Amino acid dipepetide frequency for Methylovorus sp. MM2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.791AlaAla: 9.791 ± 0.151
0.834AlaCys: 0.834 ± 0.041
5.497AlaAsp: 5.497 ± 0.099
5.971AlaGlu: 5.971 ± 0.106
3.557AlaPhe: 3.557 ± 0.082
7.111AlaGly: 7.111 ± 0.12
2.005AlaHis: 2.005 ± 0.06
6.634AlaIle: 6.634 ± 0.105
5.245AlaLys: 5.245 ± 0.105
10.683AlaLeu: 10.683 ± 0.135
2.678AlaMet: 2.678 ± 0.062
3.978AlaAsn: 3.978 ± 0.085
3.498AlaPro: 3.498 ± 0.084
3.952AlaGln: 3.952 ± 0.081
4.584AlaArg: 4.584 ± 0.092
6.064AlaSer: 6.064 ± 0.108
5.158AlaThr: 5.158 ± 0.114
6.225AlaVal: 6.225 ± 0.118
1.146AlaTrp: 1.146 ± 0.036
2.636AlaTyr: 2.636 ± 0.065
0.0AlaXaa: 0.0 ± 0.0
Cys
0.731CysAla: 0.731 ± 0.038
0.09CysCys: 0.09 ± 0.013
0.487CysAsp: 0.487 ± 0.03
0.437CysGlu: 0.437 ± 0.024
0.294CysPhe: 0.294 ± 0.018
0.757CysGly: 0.757 ± 0.039
0.212CysHis: 0.212 ± 0.017
0.446CysIle: 0.446 ± 0.029
0.327CysLys: 0.327 ± 0.022
0.696CysLeu: 0.696 ± 0.03
0.17CysMet: 0.17 ± 0.014
0.303CysAsn: 0.303 ± 0.022
0.394CysPro: 0.394 ± 0.024
0.261CysGln: 0.261 ± 0.021
0.399CysArg: 0.399 ± 0.026
0.519CysSer: 0.519 ± 0.03
0.432CysThr: 0.432 ± 0.046
0.535CysVal: 0.535 ± 0.028
0.093CysTrp: 0.093 ± 0.011
0.217CysTyr: 0.217 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
5.751AspAla: 5.751 ± 0.104
0.443AspCys: 0.443 ± 0.026
3.054AspAsp: 3.054 ± 0.09
3.577AspGlu: 3.577 ± 0.075
2.457AspPhe: 2.457 ± 0.058
4.272AspGly: 4.272 ± 0.123
1.087AspHis: 1.087 ± 0.043
4.365AspIle: 4.365 ± 0.076
2.857AspLys: 2.857 ± 0.07
5.118AspLeu: 5.118 ± 0.09
1.404AspMet: 1.404 ± 0.043
2.045AspAsn: 2.045 ± 0.061
2.236AspPro: 2.236 ± 0.069
1.815AspGln: 1.815 ± 0.048
2.517AspArg: 2.517 ± 0.068
3.196AspSer: 3.196 ± 0.08
3.143AspThr: 3.143 ± 0.175
3.925AspVal: 3.925 ± 0.078
0.816AspTrp: 0.816 ± 0.031
1.926AspTyr: 1.926 ± 0.053
0.0AspXaa: 0.0 ± 0.0
Glu
5.783GluAla: 5.783 ± 0.114
0.353GluCys: 0.353 ± 0.021
2.848GluAsp: 2.848 ± 0.074
3.151GluGlu: 3.151 ± 0.073
2.193GluPhe: 2.193 ± 0.057
3.561GluGly: 3.561 ± 0.077
1.49GluHis: 1.49 ± 0.049
4.131GluIle: 4.131 ± 0.082
3.538GluLys: 3.538 ± 0.081
5.921GluLeu: 5.921 ± 0.112
1.539GluMet: 1.539 ± 0.045
2.32GluAsn: 2.32 ± 0.076
1.99GluPro: 1.99 ± 0.057
2.704GluGln: 2.704 ± 0.073
3.297GluArg: 3.297 ± 0.078
3.508GluSer: 3.508 ± 0.07
3.069GluThr: 3.069 ± 0.076
4.212GluVal: 4.212 ± 0.089
0.715GluTrp: 0.715 ± 0.037
1.605GluTyr: 1.605 ± 0.047
0.0GluXaa: 0.0 ± 0.0
Phe
3.512PheAla: 3.512 ± 0.076
0.368PheCys: 0.368 ± 0.024
2.593PheAsp: 2.593 ± 0.06
2.115PheGlu: 2.115 ± 0.053
1.609PhePhe: 1.609 ± 0.059
3.232PheGly: 3.232 ± 0.083
0.689PheHis: 0.689 ± 0.031
2.54PheIle: 2.54 ± 0.067
1.877PheLys: 1.877 ± 0.052
3.29PheLeu: 3.29 ± 0.082
0.915PheMet: 0.915 ± 0.038
1.668PheAsn: 1.668 ± 0.051
1.448PhePro: 1.448 ± 0.045
1.114PheGln: 1.114 ± 0.04
1.613PheArg: 1.613 ± 0.055
3.046PheSer: 3.046 ± 0.073
2.202PheThr: 2.202 ± 0.055
2.671PheVal: 2.671 ± 0.064
0.515PheTrp: 0.515 ± 0.033
1.202PheTyr: 1.202 ± 0.047
0.0PheXaa: 0.0 ± 0.0
Gly
6.284GlyAla: 6.284 ± 0.132
0.689GlyCys: 0.689 ± 0.033
3.895GlyAsp: 3.895 ± 0.13
4.12GlyGlu: 4.12 ± 0.075
3.26GlyPhe: 3.26 ± 0.081
5.598GlyGly: 5.598 ± 0.197
1.676GlyHis: 1.676 ± 0.053
5.176GlyIle: 5.176 ± 0.092
4.342GlyLys: 4.342 ± 0.08
7.659GlyLeu: 7.659 ± 0.111
2.056GlyMet: 2.056 ± 0.054
3.363GlyAsn: 3.363 ± 0.233
1.74GlyPro: 1.74 ± 0.05
2.493GlyGln: 2.493 ± 0.06
3.497GlyArg: 3.497 ± 0.079
4.366GlySer: 4.366 ± 0.102
3.906GlyThr: 3.906 ± 0.118
5.352GlyVal: 5.352 ± 0.105
1.073GlyTrp: 1.073 ± 0.047
2.429GlyTyr: 2.429 ± 0.059
0.0GlyXaa: 0.0 ± 0.0
His
2.269HisAla: 2.269 ± 0.056
0.213HisCys: 0.213 ± 0.018
1.189HisAsp: 1.189 ± 0.039
1.213HisGlu: 1.213 ± 0.041
0.934HisPhe: 0.934 ± 0.042
1.747HisGly: 1.747 ± 0.06
0.671HisHis: 0.671 ± 0.031
1.491HisIle: 1.491 ± 0.051
0.893HisLys: 0.893 ± 0.034
2.246HisLeu: 2.246 ± 0.062
0.543HisMet: 0.543 ± 0.028
0.689HisAsn: 0.689 ± 0.031
1.24HisPro: 1.24 ± 0.048
0.93HisGln: 0.93 ± 0.035
0.997HisArg: 0.997 ± 0.037
1.174HisSer: 1.174 ± 0.041
1.144HisThr: 1.144 ± 0.042
1.408HisVal: 1.408 ± 0.043
0.331HisTrp: 0.331 ± 0.02
0.789HisTyr: 0.789 ± 0.033
0.0HisXaa: 0.0 ± 0.0
Ile
7.129IleAla: 7.129 ± 0.108
0.536IleCys: 0.536 ± 0.029
4.189IleAsp: 4.189 ± 0.09
4.411IleGlu: 4.411 ± 0.086
2.251IlePhe: 2.251 ± 0.062
5.293IleGly: 5.293 ± 0.11
1.284IleHis: 1.284 ± 0.047
3.632IleIle: 3.632 ± 0.082
3.501IleLys: 3.501 ± 0.081
5.683IleLeu: 5.683 ± 0.113
1.322IleMet: 1.322 ± 0.04
2.831IleAsn: 2.831 ± 0.063
2.93IlePro: 2.93 ± 0.069
2.387IleGln: 2.387 ± 0.063
2.968IleArg: 2.968 ± 0.069
4.677IleSer: 4.677 ± 0.091
4.0IleThr: 4.0 ± 0.088
4.514IleVal: 4.514 ± 0.085
0.629IleTrp: 0.629 ± 0.036
1.806IleTyr: 1.806 ± 0.05
0.0IleXaa: 0.0 ± 0.0
Lys
4.726LysAla: 4.726 ± 0.102
0.226LysCys: 0.226 ± 0.019
2.731LysAsp: 2.731 ± 0.069
2.882LysGlu: 2.882 ± 0.077
1.602LysPhe: 1.602 ± 0.05
3.031LysGly: 3.031 ± 0.07
1.167LysHis: 1.167 ± 0.041
3.29LysIle: 3.29 ± 0.07
2.849LysLys: 2.849 ± 0.083
5.783LysLeu: 5.783 ± 0.099
1.295LysMet: 1.295 ± 0.044
2.079LysAsn: 2.079 ± 0.047
2.683LysPro: 2.683 ± 0.076
2.432LysGln: 2.432 ± 0.058
2.8LysArg: 2.8 ± 0.082
3.295LysSer: 3.295 ± 0.08
3.007LysThr: 3.007 ± 0.07
3.865LysVal: 3.865 ± 0.083
0.461LysTrp: 0.461 ± 0.024
1.273LysTyr: 1.273 ± 0.049
0.0LysXaa: 0.0 ± 0.0
Leu
10.517LeuAla: 10.517 ± 0.136
0.811LeuCys: 0.811 ± 0.034
5.882LeuAsp: 5.882 ± 0.092
5.81LeuGlu: 5.81 ± 0.103
3.773LeuPhe: 3.773 ± 0.084
7.375LeuGly: 7.375 ± 0.107
2.183LeuHis: 2.183 ± 0.06
6.556LeuIle: 6.556 ± 0.106
5.603LeuLys: 5.603 ± 0.091
10.693LeuLeu: 10.693 ± 0.174
2.432LeuMet: 2.432 ± 0.067
4.264LeuAsn: 4.264 ± 0.084
5.166LeuPro: 5.166 ± 0.097
4.016LeuGln: 4.016 ± 0.081
5.238LeuArg: 5.238 ± 0.106
7.152LeuSer: 7.152 ± 0.107
5.824LeuThr: 5.824 ± 0.111
6.912LeuVal: 6.912 ± 0.116
1.042LeuTrp: 1.042 ± 0.042
2.431LeuTyr: 2.431 ± 0.059
0.0LeuXaa: 0.0 ± 0.0
Met
2.586MetAla: 2.586 ± 0.063
0.144MetCys: 0.144 ± 0.013
1.267MetAsp: 1.267 ± 0.043
1.241MetGlu: 1.241 ± 0.044
0.83MetPhe: 0.83 ± 0.037
1.58MetGly: 1.58 ± 0.055
0.591MetHis: 0.591 ± 0.03
1.378MetIle: 1.378 ± 0.044
1.248MetLys: 1.248 ± 0.044
2.802MetLeu: 2.802 ± 0.066
0.729MetMet: 0.729 ± 0.035
0.966MetAsn: 0.966 ± 0.036
1.295MetPro: 1.295 ± 0.046
1.403MetGln: 1.403 ± 0.045
1.483MetArg: 1.483 ± 0.048
1.62MetSer: 1.62 ± 0.041
1.486MetThr: 1.486 ± 0.044
1.699MetVal: 1.699 ± 0.045
0.157MetTrp: 0.157 ± 0.015
0.47MetTyr: 0.47 ± 0.028
0.0MetXaa: 0.0 ± 0.0
Asn
3.93AsnAla: 3.93 ± 0.096
0.294AsnCys: 0.294 ± 0.024
2.325AsnAsp: 2.325 ± 0.148
2.1AsnGlu: 2.1 ± 0.057
1.424AsnPhe: 1.424 ± 0.042
3.12AsnGly: 3.12 ± 0.093
0.898AsnHis: 0.898 ± 0.029
2.928AsnIle: 2.928 ± 0.079
1.845AsnLys: 1.845 ± 0.057
4.123AsnLeu: 4.123 ± 0.096
0.938AsnMet: 0.938 ± 0.038
1.84AsnAsn: 1.84 ± 0.085
2.176AsnPro: 2.176 ± 0.063
1.71AsnGln: 1.71 ± 0.044
2.005AsnArg: 2.005 ± 0.053
2.294AsnSer: 2.294 ± 0.072
2.387AsnThr: 2.387 ± 0.073
2.689AsnVal: 2.689 ± 0.063
0.525AsnTrp: 0.525 ± 0.03
1.163AsnTyr: 1.163 ± 0.051
0.0AsnXaa: 0.0 ± 0.0
Pro
4.023ProAla: 4.023 ± 0.093
0.273ProCys: 0.273 ± 0.018
2.843ProAsp: 2.843 ± 0.057
3.217ProGlu: 3.217 ± 0.065
1.665ProPhe: 1.665 ± 0.052
2.651ProGly: 2.651 ± 0.071
0.994ProHis: 0.994 ± 0.039
2.694ProIle: 2.694 ± 0.06
2.215ProLys: 2.215 ± 0.064
4.18ProLeu: 4.18 ± 0.085
0.991ProMet: 0.991 ± 0.036
1.763ProAsn: 1.763 ± 0.052
1.587ProPro: 1.587 ± 0.058
1.736ProGln: 1.736 ± 0.059
1.601ProArg: 1.601 ± 0.054
2.556ProSer: 2.556 ± 0.066
2.292ProThr: 2.292 ± 0.067
3.305ProVal: 3.305 ± 0.075
0.529ProTrp: 0.529 ± 0.024
1.208ProTyr: 1.208 ± 0.044
0.0ProXaa: 0.0 ± 0.0
Gln
4.246GlnAla: 4.246 ± 0.094
0.286GlnCys: 0.286 ± 0.019
1.988GlnAsp: 1.988 ± 0.05
2.111GlnGlu: 2.111 ± 0.058
1.363GlnPhe: 1.363 ± 0.043
2.683GlnGly: 2.683 ± 0.061
1.087GlnHis: 1.087 ± 0.038
2.466GlnIle: 2.466 ± 0.064
1.958GlnLys: 1.958 ± 0.06
4.124GlnLeu: 4.124 ± 0.097
0.999GlnMet: 0.999 ± 0.038
1.457GlnAsn: 1.457 ± 0.049
1.737GlnPro: 1.737 ± 0.053
2.16GlnGln: 2.16 ± 0.061
2.342GlnArg: 2.342 ± 0.069
2.544GlnSer: 2.544 ± 0.061
2.189GlnThr: 2.189 ± 0.06
2.824GlnVal: 2.824 ± 0.065
0.496GlnTrp: 0.496 ± 0.024
1.248GlnTyr: 1.248 ± 0.042
0.0GlnXaa: 0.0 ± 0.0
Arg
4.282ArgAla: 4.282 ± 0.088
0.354ArgCys: 0.354 ± 0.022
2.772ArgAsp: 2.772 ± 0.067
3.232ArgGlu: 3.232 ± 0.079
2.264ArgPhe: 2.264 ± 0.063
2.99ArgGly: 2.99 ± 0.066
1.144ArgHis: 1.144 ± 0.043
3.49ArgIle: 3.49 ± 0.066
2.368ArgLys: 2.368 ± 0.061
5.494ArgLeu: 5.494 ± 0.107
1.366ArgMet: 1.366 ± 0.046
2.056ArgAsn: 2.056 ± 0.054
1.859ArgPro: 1.859 ± 0.05
2.157ArgGln: 2.157 ± 0.059
2.518ArgArg: 2.518 ± 0.069
2.54ArgSer: 2.54 ± 0.064
2.29ArgThr: 2.29 ± 0.058
3.4ArgVal: 3.4 ± 0.078
0.633ArgTrp: 0.633 ± 0.03
1.813ArgTyr: 1.813 ± 0.047
0.0ArgXaa: 0.0 ± 0.0
Ser
5.981SerAla: 5.981 ± 0.096
0.518SerCys: 0.518 ± 0.038
3.325SerAsp: 3.325 ± 0.065
3.288SerGlu: 3.288 ± 0.072
2.331SerPhe: 2.331 ± 0.059
5.543SerGly: 5.543 ± 0.13
1.486SerHis: 1.486 ± 0.05
4.123SerIle: 4.123 ± 0.087
3.027SerLys: 3.027 ± 0.069
6.853SerLeu: 6.853 ± 0.112
1.502SerMet: 1.502 ± 0.047
2.662SerAsn: 2.662 ± 0.078
2.716SerPro: 2.716 ± 0.063
2.513SerGln: 2.513 ± 0.069
3.061SerArg: 3.061 ± 0.062
4.055SerSer: 4.055 ± 0.107
3.419SerThr: 3.419 ± 0.092
4.202SerVal: 4.202 ± 0.075
0.74SerTrp: 0.74 ± 0.035
1.921SerTyr: 1.921 ± 0.06
0.0SerXaa: 0.0 ± 0.0
Thr
5.102ThrAla: 5.102 ± 0.105
0.39ThrCys: 0.39 ± 0.039
2.904ThrAsp: 2.904 ± 0.065
2.908ThrGlu: 2.908 ± 0.069
2.003ThrPhe: 2.003 ± 0.051
4.709ThrGly: 4.709 ± 0.161
1.192ThrHis: 1.192 ± 0.048
3.385ThrIle: 3.385 ± 0.079
2.41ThrLys: 2.41 ± 0.064
6.566ThrLeu: 6.566 ± 0.131
1.157ThrMet: 1.157 ± 0.044
2.1ThrAsn: 2.1 ± 0.063
3.08ThrPro: 3.08 ± 0.07
2.163ThrGln: 2.163 ± 0.065
2.372ThrArg: 2.372 ± 0.055
3.456ThrSer: 3.456 ± 0.098
3.323ThrThr: 3.323 ± 0.141
4.008ThrVal: 4.008 ± 0.097
0.611ThrTrp: 0.611 ± 0.03
1.718ThrTyr: 1.718 ± 0.081
0.0ThrXaa: 0.0 ± 0.0
Val
6.876ValAla: 6.876 ± 0.105
0.601ValCys: 0.601 ± 0.032
4.083ValAsp: 4.083 ± 0.069
4.075ValGlu: 4.075 ± 0.081
2.689ValPhe: 2.689 ± 0.069
4.761ValGly: 4.761 ± 0.088
1.226ValHis: 1.226 ± 0.042
4.901ValIle: 4.901 ± 0.093
3.515ValLys: 3.515 ± 0.082
7.036ValLeu: 7.036 ± 0.124
2.005ValMet: 2.005 ± 0.061
2.908ValAsn: 2.908 ± 0.064
2.842ValPro: 2.842 ± 0.07
2.231ValGln: 2.231 ± 0.058
3.346ValArg: 3.346 ± 0.071
4.749ValSer: 4.749 ± 0.075
4.179ValThr: 4.179 ± 0.089
5.27ValVal: 5.27 ± 0.1
0.715ValTrp: 0.715 ± 0.031
1.769ValTyr: 1.769 ± 0.046
0.0ValXaa: 0.0 ± 0.0
Trp
0.863TrpAla: 0.863 ± 0.036
0.093TrpCys: 0.093 ± 0.01
0.554TrpAsp: 0.554 ± 0.03
0.54TrpGlu: 0.54 ± 0.025
0.472TrpPhe: 0.472 ± 0.027
0.733TrpGly: 0.733 ± 0.032
0.36TrpHis: 0.36 ± 0.023
0.742TrpIle: 0.742 ± 0.034
0.552TrpLys: 0.552 ± 0.032
1.69TrpLeu: 1.69 ± 0.055
0.332TrpMet: 0.332 ± 0.024
0.421TrpAsn: 0.421 ± 0.023
0.422TrpPro: 0.422 ± 0.026
0.771TrpGln: 0.771 ± 0.03
0.735TrpArg: 0.735 ± 0.037
0.638TrpSer: 0.638 ± 0.03
0.48TrpThr: 0.48 ± 0.026
0.901TrpVal: 0.901 ± 0.037
0.182TrpTrp: 0.182 ± 0.016
0.316TrpTyr: 0.316 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.867TyrAla: 2.867 ± 0.068
0.286TyrCys: 0.286 ± 0.02
1.579TyrAsp: 1.579 ± 0.055
1.528TyrGlu: 1.528 ± 0.043
1.248TyrPhe: 1.248 ± 0.043
2.227TyrGly: 2.227 ± 0.068
0.668TyrHis: 0.668 ± 0.033
1.602TyrIle: 1.602 ± 0.054
1.308TyrLys: 1.308 ± 0.04
3.039TyrLeu: 3.039 ± 0.067
0.603TyrMet: 0.603 ± 0.032
1.002TyrAsn: 1.002 ± 0.038
1.285TyrPro: 1.285 ± 0.046
1.36TyrGln: 1.36 ± 0.051
1.647TyrArg: 1.647 ± 0.048
1.814TyrSer: 1.814 ± 0.057
1.625TyrThr: 1.625 ± 0.056
1.862TyrVal: 1.862 ± 0.057
0.388TyrTrp: 0.388 ± 0.024
0.919TyrTyr: 0.919 ± 0.044
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2256 proteins (731518 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski