Amino acid dipepetide frequency for Pedobacter sp. Hv1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.969AlaAla: 5.969 ± 0.095
0.655AlaCys: 0.655 ± 0.022
4.071AlaAsp: 4.071 ± 0.055
4.378AlaGlu: 4.378 ± 0.057
3.676AlaPhe: 3.676 ± 0.058
4.921AlaGly: 4.921 ± 0.075
1.191AlaHis: 1.191 ± 0.026
5.994AlaIle: 5.994 ± 0.066
5.697AlaLys: 5.697 ± 0.075
7.11AlaLeu: 7.11 ± 0.089
1.721AlaMet: 1.721 ± 0.036
4.385AlaAsn: 4.385 ± 0.078
2.202AlaPro: 2.202 ± 0.043
3.355AlaGln: 3.355 ± 0.053
2.085AlaArg: 2.085 ± 0.044
4.244AlaSer: 4.244 ± 0.072
4.508AlaThr: 4.508 ± 0.106
4.735AlaVal: 4.735 ± 0.068
0.705AlaTrp: 0.705 ± 0.021
3.081AlaTyr: 3.081 ± 0.046
0.0AlaXaa: 0.0 ± 0.0
Cys
0.476CysAla: 0.476 ± 0.02
0.143CysCys: 0.143 ± 0.01
0.351CysAsp: 0.351 ± 0.016
0.36CysGlu: 0.36 ± 0.017
0.441CysPhe: 0.441 ± 0.021
0.586CysGly: 0.586 ± 0.021
0.147CysHis: 0.147 ± 0.01
0.615CysIle: 0.615 ± 0.02
0.552CysLys: 0.552 ± 0.022
0.775CysLeu: 0.775 ± 0.023
0.155CysMet: 0.155 ± 0.01
0.396CysAsn: 0.396 ± 0.018
0.305CysPro: 0.305 ± 0.016
0.204CysGln: 0.204 ± 0.011
0.271CysArg: 0.271 ± 0.013
0.476CysSer: 0.476 ± 0.019
0.432CysThr: 0.432 ± 0.018
0.467CysVal: 0.467 ± 0.019
0.079CysTrp: 0.079 ± 0.007
0.291CysTyr: 0.291 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
3.49AspAla: 3.49 ± 0.059
0.352AspCys: 0.352 ± 0.017
2.361AspAsp: 2.361 ± 0.044
3.282AspGlu: 3.282 ± 0.05
3.196AspPhe: 3.196 ± 0.05
3.55AspGly: 3.55 ± 0.065
0.928AspHis: 0.928 ± 0.021
3.713AspIle: 3.713 ± 0.046
3.848AspLys: 3.848 ± 0.052
4.973AspLeu: 4.973 ± 0.063
1.132AspMet: 1.132 ± 0.03
2.513AspAsn: 2.513 ± 0.045
1.926AspPro: 1.926 ± 0.042
2.276AspGln: 2.276 ± 0.04
1.933AspArg: 1.933 ± 0.033
2.671AspSer: 2.671 ± 0.047
2.41AspThr: 2.41 ± 0.039
3.199AspVal: 3.199 ± 0.049
0.706AspTrp: 0.706 ± 0.021
2.383AspTyr: 2.383 ± 0.047
0.0AspXaa: 0.0 ± 0.0
Glu
4.06GluAla: 4.06 ± 0.062
0.264GluCys: 0.264 ± 0.012
2.591GluAsp: 2.591 ± 0.047
3.815GluGlu: 3.815 ± 0.075
2.422GluPhe: 2.422 ± 0.049
3.105GluGly: 3.105 ± 0.05
1.017GluHis: 1.017 ± 0.032
4.733GluIle: 4.733 ± 0.067
5.093GluLys: 5.093 ± 0.07
6.0GluLeu: 6.0 ± 0.08
1.479GluMet: 1.479 ± 0.035
3.559GluAsn: 3.559 ± 0.055
1.557GluPro: 1.557 ± 0.035
2.495GluGln: 2.495 ± 0.042
2.371GluArg: 2.371 ± 0.048
2.564GluSer: 2.564 ± 0.042
3.096GluThr: 3.096 ± 0.056
3.748GluVal: 3.748 ± 0.055
