Amino acid dipepetide frequency for Burkholderia phage BcepNazgul

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.678AlaAla: 17.678 ± 2.335
1.537AlaCys: 1.537 ± 0.366
7.631AlaAsp: 7.631 ± 0.618
6.917AlaGlu: 6.917 ± 0.825
4.117AlaPhe: 4.117 ± 0.44
8.07AlaGly: 8.07 ± 0.859
1.976AlaHis: 1.976 ± 0.435
5.545AlaIle: 5.545 ± 0.615
5.764AlaLys: 5.764 ± 0.748
7.466AlaLeu: 7.466 ± 0.788
3.129AlaMet: 3.129 ± 0.475
3.184AlaAsn: 3.184 ± 0.338
4.447AlaPro: 4.447 ± 0.62
4.502AlaGln: 4.502 ± 0.562
6.972AlaArg: 6.972 ± 0.703
7.466AlaSer: 7.466 ± 1.032
7.357AlaThr: 7.357 ± 0.999
6.972AlaVal: 6.972 ± 0.707
1.647AlaTrp: 1.647 ± 0.325
2.8AlaTyr: 2.8 ± 0.332
0.0AlaXaa: 0.0 ± 0.0
Cys
1.702CysAla: 1.702 ± 0.374
0.11CysCys: 0.11 ± 0.068
0.659CysAsp: 0.659 ± 0.218
0.769CysGlu: 0.769 ± 0.213
0.604CysPhe: 0.604 ± 0.2
1.592CysGly: 1.592 ± 0.36
0.22CysHis: 0.22 ± 0.122
0.494CysIle: 0.494 ± 0.186
0.549CysLys: 0.549 ± 0.181
0.549CysLeu: 0.549 ± 0.213
0.11CysMet: 0.11 ± 0.073
0.439CysAsn: 0.439 ± 0.139
0.604CysPro: 0.604 ± 0.14
0.22CysGln: 0.22 ± 0.107
0.878CysArg: 0.878 ± 0.24
0.494CysSer: 0.494 ± 0.185
0.274CysThr: 0.274 ± 0.144
0.604CysVal: 0.604 ± 0.149
0.165CysTrp: 0.165 ± 0.091
0.439CysTyr: 0.439 ± 0.143
0.0CysXaa: 0.0 ± 0.0
Asp
7.082AspAla: 7.082 ± 0.608
0.933AspCys: 0.933 ± 0.276
4.941AspAsp: 4.941 ± 0.584
3.568AspGlu: 3.568 ± 0.59
2.416AspPhe: 2.416 ± 0.37
5.325AspGly: 5.325 ± 0.612
0.988AspHis: 0.988 ± 0.237
3.349AspIle: 3.349 ± 0.51
2.416AspLys: 2.416 ± 0.359
4.392AspLeu: 4.392 ± 0.566
1.537AspMet: 1.537 ± 0.368
2.141AspAsn: 2.141 ± 0.291
4.063AspPro: 4.063 ± 0.413
2.306AspGln: 2.306 ± 0.33
4.117AspArg: 4.117 ± 0.656
3.294AspSer: 3.294 ± 0.385
3.898AspThr: 3.898 ± 0.492
4.172AspVal: 4.172 ± 0.491
0.933AspTrp: 0.933 ± 0.253
1.592AspTyr: 1.592 ± 0.357
0.0AspXaa: 0.0 ± 0.0
Glu
6.478GluAla: 6.478 ± 0.624
0.604GluCys: 0.604 ± 0.198
3.568GluAsp: 3.568 ± 0.362
3.349GluGlu: 3.349 ± 0.46
1.702GluPhe: 1.702 ± 0.369
3.349GluGly: 3.349 ± 0.4
1.153GluHis: 1.153 ± 0.25
3.459GluIle: 3.459 ± 0.51
3.129GluLys: 3.129 ± 0.519
4.721GluLeu: 4.721 ± 0.715
1.537GluMet: 1.537 ± 0.346
1.757GluAsn: 1.757 ± 0.365
2.306GluPro: 2.306 ± 0.42
2.58GluGln: 2.58 ± 0.474
4.282GluArg: 4.282 ± 0.546
3.184GluSer: 3.184 ± 0.438
2.91GluThr: 2.91 ± 0.416
3.568GluVal: 3.568 ± 0.454
1.592GluTrp: 1.592 ± 0.285
