Amino acid dipepetide frequency for Staphylococcus haemolyticus (strain JCSC1435)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.682AlaAla: 3.682 ± 0.115	0.441AlaCys: 0.441 ± 0.027	2.838AlaAsp: 2.838 ± 0.086	3.372AlaGlu: 3.372 ± 0.085	2.885AlaPhe: 2.885 ± 0.075	3.853AlaGly: 3.853 ± 0.087	1.314AlaHis: 1.314 ± 0.043	6.058AlaIle: 6.058 ± 0.122	4.73AlaLys: 4.73 ± 0.21	6.241AlaLeu: 6.241 ± 0.112	1.716AlaMet: 1.716 ± 0.052	3.059AlaAsn: 3.059 ± 0.063	1.688AlaPro: 1.688 ± 0.051	2.576AlaGln: 2.576 ± 0.067	2.12AlaArg: 2.12 ± 0.067	4.131AlaSer: 4.131 ± 0.316	3.777AlaThr: 3.777 ± 0.143	3.879AlaVal: 3.879 ± 0.092	0.394AlaTrp: 0.394 ± 0.024	2.203AlaTyr: 2.203 ± 0.058	0.0AlaXaa: 0.0 ± 0.0
Cys	0.345CysAla: 0.345 ± 0.024	0.083CysCys: 0.083 ± 0.012	0.396CysAsp: 0.396 ± 0.027	0.343CysGlu: 0.343 ± 0.021	0.251CysPhe: 0.251 ± 0.017	0.549CysGly: 0.549 ± 0.033	0.174CysHis: 0.174 ± 0.018	0.539CysIle: 0.539 ± 0.026	0.365CysLys: 0.365 ± 0.026	0.561CysLeu: 0.561 ± 0.029	0.177CysMet: 0.177 ± 0.017	0.263CysAsn: 0.263 ± 0.018	0.346CysPro: 0.346 ± 0.021	0.155CysGln: 0.155 ± 0.013	0.221CysArg: 0.221 ± 0.016	0.391CysSer: 0.391 ± 0.021	0.375CysThr: 0.375 ± 0.021	0.388CysVal: 0.388 ± 0.026	0.052CysTrp: 0.052 ± 0.009	0.276CysTyr: 0.276 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	3.626AspAla: 3.626 ± 0.106	0.317AspCys: 0.317 ± 0.02	3.737AspAsp: 3.737 ± 0.089	5.018AspGlu: 5.018 ± 0.122	2.578AspPhe: 2.578 ± 0.056	3.249AspGly: 3.249 ± 0.085	1.238AspHis: 1.238 ± 0.037	5.197AspIle: 5.197 ± 0.108	4.949AspLys: 4.949 ± 0.105	5.061AspLeu: 5.061 ± 0.1	1.54AspMet: 1.54 ± 0.053	3.397AspAsn: 3.397 ± 0.089	1.522AspPro: 1.522 ± 0.099	1.971AspGln: 1.971 ± 0.078	1.961AspArg: 1.961 ± 0.058	3.509AspSer: 3.509 ± 0.297	3.014AspThr: 3.014 ± 0.091	4.221AspVal: 4.221 ± 0.084	0.498AspTrp: 0.498 ± 0.024	2.774AspTyr: 2.774 ± 0.069	0.0AspXaa: 0.0 ± 0.0
Glu	4.472GluAla: 4.472 ± 0.102	0.375GluCys: 0.375 ± 0.023	4.248GluAsp: 4.248 ± 0.106	5.094GluGlu: 5.094 ± 0.124	2.512GluPhe: 2.512 ± 0.068	3.538GluGly: 3.538 ± 0.094	1.766GluHis: 1.766 ± 0.061	5.45GluIle: 5.45 ± 0.104	5.347GluLys: 5.347 ± 0.112	6.114GluLeu: 6.114 ± 0.121	1.967GluMet: 1.967 ± 0.056	3.772GluAsn: 3.772 ± 0.094	1.791GluPro: 1.791 ± 0.057	3.178GluGln: 3.178 ± 0.088	3.001GluArg: 3.001 ± 0.078	3.711GluSer: 3.711 ± 0.13	3.74GluThr: 3.74 ± 0.079	4.404GluVal: 4.404 ± 0.093	0.559GluTrp: 0.559 ± 0.028	2.338GluTyr: 2.338 ± 0.053	0.0GluXaa: 0.0 ± 0.0
Phe	2.482PheAla: 2.482 ± 0.067	0.291PheCys: 0.291 ± 0.02	2.721PheAsp: 2.721 ± 0.055	3.059PheGlu: 3.059 ± 0.075	2.025PhePhe: 2.025 ± 0.061	2.998PheGly: 2.998 ± 0.07	0.824PheHis: 0.824 ± 0.033	4.599PheIle: 4.599 ± 0.099	3.603PheLys: 3.603 ± 0.081	3.747PheLeu: 3.747 ± 0.09	1.149PheMet: 1.149 ± 0.049	2.99PheAsn: 2.99 ± 0.069	1.219PhePro: 1.219 ± 0.041	1.29PheGln: 1.29 ± 0.039	1.272PheArg: 1.272 ± 0.04	2.96PheSer: 2.96 ± 0.074	2.453PheThr: 2.453 ± 0.059	2.996PheVal: 2.996 ± 0.074	0.347PheTrp: 0.347 ± 0.027	1.788PheTyr: 1.788 ± 0.058	0.0PheXaa: 0.0 ± 0.0
Gly	4.05GlyAla: 4.05 ± 0.096	0.427GlyCys: 0.427 ± 0.027	2.992GlyAsp: 2.992 ± 0.076	3.466GlyGlu: 3.466 ± 0.082	3.058GlyPhe: 3.058 ± 0.074	4.076GlyGly: 4.076 ± 0.105	1.552GlyHis: 1.552 ± 0.064	5.39GlyIle: 5.39 ± 0.095	4.34GlyLys: 4.34 ± 0.091	5.771GlyLeu: 5.771 ± 0.103	1.669GlyMet: 1.669 ± 0.051	2.727GlyAsn: 2.727 ± 0.102	1.531GlyPro: 1.531 ± 0.046	2.366GlyGln: 2.366 ± 0.059	2.215GlyArg: 2.215 ± 0.062	3.598GlySer: 3.598 ± 0.106	3.594GlyThr: 3.594 ± 0.107	4.409GlyVal: 4.409 ± 0.083	0.539GlyTrp: 0.539 ± 0.032	2.763GlyTyr: 2.763 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	1.289HisAla: 1.289 ± 0.048	0.162HisCys: 0.162 ± 0.015	1.392HisAsp: 1.392 ± 0.051	1.438HisGlu: 1.438 ± 0.045	1.282HisPhe: 1.282 ± 0.044	1.333HisGly: 1.333 ± 0.045	0.781HisHis: 0.781 ± 0.041	1.943HisIle: 1.943 ± 0.057	1.317HisLys: 1.317 ± 0.042	2.239HisLeu: 2.239 ± 0.065	0.589HisMet: 0.589 ± 0.032	1.146HisAsn: 1.146 ± 0.039	1.034HisPro: 1.034 ± 0.05	0.984HisGln: 0.984 ± 0.042	0.88HisArg: 0.88 ± 0.039	1.29HisSer: 1.29 ± 0.044	1.108HisThr: 1.108 ± 0.039	1.492HisVal: 1.492 ± 0.074	0.192HisTrp: 0.192 ± 0.015	1.087HisTyr: 1.087 ± 0.04	0.0HisXaa: 0.0 ± 0.0
Ile	5.778IleAla: 5.778 ± 0.117	0.646IleCys: 0.646 ± 0.033	5.51IleAsp: 5.51 ± 0.124	6.105IleGlu: 6.105 ± 0.106	3.674IlePhe: 3.674 ± 0.102	5.714IleGly: 5.714 ± 0.101	1.721IleHis: 1.721 ± 0.047	7.65IleIle: 7.65 ± 0.151	6.061IleLys: 6.061 ± 0.108	7.344IleLeu: 7.344 ± 0.158	2.104IleMet: 2.104 ± 0.06	4.983IleAsn: 4.983 ± 0.099	3.118IlePro: 3.118 ± 0.085	3.055IleGln: 3.055 ± 0.071	2.647IleArg: 2.647 ± 0.059	5.307IleSer: 5.307 ± 0.093	4.763IleThr: 4.763 ± 0.107	5.967IleVal: 5.967 ± 0.129	0.59IleTrp: 0.59 ± 0.032	2.981IleTyr: 2.981 ± 0.069	0.0IleXaa: 0.0 ± 0.0
Lys	4.961LysAla: 4.961 ± 0.184	0.333LysCys: 0.333 ± 0.023	5.397LysAsp: 5.397 ± 0.101	6.147LysGlu: 6.147 ± 0.115	2.397LysPhe: 2.397 ± 0.061	4.145LysGly: 4.145 ± 0.076	1.794LysHis: 1.794 ± 0.055	4.908LysIle: 4.908 ± 0.097	5.753LysLys: 5.753 ± 0.118	6.253LysLeu: 6.253 ± 0.101	2.251LysMet: 2.251 ± 0.056	4.343LysAsn: 4.343 ± 0.079	2.244LysPro: 2.244 ± 0.063	3.664LysGln: 3.664 ± 0.078	3.22LysArg: 3.22 ± 0.07	4.475LysSer: 4.475 ± 0.102	3.883LysThr: 3.883 ± 0.09	5.063LysVal: 5.063 ± 0.083	0.63LysTrp: 0.63 ± 0.034	3.063LysTyr: 3.063 ± 0.065	0.0LysXaa: 0.0 ± 0.0
Leu	5.597LeuAla: 5.597 ± 0.096	0.577LeuCys: 0.577 ± 0.029	4.977LeuAsp: 4.977 ± 0.103	5.571LeuGlu: 5.571 ± 0.111	4.455LeuPhe: 4.455 ± 0.107	5.667LeuGly: 5.667 ± 0.112	1.536LeuHis: 1.536 ± 0.05	8.238LeuIle: 8.238 ± 0.158	7.105LeuLys: 7.105 ± 0.121	8.609LeuLeu: 8.609 ± 0.155	2.439LeuMet: 2.439 ± 0.069	5.965LeuAsn: 5.965 ± 0.112	3.389LeuPro: 3.389 ± 0.069	2.852LeuGln: 2.852 ± 0.061	2.977LeuArg: 2.977 ± 0.08	6.611LeuSer: 6.611 ± 0.227	5.328LeuThr: 5.328 ± 0.081	5.584LeuVal: 5.584 ± 0.111	0.598LeuTrp: 0.598 ± 0.03	3.146LeuTyr: 3.146 ± 0.072	0.0LeuXaa: 0.0 ± 0.0
Met	1.713MetAla: 1.713 ± 0.059	0.166MetCys: 0.166 ± 0.014	1.345MetAsp: 1.345 ± 0.046	1.349MetGlu: 1.349 ± 0.045	1.132MetPhe: 1.132 ± 0.041	1.478MetGly: 1.478 ± 0.047	0.49MetHis: 0.49 ± 0.026	2.355MetIle: 2.355 ± 0.065	2.317MetLys: 2.317 ± 0.054	2.347MetLeu: 2.347 ± 0.062	0.909MetMet: 0.909 ± 0.037	1.787MetAsn: 1.787 ± 0.051	0.936MetPro: 0.936 ± 0.035	0.866MetGln: 0.866 ± 0.037	0.963MetArg: 0.963 ± 0.034	2.005MetSer: 2.005 ± 0.061	1.813MetThr: 1.813 ± 0.049	1.424MetVal: 1.424 ± 0.043	0.186MetTrp: 0.186 ± 0.015	0.832MetTyr: 0.832 ± 0.034	0.001MetXaa: 0.001 ± 0.001
Asn	3.344AsnAla: 3.344 ± 0.103	0.337AsnCys: 0.337 ± 0.025	3.87AsnAsp: 3.87 ± 0.1	4.359AsnGlu: 4.359 ± 0.094	2.165AsnPhe: 2.165 ± 0.061	3.404AsnGly: 3.404 ± 0.074	1.603AsnHis: 1.603 ± 0.055	4.669AsnIle: 4.669 ± 0.083	4.644AsnLys: 4.644 ± 0.092	4.356AsnLeu: 4.356 ± 0.079	1.367AsnMet: 1.367 ± 0.043	3.796AsnAsn: 3.796 ± 0.13	2.111AsnPro: 2.111 ± 0.063	2.911AsnGln: 2.911 ± 0.081	2.203AsnArg: 2.203 ± 0.064	3.15AsnSer: 3.15 ± 0.083	2.879AsnThr: 2.879 ± 0.095	3.772AsnVal: 3.772 ± 0.102	0.507AsnTrp: 0.507 ± 0.03	2.527AsnTyr: 2.527 ± 0.065	0.0AsnXaa: 0.0 ± 0.0
Pro	1.466ProAla: 1.466 ± 0.046	0.155ProCys: 0.155 ± 0.014	1.8ProAsp: 1.8 ± 0.058	2.519ProGlu: 2.519 ± 0.076	1.782ProPhe: 1.782 ± 0.05	1.828ProGly: 1.828 ± 0.053	0.767ProHis: 0.767 ± 0.039	2.743ProIle: 2.743 ± 0.096	2.432ProLys: 2.432 ± 0.068	2.878ProLeu: 2.878 ± 0.057	0.786ProMet: 0.786 ± 0.035	2.083ProAsn: 2.083 ± 0.114	0.744ProPro: 0.744 ± 0.059	1.08ProGln: 1.08 ± 0.042	0.909ProArg: 0.909 ± 0.038	2.026ProSer: 2.026 ± 0.057	2.072ProThr: 2.072 ± 0.103	2.28ProVal: 2.28 ± 0.077	0.246ProTrp: 0.246 ± 0.018	1.323ProTyr: 1.323 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	2.432GlnAla: 2.432 ± 0.086	0.244GlnCys: 0.244 ± 0.02	2.039GlnAsp: 2.039 ± 0.058	2.22GlnGlu: 2.22 ± 0.055	2.005GlnPhe: 2.005 ± 0.047	1.915GlnGly: 1.915 ± 0.054	1.076GlnHis: 1.076 ± 0.038	3.043GlnIle: 3.043 ± 0.066	2.578GlnLys: 2.578 ± 0.063	4.182GlnLeu: 4.182 ± 0.099	1.059GlnMet: 1.059 ± 0.043	2.253GlnAsn: 2.253 ± 0.069	1.31GlnPro: 1.31 ± 0.055	2.049GlnGln: 2.049 ± 0.069	1.721GlnArg: 1.721 ± 0.054	2.96GlnSer: 2.96 ± 0.088	2.245GlnThr: 2.245 ± 0.067	2.21GlnVal: 2.21 ± 0.059	0.365GlnTrp: 0.365 ± 0.022	1.601GlnTyr: 1.601 ± 0.051	0.0GlnXaa: 0.0 ± 0.0
Arg	2.03ArgAla: 2.03 ± 0.057	0.188ArgCys: 0.188 ± 0.017	2.082ArgAsp: 2.082 ± 0.057	2.541ArgGlu: 2.541 ± 0.067	1.685ArgPhe: 1.685 ± 0.045	2.026ArgGly: 2.026 ± 0.055	0.992ArgHis: 0.992 ± 0.043	2.846ArgIle: 2.846 ± 0.066	2.828ArgLys: 2.828 ± 0.065	3.42ArgLeu: 3.42 ± 0.078	1.102ArgMet: 1.102 ± 0.042	1.955ArgAsn: 1.955 ± 0.053	1.139ArgPro: 1.139 ± 0.047	1.581ArgGln: 1.581 ± 0.052	1.619ArgArg: 1.619 ± 0.054	1.787ArgSer: 1.787 ± 0.044	1.926ArgThr: 1.926 ± 0.061	2.325ArgVal: 2.325 ± 0.07	0.269ArgTrp: 0.269 ± 0.019	1.706ArgTyr: 1.706 ± 0.052	0.0ArgXaa: 0.0 ± 0.0
Ser	3.453SerAla: 3.453 ± 0.301	0.347SerCys: 0.347 ± 0.021	3.884SerAsp: 3.884 ± 0.282	4.244SerGlu: 4.244 ± 0.154	2.941SerPhe: 2.941 ± 0.067	4.056SerGly: 4.056 ± 0.098	1.475SerHis: 1.475 ± 0.049	5.398SerIle: 5.398 ± 0.089	4.65SerLys: 4.65 ± 0.09	5.835SerLeu: 5.835 ± 0.234	1.597SerMet: 1.597 ± 0.05	3.924SerAsn: 3.924 ± 0.086	1.728SerPro: 1.728 ± 0.05	2.562SerGln: 2.562 ± 0.076	2.222SerArg: 2.222 ± 0.055	4.02SerSer: 4.02 ± 0.102	4.418SerThr: 4.418 ± 0.869	3.913SerVal: 3.913 ± 0.177	0.472SerTrp: 0.472 ± 0.025	2.519SerTyr: 2.519 ± 0.056	0.0SerXaa: 0.0 ± 0.0
Thr	3.194ThrAla: 3.194 ± 0.084	0.306ThrCys: 0.306 ± 0.019	3.206ThrAsp: 3.206 ± 0.204	3.318ThrGlu: 3.318 ± 0.106	2.774ThrPhe: 2.774 ± 0.061	3.59ThrGly: 3.59 ± 0.101	1.302ThrHis: 1.302 ± 0.043	5.034ThrIle: 5.034 ± 0.081	3.816ThrLys: 3.816 ± 0.09	5.545ThrLeu: 5.545 ± 0.08	1.293ThrMet: 1.293 ± 0.044	3.149ThrAsn: 3.149 ± 0.081	2.373ThrPro: 2.373 ± 0.142	2.214ThrGln: 2.214 ± 0.068	1.839ThrArg: 1.839 ± 0.06	4.546ThrSer: 4.546 ± 0.843	3.685ThrThr: 3.685 ± 0.203	3.825ThrVal: 3.825 ± 0.097	0.417ThrTrp: 0.417 ± 0.025	2.259ThrTyr: 2.259 ± 0.065	0.0ThrXaa: 0.0 ± 0.0
Val	4.352ValAla: 4.352 ± 0.087	0.493ValCys: 0.493 ± 0.029	4.104ValAsp: 4.104 ± 0.115	4.219ValGlu: 4.219 ± 0.087	2.756ValPhe: 2.756 ± 0.074	4.237ValGly: 4.237 ± 0.084	1.288ValHis: 1.288 ± 0.042	5.903ValIle: 5.903 ± 0.104	4.713ValLys: 4.713 ± 0.085	5.946ValLeu: 5.946 ± 0.106	1.622ValMet: 1.622 ± 0.051	3.633ValAsn: 3.633 ± 0.072	2.239ValPro: 2.239 ± 0.054	2.058ValGln: 2.058 ± 0.054	2.115ValArg: 2.115 ± 0.071	4.466ValSer: 4.466 ± 0.181	4.183ValThr: 4.183 ± 0.152	4.647ValVal: 4.647 ± 0.088	0.497ValTrp: 0.497 ± 0.027	2.138ValTyr: 2.138 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	0.407TrpAla: 0.407 ± 0.027	0.055TrpCys: 0.055 ± 0.009	0.339TrpAsp: 0.339 ± 0.022	0.402TrpGlu: 0.402 ± 0.021	0.497TrpPhe: 0.497 ± 0.027	0.429TrpGly: 0.429 ± 0.027	0.156TrpHis: 0.156 ± 0.015	0.717TrpIle: 0.717 ± 0.035	0.538TrpLys: 0.538 ± 0.029	1.037TrpLeu: 1.037 ± 0.04	0.251TrpMet: 0.251 ± 0.019	0.468TrpAsn: 0.468 ± 0.027	0.189TrpPro: 0.189 ± 0.016	0.308TrpGln: 0.308 ± 0.023	0.277TrpArg: 0.277 ± 0.02	0.461TrpSer: 0.461 ± 0.025	0.404TrpThr: 0.404 ± 0.023	0.466TrpVal: 0.466 ± 0.025	0.075TrpTrp: 0.075 ± 0.01	0.297TrpTyr: 0.297 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.285TyrAla: 2.285 ± 0.064	0.306TyrCys: 0.306 ± 0.022	2.5TyrAsp: 2.5 ± 0.068	2.594TyrGlu: 2.594 ± 0.057	1.959TyrPhe: 1.959 ± 0.055	2.445TyrGly: 2.445 ± 0.062	1.129TyrHis: 1.129 ± 0.04	3.038TyrIle: 3.038 ± 0.068	2.838TyrLys: 2.838 ± 0.076	3.738TyrLeu: 3.738 ± 0.075	0.827TyrMet: 0.827 ± 0.033	2.28TyrAsn: 2.28 ± 0.067	1.268TyrPro: 1.268 ± 0.046	1.79TyrGln: 1.79 ± 0.049	1.666TyrArg: 1.666 ± 0.056	2.255TyrSer: 2.255 ± 0.058	2.022TyrThr: 2.022 ± 0.052	2.342TyrVal: 2.342 ± 0.058	0.341TyrTrp: 0.341 ± 0.025	1.654TyrTyr: 1.654 ± 0.053	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2640 proteins (757125 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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