0.581GluTrp: 0.581 ± 0.02
1.88GluTyr: 1.88 ± 0.042
0.0GluXaa: 0.0 ± 0.0
Phe
3.657PheAla: 3.657 ± 0.057
0.47PheCys: 0.47 ± 0.018
2.874PheAsp: 2.874 ± 0.05
2.934PheGlu: 2.934 ± 0.049
2.593PhePhe: 2.593 ± 0.054
3.463PheGly: 3.463 ± 0.055
0.725PheHis: 0.725 ± 0.026
3.742PheIle: 3.742 ± 0.056
3.799PheLys: 3.799 ± 0.052
4.621PheLeu: 4.621 ± 0.067
1.077PheMet: 1.077 ± 0.03
3.34PheAsn: 3.34 ± 0.055
1.577PhePro: 1.577 ± 0.031
1.332PheGln: 1.332 ± 0.028
1.599PheArg: 1.599 ± 0.03
3.757PheSer: 3.757 ± 0.059
3.158PheThr: 3.158 ± 0.045
3.025PheVal: 3.025 ± 0.043
0.609PheTrp: 0.609 ± 0.024
2.185PheTyr: 2.185 ± 0.038
0.0PheXaa: 0.0 ± 0.0
Gly
4.603GlyAla: 4.603 ± 0.077
0.557GlyCys: 0.557 ± 0.02
3.003GlyAsp: 3.003 ± 0.055
3.095GlyGlu: 3.095 ± 0.05
3.573GlyPhe: 3.573 ± 0.051
4.612GlyGly: 4.612 ± 0.086
1.104GlyHis: 1.104 ± 0.031
5.234GlyIle: 5.234 ± 0.064
5.519GlyLys: 5.519 ± 0.067
6.326GlyLeu: 6.326 ± 0.077
1.57GlyMet: 1.57 ± 0.035
3.767GlyAsn: 3.767 ± 0.075
1.419GlyPro: 1.419 ± 0.039
2.182GlyGln: 2.182 ± 0.04
2.157GlyArg: 2.157 ± 0.044
4.002GlySer: 4.002 ± 0.063
4.174GlyThr: 4.174 ± 0.07
4.209GlyVal: 4.209 ± 0.062
0.807GlyTrp: 0.807 ± 0.026
2.972GlyTyr: 2.972 ± 0.047
0.0GlyXaa: 0.0 ± 0.0
His
1.007HisAla: 1.007 ± 0.027
0.17HisCys: 0.17 ± 0.01
0.739HisAsp: 0.739 ± 0.024
0.865HisGlu: 0.865 ± 0.026
1.061HisPhe: 1.061 ± 0.029
0.967HisGly: 0.967 ± 0.029
0.474HisHis: 0.474 ± 0.019
1.399HisIle: 1.399 ± 0.037
0.999HisLys: 0.999 ± 0.03
1.794HisLeu: 1.794 ± 0.037
0.325HisMet: 0.325 ± 0.015
0.805HisAsn: 0.805 ± 0.022
0.865HisPro: 0.865 ± 0.026
0.968HisGln: 0.968 ± 0.025
0.666HisArg: 0.666 ± 0.021
0.908HisSer: 0.908 ± 0.025
0.981HisThr: 0.981 ± 0.025
0.863HisVal: 0.863 ± 0.021
0.192HisTrp: 0.192 ± 0.012
0.785HisTyr: 0.785 ± 0.025
0.0HisXaa: 0.0 ± 0.0
Ile
6.365IleAla: 6.365 ± 0.079
0.706IleCys: 0.706 ± 0.022
4.607IleAsp: 4.607 ± 0.057
4.633IleGlu: 4.633 ± 0.07
3.431IlePhe: 3.431 ± 0.061
5.072IleGly: 5.072 ± 0.072
1.22IleHis: 1.22 ± 0.031
5.288IleIle: 5.288 ± 0.075
5.816IleLys: 5.816 ± 0.065
6.764IleLeu: 6.764 ± 0.083
1.369IleMet: 1.369 ± 0.034
4.826IleAsn: 4.826 ± 0.062
3.031IlePro: 3.031 ± 0.05
2.424IleGln: 2.424 ± 0.045
2.53IleArg: 2.53 ± 0.041
5.26IleSer: 5.26 ± 0.071
4.628IleThr: 4.628 ± 0.078
4.663IleVal: 4.663 ± 0.069
0.714IleTrp: 0.714 ± 0.024
2.794IleTyr: 2.794 ± 0.046
