Amino acid dipepetide frequency for Pontibacter fetidus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.39AlaAla: 7.39 ± 0.113
0.676AlaCys: 0.676 ± 0.027
4.332AlaAsp: 4.332 ± 0.064
5.127AlaGlu: 5.127 ± 0.077
3.534AlaPhe: 3.534 ± 0.06
6.258AlaGly: 6.258 ± 0.111
1.382AlaHis: 1.382 ± 0.034
5.566AlaIle: 5.566 ± 0.083
4.762AlaLys: 4.762 ± 0.083
7.733AlaLeu: 7.733 ± 0.091
1.964AlaMet: 1.964 ± 0.041
3.719AlaAsn: 3.719 ± 0.071
2.972AlaPro: 2.972 ± 0.072
3.415AlaGln: 3.415 ± 0.061
3.16AlaArg: 3.16 ± 0.06
4.572AlaSer: 4.572 ± 0.085
5.511AlaThr: 5.511 ± 0.134
5.171AlaVal: 5.171 ± 0.084
0.77AlaTrp: 0.77 ± 0.027
3.001AlaTyr: 3.001 ± 0.049
0.0AlaXaa: 0.0 ± 0.0
Cys
0.559CysAla: 0.559 ± 0.03
0.119CysCys: 0.119 ± 0.011
0.416CysAsp: 0.416 ± 0.018
0.419CysGlu: 0.419 ± 0.019
0.334CysPhe: 0.334 ± 0.016
0.648CysGly: 0.648 ± 0.029
0.188CysHis: 0.188 ± 0.014
0.461CysIle: 0.461 ± 0.019
0.342CysLys: 0.342 ± 0.019
0.673CysLeu: 0.673 ± 0.025
0.165CysMet: 0.165 ± 0.012
0.334CysAsn: 0.334 ± 0.017
0.364CysPro: 0.364 ± 0.023
0.268CysGln: 0.268 ± 0.017
0.304CysArg: 0.304 ± 0.018
0.561CysSer: 0.561 ± 0.021
0.476CysThr: 0.476 ± 0.023
0.439CysVal: 0.439 ± 0.019
0.071CysTrp: 0.071 ± 0.009
0.273CysTyr: 0.273 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
4.276AspAla: 4.276 ± 0.07
0.353AspCys: 0.353 ± 0.017
2.406AspAsp: 2.406 ± 0.055
3.559AspGlu: 3.559 ± 0.064
2.825AspPhe: 2.825 ± 0.056
3.48AspGly: 3.48 ± 0.073
0.857AspHis: 0.857 ± 0.03
3.427AspIle: 3.427 ± 0.058
3.672AspLys: 3.672 ± 0.066
4.97AspLeu: 4.97 ± 0.073
1.262AspMet: 1.262 ± 0.032
2.562AspAsn: 2.562 ± 0.05
2.0AspPro: 2.0 ± 0.044
1.641AspGln: 1.641 ± 0.037
2.132AspArg: 2.132 ± 0.058
2.536AspSer: 2.536 ± 0.051
2.672AspThr: 2.672 ± 0.051
3.609AspVal: 3.609 ± 0.068
0.67AspTrp: 0.67 ± 0.026
2.379AspTyr: 2.379 ± 0.052
0.0AspXaa: 0.0 ± 0.0
Glu
5.307GluAla: 5.307 ± 0.1
0.306GluCys: 0.306 ± 0.017
3.043GluAsp: 3.043 ± 0.066
4.554GluGlu: 4.554 ± 0.088
2.396GluPhe: 2.396 ± 0.051
3.797GluGly: 3.797 ± 0.067
1.354GluHis: 1.354 ± 0.038
3.949GluIle: 3.949 ± 0.067
4.528GluLys: 4.528 ± 0.078
6.653GluLeu: 6.653 ± 0.1
1.567GluMet: 1.567 ± 0.034
3.359GluAsn: 3.359 ± 0.048
2.059GluPro: 2.059 ± 0.047
3.257GluGln: 3.257 ± 0.07
3.065GluArg: 3.065 ± 0.068
2.788GluSer: 2.788 ± 0.046
3.448GluThr: 3.448 ± 0.062
4.567GluVal: 4.567 ± 0.064
0.648GluTrp: 0.648 ± 0.027
2.043GluTyr: 2.043 ± 0.041
0.0GluXaa: 0.0 ± 0.0
Phe
3.439PheAla: 3.439 ± 0.064
0.389PheCys: 0.389 ± 0.022
2.581PheAsp: 2.581 ± 0.051
2.729PheGlu: 2.729 ± 0.045
2.03PhePhe: 2.03 ± 0.051
3.242PheGly: 3.242 ± 0.064
0.681PheHis: 0.681 ± 0.026
2.99PheIle: 2.99 ± 0.061
2.66PheLys: 2.66 ± 0.048
4.014PheLeu: 4.014 ± 0.082
1.096PheMet: 1.096 ± 0.035
2.254PheAsn: 2.254 ± 0.045
1.512PhePro: 1.512 ± 0.035
1.27PheGln: 1.27 ± 0.032
1.94PheArg: 1.94 ± 0.041
3.091PheSer: 3.091 ± 0.063
3.132PheThr: 3.132 ± 0.062
2.938PheVal: 2.938 ± 0.057
0.573PheTrp: 0.573 ± 0.024
1.934PheTyr: 1.934 ± 0.042
0.0PheXaa: 0.0 ± 0.0
Gly
4.982GlyAla: 4.982 ± 0.087
0.658GlyCys: 0.658 ± 0.031
3.16GlyAsp: 3.16 ± 0.053
3.737GlyGlu: 3.737 ± 0.062
3.33GlyPhe: 3.33 ± 0.063
4.971GlyGly: 4.971 ± 0.107
1.306GlyHis: 1.306 ± 0.034
5.002GlyIle: 5.002 ± 0.078
5.008GlyLys: 5.008 ± 0.077
6.289GlyLeu: 6.289 ± 0.076
1.755GlyMet: 1.755 ± 0.04
3.616GlyAsn: 3.616 ± 0.084
1.866GlyPro: 1.866 ± 0.043
2.378GlyGln: 2.378 ± 0.051
2.699GlyArg: 2.699 ± 0.054
4.249GlySer: 4.249 ± 0.09
4.635GlyThr: 4.635 ± 0.131
4.507GlyVal: 4.507 ± 0.082
0.81GlyTrp: 0.81 ± 0.034
2.977GlyTyr: 2.977 ± 0.049
0.0GlyXaa: 0.0 ± 0.0
His
1.293HisAla: 1.293 ± 0.031
0.183HisCys: 0.183 ± 0.013
0.916HisAsp: 0.916 ± 0.032
1.144HisGlu: 1.144 ± 0.037
1.047HisPhe: 1.047 ± 0.027
1.234HisGly: 1.234 ± 0.037
0.578HisHis: 0.578 ± 0.025
1.349HisIle: 1.349 ± 0.036
1.098HisLys: 1.098 ± 0.036
2.008HisLeu: 2.008 ± 0.044
0.464HisMet: 0.464 ± 0.02
0.994HisAsn: 0.994 ± 0.028
1.039HisPro: 1.039 ± 0.03
0.798HisGln: 0.798 ± 0.029
0.885HisArg: 0.885 ± 0.032
1.02HisSer: 1.02 ± 0.033
1.271HisThr: 1.271 ± 0.028
1.156HisVal: 1.156 ± 0.034
0.229HisTrp: 0.229 ± 0.015
0.89HisTyr: 0.89 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
5.819IleAla: 5.819 ± 0.079
0.604IleCys: 0.604 ± 0.032
3.471IleAsp: 3.471 ± 0.058
3.888IleGlu: 3.888 ± 0.072
2.528IlePhe: 2.528 ± 0.062
4.593IleGly: 4.593 ± 0.072
1.069IleHis: 1.069 ± 0.034
3.904IleIle: 3.904 ± 0.079
4.075IleLys: 4.075 ± 0.063
6.144IleLeu: 6.144 ± 0.084
1.243IleMet: 1.243 ± 0.034
3.31IleAsn: 3.31 ± 0.065
2.815IlePro: 2.815 ± 0.046
2.079IleGln: 2.079 ± 0.042
2.755IleArg: 2.755 ± 0.05
4.222IleSer: 4.222 ± 0.074
4.436IleThr: 4.436 ± 0.096
4.955IleVal: 4.955 ± 0.076
0.596IleTrp: 0.596 ± 0.025
2.187IleTyr: 2.187 ± 0.05
0.0IleXaa: 0.0 ± 0.0
Lys
5.435LysAla: 5.435 ± 0.08
0.247LysCys: 0.247 ± 0.017
3.415LysAsp: 3.415 ± 0.062
4.45LysGlu: 4.45 ± 0.081
2.12LysPhe: 2.12 ± 0.046
4.071LysGly: 4.071 ± 0.07
1.254LysHis: 1.254 ± 0.034
3.652LysIle: 3.652 ± 0.068
4.411LysLys: 4.411 ± 0.091
6.535LysLeu: 6.535 ± 0.085
1.639LysMet: 1.639 ± 0.042
3.132LysAsn: 3.132 ± 0.053
2.856LysPro: 2.856 ± 0.056
2.971LysGln: 2.971 ± 0.063
2.721LysArg: 2.721 ± 0.048
3.264LysSer: 3.264 ± 0.053
3.732LysThr: 3.732 ± 0.063
4.563LysVal: 4.563 ± 0.068
0.623LysTrp: 0.623 ± 0.022
2.709LysTyr: 2.709 ± 0.061
0.0LysXaa: 0.0 ± 0.0
Leu
7.94LeuAla: 7.94 ± 0.106
0.727LeuCys: 0.727 ± 0.023
4.857LeuAsp: 4.857 ± 0.085
5.811LeuGlu: 5.811 ± 0.09
4.367LeuPhe: 4.367 ± 0.074
6.113LeuGly: 6.113 ± 0.084
2.124LeuHis: 2.124 ± 0.044
5.595LeuIle: 5.595 ± 0.083
6.437LeuLys: 6.437 ± 0.089
11.038LeuLeu: 11.038 ± 0.163
2.353LeuMet: 2.353 ± 0.052
4.923LeuAsn: 4.923 ± 0.071
4.525LeuPro: 4.525 ± 0.063
4.951LeuGln: 4.951 ± 0.091
4.281LeuArg: 4.281 ± 0.08
6.167LeuSer: 6.167 ± 0.079
6.039LeuThr: 6.039 ± 0.085
6.322LeuVal: 6.322 ± 0.083
0.96LeuTrp: 0.96 ± 0.033
3.741LeuTyr: 3.741 ± 0.06
0.0LeuXaa: 0.0 ± 0.0
Met
2.269MetAla: 2.269 ± 0.045
0.113MetCys: 0.113 ± 0.009
1.183MetAsp: 1.183 ± 0.036
1.409MetGlu: 1.409 ± 0.038
0.825MetPhe: 0.825 ± 0.03
1.539MetGly: 1.539 ± 0.039
0.562MetHis: 0.562 ± 0.024
1.215MetIle: 1.215 ± 0.033
1.771MetLys: 1.771 ± 0.041
2.573MetLeu: 2.573 ± 0.053
0.625MetMet: 0.625 ± 0.027
1.114MetAsn: 1.114 ± 0.031
1.159MetPro: 1.159 ± 0.038
1.237MetGln: 1.237 ± 0.031
1.186MetArg: 1.186 ± 0.03
1.229MetSer: 1.229 ± 0.036
1.052MetThr: 1.052 ± 0.028
1.571MetVal: 1.571 ± 0.035
0.171MetTrp: 0.171 ± 0.013
0.689MetTyr: 0.689 ± 0.026
0.0MetXaa: 0.0 ± 0.0
Asn
3.794AsnAla: 3.794 ± 0.075
0.354AsnCys: 0.354 ± 0.02
2.192AsnAsp: 2.192 ± 0.045
2.703AsnGlu: 2.703 ± 0.051
2.128AsnPhe: 2.128 ± 0.047
3.608AsnGly: 3.608 ± 0.074
0.902AsnHis: 0.902 ± 0.035
3.292AsnIle: 3.292 ± 0.06
3.017AsnLys: 3.017 ± 0.059
4.977AsnLeu: 4.977 ± 0.078
1.149AsnMet: 1.149 ± 0.033
2.689AsnAsn: 2.689 ± 0.072
2.624AsnPro: 2.624 ± 0.048
1.861AsnGln: 1.861 ± 0.044
2.334AsnArg: 2.334 ± 0.042
2.804AsnSer: 2.804 ± 0.053
3.114AsnThr: 3.114 ± 0.063
3.075AsnVal: 3.075 ± 0.053
0.727AsnTrp: 0.727 ± 0.026
2.908AsnTyr: 2.908 ± 0.057
0.0AsnXaa: 0.0 ± 0.0
Pro
3.81ProAla: 3.81 ± 0.079
0.243ProCys: 0.243 ± 0.015
2.805ProAsp: 2.805 ± 0.056
3.604ProGlu: 3.604 ± 0.058
1.8ProPhe: 1.8 ± 0.04
2.675ProGly: 2.675 ± 0.054
0.811ProHis: 0.811 ± 0.034
2.302ProIle: 2.302 ± 0.052
2.211ProLys: 2.211 ± 0.047
3.446ProLeu: 3.446 ± 0.061
0.817ProMet: 0.817 ± 0.026
1.972ProAsn: 1.972 ± 0.05
1.025ProPro: 1.025 ± 0.037
1.533ProGln: 1.533 ± 0.038
1.29ProArg: 1.29 ± 0.033
1.995ProSer: 1.995 ± 0.04
2.577ProThr: 2.577 ± 0.052
3.451ProVal: 3.451 ± 0.067
0.376ProTrp: 0.376 ± 0.019
1.602ProTyr: 1.602 ± 0.038
0.0ProXaa: 0.0 ± 0.0
Gln
3.296GlnAla: 3.296 ± 0.067
0.197GlnCys: 0.197 ± 0.013
2.0GlnAsp: 2.0 ± 0.042
2.769GlnGlu: 2.769 ± 0.061
1.534GlnPhe: 1.534 ± 0.04
2.31GlnGly: 2.31 ± 0.054
1.097GlnHis: 1.097 ± 0.032
2.081GlnIle: 2.081 ± 0.043
2.674GlnLys: 2.674 ± 0.06
4.737GlnLeu: 4.737 ± 0.094
0.918GlnMet: 0.918 ± 0.029
2.125GlnAsn: 2.125 ± 0.04
1.85GlnPro: 1.85 ± 0.042
2.795GlnGln: 2.795 ± 0.074
1.855GlnArg: 1.855 ± 0.049
1.85GlnSer: 1.85 ± 0.044
2.461GlnThr: 2.461 ± 0.053
2.995GlnVal: 2.995 ± 0.056
0.395GlnTrp: 0.395 ± 0.021
1.394GlnTyr: 1.394 ± 0.038
0.0GlnXaa: 0.0 ± 0.0
Arg
2.793ArgAla: 2.793 ± 0.047
0.272ArgCys: 0.272 ± 0.017
2.123ArgAsp: 2.123 ± 0.053
2.839ArgGlu: 2.839 ± 0.06
2.172ArgPhe: 2.172 ± 0.045
2.331ArgGly: 2.331 ± 0.058
0.946ArgHis: 0.946 ± 0.031
3.022ArgIle: 3.022 ± 0.06
2.877ArgLys: 2.877 ± 0.056
4.211ArgLeu: 4.211 ± 0.07
1.196ArgMet: 1.196 ± 0.033
2.417ArgAsn: 2.417 ± 0.051
1.538ArgPro: 1.538 ± 0.043
1.935ArgGln: 1.935 ± 0.045
2.017ArgArg: 2.017 ± 0.05
2.276ArgSer: 2.276 ± 0.049
2.4ArgThr: 2.4 ± 0.05
2.754ArgVal: 2.754 ± 0.052
0.525ArgTrp: 0.525 ± 0.03
1.881ArgTyr: 1.881 ± 0.042
0.0ArgXaa: 0.0 ± 0.0
Ser
4.263SerAla: 4.263 ± 0.073
0.569SerCys: 0.569 ± 0.023
3.012SerAsp: 3.012 ± 0.051
3.538SerGlu: 3.538 ± 0.054
2.987SerPhe: 2.987 ± 0.054
4.565SerGly: 4.565 ± 0.094
1.071SerHis: 1.071 ± 0.031
3.912SerIle: 3.912 ± 0.069
3.473SerLys: 3.473 ± 0.058
5.438SerLeu: 5.438 ± 0.065
1.329SerMet: 1.329 ± 0.034
2.723SerAsn: 2.723 ± 0.058
2.267SerPro: 2.267 ± 0.049
1.962SerGln: 1.962 ± 0.044
2.47SerArg: 2.47 ± 0.051
3.687SerSer: 3.687 ± 0.087
3.33SerThr: 3.33 ± 0.073
3.931SerVal: 3.931 ± 0.065
0.655SerTrp: 0.655 ± 0.026
2.522SerTyr: 2.522 ± 0.049
0.0SerXaa: 0.0 ± 0.0
Thr
5.047ThrAla: 5.047 ± 0.109
0.397ThrCys: 0.397 ± 0.018
3.497ThrAsp: 3.497 ± 0.058
3.616ThrGlu: 3.616 ± 0.06
2.854ThrPhe: 2.854 ± 0.057
4.794ThrGly: 4.794 ± 0.117
1.104ThrHis: 1.104 ± 0.031
5.711ThrIle: 5.711 ± 0.106
3.134ThrLys: 3.134 ± 0.059
5.727ThrLeu: 5.727 ± 0.082
1.157ThrMet: 1.157 ± 0.032
2.791ThrAsn: 2.791 ± 0.068
3.075ThrPro: 3.075 ± 0.071
2.117ThrGln: 2.117 ± 0.05
2.137ThrArg: 2.137 ± 0.048
3.628ThrSer: 3.628 ± 0.078
4.314ThrThr: 4.314 ± 0.13
4.14ThrVal: 4.14 ± 0.115
0.736ThrTrp: 0.736 ± 0.038
2.656ThrTyr: 2.656 ± 0.075
0.0ThrXaa: 0.0 ± 0.0
Val
5.842ValAla: 5.842 ± 0.101
0.609ValCys: 0.609 ± 0.027
3.197ValAsp: 3.197 ± 0.057
3.969ValGlu: 3.969 ± 0.066
2.976ValPhe: 2.976 ± 0.057
4.347ValGly: 4.347 ± 0.072
1.199ValHis: 1.199 ± 0.034
4.409ValIle: 4.409 ± 0.065
4.275ValLys: 4.275 ± 0.063
6.756ValLeu: 6.756 ± 0.082
1.665ValMet: 1.665 ± 0.038
3.275ValAsn: 3.275 ± 0.056
2.899ValPro: 2.899 ± 0.057
2.713ValGln: 2.713 ± 0.047
2.797ValArg: 2.797 ± 0.047
4.192ValSer: 4.192 ± 0.078
4.584ValThr: 4.584 ± 0.113
4.809ValVal: 4.809 ± 0.075
0.69ValTrp: 0.69 ± 0.027
2.697ValTyr: 2.697 ± 0.048
0.0ValXaa: 0.0 ± 0.0
Trp
0.789TrpAla: 0.789 ± 0.031
0.094TrpCys: 0.094 ± 0.009
0.547TrpAsp: 0.547 ± 0.022
0.644TrpGlu: 0.644 ± 0.026
0.546TrpPhe: 0.546 ± 0.029
0.652TrpGly: 0.652 ± 0.026
0.273TrpHis: 0.273 ± 0.017
0.571TrpIle: 0.571 ± 0.022
0.635TrpLys: 0.635 ± 0.023
1.262TrpLeu: 1.262 ± 0.036
0.327TrpMet: 0.327 ± 0.019
0.537TrpAsn: 0.537 ± 0.02
0.309TrpPro: 0.309 ± 0.018
0.59TrpGln: 0.59 ± 0.022
0.536TrpArg: 0.536 ± 0.024
0.592TrpSer: 0.592 ± 0.024
0.56TrpThr: 0.56 ± 0.029
0.787TrpVal: 0.787 ± 0.029
0.168TrpTrp: 0.168 ± 0.013
0.437TrpTyr: 0.437 ± 0.034
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.671TyrAla: 2.671 ± 0.045
0.304TyrCys: 0.304 ± 0.017
2.133TyrAsp: 2.133 ± 0.052
2.176TyrGlu: 2.176 ± 0.044
2.165TyrPhe: 2.165 ± 0.048
2.705TyrGly: 2.705 ± 0.062
0.841TyrHis: 0.841 ± 0.027
2.282TyrIle: 2.282 ± 0.046
2.741TyrLys: 2.741 ± 0.045
4.086TyrLeu: 4.086 ± 0.07
0.804TyrMet: 0.804 ± 0.028
2.403TyrAsn: 2.403 ± 0.05
1.589TyrPro: 1.589 ± 0.043
1.566TyrGln: 1.566 ± 0.037
1.96TyrArg: 1.96 ± 0.043
2.979TyrSer: 2.979 ± 0.057
2.886TyrThr: 2.886 ± 0.072
2.163TyrVal: 2.163 ± 0.046
0.464TyrTrp: 0.464 ± 0.02
1.855TyrTyr: 1.855 ± 0.046
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3463 proteins (1154467 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski