Amino acid dipepetide frequency for Metabacillus indicus (Bacillus indicus)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.65AlaAla: 8.65 ± 0.137	0.619AlaCys: 0.619 ± 0.024	4.225AlaAsp: 4.225 ± 0.067	6.2AlaGlu: 6.2 ± 0.094	3.752AlaPhe: 3.752 ± 0.066	6.834AlaGly: 6.834 ± 0.099	1.323AlaHis: 1.323 ± 0.038	5.515AlaIle: 5.515 ± 0.076	4.823AlaLys: 4.823 ± 0.082	7.76AlaLeu: 7.76 ± 0.082	2.161AlaMet: 2.161 ± 0.048	2.394AlaAsn: 2.394 ± 0.046	2.259AlaPro: 2.259 ± 0.057	2.101AlaGln: 2.101 ± 0.046	2.827AlaArg: 2.827 ± 0.053	4.681AlaSer: 4.681 ± 0.069	2.775AlaThr: 2.775 ± 0.059	6.753AlaVal: 6.753 ± 0.08	0.629AlaTrp: 0.629 ± 0.027	2.502AlaTyr: 2.502 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	0.471CysAla: 0.471 ± 0.021	0.106CysCys: 0.106 ± 0.011	0.357CysAsp: 0.357 ± 0.018	0.411CysGlu: 0.411 ± 0.019	0.315CysPhe: 0.315 ± 0.017	0.674CysGly: 0.674 ± 0.029	0.198CysHis: 0.198 ± 0.015	0.483CysIle: 0.483 ± 0.019	0.314CysLys: 0.314 ± 0.019	0.674CysLeu: 0.674 ± 0.026	0.203CysMet: 0.203 ± 0.015	0.228CysAsn: 0.228 ± 0.015	0.328CysPro: 0.328 ± 0.018	0.184CysGln: 0.184 ± 0.013	0.338CysArg: 0.338 ± 0.017	0.555CysSer: 0.555 ± 0.025	0.419CysThr: 0.419 ± 0.022	0.394CysVal: 0.394 ± 0.019	0.059CysTrp: 0.059 ± 0.007	0.222CysTyr: 0.222 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	3.901AspAla: 3.901 ± 0.061	0.367AspCys: 0.367 ± 0.019	2.438AspAsp: 2.438 ± 0.06	4.52AspGlu: 4.52 ± 0.071	2.437AspPhe: 2.437 ± 0.047	3.661AspGly: 3.661 ± 0.064	1.19AspHis: 1.19 ± 0.032	3.608AspIle: 3.608 ± 0.058	2.99AspLys: 2.99 ± 0.049	5.404AspLeu: 5.404 ± 0.076	1.416AspMet: 1.416 ± 0.04	1.42AspAsn: 1.42 ± 0.044	2.06AspPro: 2.06 ± 0.048	2.039AspGln: 2.039 ± 0.045	2.358AspArg: 2.358 ± 0.049	2.813AspSer: 2.813 ± 0.053	2.345AspThr: 2.345 ± 0.046	3.729AspVal: 3.729 ± 0.064	0.592AspTrp: 0.592 ± 0.022	2.177AspTyr: 2.177 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	5.997GluAla: 5.997 ± 0.091	0.421GluCys: 0.421 ± 0.018	4.101GluAsp: 4.101 ± 0.065	7.383GluGlu: 7.383 ± 0.091	2.608GluPhe: 2.608 ± 0.058	4.665GluGly: 4.665 ± 0.071	1.595GluHis: 1.595 ± 0.038	5.416GluIle: 5.416 ± 0.073	7.083GluLys: 7.083 ± 0.103	7.365GluLeu: 7.365 ± 0.084	2.376GluMet: 2.376 ± 0.043	3.56GluAsn: 3.56 ± 0.06	2.063GluPro: 2.063 ± 0.045	3.219GluGln: 3.219 ± 0.064	3.639GluArg: 3.639 ± 0.058	3.707GluSer: 3.707 ± 0.066	4.186GluThr: 4.186 ± 0.057	4.772GluVal: 4.772 ± 0.076	0.878GluTrp: 0.878 ± 0.028	2.319GluTyr: 2.319 ± 0.044	0.0GluXaa: 0.0 ± 0.0
Phe	3.405PheAla: 3.405 ± 0.056	0.309PheCys: 0.309 ± 0.016	2.389PheAsp: 2.389 ± 0.045	3.034PheGlu: 3.034 ± 0.057	2.378PhePhe: 2.378 ± 0.06	3.513PheGly: 3.513 ± 0.066	1.06PheHis: 1.06 ± 0.037	3.487PheIle: 3.487 ± 0.063	2.565PheLys: 2.565 ± 0.052	4.802PheLeu: 4.802 ± 0.081	1.225PheMet: 1.225 ± 0.034	1.571PheAsn: 1.571 ± 0.041	1.679PhePro: 1.679 ± 0.037	1.609PheGln: 1.609 ± 0.041	1.567PheArg: 1.567 ± 0.035	3.446PheSer: 3.446 ± 0.068	2.6PheThr: 2.6 ± 0.051	2.947PheVal: 2.947 ± 0.056	0.48PheTrp: 0.48 ± 0.021	1.723PheTyr: 1.723 ± 0.042	0.0PheXaa: 0.0 ± 0.0
Gly	5.408GlyAla: 5.408 ± 0.079	0.624GlyCys: 0.624 ± 0.03	3.351GlyAsp: 3.351 ± 0.061	4.879GlyGlu: 4.879 ± 0.069	3.569GlyPhe: 3.569 ± 0.068	5.228GlyGly: 5.228 ± 0.08	1.409GlyHis: 1.409 ± 0.041	5.915GlyIle: 5.915 ± 0.075	5.26GlyLys: 5.26 ± 0.068	6.84GlyLeu: 6.84 ± 0.093	2.276GlyMet: 2.276 ± 0.044	2.588GlyAsn: 2.588 ± 0.055	1.845GlyPro: 1.845 ± 0.041	2.14GlyGln: 2.14 ± 0.046	2.889GlyArg: 2.889 ± 0.062	4.445GlySer: 4.445 ± 0.071	4.331GlyThr: 4.331 ± 0.065	4.959GlyVal: 4.959 ± 0.076	0.788GlyTrp: 0.788 ± 0.03	2.866GlyTyr: 2.866 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	1.552HisAla: 1.552 ± 0.041	0.165HisCys: 0.165 ± 0.013	1.064HisAsp: 1.064 ± 0.03	1.513HisGlu: 1.513 ± 0.04	1.142HisPhe: 1.142 ± 0.034	1.456HisGly: 1.456 ± 0.036	0.688HisHis: 0.688 ± 0.035	1.405HisIle: 1.405 ± 0.041	1.062HisLys: 1.062 ± 0.033	2.188HisLeu: 2.188 ± 0.053	0.562HisMet: 0.562 ± 0.022	0.645HisAsn: 0.645 ± 0.025	1.157HisPro: 1.157 ± 0.031	0.769HisGln: 0.769 ± 0.025	0.924HisArg: 0.924 ± 0.033	1.303HisSer: 1.303 ± 0.037	1.09HisThr: 1.09 ± 0.031	1.429HisVal: 1.429 ± 0.041	0.211HisTrp: 0.211 ± 0.015	0.865HisTyr: 0.865 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.917IleAla: 5.917 ± 0.083	0.589IleCys: 0.589 ± 0.025	3.96IleAsp: 3.96 ± 0.066	5.303IleGlu: 5.303 ± 0.085	3.009IlePhe: 3.009 ± 0.072	5.899IleGly: 5.899 ± 0.088	1.61IleHis: 1.61 ± 0.039	4.995IleIle: 4.995 ± 0.074	4.165IleLys: 4.165 ± 0.067	6.921IleLeu: 6.921 ± 0.093	1.742IleMet: 1.742 ± 0.039	2.562IleAsn: 2.562 ± 0.051	3.024IlePro: 3.024 ± 0.055	2.56IleGln: 2.56 ± 0.05	3.082IleArg: 3.082 ± 0.056	4.992IleSer: 4.992 ± 0.071	3.917IleThr: 3.917 ± 0.061	4.939IleVal: 4.939 ± 0.074	0.584IleTrp: 0.584 ± 0.026	2.238IleTyr: 2.238 ± 0.048	0.0IleXaa: 0.0 ± 0.0
Lys	5.309LysAla: 5.309 ± 0.086	0.284LysCys: 0.284 ± 0.018	3.876LysAsp: 3.876 ± 0.064	7.085LysGlu: 7.085 ± 0.087	1.784LysPhe: 1.784 ± 0.039	4.535LysGly: 4.535 ± 0.068	1.374LysHis: 1.374 ± 0.035	4.32LysIle: 4.32 ± 0.062	6.116LysLys: 6.116 ± 0.107	6.022LysLeu: 6.022 ± 0.077	2.286LysMet: 2.286 ± 0.046	3.085LysAsn: 3.085 ± 0.059	2.46LysPro: 2.46 ± 0.049	2.975LysGln: 2.975 ± 0.055	3.328LysArg: 3.328 ± 0.061	3.52LysSer: 3.52 ± 0.058	3.937LysThr: 3.937 ± 0.059	4.286LysVal: 4.286 ± 0.072	0.89LysTrp: 0.89 ± 0.026	1.961LysTyr: 1.961 ± 0.045	0.0LysXaa: 0.0 ± 0.0
Leu	7.972LeuAla: 7.972 ± 0.095	0.717LeuCys: 0.717 ± 0.03	4.789LeuAsp: 4.789 ± 0.065	6.561LeuGlu: 6.561 ± 0.089	5.024LeuPhe: 5.024 ± 0.082	6.515LeuGly: 6.515 ± 0.082	1.982LeuHis: 1.982 ± 0.044	7.114LeuIle: 7.114 ± 0.104	7.167LeuLys: 7.167 ± 0.081	10.276LeuLeu: 10.276 ± 0.117	2.623LeuMet: 2.623 ± 0.054	4.051LeuAsn: 4.051 ± 0.062	4.022LeuPro: 4.022 ± 0.067	3.583LeuGln: 3.583 ± 0.066	3.57LeuArg: 3.57 ± 0.07	7.415LeuSer: 7.415 ± 0.09	5.837LeuThr: 5.837 ± 0.067	5.927LeuVal: 5.927 ± 0.082	0.776LeuTrp: 0.776 ± 0.029	3.155LeuTyr: 3.155 ± 0.058	0.0LeuXaa: 0.0 ± 0.0
Met	2.184MetAla: 2.184 ± 0.05	0.152MetCys: 0.152 ± 0.013	1.478MetAsp: 1.478 ± 0.04	2.027MetGlu: 2.027 ± 0.049	1.07MetPhe: 1.07 ± 0.033	1.708MetGly: 1.708 ± 0.038	0.487MetHis: 0.487 ± 0.022	2.234MetIle: 2.234 ± 0.045	2.78MetLys: 2.78 ± 0.051	2.719MetLeu: 2.719 ± 0.042	0.924MetMet: 0.924 ± 0.03	1.76MetAsn: 1.76 ± 0.035	1.121MetPro: 1.121 ± 0.033	0.954MetGln: 0.954 ± 0.029	1.092MetArg: 1.092 ± 0.034	1.74MetSer: 1.74 ± 0.04	1.824MetThr: 1.824 ± 0.044	1.606MetVal: 1.606 ± 0.041	0.175MetTrp: 0.175 ± 0.013	0.734MetTyr: 0.734 ± 0.027	0.0MetXaa: 0.0 ± 0.0
Asn	2.697AsnAla: 2.697 ± 0.053	0.256AsnCys: 0.256 ± 0.016	1.974AsnAsp: 1.974 ± 0.044	3.28AsnGlu: 3.28 ± 0.06	1.313AsnPhe: 1.313 ± 0.033	3.232AsnGly: 3.232 ± 0.057	0.886AsnHis: 0.886 ± 0.027	2.605AsnIle: 2.605 ± 0.055	2.341AsnLys: 2.341 ± 0.048	3.495AsnLeu: 3.495 ± 0.056	1.134AsnMet: 1.134 ± 0.032	1.345AsnAsn: 1.345 ± 0.043	1.991AsnPro: 1.991 ± 0.044	1.635AsnGln: 1.635 ± 0.04	1.887AsnArg: 1.887 ± 0.04	1.961AsnSer: 1.961 ± 0.047	1.899AsnThr: 1.899 ± 0.044	2.765AsnVal: 2.765 ± 0.054	0.466AsnTrp: 0.466 ± 0.023	1.232AsnTyr: 1.232 ± 0.04	0.0AsnXaa: 0.0 ± 0.0
Pro	3.024ProAla: 3.024 ± 0.064	0.199ProCys: 0.199 ± 0.014	2.291ProAsp: 2.291 ± 0.05	3.406ProGlu: 3.406 ± 0.061	2.129ProPhe: 2.129 ± 0.045	2.51ProGly: 2.51 ± 0.058	0.812ProHis: 0.812 ± 0.027	2.249ProIle: 2.249 ± 0.042	2.063ProLys: 2.063 ± 0.045	3.62ProLeu: 3.62 ± 0.064	0.787ProMet: 0.787 ± 0.025	1.371ProAsn: 1.371 ± 0.033	1.023ProPro: 1.023 ± 0.032	1.141ProGln: 1.141 ± 0.033	1.058ProArg: 1.058 ± 0.035	2.342ProSer: 2.342 ± 0.05	1.461ProThr: 1.461 ± 0.037	3.186ProVal: 3.186 ± 0.052	0.351ProTrp: 0.351 ± 0.018	1.384ProTyr: 1.384 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	2.781GlnAla: 2.781 ± 0.052	0.167GlnCys: 0.167 ± 0.012	1.658GlnAsp: 1.658 ± 0.039	2.63GlnGlu: 2.63 ± 0.057	1.53GlnPhe: 1.53 ± 0.034	2.002GlnGly: 2.002 ± 0.043	0.81GlnHis: 0.81 ± 0.029	2.322GlnIle: 2.322 ± 0.044	2.794GlnLys: 2.794 ± 0.054	3.767GlnLeu: 3.767 ± 0.056	1.114GlnMet: 1.114 ± 0.031	1.506GlnAsn: 1.506 ± 0.034	1.203GlnPro: 1.203 ± 0.035	1.573GlnGln: 1.573 ± 0.045	1.328GlnArg: 1.328 ± 0.039	2.229GlnSer: 2.229 ± 0.046	2.044GlnThr: 2.044 ± 0.042	2.096GlnVal: 2.096 ± 0.042	0.356GlnTrp: 0.356 ± 0.018	1.183GlnTyr: 1.183 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	2.671ArgAla: 2.671 ± 0.049	0.237ArgCys: 0.237 ± 0.014	2.133ArgAsp: 2.133 ± 0.048	3.414ArgGlu: 3.414 ± 0.061	1.94ArgPhe: 1.94 ± 0.039	2.414ArgGly: 2.414 ± 0.055	0.847ArgHis: 0.847 ± 0.028	2.978ArgIle: 2.978 ± 0.047	3.287ArgLys: 3.287 ± 0.056	4.04ArgLeu: 4.04 ± 0.068	1.405ArgMet: 1.405 ± 0.037	1.795ArgAsn: 1.795 ± 0.043	1.335ArgPro: 1.335 ± 0.042	1.458ArgGln: 1.458 ± 0.04	1.887ArgArg: 1.887 ± 0.049	2.468ArgSer: 2.468 ± 0.048	2.204ArgThr: 2.204 ± 0.049	2.562ArgVal: 2.562 ± 0.051	0.382ArgTrp: 0.382 ± 0.018	1.414ArgTyr: 1.414 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	4.654SerAla: 4.654 ± 0.078	0.451SerCys: 0.451 ± 0.021	3.042SerAsp: 3.042 ± 0.051	4.506SerGlu: 4.506 ± 0.064	3.495SerPhe: 3.495 ± 0.065	5.129SerGly: 5.129 ± 0.08	1.28SerHis: 1.28 ± 0.031	4.794SerIle: 4.794 ± 0.071	3.938SerLys: 3.938 ± 0.059	6.314SerLeu: 6.314 ± 0.091	1.875SerMet: 1.875 ± 0.039	2.157SerAsn: 2.157 ± 0.049	2.169SerPro: 2.169 ± 0.042	1.848SerGln: 1.848 ± 0.04	2.549SerArg: 2.549 ± 0.056	4.279SerSer: 4.279 ± 0.079	2.721SerThr: 2.721 ± 0.055	4.394SerVal: 4.394 ± 0.067	0.608SerTrp: 0.608 ± 0.026	2.313SerTyr: 2.313 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	4.801ThrAla: 4.801 ± 0.073	0.337ThrCys: 0.337 ± 0.02	2.843ThrAsp: 2.843 ± 0.055	3.717ThrGlu: 3.717 ± 0.06	2.612ThrPhe: 2.612 ± 0.049	4.551ThrGly: 4.551 ± 0.067	1.012ThrHis: 1.012 ± 0.034	3.996ThrIle: 3.996 ± 0.066	2.914ThrLys: 2.914 ± 0.056	5.11ThrLeu: 5.11 ± 0.071	1.33ThrMet: 1.33 ± 0.034	1.91ThrAsn: 1.91 ± 0.045	2.082ThrPro: 2.082 ± 0.044	1.236ThrGln: 1.236 ± 0.033	1.764ThrArg: 1.764 ± 0.042	3.039ThrSer: 3.039 ± 0.052	2.269ThrThr: 2.269 ± 0.058	4.346ThrVal: 4.346 ± 0.077	0.443ThrTrp: 0.443 ± 0.021	1.905ThrTyr: 1.905 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	4.469ValAla: 4.469 ± 0.069	0.588ValCys: 0.588 ± 0.028	3.102ValAsp: 3.102 ± 0.051	4.293ValGlu: 4.293 ± 0.067	3.391ValPhe: 3.391 ± 0.064	3.972ValGly: 3.972 ± 0.074	1.574ValHis: 1.574 ± 0.038	5.588ValIle: 5.588 ± 0.069	4.971ValLys: 4.971 ± 0.064	7.285ValLeu: 7.285 ± 0.081	2.039ValMet: 2.039 ± 0.048	2.774ValAsn: 2.774 ± 0.051	2.905ValPro: 2.905 ± 0.052	2.395ValGln: 2.395 ± 0.047	2.748ValArg: 2.748 ± 0.048	4.735ValSer: 4.735 ± 0.068	3.949ValThr: 3.949 ± 0.059	4.388ValVal: 4.388 ± 0.078	0.642ValTrp: 0.642 ± 0.026	2.318ValTyr: 2.318 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	0.632TrpAla: 0.632 ± 0.025	0.068TrpCys: 0.068 ± 0.007	0.502TrpAsp: 0.502 ± 0.021	0.619TrpGlu: 0.619 ± 0.024	0.507TrpPhe: 0.507 ± 0.022	0.617TrpGly: 0.617 ± 0.025	0.22TrpHis: 0.22 ± 0.015	0.796TrpIle: 0.796 ± 0.029	0.747TrpLys: 0.747 ± 0.03	1.05TrpLeu: 1.05 ± 0.036	0.379TrpMet: 0.379 ± 0.019	0.493TrpAsn: 0.493 ± 0.023	0.266TrpPro: 0.266 ± 0.016	0.324TrpGln: 0.324 ± 0.018	0.378TrpArg: 0.378 ± 0.021	0.58TrpSer: 0.58 ± 0.026	0.561TrpThr: 0.561 ± 0.023	0.595TrpVal: 0.595 ± 0.026	0.134TrpTrp: 0.134 ± 0.012	0.338TrpTyr: 0.338 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.288TyrAla: 2.288 ± 0.046	0.275TyrCys: 0.275 ± 0.018	1.892TyrAsp: 1.892 ± 0.041	2.572TyrGlu: 2.572 ± 0.05	1.785TyrPhe: 1.785 ± 0.041	2.499TyrGly: 2.499 ± 0.051	0.833TyrHis: 0.833 ± 0.03	2.19TyrIle: 2.19 ± 0.051	2.055TyrLys: 2.055 ± 0.051	3.423TyrLeu: 3.423 ± 0.058	0.909TyrMet: 0.909 ± 0.03	1.176TyrAsn: 1.176 ± 0.035	1.414TyrPro: 1.414 ± 0.039	1.349TyrGln: 1.349 ± 0.037	1.655TyrArg: 1.655 ± 0.04	2.268TyrSer: 2.268 ± 0.044	1.847TyrThr: 1.847 ± 0.038	2.051TyrVal: 2.051 ± 0.044	0.365TyrTrp: 0.365 ± 0.018	1.322TyrTyr: 1.322 ± 0.037	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3781 proteins (1086472 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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