Amino acid dipepetide frequency for Vibrio phage Va_PF430-3_p42

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.929AlaAla: 7.929 ± 0.986
1.177AlaCys: 1.177 ± 0.283
4.212AlaAsp: 4.212 ± 0.495
5.946AlaGlu: 5.946 ± 0.521
2.973AlaPhe: 2.973 ± 0.483
4.955AlaGly: 4.955 ± 0.599
1.734AlaHis: 1.734 ± 0.31
5.265AlaIle: 5.265 ± 0.668
5.637AlaLys: 5.637 ± 0.586
9.044AlaLeu: 9.044 ± 0.898
3.097AlaMet: 3.097 ± 0.403
3.655AlaAsn: 3.655 ± 0.508
3.221AlaPro: 3.221 ± 0.398
3.531AlaGln: 3.531 ± 0.545
4.522AlaArg: 4.522 ± 0.563
5.451AlaSer: 5.451 ± 0.537
4.46AlaThr: 4.46 ± 0.594
4.584AlaVal: 4.584 ± 0.645
1.177AlaTrp: 1.177 ± 0.335
2.664AlaTyr: 2.664 ± 0.385
0.0AlaXaa: 0.0 ± 0.0
Cys
0.867CysAla: 0.867 ± 0.192
0.248CysCys: 0.248 ± 0.123
0.929CysAsp: 0.929 ± 0.208
0.557CysGlu: 0.557 ± 0.208
0.743CysPhe: 0.743 ± 0.21
1.115CysGly: 1.115 ± 0.281
0.434CysHis: 0.434 ± 0.163
0.557CysIle: 0.557 ± 0.21
0.867CysLys: 0.867 ± 0.255
0.805CysLeu: 0.805 ± 0.259
0.186CysMet: 0.186 ± 0.112
0.619CysAsn: 0.619 ± 0.183
0.681CysPro: 0.681 ± 0.222
0.557CysGln: 0.557 ± 0.193
0.496CysArg: 0.496 ± 0.179
0.991CysSer: 0.991 ± 0.232
0.557CysThr: 0.557 ± 0.156
0.557CysVal: 0.557 ± 0.175
0.31CysTrp: 0.31 ± 0.186
0.31CysTyr: 0.31 ± 0.155
0.0CysXaa: 0.0 ± 0.0
Asp
4.708AspAla: 4.708 ± 0.508
1.053AspCys: 1.053 ± 0.279
2.911AspAsp: 2.911 ± 0.541
4.15AspGlu: 4.15 ± 0.495
3.221AspPhe: 3.221 ± 0.467
4.584AspGly: 4.584 ± 0.634
1.115AspHis: 1.115 ± 0.259
3.655AspIle: 3.655 ± 0.426
3.84AspLys: 3.84 ± 0.449
5.327AspLeu: 5.327 ± 0.601
1.425AspMet: 1.425 ± 0.281
2.168AspAsn: 2.168 ± 0.448
2.044AspPro: 2.044 ± 0.319
1.734AspGln: 1.734 ± 0.366
2.54AspArg: 2.54 ± 0.365
3.221AspSer: 3.221 ± 0.513
2.23AspThr: 2.23 ± 0.347
3.593AspVal: 3.593 ± 0.48
1.487AspTrp: 1.487 ± 0.389
1.796AspTyr: 1.796 ± 0.309
0.0AspXaa: 0.0 ± 0.0
Glu
5.265GluAla: 5.265 ± 0.51
0.929GluCys: 0.929 ± 0.227
2.664GluAsp: 2.664 ± 0.393
4.522GluGlu: 4.522 ± 0.493
3.221GluPhe: 3.221 ± 0.459
4.46GluGly: 4.46 ± 0.558
1.115GluHis: 1.115 ± 0.231
4.646GluIle: 4.646 ± 0.439
3.283GluLys: 3.283 ± 0.422
5.885GluLeu: 5.885 ± 0.65
2.292GluMet: 2.292 ± 0.293
3.097GluAsn: 3.097 ± 0.51
2.911GluPro: 2.911 ± 0.503
3.097GluGln: 3.097 ± 0.486
4.336GluArg: 4.336 ± 0.539
4.212GluSer: 4.212 ± 0.456
4.15GluThr: 4.15 ± 0.466
6.008GluVal: 6.008 ± 0.617
0.805GluTrp: 0.805 ± 0.228
2.044GluTyr: 2.044 ± 0.331
0.0GluXaa: 0.0 ± 0.0
Phe
3.407PheAla: 3.407 ± 0.417
0.372PheCys: 0.372 ± 0.177
2.973PheAsp: 2.973 ± 0.38
3.097PheGlu: 3.097 ± 0.45
1.672PhePhe: 1.672 ± 0.338
2.416PheGly: 2.416 ± 0.367
0.867PheHis: 0.867 ± 0.225
2.54PheIle: 2.54 ± 0.405
2.23PheLys: 2.23 ± 0.338
2.725PheLeu: 2.725 ± 0.44
0.867PheMet: 0.867 ± 0.257
2.044PheAsn: 2.044 ± 0.377
1.549PhePro: 1.549 ± 0.284
0.929PheGln: 0.929 ± 0.277
2.416PheArg: 2.416 ± 0.38
2.54PheSer: 2.54 ± 0.38
1.982PheThr: 1.982 ± 0.385
2.787PheVal: 2.787 ± 0.526
0.372PheTrp: 0.372 ± 0.155
1.239PheTyr: 1.239 ± 0.33
0.0PheXaa: 0.0 ± 0.0
Gly
5.141GlyAla: 5.141 ± 0.78
0.372GlyCys: 0.372 ± 0.164
4.893GlyAsp: 4.893 ± 0.691
5.203GlyGlu: 5.203 ± 0.457
3.469GlyPhe: 3.469 ± 0.557
5.575GlyGly: 5.575 ± 0.944
1.487GlyHis: 1.487 ± 0.32
3.593GlyIle: 3.593 ± 0.528
4.77GlyLys: 4.77 ± 0.47
5.699GlyLeu: 5.699 ± 0.747
1.92GlyMet: 1.92 ± 0.357
2.54GlyAsn: 2.54 ± 0.409
1.549GlyPro: 1.549 ± 0.351
1.858GlyGln: 1.858 ± 0.307
3.964GlyArg: 3.964 ± 0.752
3.778GlySer: 3.778 ± 0.477
3.655GlyThr: 3.655 ± 0.485
4.893GlyVal: 4.893 ± 0.537
0.743GlyTrp: 0.743 ± 0.215
2.106GlyTyr: 2.106 ± 0.279
0.0GlyXaa: 0.0 ± 0.0
His
1.672HisAla: 1.672 ± 0.36
0.434HisCys: 0.434 ± 0.167
0.867HisAsp: 0.867 ± 0.21
0.929HisGlu: 0.929 ± 0.15
0.867HisPhe: 0.867 ± 0.264
1.301HisGly: 1.301 ± 0.238
0.681HisHis: 0.681 ± 0.191
1.796HisIle: 1.796 ± 0.321
1.239HisLys: 1.239 ± 0.268
1.734HisLeu: 1.734 ± 0.324
0.434HisMet: 0.434 ± 0.162
0.805HisAsn: 0.805 ± 0.237
1.425HisPro: 1.425 ± 0.28
0.867HisGln: 0.867 ± 0.221
1.115HisArg: 1.115 ± 0.263
1.177HisSer: 1.177 ± 0.304
1.301HisThr: 1.301 ± 0.22
1.177HisVal: 1.177 ± 0.203
0.248HisTrp: 0.248 ± 0.111
0.867HisTyr: 0.867 ± 0.194
0.0HisXaa: 0.0 ± 0.0
Ile
5.389IleAla: 5.389 ± 0.691
0.434IleCys: 0.434 ± 0.156
4.646IleAsp: 4.646 ± 0.471
5.017IleGlu: 5.017 ± 0.62
1.672IlePhe: 1.672 ± 0.315
4.212IleGly: 4.212 ± 0.587
1.115IleHis: 1.115 ± 0.274
2.354IleIle: 2.354 ± 0.391
5.017IleLys: 5.017 ± 0.479
3.84IleLeu: 3.84 ± 0.449
1.425IleMet: 1.425 ± 0.235
3.283IleAsn: 3.283 ± 0.633
2.168IlePro: 2.168 ± 0.306
2.416IleGln: 2.416 ± 0.42
3.159IleArg: 3.159 ± 0.314
3.964IleSer: 3.964 ± 0.659
4.026IleThr: 4.026 ± 0.419
3.097IleVal: 3.097 ± 0.522
0.31IleTrp: 0.31 ± 0.158
1.549IleTyr: 1.549 ± 0.332
0.0IleXaa: 0.0 ± 0.0
Lys
6.256LysAla: 6.256 ± 0.608
0.805LysCys: 0.805 ± 0.215
2.725LysAsp: 2.725 ± 0.375
3.778LysGlu: 3.778 ± 0.49
1.982LysPhe: 1.982 ± 0.362
4.708LysGly: 4.708 ± 0.537
1.487LysHis: 1.487 ± 0.292
3.035LysIle: 3.035 ± 0.408
4.77LysLys: 4.77 ± 0.49
6.132LysLeu: 6.132 ± 0.685
1.92LysMet: 1.92 ± 0.353
3.159LysAsn: 3.159 ± 0.353
3.097LysPro: 3.097 ± 0.475
3.655LysGln: 3.655 ± 0.507
4.398LysArg: 4.398 ± 0.478
4.522LysSer: 4.522 ± 0.574
4.15LysThr: 4.15 ± 0.547
3.407LysVal: 3.407 ± 0.383
1.177LysTrp: 1.177 ± 0.319
1.425LysTyr: 1.425 ± 0.267
0.0LysXaa: 0.0 ± 0.0
Leu
8.053LeuAla: 8.053 ± 0.669
1.363LeuCys: 1.363 ± 0.338
5.017LeuAsp: 5.017 ± 0.579
6.38LeuGlu: 6.38 ± 0.643
2.849LeuPhe: 2.849 ± 0.419
5.265LeuGly: 5.265 ± 0.588
1.982LeuHis: 1.982 ± 0.309
4.212LeuIle: 4.212 ± 0.554
6.132LeuLys: 6.132 ± 0.593
6.38LeuLeu: 6.38 ± 0.76
2.602LeuMet: 2.602 ± 0.402
4.955LeuAsn: 4.955 ± 0.652
3.717LeuPro: 3.717 ± 0.481
3.531LeuGln: 3.531 ± 0.462
4.708LeuArg: 4.708 ± 0.626
5.946LeuSer: 5.946 ± 0.561
5.823LeuThr: 5.823 ± 0.71
5.141LeuVal: 5.141 ± 0.63
0.867LeuTrp: 0.867 ± 0.188
1.92LeuTyr: 1.92 ± 0.323
0.0LeuXaa: 0.0 ± 0.0
Met
2.478MetAla: 2.478 ± 0.349
0.248MetCys: 0.248 ± 0.122
1.177MetAsp: 1.177 ± 0.245
1.611MetGlu: 1.611 ± 0.274
1.239MetPhe: 1.239 ± 0.269
2.044MetGly: 2.044 ± 0.355
0.496MetHis: 0.496 ± 0.133
1.549MetIle: 1.549 ± 0.351
1.363MetLys: 1.363 ± 0.259
2.54MetLeu: 2.54 ± 0.399
0.743MetMet: 0.743 ± 0.199
0.867MetAsn: 0.867 ± 0.212
1.672MetPro: 1.672 ± 0.317
0.991MetGln: 0.991 ± 0.228
1.487MetArg: 1.487 ± 0.244
2.292MetSer: 2.292 ± 0.42
1.177MetThr: 1.177 ± 0.247
2.044MetVal: 2.044 ± 0.301
0.186MetTrp: 0.186 ± 0.106
0.434MetTyr: 0.434 ± 0.16
0.0MetXaa: 0.0 ± 0.0
Asn
4.026AsnAla: 4.026 ± 0.612
0.496AsnCys: 0.496 ± 0.168
2.292AsnAsp: 2.292 ± 0.392
3.469AsnGlu: 3.469 ± 0.431
1.425AsnPhe: 1.425 ± 0.289
3.097AsnGly: 3.097 ± 0.339
1.177AsnHis: 1.177 ± 0.262
2.416AsnIle: 2.416 ± 0.336
3.159AsnLys: 3.159 ± 0.476
4.088AsnLeu: 4.088 ± 0.455
0.743AsnMet: 0.743 ± 0.214
2.416AsnAsn: 2.416 ± 0.379
2.478AsnPro: 2.478 ± 0.397
1.92AsnGln: 1.92 ± 0.306
3.531AsnArg: 3.531 ± 0.461
2.911AsnSer: 2.911 ± 0.375
1.92AsnThr: 1.92 ± 0.268
2.478AsnVal: 2.478 ± 0.408
0.805AsnTrp: 0.805 ± 0.176
1.672AsnTyr: 1.672 ± 0.321
0.0AsnXaa: 0.0 ± 0.0
Pro
2.787ProAla: 2.787 ± 0.38
0.31ProCys: 0.31 ± 0.13
2.292ProAsp: 2.292 ± 0.399
2.478ProGlu: 2.478 ± 0.381
1.858ProPhe: 1.858 ± 0.386
1.549ProGly: 1.549 ± 0.359
1.301ProHis: 1.301 ± 0.3
2.664ProIle: 2.664 ± 0.409
2.725ProLys: 2.725 ± 0.525
3.593ProLeu: 3.593 ± 0.363
0.991ProMet: 0.991 ± 0.259
1.92ProAsn: 1.92 ± 0.376
1.611ProPro: 1.611 ± 0.281
1.549ProGln: 1.549 ± 0.276
1.549ProArg: 1.549 ± 0.303
2.54ProSer: 2.54 ± 0.407
2.973ProThr: 2.973 ± 0.44
2.725ProVal: 2.725 ± 0.417
0.372ProTrp: 0.372 ± 0.121
1.982ProTyr: 1.982 ± 0.357
0.0ProXaa: 0.0 ± 0.0
Gln
4.584GlnAla: 4.584 ± 0.602
0.805GlnCys: 0.805 ± 0.221
1.672GlnAsp: 1.672 ± 0.307
2.664GlnGlu: 2.664 ± 0.483
1.672GlnPhe: 1.672 ± 0.329
2.106GlnGly: 2.106 ± 0.396
0.557GlnHis: 0.557 ± 0.176
2.725GlnIle: 2.725 ± 0.355
2.54GlnLys: 2.54 ± 0.417
4.088GlnLeu: 4.088 ± 0.451
0.619GlnMet: 0.619 ± 0.176
2.23GlnAsn: 2.23 ± 0.395
1.982GlnPro: 1.982 ± 0.365
1.92GlnGln: 1.92 ± 0.312
2.602GlnArg: 2.602 ± 0.364
1.92GlnSer: 1.92 ± 0.356
1.239GlnThr: 1.239 ± 0.23
3.283GlnVal: 3.283 ± 0.439
0.496GlnTrp: 0.496 ± 0.18
1.053GlnTyr: 1.053 ± 0.228
0.0GlnXaa: 0.0 ± 0.0
Arg
3.964ArgAla: 3.964 ± 0.472
0.557ArgCys: 0.557 ± 0.162
3.469ArgAsp: 3.469 ± 0.719
4.274ArgGlu: 4.274 ± 0.695
2.478ArgPhe: 2.478 ± 0.398
4.15ArgGly: 4.15 ± 0.645
1.239ArgHis: 1.239 ± 0.273
3.84ArgIle: 3.84 ± 0.539
4.212ArgLys: 4.212 ± 0.468
5.699ArgLeu: 5.699 ± 0.577
1.239ArgMet: 1.239 ± 0.211
2.602ArgAsn: 2.602 ± 0.36
1.734ArgPro: 1.734 ± 0.274
2.23ArgGln: 2.23 ± 0.379
3.159ArgArg: 3.159 ± 0.577
3.221ArgSer: 3.221 ± 0.466
3.159ArgThr: 3.159 ± 0.46
4.026ArgVal: 4.026 ± 0.496
0.805ArgTrp: 0.805 ± 0.232
2.044ArgTyr: 2.044 ± 0.383
0.0ArgXaa: 0.0 ± 0.0
Ser
4.646SerAla: 4.646 ± 0.559
0.743SerCys: 0.743 ± 0.255
3.717SerAsp: 3.717 ± 0.555
4.212SerGlu: 4.212 ± 0.56
2.416SerPhe: 2.416 ± 0.353
4.77SerGly: 4.77 ± 0.718
1.053SerHis: 1.053 ± 0.22
4.77SerIle: 4.77 ± 0.532
4.212SerLys: 4.212 ± 0.645
5.451SerLeu: 5.451 ± 0.691
1.982SerMet: 1.982 ± 0.318
2.973SerAsn: 2.973 ± 0.457
1.92SerPro: 1.92 ± 0.407
2.23SerGln: 2.23 ± 0.332
3.655SerArg: 3.655 ± 0.615
3.717SerSer: 3.717 ± 0.647
3.345SerThr: 3.345 ± 0.594
4.274SerVal: 4.274 ± 0.525
0.681SerTrp: 0.681 ± 0.238
1.425SerTyr: 1.425 ± 0.409
0.0SerXaa: 0.0 ± 0.0
Thr
5.389ThrAla: 5.389 ± 0.56
0.372ThrCys: 0.372 ± 0.171
3.221ThrAsp: 3.221 ± 0.565
3.469ThrGlu: 3.469 ± 0.419
1.425ThrPhe: 1.425 ± 0.287
4.088ThrGly: 4.088 ± 0.555
1.363ThrHis: 1.363 ± 0.293
3.407ThrIle: 3.407 ± 0.457
3.778ThrLys: 3.778 ± 0.45
5.141ThrLeu: 5.141 ± 0.564
1.053ThrMet: 1.053 ± 0.224
2.725ThrAsn: 2.725 ± 0.378
2.106ThrPro: 2.106 ± 0.378
2.354ThrGln: 2.354 ± 0.374
3.655ThrArg: 3.655 ± 0.441
2.725ThrSer: 2.725 ± 0.328
3.655ThrThr: 3.655 ± 0.366
2.787ThrVal: 2.787 ± 0.453
0.929ThrTrp: 0.929 ± 0.218
1.858ThrTyr: 1.858 ± 0.272
0.0ThrXaa: 0.0 ± 0.0
Val
4.955ValAla: 4.955 ± 0.543
1.115ValCys: 1.115 ± 0.247
4.708ValAsp: 4.708 ± 0.473
4.832ValGlu: 4.832 ± 0.577
2.292ValPhe: 2.292 ± 0.313
4.088ValGly: 4.088 ± 0.585
0.929ValHis: 0.929 ± 0.222
3.345ValIle: 3.345 ± 0.441
4.646ValLys: 4.646 ± 0.534
4.522ValLeu: 4.522 ± 0.514
1.982ValMet: 1.982 ± 0.318
2.787ValAsn: 2.787 ± 0.432
2.168ValPro: 2.168 ± 0.356
2.973ValGln: 2.973 ± 0.432
3.531ValArg: 3.531 ± 0.481
4.026ValSer: 4.026 ± 0.53
3.655ValThr: 3.655 ± 0.59
5.203ValVal: 5.203 ± 0.652
0.619ValTrp: 0.619 ± 0.207
2.168ValTyr: 2.168 ± 0.428
0.0ValXaa: 0.0 ± 0.0
Trp
0.929TrpAla: 0.929 ± 0.244
0.248TrpCys: 0.248 ± 0.111
0.743TrpAsp: 0.743 ± 0.18
0.743TrpGlu: 0.743 ± 0.212
0.805TrpPhe: 0.805 ± 0.225
0.619TrpGly: 0.619 ± 0.243
0.372TrpHis: 0.372 ± 0.144
0.867TrpIle: 0.867 ± 0.229
0.557TrpLys: 0.557 ± 0.171
1.363TrpLeu: 1.363 ± 0.27
0.186TrpMet: 0.186 ± 0.108
0.681TrpAsn: 0.681 ± 0.184
0.434TrpPro: 0.434 ± 0.156
0.805TrpGln: 0.805 ± 0.214
1.053TrpArg: 1.053 ± 0.229
0.681TrpSer: 0.681 ± 0.194
0.743TrpThr: 0.743 ± 0.235
1.115TrpVal: 1.115 ± 0.25
0.248TrpTrp: 0.248 ± 0.108
0.31TrpTyr: 0.31 ± 0.143
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.787TyrAla: 2.787 ± 0.426
0.31TyrCys: 0.31 ± 0.133
1.672TyrAsp: 1.672 ± 0.272
1.611TyrGlu: 1.611 ± 0.292
0.805TyrPhe: 0.805 ± 0.203
2.106TyrGly: 2.106 ± 0.318
0.434TyrHis: 0.434 ± 0.148
1.858TyrIle: 1.858 ± 0.342
1.611TyrLys: 1.611 ± 0.328
2.787TyrLeu: 2.787 ± 0.457
0.867TyrMet: 0.867 ± 0.221
0.991TyrAsn: 0.991 ± 0.264
1.301TyrPro: 1.301 ± 0.284
1.611TyrGln: 1.611 ± 0.251
2.23TyrArg: 2.23 ± 0.346
2.354TyrSer: 2.354 ± 0.381
1.301TyrThr: 1.301 ± 0.356
1.363TyrVal: 1.363 ± 0.286
0.867TyrTrp: 0.867 ± 0.234
0.557TyrTyr: 0.557 ± 0.183
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 64 proteins (16145 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski