Amino acid dipepetide frequency for Paraburkholderia megapolitana

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.277AlaAla: 17.277 ± 0.146	1.189AlaCys: 1.189 ± 0.026	6.494AlaAsp: 6.494 ± 0.065	5.52AlaGlu: 5.52 ± 0.055	4.245AlaPhe: 4.245 ± 0.049	10.542AlaGly: 10.542 ± 0.098	2.977AlaHis: 2.977 ± 0.035	5.815AlaIle: 5.815 ± 0.052	3.352AlaLys: 3.352 ± 0.053	14.174AlaLeu: 14.174 ± 0.101	2.933AlaMet: 2.933 ± 0.036	3.369AlaAsn: 3.369 ± 0.051	5.87AlaPro: 5.87 ± 0.065	5.547AlaGln: 5.547 ± 0.055	8.357AlaArg: 8.357 ± 0.074	7.574AlaSer: 7.574 ± 0.072	6.963AlaThr: 6.963 ± 0.062	8.746AlaVal: 8.746 ± 0.07	1.752AlaTrp: 1.752 ± 0.031	2.715AlaTyr: 2.715 ± 0.036	0.0AlaXaa: 0.0 ± 0.0
Cys	1.166CysAla: 1.166 ± 0.027	0.12CysCys: 0.12 ± 0.007	0.503CysAsp: 0.503 ± 0.015	0.47CysGlu: 0.47 ± 0.015	0.329CysPhe: 0.329 ± 0.013	0.959CysGly: 0.959 ± 0.024	0.227CysHis: 0.227 ± 0.009	0.409CysIle: 0.409 ± 0.014	0.2CysLys: 0.2 ± 0.009	0.762CysLeu: 0.762 ± 0.018	0.18CysMet: 0.18 ± 0.009	0.235CysAsn: 0.235 ± 0.01	0.414CysPro: 0.414 ± 0.015	0.193CysGln: 0.193 ± 0.009	0.589CysArg: 0.589 ± 0.02	0.525CysSer: 0.525 ± 0.016	0.497CysThr: 0.497 ± 0.014	0.775CysVal: 0.775 ± 0.021	0.118CysTrp: 0.118 ± 0.007	0.228CysTyr: 0.228 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.641AspAla: 7.641 ± 0.072	0.434AspCys: 0.434 ± 0.016	3.173AspAsp: 3.173 ± 0.045	3.28AspGlu: 3.28 ± 0.041	1.955AspPhe: 1.955 ± 0.033	4.752AspGly: 4.752 ± 0.059	1.196AspHis: 1.196 ± 0.024	2.616AspIle: 2.616 ± 0.04	1.333AspLys: 1.333 ± 0.031	5.248AspLeu: 5.248 ± 0.048	1.123AspMet: 1.123 ± 0.024	1.474AspAsn: 1.474 ± 0.028	3.017AspPro: 3.017 ± 0.042	1.608AspGln: 1.608 ± 0.03	3.407AspArg: 3.407 ± 0.047	2.711AspSer: 2.711 ± 0.049	3.217AspThr: 3.217 ± 0.048	4.387AspVal: 4.387 ± 0.057	0.912AspTrp: 0.912 ± 0.022	1.554AspTyr: 1.554 ± 0.029	0.0AspXaa: 0.0 ± 0.0
Glu	6.122GluAla: 6.122 ± 0.081	0.393GluCys: 0.393 ± 0.014	1.953GluAsp: 1.953 ± 0.033	2.084GluGlu: 2.084 ± 0.04	1.704GluPhe: 1.704 ± 0.029	3.063GluGly: 3.063 ± 0.039	1.439GluHis: 1.439 ± 0.029	2.636GluIle: 2.636 ± 0.038	1.566GluLys: 1.566 ± 0.029	5.254GluLeu: 5.254 ± 0.066	1.066GluMet: 1.066 ± 0.024	1.302GluAsn: 1.302 ± 0.028	2.43GluPro: 2.43 ± 0.035	2.345GluGln: 2.345 ± 0.036	4.616GluArg: 4.616 ± 0.058	2.532GluSer: 2.532 ± 0.036	2.763GluThr: 2.763 ± 0.037	3.418GluVal: 3.418 ± 0.049	0.713GluTrp: 0.713 ± 0.017	1.144GluTyr: 1.144 ± 0.023	0.0GluXaa: 0.0 ± 0.0