0.0IleXaa: 0.0 ± 0.0
Lys
5.837LysAla: 5.837 ± 0.075
0.341LysCys: 0.341 ± 0.014
4.471LysAsp: 4.471 ± 0.064
5.156LysGlu: 5.156 ± 0.077
2.864LysPhe: 2.864 ± 0.047
4.757LysGly: 4.757 ± 0.06
1.311LysHis: 1.311 ± 0.035
5.827LysIle: 5.827 ± 0.07
6.444LysLys: 6.444 ± 0.088
6.857LysLeu: 6.857 ± 0.081
2.137LysMet: 2.137 ± 0.042
4.994LysAsn: 4.994 ± 0.064
2.835LysPro: 2.835 ± 0.054
3.159LysGln: 3.159 ± 0.054
2.776LysArg: 2.776 ± 0.046
4.244LysSer: 4.244 ± 0.062
4.746LysThr: 4.746 ± 0.062
4.849LysVal: 4.849 ± 0.06
0.823LysTrp: 0.823 ± 0.023
3.029LysTyr: 3.029 ± 0.049
0.0LysXaa: 0.0 ± 0.0
Leu
7.473LeuAla: 7.473 ± 0.083
0.797LeuCys: 0.797 ± 0.024
4.525LeuAsp: 4.525 ± 0.06
4.688LeuGlu: 4.688 ± 0.071
5.015LeuPhe: 5.015 ± 0.075
5.85LeuGly: 5.85 ± 0.075
1.555LeuHis: 1.555 ± 0.041
7.329LeuIle: 7.329 ± 0.1
8.111LeuLys: 8.111 ± 0.087
9.767LeuLeu: 9.767 ± 0.117
2.299LeuMet: 2.299 ± 0.043
6.169LeuAsn: 6.169 ± 0.077
3.959LeuPro: 3.959 ± 0.056
3.741LeuGln: 3.741 ± 0.063
3.246LeuArg: 3.246 ± 0.053
7.113LeuSer: 7.113 ± 0.076
5.96LeuThr: 5.96 ± 0.071
5.636LeuVal: 5.636 ± 0.069
0.91LeuTrp: 0.91 ± 0.031
3.296LeuTyr: 3.296 ± 0.052
0.0LeuXaa: 0.0 ± 0.0
Met
1.858MetAla: 1.858 ± 0.035
0.134MetCys: 0.134 ± 0.011
1.182MetAsp: 1.182 ± 0.026
1.362MetGlu: 1.362 ± 0.036
0.851MetPhe: 0.851 ± 0.029
1.529MetGly: 1.529 ± 0.035
0.365MetHis: 0.365 ± 0.015
1.554MetIle: 1.554 ± 0.035
2.1MetLys: 2.1 ± 0.041
2.162MetLeu: 2.162 ± 0.039
0.622MetMet: 0.622 ± 0.023
1.26MetAsn: 1.26 ± 0.032
1.039MetPro: 1.039 ± 0.025
0.991MetGln: 0.991 ± 0.026
0.867MetArg: 0.867 ± 0.028
1.32MetSer: 1.32 ± 0.034
0.977MetThr: 0.977 ± 0.025
1.554MetVal: 1.554 ± 0.034
0.154MetTrp: 0.154 ± 0.01
0.634MetTyr: 0.634 ± 0.023
0.0MetXaa: 0.0 ± 0.0
Asn
4.484AsnAla: 4.484 ± 0.068
0.431AsnCys: 0.431 ± 0.019
2.854AsnAsp: 2.854 ± 0.048
3.326AsnGlu: 3.326 ± 0.048
2.978AsnPhe: 2.978 ± 0.053
4.299AsnGly: 4.299 ± 0.071
1.025AsnHis: 1.025 ± 0.029
4.445AsnIle: 4.445 ± 0.067
4.281AsnLys: 4.281 ± 0.067
5.677AsnLeu: 5.677 ± 0.062
1.281AsnMet: 1.281 ± 0.031
3.621AsnAsn: 3.621 ± 0.065
2.71AsnPro: 2.71 ± 0.045
2.341AsnGln: 2.341 ± 0.045
2.268AsnArg: 2.268 ± 0.051
3.579AsnSer: 3.579 ± 0.058
3.627AsnThr: 3.627 ± 0.076
3.495AsnVal: 3.495 ± 0.059
0.791AsnTrp: 0.791 ± 0.025
2.968AsnTyr: 2.968 ± 0.055
0.0AsnXaa: 0.0 ± 0.0
Pro
2.726ProAla: 2.726 ± 0.054