1.702GluTyr: 1.702 ± 0.282
0.0GluXaa: 0.0 ± 0.0
Phe
3.678PheAla: 3.678 ± 0.523
0.329PheCys: 0.329 ± 0.114
3.184PheAsp: 3.184 ± 0.432
2.251PheGlu: 2.251 ± 0.378
1.043PhePhe: 1.043 ± 0.267
2.306PheGly: 2.306 ± 0.363
0.549PheHis: 0.549 ± 0.166
1.647PheIle: 1.647 ± 0.277
1.921PheLys: 1.921 ± 0.4
2.965PheLeu: 2.965 ± 0.399
0.933PheMet: 0.933 ± 0.239
2.086PheAsn: 2.086 ± 0.309
1.647PhePro: 1.647 ± 0.306
1.098PheGln: 1.098 ± 0.228
1.976PheArg: 1.976 ± 0.361
2.251PheSer: 2.251 ± 0.368
2.141PheThr: 2.141 ± 0.406
2.69PheVal: 2.69 ± 0.364
0.329PheTrp: 0.329 ± 0.129
1.098PheTyr: 1.098 ± 0.205
0.0PheXaa: 0.0 ± 0.0
Gly
7.357GlyAla: 7.357 ± 1.026
1.043GlyCys: 1.043 ± 0.248
5.27GlyAsp: 5.27 ± 0.642
4.172GlyGlu: 4.172 ± 0.503
1.702GlyPhe: 1.702 ± 0.359
6.478GlyGly: 6.478 ± 1.088
1.153GlyHis: 1.153 ± 0.227
3.568GlyIle: 3.568 ± 0.528
4.063GlyLys: 4.063 ± 0.508
6.753GlyLeu: 6.753 ± 0.617
1.921GlyMet: 1.921 ± 0.288
3.019GlyAsn: 3.019 ± 0.354
1.976GlyPro: 1.976 ± 0.332
2.525GlyGln: 2.525 ± 0.333
5.545GlyArg: 5.545 ± 0.581
4.337GlySer: 4.337 ± 1.026
5.325GlyThr: 5.325 ± 1.101
4.117GlyVal: 4.117 ± 0.411
1.647GlyTrp: 1.647 ± 0.333
2.416GlyTyr: 2.416 ± 0.4
0.0GlyXaa: 0.0 ± 0.0
His
1.921HisAla: 1.921 ± 0.355
0.165HisCys: 0.165 ± 0.088
1.098HisAsp: 1.098 ± 0.242
1.482HisGlu: 1.482 ± 0.346
0.494HisPhe: 0.494 ± 0.137
1.757HisGly: 1.757 ± 0.324
0.823HisHis: 0.823 ± 0.253
1.537HisIle: 1.537 ± 0.289
0.878HisLys: 0.878 ± 0.258
1.537HisLeu: 1.537 ± 0.269
0.494HisMet: 0.494 ± 0.157
0.549HisAsn: 0.549 ± 0.156
1.263HisPro: 1.263 ± 0.274
0.384HisGln: 0.384 ± 0.173
1.263HisArg: 1.263 ± 0.306
0.714HisSer: 0.714 ± 0.245
0.769HisThr: 0.769 ± 0.222
1.153HisVal: 1.153 ± 0.252
0.384HisTrp: 0.384 ± 0.137
0.714HisTyr: 0.714 ± 0.161
0.0HisXaa: 0.0 ± 0.0
Ile
5.435IleAla: 5.435 ± 0.497
0.329IleCys: 0.329 ± 0.133
3.459IleAsp: 3.459 ± 0.342
4.063IleGlu: 4.063 ± 0.474
1.098IlePhe: 1.098 ± 0.218
2.965IleGly: 2.965 ± 0.459
0.659IleHis: 0.659 ± 0.163
1.867IleIle: 1.867 ± 0.42
2.361IleLys: 2.361 ± 0.378
3.239IleLeu: 3.239 ± 0.479
0.988IleMet: 0.988 ± 0.244
2.251IleAsn: 2.251 ± 0.376
2.141IlePro: 2.141 ± 0.301
1.976IleGln: 1.976 ± 0.353
2.965IleArg: 2.965 ± 0.514
2.031IleSer: 2.031 ± 0.322
3.349IleThr: 3.349 ± 0.496
3.129IleVal: 3.129 ± 0.423
0.11IleTrp: 0.11 ± 0.08
1.757IleTyr: 1.757 ± 0.34
0.0IleXaa: 0.0 ± 0.0
Lys
5.6LysAla: 5.6 ± 0.845
0.494LysCys: 0.494 ± 0.168
2.525LysAsp: 2.525 ± 0.44
2.635LysGlu: 2.635 ± 0.445
2.361LysPhe: 2.361 ± 0.403
2.635LysGly: 2.635 ± 0.401
1.098LysHis: 1.098 ± 0.283
2.196LysIle: 2.196 ± 0.425
3.074LysLys: 3.074 ± 0.613
4.337LysLeu: 4.337 ± 0.589
1.867LysMet: 1.867 ± 0.361
1.757LysAsn: 1.757 ± 0.314
2.8LysPro: 2.8 ± 0.447
2.141LysGln: 2.141 ± 0.315
3.623LysArg: 3.623 ± 0.455
2.525LysSer: 2.525 ± 0.422
2.8LysThr: 2.8 ± 0.496
2.196LysVal: 2.196 ± 0.387
1.318LysTrp: 1.318 ± 0.321
1.592LysTyr: 1.592 ± 0.319
0.0LysXaa: 0.0 ± 0.0
Leu
8.729LeuAla: 8.729 ± 0.801
0.549LeuCys: 0.549 ± 0.193
4.557LeuAsp: 4.557 ± 0.454
3.788LeuGlu: 3.788 ± 0.517
2.361LeuPhe: 2.361 ± 0.432
5.655LeuGly: 5.655 ± 0.651
2.141LeuHis: 2.141 ± 0.477
3.074LeuIle: 3.074 ± 0.464
4.612LeuLys: 4.612 ± 0.569
6.862LeuLeu: 6.862 ± 0.835
2.58LeuMet: 2.58 ± 0.406
4.447LeuAsn: 4.447 ± 0.568
3.568LeuPro: 3.568 ± 0.464
2.251LeuGln: 2.251 ± 0.381
5.27LeuArg: 5.27 ± 0.463
3.568LeuSer: 3.568 ± 0.553
5.215LeuThr: 5.215 ± 0.569
5.819LeuVal: 5.819 ± 0.549
0.933LeuTrp: 0.933 ± 0.244
2.251LeuTyr: 2.251 ± 0.331
0.0LeuXaa: 0.0 ± 0.0
Met
3.294MetAla: 3.294 ± 0.435
0.329MetCys: 0.329 ± 0.132
1.208MetAsp: 1.208 ± 0.288
1.043MetGlu: 1.043 ± 0.248
0.494MetPhe: 0.494 ± 0.163
1.592MetGly: 1.592 ± 0.234
0.439MetHis: 0.439 ± 0.133
0.933MetIle: 0.933 ± 0.21
1.592MetLys: 1.592 ± 0.372
1.537MetLeu: 1.537 ± 0.244
0.878MetMet: 0.878 ± 0.18
1.427MetAsn: 1.427 ± 0.335
1.647MetPro: 1.647 ± 0.268
1.318MetGln: 1.318 ± 0.281
1.812MetArg: 1.812 ± 0.312
2.031MetSer: 2.031 ± 0.457
2.031MetThr: 2.031 ± 0.354
1.921MetVal: 1.921 ± 0.325
0.549MetTrp: 0.549 ± 0.162
1.098MetTyr: 1.098 ± 0.212
0.0MetXaa: 0.0 ± 0.0
Asn
4.666AsnAla: 4.666 ± 0.494
0.714AsnCys: 0.714 ± 0.212
1.702AsnAsp: 1.702 ± 0.28
2.086AsnGlu: 2.086 ± 0.342
1.592AsnPhe: 1.592 ± 0.291
3.733AsnGly: 3.733 ± 0.551
0.823AsnHis: 0.823 ± 0.19
1.976AsnIle: 1.976 ± 0.281
1.153AsnLys: 1.153 ± 0.229
2.525AsnLeu: 2.525 ± 0.364
1.098AsnMet: 1.098 ± 0.233
1.208AsnAsn: 1.208 ± 0.258
3.019AsnPro: 3.019 ± 0.382
1.372AsnGln: 1.372 ± 0.245
2.47AsnArg: 2.47 ± 0.341
1.867AsnSer: 1.867 ± 0.287
2.251AsnThr: 2.251 ± 0.398
2.525AsnVal: 2.525 ± 0.347
0.604AsnTrp: 0.604 ± 0.163
1.043AsnTyr: 1.043 ± 0.208
0.0AsnXaa: 0.0 ± 0.0
Pro
5.325ProAla: 5.325 ± 0.646
0.604ProCys: 0.604 ± 0.229
4.063ProAsp: 4.063 ± 0.511
3.514ProGlu: 3.514 ± 0.434
1.647ProPhe: 1.647 ± 0.307
4.172ProGly: 4.172 ± 0.538
1.153ProHis: 1.153 ± 0.244
1.537ProIle: 1.537 ± 0.234
2.69ProLys: 2.69 ± 0.334
3.294ProLeu: 3.294 ± 0.435
1.318ProMet: 1.318 ± 0.216
1.757ProAsn: 1.757 ± 0.374
2.196ProPro: 2.196 ± 0.49
1.702ProGln: 1.702 ± 0.328
2.306ProArg: 2.306 ± 0.445
2.58ProSer: 2.58 ± 0.398
2.251ProThr: 2.251 ± 0.36
3.623ProVal: 3.623 ± 0.46
0.878ProTrp: 0.878 ± 0.231
2.031ProTyr: 2.031 ± 0.307
0.0ProXaa: 0.0 ± 0.0
Gln
4.941GlnAla: 4.941 ± 0.918
0.439GlnCys: 0.439 ± 0.149
1.757GlnAsp: 1.757 ± 0.352
1.537GlnGlu: 1.537 ± 0.295
1.647GlnPhe: 1.647 ± 0.366
2.306GlnGly: 2.306 ± 0.404
0.549GlnHis: 0.549 ± 0.186
1.867GlnIle: 1.867 ± 0.361
1.647GlnLys: 1.647 ± 0.4
4.172GlnLeu: 4.172 ± 0.46
1.702GlnMet: 1.702 ± 0.33
0.988GlnAsn: 0.988 ± 0.278
1.208GlnPro: 1.208 ± 0.22
2.416GlnGln: 2.416 ± 0.379
2.745GlnArg: 2.745 ± 0.334
2.141GlnSer: 2.141 ± 0.33
2.58GlnThr: 2.58 ± 0.383
2.361GlnVal: 2.361 ± 0.392
0.659GlnTrp: 0.659 ± 0.19
1.647GlnTyr: 1.647 ± 0.293
0.0GlnXaa: 0.0 ± 0.0
Arg
6.917ArgAla: 6.917 ± 0.981
0.604ArgCys: 0.604 ± 0.193
3.843ArgAsp: 3.843 ± 0.673
4.172ArgGlu: 4.172 ± 0.576
2.965ArgPhe: 2.965 ± 0.346
4.063ArgGly: 4.063 ± 0.387
1.702ArgHis: 1.702 ± 0.338
3.129ArgIle: 3.129 ± 0.469
2.855ArgLys: 2.855 ± 0.338
6.423ArgLeu: 6.423 ± 0.768
1.921ArgMet: 1.921 ± 0.3
2.69ArgAsn: 2.69 ± 0.484
2.855ArgPro: 2.855 ± 0.398
2.965ArgGln: 2.965 ± 0.413
5.6ArgArg: 5.6 ± 0.92
3.349ArgSer: 3.349 ± 0.408
3.514ArgThr: 3.514 ± 0.492
4.447ArgVal: 4.447 ± 0.489
0.769ArgTrp: 0.769 ± 0.215
1.757ArgTyr: 1.757 ± 0.348
0.0ArgXaa: 0.0 ± 0.0
Ser
5.545SerAla: 5.545 ± 0.525
0.549SerCys: 0.549 ± 0.175
3.678SerAsp: 3.678 ± 0.523
2.635SerGlu: 2.635 ± 0.462
2.251SerPhe: 2.251 ± 0.332
5.655SerGly: 5.655 ± 1.195
1.043SerHis: 1.043 ± 0.298
2.251SerIle: 2.251 ± 0.348
2.69SerLys: 2.69 ± 0.457
3.953SerLeu: 3.953 ± 0.531
0.988SerMet: 0.988 ± 0.197
1.921SerAsn: 1.921 ± 0.337
2.855SerPro: 2.855 ± 0.467
1.976SerGln: 1.976 ± 0.335
3.568SerArg: 3.568 ± 0.42
3.349SerSer: 3.349 ± 0.566
3.184SerThr: 3.184 ± 0.482
4.557SerVal: 4.557 ± 0.421
0.988SerTrp: 0.988 ± 0.274
1.592SerTyr: 1.592 ± 0.312
0.0SerXaa: 0.0 ± 0.0
Thr
7.027ThrAla: 7.027 ± 0.897
1.043ThrCys: 1.043 ± 0.283
3.349ThrAsp: 3.349 ± 0.507
3.184ThrGlu: 3.184 ± 0.427
2.416ThrPhe: 2.416 ± 0.363
4.172ThrGly: 4.172 ± 0.532
0.933ThrHis: 0.933 ± 0.218
2.965ThrIle: 2.965 ± 0.37
3.184ThrLys: 3.184 ± 0.483
4.831ThrLeu: 4.831 ± 0.595
1.702ThrMet: 1.702 ± 0.287
2.251ThrAsn: 2.251 ± 0.339
3.568ThrPro: 3.568 ± 0.557
1.976ThrGln: 1.976 ± 0.279
3.239ThrArg: 3.239 ± 0.411
3.184ThrSer: 3.184 ± 0.504
4.776ThrThr: 4.776 ± 1.258
4.282ThrVal: 4.282 ± 0.474
1.318ThrTrp: 1.318 ± 0.618
1.921ThrTyr: 1.921 ± 0.377
0.0ThrXaa: 0.0 ± 0.0
Val
7.082ValAla: 7.082 ± 0.683
0.659ValCys: 0.659 ± 0.186
3.678ValAsp: 3.678 ± 0.407
3.019ValGlu: 3.019 ± 0.479
2.965ValPhe: 2.965 ± 0.528
5.38ValGly: 5.38 ± 0.605
1.263ValHis: 1.263 ± 0.313
2.745ValIle: 2.745 ± 0.362
3.074ValLys: 3.074 ± 0.355
4.776ValLeu: 4.776 ± 0.56
1.427ValMet: 1.427 ± 0.243
2.086ValAsn: 2.086 ± 0.408
3.788ValPro: 3.788 ± 0.606
3.623ValGln: 3.623 ± 0.406
4.666ValArg: 4.666 ± 0.59
4.008ValSer: 4.008 ± 0.394
4.282ValThr: 4.282 ± 0.594
4.117ValVal: 4.117 ± 0.494
0.933ValTrp: 0.933 ± 0.272
1.702ValTyr: 1.702 ± 0.331
0.0ValXaa: 0.0 ± 0.0
Trp
1.976TrpAla: 1.976 ± 0.486
0.165TrpCys: 0.165 ± 0.094
0.823TrpAsp: 0.823 ± 0.222
0.549TrpGlu: 0.549 ± 0.166
0.988TrpPhe: 0.988 ± 0.229
1.098TrpGly: 1.098 ± 0.209
0.165TrpHis: 0.165 ± 0.091
0.714TrpIle: 0.714 ± 0.174
0.769TrpLys: 0.769 ± 0.182
1.647TrpLeu: 1.647 ± 0.322
0.22TrpMet: 0.22 ± 0.1
0.988TrpAsn: 0.988 ± 0.23
0.933TrpPro: 0.933 ± 0.242
0.878TrpGln: 0.878 ± 0.179
1.043TrpArg: 1.043 ± 0.243
1.372TrpSer: 1.372 ± 0.274
0.823TrpThr: 0.823 ± 0.317
0.933TrpVal: 0.933 ± 0.221
0.22TrpTrp: 0.22 ± 0.106
0.329TrpTyr: 0.329 ± 0.141
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.745TyrAla: 2.745 ± 0.396
0.274TyrCys: 0.274 ± 0.134
2.47TyrAsp: 2.47 ± 0.332
2.196TyrGlu: 2.196 ± 0.386
1.263TyrPhe: 1.263 ± 0.261
2.086TyrGly: 2.086 ± 0.311
0.549TyrHis: 0.549 ± 0.169
1.318TyrIle: 1.318 ± 0.237
1.153TyrLys: 1.153 ± 0.223
2.306TyrLeu: 2.306 ± 0.38
0.769TyrMet: 0.769 ± 0.192
1.482TyrAsn: 1.482 ± 0.267
1.757TyrPro: 1.757 ± 0.395
1.098TyrGln: 1.098 ± 0.304
2.196TyrArg: 2.196 ± 0.375
1.482TyrSer: 1.482 ± 0.311
1.592TyrThr: 1.592 ± 0.354
2.086TyrVal: 2.086 ± 0.308
0.659TyrTrp: 0.659 ± 0.165
1.043TyrTyr: 1.043 ± 0.204
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 73 proteins (18216 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski