Amino acid dipepetide frequency for Halomonas urumqiensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.251AlaAla: 12.251 ± 0.131	1.211AlaCys: 1.211 ± 0.036	6.209AlaAsp: 6.209 ± 0.096	7.803AlaGlu: 7.803 ± 0.119	3.971AlaPhe: 3.971 ± 0.069	9.657AlaGly: 9.657 ± 0.127	2.419AlaHis: 2.419 ± 0.044	5.598AlaIle: 5.598 ± 0.081	2.555AlaLys: 2.555 ± 0.056	13.953AlaLeu: 13.953 ± 0.147	3.547AlaMet: 3.547 ± 0.056	2.782AlaAsn: 2.782 ± 0.054	4.713AlaPro: 4.713 ± 0.062	3.85AlaGln: 3.85 ± 0.053	8.348AlaArg: 8.348 ± 0.104	6.689AlaSer: 6.689 ± 0.083	5.533AlaThr: 5.533 ± 0.092	7.498AlaVal: 7.498 ± 0.079	1.899AlaTrp: 1.899 ± 0.04	2.254AlaTyr: 2.254 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	0.881CysAla: 0.881 ± 0.029	0.103CysCys: 0.103 ± 0.01	0.574CysAsp: 0.574 ± 0.024	0.54CysGlu: 0.54 ± 0.024	0.329CysPhe: 0.329 ± 0.017	0.877CysGly: 0.877 ± 0.028	0.342CysHis: 0.342 ± 0.019	0.347CysIle: 0.347 ± 0.018	0.177CysLys: 0.177 ± 0.013	1.035CysLeu: 1.035 ± 0.034	0.199CysMet: 0.199 ± 0.013	0.206CysAsn: 0.206 ± 0.013	0.482CysPro: 0.482 ± 0.022	0.381CysGln: 0.381 ± 0.018	0.706CysArg: 0.706 ± 0.028	0.434CysSer: 0.434 ± 0.018	0.405CysThr: 0.405 ± 0.018	0.648CysVal: 0.648 ± 0.025	0.122CysTrp: 0.122 ± 0.01	0.238CysTyr: 0.238 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	7.077AspAla: 7.077 ± 0.105	0.459AspCys: 0.459 ± 0.02	4.048AspAsp: 4.048 ± 0.096	4.327AspGlu: 4.327 ± 0.074	2.076AspPhe: 2.076 ± 0.044	4.916AspGly: 4.916 ± 0.1	1.525AspHis: 1.525 ± 0.036	3.002AspIle: 3.002 ± 0.054	1.496AspLys: 1.496 ± 0.036	5.628AspLeu: 5.628 ± 0.076	1.35AspMet: 1.35 ± 0.04	1.603AspAsn: 1.603 ± 0.045	3.168AspPro: 3.168 ± 0.051	2.101AspGln: 2.101 ± 0.046	3.525AspArg: 3.525 ± 0.06	2.95AspSer: 2.95 ± 0.058	3.226AspThr: 3.226 ± 0.07	4.103AspVal: 4.103 ± 0.073	0.984AspTrp: 0.984 ± 0.028	1.623AspTyr: 1.623 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	8.096GluAla: 8.096 ± 0.113	0.462GluCys: 0.462 ± 0.019	3.071GluAsp: 3.071 ± 0.056	3.779GluGlu: 3.779 ± 0.076	1.759GluPhe: 1.759 ± 0.042	5.053GluGly: 5.053 ± 0.064	1.782GluHis: 1.782 ± 0.043	2.969GluIle: 2.969 ± 0.053	1.614GluLys: 1.614 ± 0.043	7.329GluLeu: 7.329 ± 0.102	1.563GluMet: 1.563 ± 0.034	1.435GluAsn: 1.435 ± 0.037	2.883GluPro: 2.883 ± 0.053	3.186GluGln: 3.186 ± 0.084	6.306GluArg: 6.306 ± 0.102	3.452GluSer: 3.452 ± 0.057	3.189GluThr: 3.189 ± 0.051	4.873GluVal: 4.873 ± 0.057	0.915GluTrp: 0.915 ± 0.029	1.179GluTyr: 1.179 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	3.629PheAla: 3.629 ± 0.059	0.352PheCys: 0.352 ± 0.015	2.556PheAsp: 2.556 ± 0.049	2.186PheGlu: 2.186 ± 0.045	1.297PhePhe: 1.297 ± 0.035	3.224PheGly: 3.224 ± 0.058	0.873PheHis: 0.873 ± 0.027	1.696PheIle: 1.696 ± 0.046	0.893PheLys: 0.893 ± 0.034	3.162PheLeu: 3.162 ± 0.063	0.891PheMet: 0.891 ± 0.03	1.053PheAsn: 1.053 ± 0.031	1.441PhePro: 1.441 ± 0.037	1.123PheGln: 1.123 ± 0.029	1.988PheArg: 1.988 ± 0.045	2.203PheSer: 2.203 ± 0.04	1.886PheThr: 1.886 ± 0.042	2.4PheVal: 2.4 ± 0.048	0.498PheTrp: 0.498 ± 0.024	0.891PheTyr: 0.891 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	7.614GlyAla: 7.614 ± 0.14	0.934GlyCys: 0.934 ± 0.027	4.939GlyAsp: 4.939 ± 0.105	6.042GlyGlu: 6.042 ± 0.078	3.244GlyPhe: 3.244 ± 0.055	6.971GlyGly: 6.971 ± 0.145	2.185GlyHis: 2.185 ± 0.045	4.685GlyIle: 4.685 ± 0.07	2.663GlyLys: 2.663 ± 0.064	9.44GlyLeu: 9.44 ± 0.1	2.643GlyMet: 2.643 ± 0.067	2.329GlyAsn: 2.329 ± 0.072	2.791GlyPro: 2.791 ± 0.055	3.396GlyGln: 3.396 ± 0.063	5.583GlyArg: 5.583 ± 0.075	4.528GlySer: 4.528 ± 0.078	3.891GlyThr: 3.891 ± 0.074	6.716GlyVal: 6.716 ± 0.089	1.432GlyTrp: 1.432 ± 0.039	2.301GlyTyr: 2.301 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	2.722HisAla: 2.722 ± 0.052	0.308HisCys: 0.308 ± 0.017	1.635HisAsp: 1.635 ± 0.035	1.398HisGlu: 1.398 ± 0.035	1.097HisPhe: 1.097 ± 0.034	2.43HisGly: 2.43 ± 0.056	0.823HisHis: 0.823 ± 0.029	0.924HisIle: 0.924 ± 0.028	0.525HisLys: 0.525 ± 0.024	2.768HisLeu: 2.768 ± 0.052	0.46HisMet: 0.46 ± 0.021	0.551HisAsn: 0.551 ± 0.022	1.629HisPro: 1.629 ± 0.047	1.025HisGln: 1.025 ± 0.034	1.864HisArg: 1.864 ± 0.04	1.131HisSer: 1.131 ± 0.034	1.023HisThr: 1.023 ± 0.032	1.558HisVal: 1.558 ± 0.035	0.433HisTrp: 0.433 ± 0.02	0.741HisTyr: 0.741 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.632IleAla: 5.632 ± 0.087	0.402IleCys: 0.402 ± 0.019	3.583IleAsp: 3.583 ± 0.063	3.69IleGlu: 3.69 ± 0.051	1.47IlePhe: 1.47 ± 0.042	4.464IleGly: 4.464 ± 0.075	1.1IleHis: 1.1 ± 0.03	2.134IleIle: 2.134 ± 0.048	1.237IleLys: 1.237 ± 0.037	4.042IleLeu: 4.042 ± 0.071	0.993IleMet: 0.993 ± 0.034	1.577IleAsn: 1.577 ± 0.039	2.221IlePro: 2.221 ± 0.049	1.438IleGln: 1.438 ± 0.038	2.972IleArg: 2.972 ± 0.046	2.75IleSer: 2.75 ± 0.052	2.789IleThr: 2.789 ± 0.054	3.12IleVal: 3.12 ± 0.057	0.461IleTrp: 0.461 ± 0.018	0.992IleTyr: 0.992 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	3.099LysAla: 3.099 ± 0.063	0.144LysCys: 0.144 ± 0.013	1.179LysAsp: 1.179 ± 0.034	1.301LysGlu: 1.301 ± 0.041	0.568LysPhe: 0.568 ± 0.024	2.097LysGly: 2.097 ± 0.047	0.587LysHis: 0.587 ± 0.026	1.055LysIle: 1.055 ± 0.035	0.835LysLys: 0.835 ± 0.035	2.568LysLeu: 2.568 ± 0.057	0.534LysMet: 0.534 ± 0.024	0.536LysAsn: 0.536 ± 0.023	1.483LysPro: 1.483 ± 0.042	1.055LysGln: 1.055 ± 0.034	2.201LysArg: 2.201 ± 0.047	1.391LysSer: 1.391 ± 0.041	1.271LysThr: 1.271 ± 0.037	2.009LysVal: 2.009 ± 0.05	0.249LysTrp: 0.249 ± 0.015	0.444LysTyr: 0.444 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	15.622LeuAla: 15.622 ± 0.171	1.099LeuCys: 1.099 ± 0.033	7.452LeuAsp: 7.452 ± 0.101	7.592LeuGlu: 7.592 ± 0.101	3.681LeuPhe: 3.681 ± 0.071	9.671LeuGly: 9.671 ± 0.108	2.377LeuHis: 2.377 ± 0.05	5.232LeuIle: 5.232 ± 0.09	3.073LeuLys: 3.073 ± 0.056	12.095LeuLeu: 12.095 ± 0.171	2.949LeuMet: 2.949 ± 0.058	2.773LeuAsn: 2.773 ± 0.051	6.218LeuPro: 6.218 ± 0.087	2.965LeuGln: 2.965 ± 0.054	6.849LeuArg: 6.849 ± 0.084	6.633LeuSer: 6.633 ± 0.068	5.877LeuThr: 5.877 ± 0.083	8.659LeuVal: 8.659 ± 0.098	1.449LeuTrp: 1.449 ± 0.045	2.325LeuTyr: 2.325 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	3.344MetAla: 3.344 ± 0.054	0.173MetCys: 0.173 ± 0.011	1.169MetAsp: 1.169 ± 0.04	1.231MetGlu: 1.231 ± 0.031	0.719MetPhe: 0.719 ± 0.028	2.02MetGly: 2.02 ± 0.053	0.564MetHis: 0.564 ± 0.023	1.302MetIle: 1.302 ± 0.036	0.756MetLys: 0.756 ± 0.027	2.929MetLeu: 2.929 ± 0.061	0.673MetMet: 0.673 ± 0.031	0.752MetAsn: 0.752 ± 0.027	1.515MetPro: 1.515 ± 0.038	0.95MetGln: 0.95 ± 0.033	1.711MetArg: 1.711 ± 0.039	1.728MetSer: 1.728 ± 0.042	1.759MetThr: 1.759 ± 0.045	1.853MetVal: 1.853 ± 0.048	0.218MetTrp: 0.218 ± 0.016	0.322MetTyr: 0.322 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.89AsnAla: 2.89 ± 0.063	0.212AsnCys: 0.212 ± 0.014	1.554AsnAsp: 1.554 ± 0.045	1.371AsnGlu: 1.371 ± 0.041	0.828AsnPhe: 0.828 ± 0.029	2.161AsnGly: 2.161 ± 0.055	0.607AsnHis: 0.607 ± 0.024	1.256AsnIle: 1.256 ± 0.037	0.518AsnLys: 0.518 ± 0.023	2.757AsnLeu: 2.757 ± 0.05	0.546AsnMet: 0.546 ± 0.023	0.715AsnAsn: 0.715 ± 0.029	1.694AsnPro: 1.694 ± 0.038	0.978AsnGln: 0.978 ± 0.033	1.844AsnArg: 1.844 ± 0.04	1.188AsnSer: 1.188 ± 0.04	1.288AsnThr: 1.288 ± 0.044	1.852AsnVal: 1.852 ± 0.051	0.335AsnTrp: 0.335 ± 0.016	0.587AsnTyr: 0.587 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	5.307ProAla: 5.307 ± 0.066	0.341ProCys: 0.341 ± 0.019	3.367ProAsp: 3.367 ± 0.056	3.868ProGlu: 3.868 ± 0.054	1.756ProPhe: 1.756 ± 0.041	4.548ProGly: 4.548 ± 0.065	1.166ProHis: 1.166 ± 0.034	2.023ProIle: 2.023 ± 0.041	1.056ProLys: 1.056 ± 0.043	5.661ProLeu: 5.661 ± 0.08	1.266ProMet: 1.266 ± 0.034	1.116ProAsn: 1.116 ± 0.032	2.3ProPro: 2.3 ± 0.053	1.617ProGln: 1.617 ± 0.036	3.188ProArg: 3.188 ± 0.059	2.7ProSer: 2.7 ± 0.047	2.335ProThr: 2.335 ± 0.045	3.864ProVal: 3.864 ± 0.062	0.831ProTrp: 0.831 ± 0.029	1.001ProTyr: 1.001 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	5.26GlnAla: 5.26 ± 0.076	0.291GlnCys: 0.291 ± 0.015	1.764GlnAsp: 1.764 ± 0.041	1.893GlnGlu: 1.893 ± 0.042	1.022GlnPhe: 1.022 ± 0.031	3.308GlnGly: 3.308 ± 0.061	0.955GlnHis: 0.955 ± 0.032	1.36GlnIle: 1.36 ± 0.033	0.773GlnLys: 0.773 ± 0.027	4.155GlnLeu: 4.155 ± 0.061	0.802GlnMet: 0.802 ± 0.027	0.719GlnAsn: 0.719 ± 0.029	1.949GlnPro: 1.949 ± 0.037	2.011GlnGln: 2.011 ± 0.052	3.492GlnArg: 3.492 ± 0.065	1.806GlnSer: 1.806 ± 0.041	1.579GlnThr: 1.579 ± 0.04	2.995GlnVal: 2.995 ± 0.045	0.578GlnTrp: 0.578 ± 0.023	0.653GlnTyr: 0.653 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	6.57ArgAla: 6.57 ± 0.085	0.591ArgCys: 0.591 ± 0.025	4.451ArgAsp: 4.451 ± 0.064	5.415ArgGlu: 5.415 ± 0.083	2.853ArgPhe: 2.853 ± 0.057	4.778ArgGly: 4.778 ± 0.073	2.504ArgHis: 2.504 ± 0.052	3.372ArgIle: 3.372 ± 0.053	1.733ArgLys: 1.733 ± 0.043	10.047ArgLeu: 10.047 ± 0.142	1.859ArgMet: 1.859 ± 0.041	1.639ArgAsn: 1.639 ± 0.039	2.966ArgPro: 2.966 ± 0.049	3.424ArgGln: 3.424 ± 0.066	5.785ArgArg: 5.785 ± 0.098	3.211ArgSer: 3.211 ± 0.055	2.793ArgThr: 2.793 ± 0.05	5.106ArgVal: 5.106 ± 0.076	1.078ArgTrp: 1.078 ± 0.038	2.053ArgTyr: 2.053 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	5.794SerAla: 5.794 ± 0.077	0.419SerCys: 0.419 ± 0.02	3.088SerAsp: 3.088 ± 0.063	3.233SerGlu: 3.233 ± 0.056	1.836SerPhe: 1.836 ± 0.038	5.271SerGly: 5.271 ± 0.088	1.375SerHis: 1.375 ± 0.036	2.504SerIle: 2.504 ± 0.051	1.142SerLys: 1.142 ± 0.032	6.844SerLeu: 6.844 ± 0.078	1.414SerMet: 1.414 ± 0.038	1.295SerAsn: 1.295 ± 0.035	2.955SerPro: 2.955 ± 0.046	2.007SerGln: 2.007 ± 0.049	4.37SerArg: 4.37 ± 0.064	3.03SerSer: 3.03 ± 0.061	2.619SerThr: 2.619 ± 0.052	3.891SerVal: 3.891 ± 0.066	0.737SerTrp: 0.737 ± 0.029	1.067SerTyr: 1.067 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	5.013ThrAla: 5.013 ± 0.091	0.444ThrCys: 0.444 ± 0.022	2.441ThrAsp: 2.441 ± 0.053	2.568ThrGlu: 2.568 ± 0.053	1.815ThrPhe: 1.815 ± 0.049	4.475ThrGly: 4.475 ± 0.078	1.285ThrHis: 1.285 ± 0.033	2.098ThrIle: 2.098 ± 0.051	0.839ThrLys: 0.839 ± 0.03	7.353ThrLeu: 7.353 ± 0.092	1.028ThrMet: 1.028 ± 0.03	1.169ThrAsn: 1.169 ± 0.036	3.485ThrPro: 3.485 ± 0.059	1.736ThrGln: 1.736 ± 0.043	3.744ThrArg: 3.744 ± 0.055	2.789ThrSer: 2.789 ± 0.046	2.588ThrThr: 2.588 ± 0.06	3.361ThrVal: 3.361 ± 0.082	0.704ThrTrp: 0.704 ± 0.026	0.995ThrTyr: 0.995 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	8.535ValAla: 8.535 ± 0.103	0.68ValCys: 0.68 ± 0.025	4.301ValAsp: 4.301 ± 0.076	4.963ValGlu: 4.963 ± 0.072	2.556ValPhe: 2.556 ± 0.051	5.617ValGly: 5.617 ± 0.078	1.475ValHis: 1.475 ± 0.037	4.061ValIle: 4.061 ± 0.078	1.928ValLys: 1.928 ± 0.048	7.727ValLeu: 7.727 ± 0.102	2.174ValMet: 2.174 ± 0.038	2.025ValAsn: 2.025 ± 0.046	3.45ValPro: 3.45 ± 0.059	2.101ValGln: 2.101 ± 0.041	4.425ValArg: 4.425 ± 0.068	4.338ValSer: 4.338 ± 0.067	4.239ValThr: 4.239 ± 0.08	6.098ValVal: 6.098 ± 0.098	0.895ValTrp: 0.895 ± 0.029	1.508ValTyr: 1.508 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	1.129TrpAla: 1.129 ± 0.034	0.175TrpCys: 0.175 ± 0.011	0.585TrpAsp: 0.585 ± 0.024	0.646TrpGlu: 0.646 ± 0.025	0.53TrpPhe: 0.53 ± 0.023	0.894TrpGly: 0.894 ± 0.029	0.449TrpHis: 0.449 ± 0.018	0.624TrpIle: 0.624 ± 0.024	0.348TrpLys: 0.348 ± 0.019	2.394TrpLeu: 2.394 ± 0.063	0.38TrpMet: 0.38 ± 0.019	0.384TrpAsn: 0.384 ± 0.019	0.739TrpPro: 0.739 ± 0.023	0.973TrpGln: 0.973 ± 0.032	1.272TrpArg: 1.272 ± 0.042	0.738TrpSer: 0.738 ± 0.025	0.579TrpThr: 0.579 ± 0.024	1.0TrpVal: 1.0 ± 0.032	0.301TrpTrp: 0.301 ± 0.015	0.316TrpTyr: 0.316 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.277TyrAla: 2.277 ± 0.043	0.225TyrCys: 0.225 ± 0.014	1.222TyrAsp: 1.222 ± 0.035	1.045TyrGlu: 1.045 ± 0.03	0.839TyrPhe: 0.839 ± 0.027	1.896TyrGly: 1.896 ± 0.045	0.651TyrHis: 0.651 ± 0.022	0.823TyrIle: 0.823 ± 0.026	0.444TyrLys: 0.444 ± 0.023	2.703TyrLeu: 2.703 ± 0.055	0.416TyrMet: 0.416 ± 0.021	0.523TyrAsn: 0.523 ± 0.021	1.229TyrPro: 1.229 ± 0.035	1.047TyrGln: 1.047 ± 0.026	2.053TyrArg: 2.053 ± 0.046	1.204TyrSer: 1.204 ± 0.033	1.063TyrThr: 1.063 ± 0.031	1.495TyrVal: 1.495 ± 0.035	0.336TyrTrp: 0.336 ± 0.018	0.637TyrTyr: 0.637 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3488 proteins (1180462 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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