Phe	4.723PheAla: 4.723 ± 0.054	0.399PheCys: 0.399 ± 0.014	2.783PheAsp: 2.783 ± 0.043	1.967PheGlu: 1.967 ± 0.033	1.438PhePhe: 1.438 ± 0.029	3.735PheGly: 3.735 ± 0.045	0.778PheHis: 0.778 ± 0.02	1.654PheIle: 1.654 ± 0.03	0.909PheLys: 0.909 ± 0.023	2.979PheLeu: 2.979 ± 0.044	0.767PheMet: 0.767 ± 0.017	1.237PheAsn: 1.237 ± 0.026	1.578PhePro: 1.578 ± 0.028	0.992PheGln: 0.992 ± 0.022	1.972PheArg: 1.972 ± 0.032	2.337PheSer: 2.337 ± 0.03	2.038PheThr: 2.038 ± 0.032	3.118PheVal: 3.118 ± 0.045	0.504PheTrp: 0.504 ± 0.016	0.947PheTyr: 0.947 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	9.355GlyAla: 9.355 ± 0.113	0.789GlyCys: 0.789 ± 0.017	4.039GlyAsp: 4.039 ± 0.046	4.004GlyGlu: 4.004 ± 0.047	3.474GlyPhe: 3.474 ± 0.047	6.945GlyGly: 6.945 ± 0.133	1.908GlyHis: 1.908 ± 0.033	4.411GlyIle: 4.411 ± 0.053	2.979GlyLys: 2.979 ± 0.043	8.068GlyLeu: 8.068 ± 0.09	2.081GlyMet: 2.081 ± 0.033	2.611GlyAsn: 2.611 ± 0.066	2.937GlyPro: 2.937 ± 0.039	2.718GlyGln: 2.718 ± 0.039	5.032GlyArg: 5.032 ± 0.057	5.07GlySer: 5.07 ± 0.075	5.195GlyThr: 5.195 ± 0.131	6.749GlyVal: 6.749 ± 0.061	1.421GlyTrp: 1.421 ± 0.028	2.503GlyTyr: 2.503 ± 0.039	0.0GlyXaa: 0.0 ± 0.0
His	3.119HisAla: 3.119 ± 0.046	0.258HisCys: 0.258 ± 0.01	1.459HisAsp: 1.459 ± 0.028	1.183HisGlu: 1.183 ± 0.026	0.966HisPhe: 0.966 ± 0.021	2.19HisGly: 2.19 ± 0.035	0.656HisHis: 0.656 ± 0.018	0.955HisIle: 0.955 ± 0.02	0.482HisLys: 0.482 ± 0.015	2.253HisLeu: 2.253 ± 0.035	0.468HisMet: 0.468 ± 0.013	0.557HisAsn: 0.557 ± 0.015	1.439HisPro: 1.439 ± 0.029	0.64HisGln: 0.64 ± 0.016	1.621HisArg: 1.621 ± 0.03	1.128HisSer: 1.128 ± 0.02	1.246HisThr: 1.246 ± 0.021	1.785HisVal: 1.785 ± 0.03	0.402HisTrp: 0.402 ± 0.015	0.7HisTyr: 0.7 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	7.17IleAla: 7.17 ± 0.063	0.449IleCys: 0.449 ± 0.015	3.689IleAsp: 3.689 ± 0.046	3.226IleGlu: 3.226 ± 0.04	1.425IlePhe: 1.425 ± 0.031	4.791IleGly: 4.791 ± 0.066	0.957IleHis: 0.957 ± 0.02	1.521IleIle: 1.521 ± 0.031	1.276IleLys: 1.276 ± 0.029	3.34IleLeu: 3.34 ± 0.041	0.707IleMet: 0.707 ± 0.018	1.433IleAsn: 1.433 ± 0.028	2.168IlePro: 2.168 ± 0.028	1.287IleGln: 1.287 ± 0.024	2.75IleArg: 2.75 ± 0.036	2.545IleSer: 2.545 ± 0.039	2.423IleThr: 2.423 ± 0.035	4.563IleVal: 4.563 ± 0.05	0.534IleTrp: 0.534 ± 0.017	1.067IleTyr: 1.067 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	3.147LysAla: 3.147 ± 0.049	0.137LysCys: 0.137 ± 0.007	1.364LysAsp: 1.364 ± 0.026	1.256LysGlu: 1.256 ± 0.026	0.82LysPhe: 0.82 ± 0.02	1.982LysGly: 1.982 ± 0.036	0.626LysHis: 0.626 ± 0.016	1.522LysIle: 1.522 ± 0.031	1.087LysLys: 1.087 ± 0.028	3.105LysLeu: 3.105 ± 0.042	0.699LysMet: 0.699 ± 0.018	0.86LysAsn: 0.86 ± 0.023	1.823LysPro: 1.823 ± 0.031	1.212LysGln: 1.212 ± 0.026	2.085LysArg: 2.085 ± 0.031	1.605LysSer: 1.605 ± 0.035	1.811LysThr: 1.811 ± 0.031	2.114LysVal: 2.114 ± 0.033	0.347LysTrp: 0.347 ± 0.011	0.652LysTyr: 0.652 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	13.83LeuAla: 13.83 ± 0.101	1.008LeuCys: 1.008 ± 0.022	6.215LeuAsp: 6.215 ± 0.066	4.807LeuGlu: 4.807 ± 0.055	3.608LeuPhe: 3.608 ± 0.05	8.292LeuGly: 8.292 ± 0.087	2.324LeuHis: 2.324 ± 0.032	4.822LeuIle: 4.822 ± 0.055	3.13LeuLys: 3.13 ± 0.039	10.272LeuLeu: 10.272 ± 0.089	2.14LeuMet: 2.14 ± 0.038	2.917LeuAsn: 2.917 ± 0.039	5.905LeuPro: 5.905 ± 0.062	3.553LeuGln: 3.553 ± 0.051	6.968LeuArg: 6.968 ± 0.066	6.536LeuSer: 6.536 ± 0.081	5.977LeuThr: 5.977 ± 0.066	7.488LeuVal: 7.488 ± 0.069	1.176LeuTrp: 1.176 ± 0.024	2.247LeuTyr: 2.247 ± 0.034	0.0LeuXaa: 0.0 ± 0.0
Met	2.242MetAla: 2.242 ± 0.034	0.166MetCys: 0.166 ± 0.008	0.844MetAsp: 0.844 ± 0.02	0.826MetGlu: 0.826 ± 0.019	0.714MetPhe: 0.714 ± 0.019	1.42MetGly: 1.42 ± 0.028	0.54MetHis: 0.54 ± 0.015	1.097MetIle: 1.097 ± 0.025	0.958MetLys: 0.958 ± 0.021	2.56MetLeu: 2.56 ± 0.036	0.543MetMet: 0.543 ± 0.016	0.932MetAsn: 0.932 ± 0.023	1.377MetPro: 1.377 ± 0.035	1.014MetGln: 1.014 ± 0.02	1.644MetArg: 1.644 ± 0.029	1.685MetSer: 1.685 ± 0.029	1.594MetThr: 1.594 ± 0.027	1.381MetVal: 1.381 ± 0.026	0.218MetTrp: 0.218 ± 0.01	0.397MetTyr: 0.397 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.636AsnAla: 3.636 ± 0.059	0.244AsnCys: 0.244 ± 0.01	1.551AsnAsp: 1.551 ± 0.028	1.32AsnGlu: 1.32 ± 0.027	1.049AsnPhe: 1.049 ± 0.021	2.765AsnGly: 2.765 ± 0.052	0.57AsnHis: 0.57 ± 0.015	1.254AsnIle: 1.254 ± 0.025	0.621AsnLys: 0.621 ± 0.02	2.926AsnLeu: 2.926 ± 0.049	0.545AsnMet: 0.545 ± 0.015	0.963AsnAsn: 0.963 ± 0.036	1.919AsnPro: 1.919 ± 0.032	1.035AsnGln: 1.035 ± 0.026	1.853AsnArg: 1.853 ± 0.03	1.519AsnSer: 1.519 ± 0.042	1.701AsnThr: 1.701 ± 0.039	2.377AsnVal: 2.377 ± 0.041	0.449AsnTrp: 0.449 ± 0.014	0.796AsnTyr: 0.796 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	6.735ProAla: 6.735 ± 0.069	0.329ProCys: 0.329 ± 0.013	3.416ProAsp: 3.416 ± 0.041	2.768ProGlu: 2.768 ± 0.042	1.947ProPhe: 1.947 ± 0.031	4.209ProGly: 4.209 ± 0.041	1.296ProHis: 1.296 ± 0.025	2.009ProIle: 2.009 ± 0.033	1.323ProLys: 1.323 ± 0.025	5.332ProLeu: 5.332 ± 0.055	1.067ProMet: 1.067 ± 0.025	1.419ProAsn: 1.419 ± 0.028	2.452ProPro: 2.452 ± 0.044	1.987ProGln: 1.987 ± 0.035	2.789ProArg: 2.789 ± 0.035	2.909ProSer: 2.909 ± 0.039	2.914ProThr: 2.914 ± 0.055	4.615ProVal: 4.615 ± 0.074	0.661ProTrp: 0.661 ± 0.018	1.202ProTyr: 1.202 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	4.353GlnAla: 4.353 ± 0.048	0.277GlnCys: 0.277 ± 0.013	1.373GlnAsp: 1.373 ± 0.028	1.282GlnGlu: 1.282 ± 0.028	1.336GlnPhe: 1.336 ± 0.025	2.448GlnGly: 2.448 ± 0.037	0.98GlnHis: 0.98 ± 0.022	2.074GlnIle: 2.074 ± 0.031	1.064GlnLys: 1.064 ± 0.027	3.936GlnLeu: 3.936 ± 0.047	0.988GlnMet: 0.988 ± 0.022	1.023GlnAsn: 1.023 ± 0.028	2.138GlnPro: 2.138 ± 0.032	2.083GlnGln: 2.083 ± 0.044	3.015GlnArg: 3.015 ± 0.042	2.16GlnSer: 2.16 ± 0.031	2.237GlnThr: 2.237 ± 0.035	2.592GlnVal: 2.592 ± 0.034	0.598GlnTrp: 0.598 ± 0.015	0.978GlnTyr: 0.978 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	7.663ArgAla: 7.663 ± 0.067	0.587ArgCys: 0.587 ± 0.019	3.704ArgAsp: 3.704 ± 0.047	3.916ArgGlu: 3.916 ± 0.053	2.932ArgPhe: 2.932 ± 0.04	4.358ArgGly: 4.358 ± 0.044	1.853ArgHis: 1.853 ± 0.031	3.579ArgIle: 3.579 ± 0.043	1.863ArgLys: 1.863 ± 0.028	7.151ArgLeu: 7.151 ± 0.075	1.682ArgMet: 1.682 ± 0.03	1.934ArgAsn: 1.934 ± 0.031	3.035ArgPro: 3.035 ± 0.043	2.416ArgGln: 2.416 ± 0.036	5.096ArgArg: 5.096 ± 0.056	3.626ArgSer: 3.626 ± 0.045	3.554ArgThr: 3.554 ± 0.046	5.203ArgVal: 5.203 ± 0.051	1.042ArgTrp: 1.042 ± 0.023	2.031ArgTyr: 2.031 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	7.097SerAla: 7.097 ± 0.066	0.447SerCys: 0.447 ± 0.016	2.985SerAsp: 2.985 ± 0.043	2.554SerGlu: 2.554 ± 0.044	2.29SerPhe: 2.29 ± 0.036	5.786SerGly: 5.786 ± 0.09	1.241SerHis: 1.241 ± 0.024	2.904SerIle: 2.904 ± 0.042	1.55SerLys: 1.55 ± 0.033	6.062SerLeu: 6.062 ± 0.068	1.41SerMet: 1.41 ± 0.025	1.836SerAsn: 1.836 ± 0.045	2.924SerPro: 2.924 ± 0.038	1.902SerGln: 1.902 ± 0.034	3.616SerArg: 3.616 ± 0.048	3.913SerSer: 3.913 ± 0.062	3.72SerThr: 3.72 ± 0.081	4.495SerVal: 4.495 ± 0.051	0.794SerTrp: 0.794 ± 0.019	1.423SerTyr: 1.423 ± 0.026	0.0SerXaa: 0.0 ± 0.0
Thr	6.457ThrAla: 6.457 ± 0.061	0.449ThrCys: 0.449 ± 0.017	2.924ThrAsp: 2.924 ± 0.036	2.283ThrGlu: 2.283 ± 0.037	2.159ThrPhe: 2.159 ± 0.039	5.315ThrGly: 5.315 ± 0.114	1.392ThrHis: 1.392 ± 0.022	2.745ThrIle: 2.745 ± 0.04	1.288ThrLys: 1.288 ± 0.029	7.078ThrLeu: 7.078 ± 0.091	1.174ThrMet: 1.174 ± 0.024	1.521ThrAsn: 1.521 ± 0.04	3.807ThrPro: 3.807 ± 0.061	2.195ThrGln: 2.195 ± 0.033	3.661ThrArg: 3.661 ± 0.043	3.474ThrSer: 3.474 ± 0.051	3.531ThrThr: 3.531 ± 0.07	4.755ThrVal: 4.755 ± 0.057	0.76ThrTrp: 0.76 ± 0.02	1.39ThrTyr: 1.39 ± 0.025	0.0ThrXaa: 0.0 ± 0.0
Val	9.654ValAla: 9.654 ± 0.069	0.814ValCys: 0.814 ± 0.02	4.52ValAsp: 4.52 ± 0.087	4.084ValGlu: 4.084 ± 0.062	2.833ValPhe: 2.833 ± 0.037	5.618ValGly: 5.618 ± 0.057	1.589ValHis: 1.589 ± 0.028	3.711ValIle: 3.711 ± 0.045	2.291ValLys: 2.291 ± 0.036	8.21ValLeu: 8.21 ± 0.073	1.766ValMet: 1.766 ± 0.031	2.284ValAsn: 2.284 ± 0.042	4.178ValPro: 4.178 ± 0.047	2.581ValGln: 2.581 ± 0.036	4.987ValArg: 4.987 ± 0.051	4.84ValSer: 4.84 ± 0.052	4.778ValThr: 4.778 ± 0.058	6.345ValVal: 6.345 ± 0.068	1.008ValTrp: 1.008 ± 0.023	1.723ValTyr: 1.723 ± 0.027	0.0ValXaa: 0.0 ± 0.0
Trp	1.196TrpAla: 1.196 ± 0.022	0.149TrpCys: 0.149 ± 0.009	0.625TrpAsp: 0.625 ± 0.015	0.51TrpGlu: 0.51 ± 0.015	0.592TrpPhe: 0.592 ± 0.017	0.881TrpGly: 0.881 ± 0.022	0.426TrpHis: 0.426 ± 0.014	0.712TrpIle: 0.712 ± 0.018	0.402TrpLys: 0.402 ± 0.013	1.954TrpLeu: 1.954 ± 0.034	0.373TrpMet: 0.373 ± 0.013	0.485TrpAsn: 0.485 ± 0.017	0.665TrpPro: 0.665 ± 0.02	0.736TrpGln: 0.736 ± 0.021	1.182TrpArg: 1.182 ± 0.026	0.888TrpSer: 0.888 ± 0.021	0.769TrpThr: 0.769 ± 0.02	0.935TrpVal: 0.935 ± 0.021	0.238TrpTrp: 0.238 ± 0.013	0.331TrpTyr: 0.331 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.826TyrAla: 2.826 ± 0.038	0.261TyrCys: 0.261 ± 0.009	1.425TyrAsp: 1.425 ± 0.03	1.202TyrGlu: 1.202 ± 0.023	1.039TyrPhe: 1.039 ± 0.022	2.239TyrGly: 2.239 ± 0.039	0.53TyrHis: 0.53 ± 0.018	0.874TyrIle: 0.874 ± 0.021	0.583TyrLys: 0.583 ± 0.016	2.551TyrLeu: 2.551 ± 0.037	0.438TyrMet: 0.438 ± 0.013	0.699TyrAsn: 0.699 ± 0.02	1.303TyrPro: 1.303 ± 0.027	0.891TyrGln: 0.891 ± 0.02	1.986TyrArg: 1.986 ± 0.03	1.375TyrSer: 1.375 ± 0.027	1.425TyrThr: 1.425 ± 0.027	1.976TyrVal: 1.976 ± 0.033	0.402TyrTrp: 0.402 ± 0.012	0.686TyrTyr: 0.686 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6692 proteins (2228779 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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