0.222ProCys: 0.222 ± 0.013
2.05ProAsp: 2.05 ± 0.039
2.559ProGlu: 2.559 ± 0.038
1.942ProPhe: 1.942 ± 0.037
2.15ProGly: 2.15 ± 0.045
0.577ProHis: 0.577 ± 0.02
2.778ProIle: 2.778 ± 0.037
2.521ProLys: 2.521 ± 0.042
3.225ProLeu: 3.225 ± 0.05
0.751ProMet: 0.751 ± 0.027
2.237ProAsn: 2.237 ± 0.042
0.864ProPro: 0.864 ± 0.028
1.407ProGln: 1.407 ± 0.031
0.917ProArg: 0.917 ± 0.03
2.187ProSer: 2.187 ± 0.044
2.277ProThr: 2.277 ± 0.043
2.586ProVal: 2.586 ± 0.049
0.332ProTrp: 0.332 ± 0.019
1.46ProTyr: 1.46 ± 0.029
0.0ProXaa: 0.0 ± 0.0
Gln
2.646GlnAla: 2.646 ± 0.047
0.192GlnCys: 0.192 ± 0.011
1.572GlnAsp: 1.572 ± 0.033
2.104GlnGlu: 2.104 ± 0.041
1.837GlnPhe: 1.837 ± 0.038
1.946GlnGly: 1.946 ± 0.04
0.806GlnHis: 0.806 ± 0.025
2.868GlnIle: 2.868 ± 0.053
3.187GlnLys: 3.187 ± 0.053
4.472GlnLeu: 4.472 ± 0.069
0.963GlnMet: 0.963 ± 0.028
2.4GlnAsn: 2.4 ± 0.042
1.36GlnPro: 1.36 ± 0.032
2.312GlnGln: 2.312 ± 0.052
1.368GlnArg: 1.368 ± 0.026
2.246GlnSer: 2.246 ± 0.038
2.473GlnThr: 2.473 ± 0.054
2.327GlnVal: 2.327 ± 0.043
0.386GlnTrp: 0.386 ± 0.018
1.501GlnTyr: 1.501 ± 0.034
0.0GlnXaa: 0.0 ± 0.0
Arg
2.219ArgAla: 2.219 ± 0.036
0.193ArgCys: 0.193 ± 0.012
1.586ArgAsp: 1.586 ± 0.035
1.94ArgGlu: 1.94 ± 0.044
1.928ArgPhe: 1.928 ± 0.041
1.862ArgGly: 1.862 ± 0.043
0.519ArgHis: 0.519 ± 0.021
2.851ArgIle: 2.851 ± 0.046
2.735ArgLys: 2.735 ± 0.043
3.575ArgLeu: 3.575 ± 0.051
0.926ArgMet: 0.926 ± 0.026
2.232ArgAsn: 2.232 ± 0.044
1.207ArgPro: 1.207 ± 0.029
1.17ArgGln: 1.17 ± 0.028
1.302ArgArg: 1.302 ± 0.036
2.013ArgSer: 2.013 ± 0.039
1.983ArgThr: 1.983 ± 0.033
1.988ArgVal: 1.988 ± 0.042
0.392ArgTrp: 0.392 ± 0.016
1.631ArgTyr: 1.631 ± 0.041
0.0ArgXaa: 0.0 ± 0.0
Ser
4.507SerAla: 4.507 ± 0.059
0.537SerCys: 0.537 ± 0.02
2.774SerAsp: 2.774 ± 0.047
2.854SerGlu: 2.854 ± 0.05
3.753SerPhe: 3.753 ± 0.061
4.423SerGly: 4.423 ± 0.055
0.95SerHis: 0.95 ± 0.027
4.972SerIle: 4.972 ± 0.06
4.269SerLys: 4.269 ± 0.064
6.275SerLeu: 6.275 ± 0.067
1.225SerMet: 1.225 ± 0.029
3.532SerAsn: 3.532 ± 0.07
2.216SerPro: 2.216 ± 0.04
1.904SerGln: 1.904 ± 0.039
2.067SerArg: 2.067 ± 0.045
4.11SerSer: 4.11 ± 0.059
3.755SerThr: 3.755 ± 0.059
3.77SerVal: 3.77 ± 0.053
0.668SerTrp: 0.668 ± 0.023
2.825SerTyr: 2.825 ± 0.051
0.0SerXaa: 0.0 ± 0.0
Thr
4.877ThrAla: 4.877 ± 0.092
0.349ThrCys: 0.349 ± 0.017
3.242ThrAsp: 3.242 ± 0.054
