 1.039 ± 0.182
5.494AspAsp: 5.494 ± 0.443
4.317AspGlu: 4.317 ± 0.356
1.87AspPhe: 1.87 ± 0.188
4.363AspGly: 4.363 ± 0.346
1.477AspHis: 1.477 ± 0.21
3.278AspIle: 3.278 ± 0.271
2.239AspLys: 2.239 ± 0.28
4.686AspLeu: 4.686 ± 0.352
1.362AspMet: 1.362 ± 0.217
2.401AspAsn: 2.401 ± 0.224
2.678AspPro: 2.678 ± 0.296
1.708AspGln: 1.708 ± 0.185
3.717AspArg: 3.717 ± 0.36
4.825AspSer: 4.825 ± 0.354
3.324AspThr: 3.324 ± 0.253
4.848AspVal: 4.848 ± 0.319
0.762AspTrp: 0.762 ± 0.116
2.078AspTyr: 2.078 ± 0.234
0.0AspXaa: 0.0 ± 0.0
Glu
5.032GluAla: 5.032 ± 0.36
1.27GluCys: 1.27 ± 0.199
3.809GluAsp: 3.809 ± 0.298
3.278GluGlu: 3.278 ± 0.322
1.662GluPhe: 1.662 ± 0.194
2.285GluGly: 2.285 ± 0.225
1.524GluHis: 1.524 ± 0.188
3.116GluIle: 3.116 ± 0.259
2.216GluLys: 2.216 ± 0.187
5.148GluLeu: 5.148 ± 0.371
1.223GluMet: 1.223 ± 0.158
3.07GluAsn: 3.07 ± 0.312
2.285GluPro: 2.285 ± 0.218
1.777GluGln: 1.777 ± 0.19
4.34GluArg: 4.34 ± 0.283
4.34GluSer: 4.34 ± 0.388
4.363GluThr: 4.363 ± 0.36
3.232GluVal: 3.232 ± 0.27
0.623GluTrp: 0.623 ± 0.124
2.17GluTyr: 2.17 ± 0.19
0.0GluXaa: 0.0 ± 0.0
Phe
2.909PheAla: 2.909 ± 0.226
1.085PheCys: 1.085 ± 0.161
2.239PheAsp: 2.239 ± 0.229
1.708PheGlu: 1.708 ± 0.178
1.662PhePhe: 1.662 ± 0.243
2.493PheGly: 2.493 ± 0.253
0.669PheHis: 0.669 ± 0.105
2.17PheIle: 2.17 ± 0.335
1.247PheLys: 1.247 ± 0.199
3.278PheLeu: 3.278 ± 0.373
1.177PheMet: 1.177 ± 0.217
1.362PheAsn: 1.362 ± 0.182
1.685PhePro: 1.685 ± 0.166
0.739PheGln: 0.739 ± 0.131
2.078PheArg: 2.078 ± 0.214
3.901PheSer: 3.901 ± 0.32
2.424PheThr: 2.424 ± 0.304
2.955PheVal: 2.955 ± 0.227
0.439PheTrp: 0.439 ± 0.135
1.385PheTyr: 1.385 ± 0.178
0.0PheXaa: 0.0 ± 0.0
Gly
4.363GlyAla: 4.363 ± 0.347
1.454GlyCys: 1.454 ± 0.181
3.555GlyAsp: 3.555 ± 0.299
3.578GlyGlu: 3.578 ± 0.249
2.331GlyPhe: 2.331 ± 0.258
4.294GlyGly: 4.294 ± 0.36
1.223GlyHis: 1.223 ± 0.165
3.001GlyIle: 3.001 ± 0.241
2.886GlyLys: 2.886 ± 0.35
5.078GlyLeu: 5.078 ± 0.308
1.016GlyMet: 1.016 ± 0.154
2.77GlyAsn: 2.77 ± 0.309
2.839GlyPro: 2.839 ± 0.252
2.054GlyGln: 2.054 ± 0.216
4.363GlyArg: 4.363 ± 0.323
5.309GlySer: 5.309 ± 0.274
3.255GlyThr: 3.255 ± 0.272
3.601GlyVal: 3.601 ± 0.341
0.762GlyTrp: 0.762 ± 0.128
2.101GlyTyr: 2.101 ± 0.249
0.0GlyXaa: 0.0 ± 0.0
His
1.339HisAla: 1.339 ± 0.17
0.485HisCys: 0.485 ± 0.123
1.131HisAsp: 1.131 ± 0.167
1.2HisGlu: 1.2 ± 0.166
0.831HisPhe: 0.831 ± 0.117
1.777HisGly: 1.777 ± 0.215
0.577HisHis: 0.577 ± 0.135
1.223HisIle: 1.223 ± 0.171
0.669HisLys: 0.669 ± 0.111
2.124HisLeu: 2.124 ± 0.207
0.6HisMet: 0.6 ± 0.114
0.854HisAsn: 0.854 ± 0.168
1.154HisPro: 1.154 ± 0.15
0.462HisGln: 0.462 ± 0.098
1.731HisArg: 1.731 ± 0.227
1.616HisSer: 1.616 ± 0.212
1.339HisThr: 1.339 ± 0.195
1.5HisVal: 1.5 ± 0.154
0.069HisTrp: 0.069 ± 0.036
0.693HisTyr: 0.693 ± 0.128
0.0HisXaa: 0.0 ± 0.0
Ile
3.67IleAla: 3.67 ± 0.373
1.154IleCys: 1.154 ± 0.163
3.347IleAsp: 3.347 ± 0.231
3.116IleGlu: 3.116 ± 0.261
1.662IlePhe: 1.662 ± 0.174
3.578IleGly: 3.578 ± 0.244
1.247IleHis: 1.247 ± 0.149
2.816IleIle: 2.816 ± 0.339
2.378IleLys: 2.378 ± 0.245
4.017IleLeu: 4.017 ± 0.356
1.316IleMet: 1.316 ± 0.175
2.655IleAsn: 2.655 ± 0.257
3.163IlePro: 3.163 ± 0.271
1.685IleGln: 1.685 ± 0.182
3.301IleArg: 3.301 ± 0.335
3.693IleSer: 3.693 ± 0.298
3.393IleThr: 3.393 ± 0.353
3.255IleVal: 3.255 ± 0.226
0.508IleTrp: 0.508 ± 0.126
1.454IleTyr: 1.454 ± 0.165
0.0IleXaa: 0.0 ± 0.0
Lys
2.862LysAla: 2.862 ± 0.269
1.131LysCys: 1.131 ± 0.165
1.731LysAsp: 1.731 ± 0.204
2.078LysGlu: 2.078 ± 0.283
1.5LysPhe: 1.5 ± 0.189
1.593LysGly: 1.593 ± 0.204
1.085LysHis: 1.085 ± 0.19
2.147LysIle: 2.147 ± 0.246
2.239LysLys: 2.239 ± 0.275
3.924LysLeu: 3.924 ± 0.341
0.923LysMet: 0.923 ± 0.148
1.985LysAsn: 1.985 ± 0.211
2.239LysPro: 2.239 ± 0.244
1.593LysGln: 1.593 ± 0.182
3.578LysArg: 3.578 ± 0.325
3.486LysSer: 3.486 ± 0.313
3.232LysThr: 3.232 ± 0.258
2.308LysVal: 2.308 ± 0.292
0.462LysTrp: 0.462 ± 0.105
1.639LysTyr: 1.639 ± 0.156
0.0LysXaa: 0.0 ± 0.0
Leu
7.364LeuAla: 7.364 ± 0.457
2.193LeuCys: 2.193 ± 0.262
4.709LeuAsp: 4.709 ± 0.337
4.317LeuGlu: 4.317 ± 0.308
4.271LeuPhe: 4.271 ± 0.383
4.732LeuGly: 4.732 ± 0.333
1.708LeuHis: 1.708 ± 0.197
4.271LeuIle: 4.271 ± 0.356
3.486LeuLys: 3.486 ± 0.299
8.264LeuLeu: 8.264 ± 0.522
2.331LeuMet: 2.331 ± 0.238
3.209LeuAsn: 3.209 ± 0.306
3.97LeuPro: 3.97 ± 0.338
2.17LeuGln: 2.17 ± 0.193
5.979LeuArg: 5.979 ± 0.363
7.225LeuSer: 7.225 ± 0.378
5.425LeuThr: 5.425 ± 0.414
5.032LeuVal: 5.032 ± 0.453
1.131LeuTrp: 1.131 ± 0.162
3.07LeuTyr: 3.07 ± 0.368
0.0LeuXaa: 0.0 ± 0.0
Met
2.539MetAla: 2.539 ± 0.26
0.485MetCys: 0.485 ± 0.11
1.362MetAsp: 1.362 ± 0.189
1.385MetGlu: 1.385 ± 0.199
1.2MetPhe: 1.2 ± 0.193
1.108MetGly: 1.108 ± 0.181
0.554MetHis: 0.554 ± 0.118
1.062MetIle: 1.062 ± 0.156
1.062MetLys: 1.062 ± 0.16
2.262MetLeu: 2.262 ± 0.25
0.623MetMet: 0.623 ± 0.168
0.993MetAsn: 0.993 ± 0.153
0.923MetPro: 0.923 ± 0.134
0.854MetGln: 0.854 ± 0.173
1.731MetArg: 1.731 ± 0.198
1.962MetSer: 1.962 ± 0.206
1.685MetThr: 1.685 ± 0.223
1.177MetVal: 1.177 ± 0.155
0.369MetTrp: 0.369 ± 0.088
0.831MetTyr: 0.831 ± 0.134
0.0MetXaa: 0.0 ± 0.0
Asn
3.232AsnAla: 3.232 ± 0.307
0.9AsnCys: 0.9 ± 0.152
3.07AsnAsp: 3.07 ± 0.309
2.608AsnGlu: 2.608 ± 0.263
1.039AsnPhe: 1.039 ± 0.172
3.555AsnGly: 3.555 ± 0.356
0.854AsnHis: 0.854 ± 0.147
2.378AsnIle: 2.378 ± 0.222
1.593AsnLys: 1.593 ± 0.183
2.862AsnLeu: 2.862 ± 0.249
0.97AsnMet: 0.97 ± 0.147
2.193AsnAsn: 2.193 ± 0.264
2.262AsnPro: 2.262 ± 0.188
1.223AsnGln: 1.223 ± 0.178
2.424AsnArg: 2.424 ± 0.223
3.832AsnSer: 3.832 ± 0.311
2.839AsnThr: 2.839 ± 0.218
3.07AsnVal: 3.07 ± 0.263
0.439AsnTrp: 0.439 ± 0.104
1.685AsnTyr: 1.685 ± 0.208
0.0AsnXaa: 0.0 ± 0.0
Pro
3.37ProAla: 3.37 ± 0.325
1.085ProCys: 1.085 ± 0.144
2.493ProAsp: 2.493 ± 0.23
3.024ProGlu: 3.024 ± 0.335
1.593ProPhe: 1.593 ± 0.161
2.886ProGly: 2.886 ± 0.28
1.223ProHis: 1.223 ± 0.196
2.539ProIle: 2.539 ± 0.258
2.47ProLys: 2.47 ± 0.203
3.74ProLeu: 3.74 ± 0.349
1.085ProMet: 1.085 ± 0.151
1.847ProAsn: 1.847 ± 0.234
4.363ProPro: 4.363 ± 0.467
1.477ProGln: 1.477 ± 0.232
3.001ProArg: 3.001 ± 0.361
4.317ProSer: 4.317 ± 0.332
3.116ProThr: 3.116 ± 0.408
3.809ProVal: 3.809 ± 0.392
0.577ProTrp: 0.577 ± 0.097
1.431ProTyr: 1.431 ± 0.156
0.0ProXaa: 0.0 ± 0.0
Gln
2.124GlnAla: 2.124 ± 0.196
0.693GlnCys: 0.693 ± 0.141
1.5GlnAsp: 1.5 ± 0.191
1.223GlnGlu: 1.223 ± 0.186
1.016GlnPhe: 1.016 ± 0.159
0.97GlnGly: 0.97 ± 0.148
0.531GlnHis: 0.531 ± 0.129
1.524GlnIle: 1.524 ± 0.155
1.339GlnLys: 1.339 ± 0.17
2.516GlnLeu: 2.516 ± 0.262
0.97GlnMet: 0.97 ± 0.164
1.316GlnAsn: 1.316 ± 0.161
1.962GlnPro: 1.962 ± 0.275
1.477GlnGln: 1.477 ± 0.308
2.124GlnArg: 2.124 ± 0.226
2.308GlnSer: 2.308 ± 0.237
2.193GlnThr: 2.193 ± 0.192
1.777GlnVal: 1.777 ± 0.181
0.369GlnTrp: 0.369 ± 0.078
0.877GlnTyr: 0.877 ± 0.136
0.0GlnXaa: 0.0 ± 0.0
Arg
4.617ArgAla: 4.617 ± 0.316
1.524ArgCys: 1.524 ± 0.224
4.34ArgAsp: 4.34 ± 0.335
4.409ArgGlu: 4.409 ± 0.365
2.424ArgPhe: 2.424 ± 0.232
4.04ArgGly: 4.04 ± 0.339
1.731ArgHis: 1.731 ± 0.211
3.601ArgIle: 3.601 ± 0.228
2.932ArgLys: 2.932 ± 0.253
6.094ArgLeu: 6.094 ± 0.472
1.154ArgMet: 1.154 ± 0.158
2.793ArgAsn: 2.793 ± 0.215
3.232ArgPro: 3.232 ± 0.358
2.124ArgGln: 2.124 ± 0.251
6.81ArgArg: 6.81 ± 0.557
6.279ArgSer: 6.279 ± 0.462
4.178ArgThr: 4.178 ± 0.304
4.247ArgVal: 4.247 ± 0.243
0.531ArgTrp: 0.531 ± 0.11
2.101ArgTyr: 2.101 ± 0.258
0.0ArgXaa: 0.0 ± 0.0
Ser
6.671SerAla: 6.671 ± 0.538
2.008SerCys: 2.008 ± 0.214
5.332SerAsp: 5.332 ± 0.421
5.633SerGlu: 5.633 ± 0.387
2.978SerPhe: 2.978 ± 0.265
6.094SerGly: 6.094 ± 0.372
1.847SerHis: 1.847 ± 0.191
4.04SerIle: 4.04 ± 0.324
3.486SerLys: 3.486 ± 0.223
6.671SerLeu: 6.671 ± 0.392
1.847SerMet: 1.847 ± 0.18
3.693SerAsn: 3.693 ± 0.25
3.186SerPro: 3.186 ± 0.273
2.262SerGln: 2.262 ± 0.213
5.448SerArg: 5.448 ± 0.333
10.042SerSer: 10.042 ± 0.944
6.187SerThr: 6.187 ± 0.515
6.902SerVal: 6.902 ± 0.38
0.854SerTrp: 0.854 ± 0.116
2.608SerTyr: 2.608 ± 0.241
0.0SerXaa: 0.0 ± 0.0
Thr
5.402ThrAla: 5.402 ± 0.464
1.639ThrCys: 1.639 ± 0.232
3.763ThrAsp: 3.763 ± 0.283
3.74ThrGlu: 3.74 ± 0.261
2.678ThrPhe: 2.678 ± 0.293
3.832ThrGly: 3.832 ± 0.342
1.339ThrHis: 1.339 ± 0.208
3.07ThrIle: 3.07 ± 0.251
2.608ThrLys: 2.608 ± 0.246
4.94ThrLeu: 4.94 ± 0.437
1.477ThrMet: 1.477 ± 0.165
2.886ThrAsn: 2.886 ± 0.268
3.324ThrPro: 3.324 ± 0.333
2.239ThrGln: 2.239 ± 0.24
4.063ThrArg: 4.063 ± 0.295
5.794ThrSer: 5.794 ± 0.458
5.771ThrThr: 5.771 ± 0.642
5.355ThrVal: 5.355 ± 0.396
0.9ThrTrp: 0.9 ± 0.168
2.008ThrTyr: 2.008 ± 0.214
0.0ThrXaa: 0.0 ± 0.0
Val
5.817ValAla: 5.817 ± 0.441
1.616ValCys: 1.616 ± 0.224
3.717ValAsp: 3.717 ± 0.298
2.978ValGlu: 2.978 ± 0.289
3.163ValPhe: 3.163 ± 0.281
3.416ValGly: 3.416 ± 0.285
1.062ValHis: 1.062 ± 0.183
3.486ValIle: 3.486 ± 0.304
2.932ValLys: 2.932 ± 0.311
6.233ValLeu: 6.233 ± 0.473
1.824ValMet: 1.824 ± 0.2
2.909ValAsn: 2.909 ± 0.302
3.994ValPro: 3.994 ± 0.34
1.939ValGln: 1.939 ± 0.23
4.617ValArg: 4.617 ± 0.367
6.233ValSer: 6.233 ± 0.37
4.986ValThr: 4.986 ± 0.346
4.64ValVal: 4.64 ± 0.327
0.462ValTrp: 0.462 ± 0.117
2.632ValTyr: 2.632 ± 0.226
0.0ValXaa: 0.0 ± 0.0
Trp
0.762TrpAla: 0.762 ± 0.124
0.277TrpCys: 0.277 ± 0.078
0.669TrpAsp: 0.669 ± 0.099
0.485TrpGlu: 0.485 ± 0.106
0.554TrpPhe: 0.554 ± 0.131
0.646TrpGly: 0.646 ± 0.099
0.254TrpHis: 0.254 ± 0.072
0.462TrpIle: 0.462 ± 0.116
0.739TrpLys: 0.739 ± 0.131
0.808TrpLeu: 0.808 ± 0.122
0.185TrpMet: 0.185 ± 0.06
0.554TrpAsn: 0.554 ± 0.11
0.739TrpPro: 0.739 ± 0.143
0.231TrpGln: 0.231 ± 0.065
0.646TrpArg: 0.646 ± 0.132
0.993TrpSer: 0.993 ± 0.153
0.9TrpThr: 0.9 ± 0.125
0.531TrpVal: 0.531 ± 0.128
0.092TrpTrp: 0.092 ± 0.041
0.416TrpTyr: 0.416 ± 0.09
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.424TyrAla: 2.424 ± 0.208
0.693TyrCys: 0.693 ± 0.121
2.262TyrAsp: 2.262 ± 0.252
1.939TyrGlu: 1.939 ± 0.167
1.408TyrPhe: 1.408 ± 0.162
2.401TyrGly: 2.401 ± 0.237
0.808TyrHis: 0.808 ± 0.171
1.893TyrIle: 1.893 ± 0.205
1.385TyrLys: 1.385 ± 0.225
2.747TyrLeu: 2.747 ± 0.263
0.97TyrMet: 0.97 ± 0.158
1.639TyrAsn: 1.639 ± 0.196
1.454TyrPro: 1.454 ± 0.174
0.623TyrGln: 0.623 ± 0.113
2.378TyrArg: 2.378 ± 0.209
2.608TyrSer: 2.608 ± 0.232
2.147TyrThr: 2.147 ± 0.28
2.539TyrVal: 2.539 ± 0.287
0.531TyrTrp: 0.531 ± 0.115
1.316TyrTyr: 1.316 ± 0.215
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 83 proteins (43321 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski