Amino acid dipepetide frequency for Amanita muscaria Koide BX008

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.865AlaAla: 6.865 ± 0.042	1.098AlaCys: 1.098 ± 0.015	3.689AlaAsp: 3.689 ± 0.025	4.204AlaGlu: 4.204 ± 0.033	3.076AlaPhe: 3.076 ± 0.025	4.437AlaGly: 4.437 ± 0.03	1.841AlaHis: 1.841 ± 0.021	4.239AlaIle: 4.239 ± 0.03	3.75AlaLys: 3.75 ± 0.032	7.716AlaLeu: 7.716 ± 0.038	1.732AlaMet: 1.732 ± 0.017	2.794AlaAsn: 2.794 ± 0.023	4.051AlaPro: 4.051 ± 0.036	3.131AlaGln: 3.131 ± 0.025	4.631AlaArg: 4.631 ± 0.033	6.803AlaSer: 6.803 ± 0.043	4.898AlaThr: 4.898 ± 0.03	4.869AlaVal: 4.869 ± 0.028	1.016AlaTrp: 1.016 ± 0.014	2.083AlaTyr: 2.083 ± 0.018	0.0AlaXaa: 0.0 ± 0.0
Cys	0.973CysAla: 0.973 ± 0.013	0.32CysCys: 0.32 ± 0.009	0.716CysAsp: 0.716 ± 0.012	0.609CysGlu: 0.609 ± 0.012	0.643CysPhe: 0.643 ± 0.012	0.962CysGly: 0.962 ± 0.015	0.424CysHis: 0.424 ± 0.009	0.806CysIle: 0.806 ± 0.012	0.642CysLys: 0.642 ± 0.01	1.441CysLeu: 1.441 ± 0.018	0.31CysMet: 0.31 ± 0.007	0.536CysAsn: 0.536 ± 0.01	0.82CysPro: 0.82 ± 0.013	0.535CysGln: 0.535 ± 0.01	0.916CysArg: 0.916 ± 0.015	1.232CysSer: 1.232 ± 0.015	0.845CysThr: 0.845 ± 0.015	0.833CysVal: 0.833 ± 0.011	0.225CysTrp: 0.225 ± 0.007	0.411CysTyr: 0.411 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	4.342AspAla: 4.342 ± 0.026	0.709AspCys: 0.709 ± 0.012	4.106AspAsp: 4.106 ± 0.036	4.313AspGlu: 4.313 ± 0.033	2.113AspPhe: 2.113 ± 0.019	3.941AspGly: 3.941 ± 0.033	1.32AspHis: 1.32 ± 0.015	3.326AspIle: 3.326 ± 0.027	2.431AspLys: 2.431 ± 0.023	4.981AspLeu: 4.981 ± 0.031	1.201AspMet: 1.201 ± 0.015	2.069AspAsn: 2.069 ± 0.022	3.198AspPro: 3.198 ± 0.026	1.759AspGln: 1.759 ± 0.017	2.841AspArg: 2.841 ± 0.024	4.12AspSer: 4.12 ± 0.032	2.845AspThr: 2.845 ± 0.024	3.874AspVal: 3.874 ± 0.029	0.877AspTrp: 0.877 ± 0.013	1.513AspTyr: 1.513 ± 0.019	0.0AspXaa: 0.0 ± 0.0
Glu	4.502GluAla: 4.502 ± 0.035	0.75GluCys: 0.75 ± 0.012	3.914GluAsp: 3.914 ± 0.029	5.236GluGlu: 5.236 ± 0.052	1.867GluPhe: 1.867 ± 0.019	3.372GluGly: 3.372 ± 0.026	1.459GluHis: 1.459 ± 0.016	2.98GluIle: 2.98 ± 0.026	3.375GluLys: 3.375 ± 0.028	5.241GluLeu: 5.241 ± 0.035	1.332GluMet: 1.332 ± 0.017	2.187GluAsn: 2.187 ± 0.018	2.54GluPro: 2.54 ± 0.024	2.35GluGln: 2.35 ± 0.021	4.01GluArg: 4.01 ± 0.033	4.077GluSer: 4.077 ± 0.029	3.095GluThr: 3.095 ± 0.023	3.329GluVal: 3.329 ± 0.026	0.859GluTrp: 0.859 ± 0.013	1.637GluTyr: 1.637 ± 0.017	0.0GluXaa: 0.0 ± 0.0
Phe	2.846PheAla: 2.846 ± 0.021	0.615PheCys: 0.615 ± 0.01	2.352PheAsp: 2.352 ± 0.021	2.025PheGlu: 2.025 ± 0.02	1.754PhePhe: 1.754 ± 0.021	2.544PheGly: 2.544 ± 0.027	1.043PheHis: 1.043 ± 0.011	2.005PheIle: 2.005 ± 0.02	1.686PheLys: 1.686 ± 0.017	3.721PheLeu: 3.721 ± 0.03	0.793PheMet: 0.793 ± 0.011	1.517PheAsn: 1.517 ± 0.016	2.111PhePro: 2.111 ± 0.019	1.39PheGln: 1.39 ± 0.015	2.088PheArg: 2.088 ± 0.019	3.515PheSer: 3.515 ± 0.026	2.3PheThr: 2.3 ± 0.02	2.492PheVal: 2.492 ± 0.02	0.583PheTrp: 0.583 ± 0.011	1.129PheTyr: 1.129 ± 0.013	0.0PheXaa: 0.0 ± 0.0
Gly	4.168GlyAla: 4.168 ± 0.029	0.848GlyCys: 0.848 ± 0.012	3.178GlyAsp: 3.178 ± 0.026	3.162GlyGlu: 3.162 ± 0.022	2.346GlyPhe: 2.346 ± 0.018	4.601GlyGly: 4.601 ± 0.044	1.682GlyHis: 1.682 ± 0.018	3.388GlyIle: 3.388 ± 0.025	3.347GlyLys: 3.347 ± 0.026	5.279GlyLeu: 5.279 ± 0.034	1.359GlyMet: 1.359 ± 0.019	2.454GlyAsn: 2.454 ± 0.021	2.965GlyPro: 2.965 ± 0.025	2.239GlyGln: 2.239 ± 0.022	3.795GlyArg: 3.795 ± 0.024	5.234GlySer: 5.234 ± 0.036	3.826GlyThr: 3.826 ± 0.022	3.818GlyVal: 3.818 ± 0.026	0.939GlyTrp: 0.939 ± 0.014	1.725GlyTyr: 1.725 ± 0.018	0.0GlyXaa: 0.0 ± 0.0
His	1.922HisAla: 1.922 ± 0.017	0.441HisCys: 0.441 ± 0.009	1.443HisAsp: 1.443 ± 0.016	1.347HisGlu: 1.347 ± 0.015	1.069HisPhe: 1.069 ± 0.017	1.677HisGly: 1.677 ± 0.017	0.975HisHis: 0.975 ± 0.02	1.457HisIle: 1.457 ± 0.016	1.062HisLys: 1.062 ± 0.012	2.71HisLeu: 2.71 ± 0.026	0.512HisMet: 0.512 ± 0.009	0.973HisAsn: 0.973 ± 0.012	1.896HisPro: 1.896 ± 0.022	1.085HisGln: 1.085 ± 0.014	1.719HisArg: 1.719 ± 0.016	2.234HisSer: 2.234 ± 0.018	1.482HisThr: 1.482 ± 0.019	1.693HisVal: 1.693 ± 0.018	0.37HisTrp: 0.37 ± 0.008	0.755HisTyr: 0.755 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.272IleAla: 4.272 ± 0.028	0.912IleCys: 0.912 ± 0.012	3.076IleAsp: 3.076 ± 0.023	2.825IleGlu: 2.825 ± 0.022	2.059IlePhe: 2.059 ± 0.017	3.03IleGly: 3.03 ± 0.025	1.422IleHis: 1.422 ± 0.017	2.854IleIle: 2.854 ± 0.022	2.406IleLys: 2.406 ± 0.021	5.068IleLeu: 5.068 ± 0.032	1.045IleMet: 1.045 ± 0.014	1.948IleAsn: 1.948 ± 0.018	3.481IlePro: 3.481 ± 0.027	2.114IleGln: 2.114 ± 0.022	3.149IleArg: 3.149 ± 0.025	4.361IleSer: 4.361 ± 0.028	3.044IleThr: 3.044 ± 0.023	3.507IleVal: 3.507 ± 0.027	0.754IleTrp: 0.754 ± 0.014	1.494IleTyr: 1.494 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	3.879LysAla: 3.879 ± 0.034	0.627LysCys: 0.627 ± 0.011	2.714LysAsp: 2.714 ± 0.024	3.349LysGlu: 3.349 ± 0.033	1.573LysPhe: 1.573 ± 0.017	2.82LysGly: 2.82 ± 0.026	1.231LysHis: 1.231 ± 0.016	2.322LysIle: 2.322 ± 0.02	3.25LysLys: 3.25 ± 0.033	4.393LysLeu: 4.393 ± 0.029	0.996LysMet: 0.996 ± 0.011	1.757LysAsn: 1.757 ± 0.018	2.517LysPro: 2.517 ± 0.024	1.841LysGln: 1.841 ± 0.02	3.67LysArg: 3.67 ± 0.026	3.626LysSer: 3.626 ± 0.029	2.855LysThr: 2.855 ± 0.024	2.797LysVal: 2.797 ± 0.023	0.715LysTrp: 0.715 ± 0.012	1.393LysTyr: 1.393 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	7.49LeuAla: 7.49 ± 0.039	1.372LeuCys: 1.372 ± 0.016	5.342LeuAsp: 5.342 ± 0.033	5.469LeuGlu: 5.469 ± 0.038	3.62LeuPhe: 3.62 ± 0.028	5.217LeuGly: 5.217 ± 0.03	2.709LeuHis: 2.709 ± 0.024	4.425LeuIle: 4.425 ± 0.029	4.508LeuLys: 4.508 ± 0.031	9.195LeuLeu: 9.195 ± 0.052	1.818LeuMet: 1.818 ± 0.014	3.396LeuAsn: 3.396 ± 0.025	6.099LeuPro: 6.099 ± 0.035	4.03LeuGln: 4.03 ± 0.03	6.186LeuArg: 6.186 ± 0.034	8.263LeuSer: 8.263 ± 0.043	5.289LeuThr: 5.289 ± 0.035	5.94LeuVal: 5.94 ± 0.034	1.348LeuTrp: 1.348 ± 0.019	2.653LeuTyr: 2.653 ± 0.027	0.0LeuXaa: 0.0 ± 0.0
Met	1.749MetAla: 1.749 ± 0.018	0.257MetCys: 0.257 ± 0.007	1.23MetAsp: 1.23 ± 0.016	1.224MetGlu: 1.224 ± 0.016	0.767MetPhe: 0.767 ± 0.011	1.165MetGly: 1.165 ± 0.017	0.557MetHis: 0.557 ± 0.01	1.052MetIle: 1.052 ± 0.014	1.057MetLys: 1.057 ± 0.014	1.866MetLeu: 1.866 ± 0.018	0.526MetMet: 0.526 ± 0.01	0.865MetAsn: 0.865 ± 0.013	1.197MetPro: 1.197 ± 0.014	0.826MetGln: 0.826 ± 0.012	1.242MetArg: 1.242 ± 0.016	1.968MetSer: 1.968 ± 0.021	1.362MetThr: 1.362 ± 0.014	1.211MetVal: 1.211 ± 0.014	0.243MetTrp: 0.243 ± 0.007	0.536MetTyr: 0.536 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	3.18AsnAla: 3.18 ± 0.024	0.473AsnCys: 0.473 ± 0.009	2.049AsnAsp: 2.049 ± 0.02	2.101AsnGlu: 2.101 ± 0.019	1.362AsnPhe: 1.362 ± 0.018	2.698AsnGly: 2.698 ± 0.023	1.026AsnHis: 1.026 ± 0.013	2.228AsnIle: 2.228 ± 0.02	1.626AsnLys: 1.626 ± 0.016	3.561AsnLeu: 3.561 ± 0.029	0.814AsnMet: 0.814 ± 0.012	1.651AsnAsn: 1.651 ± 0.021	2.437AsnPro: 2.437 ± 0.02	1.408AsnGln: 1.408 ± 0.018	2.023AsnArg: 2.023 ± 0.02	2.903AsnSer: 2.903 ± 0.022	2.293AsnThr: 2.293 ± 0.02	2.62AsnVal: 2.62 ± 0.023	0.544AsnTrp: 0.544 ± 0.01	1.022AsnTyr: 1.022 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	4.405ProAla: 4.405 ± 0.035	0.672ProCys: 0.672 ± 0.014	3.195ProAsp: 3.195 ± 0.024	3.295ProGlu: 3.295 ± 0.026	2.301ProPhe: 2.301 ± 0.022	3.342ProGly: 3.342 ± 0.03	1.578ProHis: 1.578 ± 0.02	2.837ProIle: 2.837 ± 0.023	2.483ProLys: 2.483 ± 0.021	5.313ProLeu: 5.313 ± 0.033	0.999ProMet: 0.999 ± 0.013	2.306ProAsn: 2.306 ± 0.023	5.678ProPro: 5.678 ± 0.065	2.437ProGln: 2.437 ± 0.028	3.458ProArg: 3.458 ± 0.028	6.655ProSer: 6.655 ± 0.05	4.214ProThr: 4.214 ± 0.03	3.669ProVal: 3.669 ± 0.029	0.684ProTrp: 0.684 ± 0.011	1.551ProTyr: 1.551 ± 0.018	0.0ProXaa: 0.0 ± 0.0
Gln	3.042GlnAla: 3.042 ± 0.026	0.545GlnCys: 0.545 ± 0.009	2.071GlnAsp: 2.071 ± 0.017	2.391GlnGlu: 2.391 ± 0.025	1.399GlnPhe: 1.399 ± 0.017	2.186GlnGly: 2.186 ± 0.021	1.173GlnHis: 1.173 ± 0.014	1.965GlnIle: 1.965 ± 0.022	1.813GlnLys: 1.813 ± 0.017	3.765GlnLeu: 3.765 ± 0.029	0.814GlnMet: 0.814 ± 0.011	1.529GlnAsn: 1.529 ± 0.017	2.434GlnPro: 2.434 ± 0.029	2.146GlnGln: 2.146 ± 0.036	2.697GlnArg: 2.697 ± 0.023	3.205GlnSer: 3.205 ± 0.026	2.313GlnThr: 2.313 ± 0.021	2.319GlnVal: 2.319 ± 0.023	0.558GlnTrp: 0.558 ± 0.009	1.122GlnTyr: 1.122 ± 0.014	0.0GlnXaa: 0.0 ± 0.0
Arg	4.475ArgAla: 4.475 ± 0.028	0.988ArgCys: 0.988 ± 0.014	3.254ArgAsp: 3.254 ± 0.024	3.615ArgGlu: 3.615 ± 0.03	2.39ArgPhe: 2.39 ± 0.02	3.405ArgGly: 3.405 ± 0.023	1.733ArgHis: 1.733 ± 0.017	3.351ArgIle: 3.351 ± 0.022	3.567ArgLys: 3.567 ± 0.028	5.925ArgLeu: 5.925 ± 0.035	1.387ArgMet: 1.387 ± 0.017	2.37ArgAsn: 2.37 ± 0.021	3.531ArgPro: 3.531 ± 0.032	2.53ArgGln: 2.53 ± 0.023	5.061ArgArg: 5.061 ± 0.038	5.21ArgSer: 5.21 ± 0.04	3.453ArgThr: 3.453 ± 0.027	3.584ArgVal: 3.584 ± 0.03	0.941ArgTrp: 0.941 ± 0.014	1.774ArgTyr: 1.774 ± 0.018	0.0ArgXaa: 0.0 ± 0.0
Ser	6.323SerAla: 6.323 ± 0.037	1.138SerCys: 1.138 ± 0.017	4.476SerAsp: 4.476 ± 0.03	4.141SerGlu: 4.141 ± 0.032	3.401SerPhe: 3.401 ± 0.023	5.182SerGly: 5.182 ± 0.031	2.259SerHis: 2.259 ± 0.02	4.359SerIle: 4.359 ± 0.025	3.713SerLys: 3.713 ± 0.025	8.176SerLeu: 8.176 ± 0.05	1.782SerMet: 1.782 ± 0.018	3.294SerAsn: 3.294 ± 0.024	5.941SerPro: 5.941 ± 0.052	3.343SerGln: 3.343 ± 0.025	5.403SerArg: 5.403 ± 0.039	9.868SerSer: 9.868 ± 0.078	6.038SerThr: 6.038 ± 0.04	4.96SerVal: 4.96 ± 0.031	1.077SerTrp: 1.077 ± 0.012	2.133SerTyr: 2.133 ± 0.02	0.0SerXaa: 0.0 ± 0.0
Thr	4.64ThrAla: 4.64 ± 0.03	0.841ThrCys: 0.841 ± 0.013	2.78ThrAsp: 2.78 ± 0.024	2.885ThrGlu: 2.885 ± 0.021	2.526ThrPhe: 2.526 ± 0.023	3.736ThrGly: 3.736 ± 0.031	1.481ThrHis: 1.481 ± 0.015	3.464ThrIle: 3.464 ± 0.029	2.622ThrLys: 2.622 ± 0.023	5.829ThrLeu: 5.829 ± 0.039	1.247ThrMet: 1.247 ± 0.014	2.217ThrAsn: 2.217 ± 0.02	4.242ThrPro: 4.242 ± 0.031	2.137ThrGln: 2.137 ± 0.021	3.574ThrArg: 3.574 ± 0.024	5.704ThrSer: 5.704 ± 0.038	4.354ThrThr: 4.354 ± 0.034	3.921ThrVal: 3.921 ± 0.025	0.855ThrTrp: 0.855 ± 0.013	1.577ThrTyr: 1.577 ± 0.016	0.0ThrXaa: 0.0 ± 0.0
Val	4.913ValAla: 4.913 ± 0.034	0.892ValCys: 0.892 ± 0.012	3.691ValAsp: 3.691 ± 0.022	3.685ValGlu: 3.685 ± 0.026	2.511ValPhe: 2.511 ± 0.023	3.538ValGly: 3.538 ± 0.025	1.654ValHis: 1.654 ± 0.016	3.367ValIle: 3.367 ± 0.02	3.015ValLys: 3.015 ± 0.023	6.125ValLeu: 6.125 ± 0.029	1.323ValMet: 1.323 ± 0.018	2.365ValAsn: 2.365 ± 0.024	3.802ValPro: 3.802 ± 0.025	2.535ValGln: 2.535 ± 0.022	3.445ValArg: 3.445 ± 0.028	4.801ValSer: 4.801 ± 0.032	3.618ValThr: 3.618 ± 0.026	4.36ValVal: 4.36 ± 0.03	0.878ValTrp: 0.878 ± 0.013	1.759ValTyr: 1.759 ± 0.019	0.0ValXaa: 0.0 ± 0.0
Trp	0.931TrpAla: 0.931 ± 0.016	0.238TrpCys: 0.238 ± 0.007	0.945TrpAsp: 0.945 ± 0.017	0.803TrpGlu: 0.803 ± 0.011	0.578TrpPhe: 0.578 ± 0.011	0.765TrpGly: 0.765 ± 0.013	0.394TrpHis: 0.394 ± 0.007	0.812TrpIle: 0.812 ± 0.013	0.833TrpLys: 0.833 ± 0.014	1.316TrpLeu: 1.316 ± 0.013	0.349TrpMet: 0.349 ± 0.008	0.663TrpAsn: 0.663 ± 0.011	0.562TrpPro: 0.562 ± 0.009	0.538TrpGln: 0.538 ± 0.009	0.977TrpArg: 0.977 ± 0.013	1.1TrpSer: 1.1 ± 0.014	0.889TrpThr: 0.889 ± 0.013	0.788TrpVal: 0.788 ± 0.011	0.272TrpTrp: 0.272 ± 0.008	0.397TrpTyr: 0.397 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.006TyrAla: 2.006 ± 0.019	0.465TyrCys: 0.465 ± 0.009	1.656TyrAsp: 1.656 ± 0.017	1.434TyrGlu: 1.434 ± 0.015	1.155TyrPhe: 1.155 ± 0.015	1.735TyrGly: 1.735 ± 0.018	0.859TyrHis: 0.859 ± 0.014	1.582TyrIle: 1.582 ± 0.017	1.138TyrLys: 1.138 ± 0.013	2.746TyrLeu: 2.746 ± 0.019	0.563TyrMet: 0.563 ± 0.009	1.129TyrAsn: 1.129 ± 0.014	1.57TyrPro: 1.57 ± 0.016	1.116TyrGln: 1.116 ± 0.014	1.659TyrArg: 1.659 ± 0.017	2.129TyrSer: 2.129 ± 0.018	1.62TyrThr: 1.62 ± 0.017	1.691TyrVal: 1.691 ± 0.017	0.409TyrTrp: 0.409 ± 0.008	0.934TyrTyr: 0.934 ± 0.013	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 17954 proteins (5887322 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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