3.217ThrGlu: 3.217 ± 0.048
2.886ThrPhe: 2.886 ± 0.054
4.484ThrGly: 4.484 ± 0.078
0.943ThrHis: 0.943 ± 0.027
4.887ThrIle: 4.887 ± 0.099
3.935ThrLys: 3.935 ± 0.052
5.851ThrLeu: 5.851 ± 0.065
1.027ThrMet: 1.027 ± 0.029
3.289ThrAsn: 3.289 ± 0.063
2.526ThrPro: 2.526 ± 0.052
2.102ThrGln: 2.102 ± 0.038
1.68ThrArg: 1.68 ± 0.035
3.447ThrSer: 3.447 ± 0.057
3.983ThrThr: 3.983 ± 0.081
3.941ThrVal: 3.941 ± 0.066
0.652ThrTrp: 0.652 ± 0.023
2.55ThrTyr: 2.55 ± 0.069
0.0ThrXaa: 0.0 ± 0.0
Val
4.805ValAla: 4.805 ± 0.066
0.542ValCys: 0.542 ± 0.021
3.287ValAsp: 3.287 ± 0.049
3.379ValGlu: 3.379 ± 0.056
3.148ValPhe: 3.148 ± 0.042
3.852ValGly: 3.852 ± 0.066
0.918ValHis: 0.918 ± 0.026
4.569ValIle: 4.569 ± 0.065
4.923ValLys: 4.923 ± 0.064
6.049ValLeu: 6.049 ± 0.076
1.426ValMet: 1.426 ± 0.033
3.98ValAsn: 3.98 ± 0.065
2.256ValPro: 2.256 ± 0.039
2.1ValGln: 2.1 ± 0.038
1.962ValArg: 1.962 ± 0.037
4.118ValSer: 4.118 ± 0.05
3.548ValThr: 3.548 ± 0.068
4.264ValVal: 4.264 ± 0.07
0.656ValTrp: 0.656 ± 0.023
2.424ValTyr: 2.424 ± 0.039
0.0ValXaa: 0.0 ± 0.0
Trp
0.711TrpAla: 0.711 ± 0.027
0.125TrpCys: 0.125 ± 0.01
0.59TrpAsp: 0.59 ± 0.025
0.538TrpGlu: 0.538 ± 0.022
0.581TrpPhe: 0.581 ± 0.023
0.756TrpGly: 0.756 ± 0.024
0.203TrpHis: 0.203 ± 0.012
0.719TrpIle: 0.719 ± 0.024
0.805TrpLys: 0.805 ± 0.025
1.129TrpLeu: 1.129 ± 0.029
0.312TrpMet: 0.312 ± 0.014
0.628TrpAsn: 0.628 ± 0.021
0.291TrpPro: 0.291 ± 0.016
0.495TrpGln: 0.495 ± 0.018
0.432TrpArg: 0.432 ± 0.019
0.639TrpSer: 0.639 ± 0.024
0.577TrpThr: 0.577 ± 0.022
0.645TrpVal: 0.645 ± 0.021
0.177TrpTrp: 0.177 ± 0.011
0.457TrpTyr: 0.457 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.915TyrAla: 2.915 ± 0.045
0.344TyrCys: 0.344 ± 0.016
2.111TyrAsp: 2.111 ± 0.037
1.945TyrGlu: 1.945 ± 0.037
2.362TyrPhe: 2.362 ± 0.042
2.698TyrGly: 2.698 ± 0.045
0.855TyrHis: 0.855 ± 0.026
2.623TyrIle: 2.623 ± 0.038
2.824TyrLys: 2.824 ± 0.047
4.037TyrLeu: 4.037 ± 0.055
0.714TyrMet: 0.714 ± 0.02
2.548TyrAsn: 2.548 ± 0.054
1.623TyrPro: 1.623 ± 0.037
2.008TyrGln: 2.008 ± 0.039
1.757TyrArg: 1.757 ± 0.036
2.49TyrSer: 2.49 ± 0.045
2.575TyrThr: 2.575 ± 0.047
2.24TyrVal: 2.24 ± 0.043
0.478TyrTrp: 0.478 ± 0.017
1.833TyrTyr: 1.833 ± 0.045
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4261 proteins (1437873 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski