Amino acid dipepetide frequency for Heliobacterium modesticaldum (strain ATCC 51547 / Ice1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.56AlaAla: 11.56 ± 0.198	1.186AlaCys: 1.186 ± 0.041	5.151AlaAsp: 5.151 ± 0.084	6.881AlaGlu: 6.881 ± 0.101	3.739AlaPhe: 3.739 ± 0.083	8.485AlaGly: 8.485 ± 0.128	1.614AlaHis: 1.614 ± 0.052	5.889AlaIle: 5.889 ± 0.094	4.6AlaLys: 4.6 ± 0.085	10.711AlaLeu: 10.711 ± 0.151	2.75AlaMet: 2.75 ± 0.063	2.558AlaAsn: 2.558 ± 0.068	4.025AlaPro: 4.025 ± 0.075	3.415AlaGln: 3.415 ± 0.065	6.075AlaArg: 6.075 ± 0.086	4.786AlaSer: 4.786 ± 0.08	4.495AlaThr: 4.495 ± 0.127	8.039AlaVal: 8.039 ± 0.121	0.99AlaTrp: 0.99 ± 0.038	2.627AlaTyr: 2.627 ± 0.062	0.0AlaXaa: 0.0 ± 0.0
Cys	0.997CysAla: 0.997 ± 0.035	0.224CysCys: 0.224 ± 0.016	0.603CysAsp: 0.603 ± 0.026	0.542CysGlu: 0.542 ± 0.029	0.401CysPhe: 0.401 ± 0.022	1.175CysGly: 1.175 ± 0.052	0.345CysHis: 0.345 ± 0.02	0.581CysIle: 0.581 ± 0.028	0.395CysLys: 0.395 ± 0.025	1.06CysLeu: 1.06 ± 0.035	0.25CysMet: 0.25 ± 0.016	0.321CysAsn: 0.321 ± 0.02	0.826CysPro: 0.826 ± 0.041	0.408CysGln: 0.408 ± 0.02	0.953CysArg: 0.953 ± 0.04	0.611CysSer: 0.611 ± 0.028	0.446CysThr: 0.446 ± 0.024	0.641CysVal: 0.641 ± 0.028	0.121CysTrp: 0.121 ± 0.011	0.339CysTyr: 0.339 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	4.588AspAla: 4.588 ± 0.078	0.671AspCys: 0.671 ± 0.031	2.717AspAsp: 2.717 ± 0.065	3.783AspGlu: 3.783 ± 0.081	2.106AspPhe: 2.106 ± 0.054	4.343AspGly: 4.343 ± 0.084	1.011AspHis: 1.011 ± 0.04	3.253AspIle: 3.253 ± 0.066	2.603AspLys: 2.603 ± 0.06	5.372AspLeu: 5.372 ± 0.097	1.353AspMet: 1.353 ± 0.041	1.464AspAsn: 1.464 ± 0.048	2.607AspPro: 2.607 ± 0.059	1.505AspGln: 1.505 ± 0.037	3.675AspArg: 3.675 ± 0.073	2.299AspSer: 2.299 ± 0.052	2.276AspThr: 2.276 ± 0.065	3.866AspVal: 3.866 ± 0.072	0.689AspTrp: 0.689 ± 0.027	1.647AspTyr: 1.647 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	7.64GluAla: 7.64 ± 0.111	0.544GluCys: 0.544 ± 0.027	2.825GluAsp: 2.825 ± 0.061	5.66GluGlu: 5.66 ± 0.113	1.791GluPhe: 1.791 ± 0.05	5.132GluGly: 5.132 ± 0.095	1.121GluHis: 1.121 ± 0.038	4.25GluIle: 4.25 ± 0.078	4.75GluLys: 4.75 ± 0.087	6.457GluLeu: 6.457 ± 0.119	2.095GluMet: 2.095 ± 0.053	2.195GluAsn: 2.195 ± 0.054	2.406GluPro: 2.406 ± 0.065	3.076GluGln: 3.076 ± 0.074	5.163GluArg: 5.163 ± 0.083	2.977GluSer: 2.977 ± 0.064	3.393GluThr: 3.393 ± 0.063	4.642GluVal: 4.642 ± 0.086	0.714GluTrp: 0.714 ± 0.03	1.715GluTyr: 1.715 ± 0.047	0.0GluXaa: 0.0 ± 0.0
Phe	3.349PheAla: 3.349 ± 0.062	0.526PheCys: 0.526 ± 0.026	2.095PheAsp: 2.095 ± 0.05	1.997PheGlu: 1.997 ± 0.05	1.926PhePhe: 1.926 ± 0.059	3.144PheGly: 3.144 ± 0.068	0.806PheHis: 0.806 ± 0.032	2.207PheIle: 2.207 ± 0.049	1.302PheLys: 1.302 ± 0.047	3.764PheLeu: 3.764 ± 0.08	0.808PheMet: 0.808 ± 0.031	1.154PheAsn: 1.154 ± 0.038	1.695PhePro: 1.695 ± 0.05	1.295PheGln: 1.295 ± 0.04	2.357PheArg: 2.357 ± 0.048	2.401PheSer: 2.401 ± 0.063	2.062PheThr: 2.062 ± 0.056	2.529PheVal: 2.529 ± 0.056	0.483PheTrp: 0.483 ± 0.027	1.177PheTyr: 1.177 ± 0.042	0.0PheXaa: 0.0 ± 0.0
Gly	7.318GlyAla: 7.318 ± 0.117	1.111GlyCys: 1.111 ± 0.039	4.143GlyAsp: 4.143 ± 0.085	5.226GlyGlu: 5.226 ± 0.076	3.298GlyPhe: 3.298 ± 0.06	6.457GlyGly: 6.457 ± 0.121	1.614GlyHis: 1.614 ± 0.048	5.095GlyIle: 5.095 ± 0.083	4.701GlyLys: 4.701 ± 0.071	8.12GlyLeu: 8.12 ± 0.114	2.425GlyMet: 2.425 ± 0.052	2.465GlyAsn: 2.465 ± 0.068	2.635GlyPro: 2.635 ± 0.065	3.031GlyGln: 3.031 ± 0.073	5.348GlyArg: 5.348 ± 0.086	4.103GlySer: 4.103 ± 0.082	4.216GlyThr: 4.216 ± 0.105	5.89GlyVal: 5.89 ± 0.102	0.951GlyTrp: 0.951 ± 0.031	2.456GlyTyr: 2.456 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	1.469HisAla: 1.469 ± 0.042	0.325HisCys: 0.325 ± 0.022	0.933HisAsp: 0.933 ± 0.036	0.919HisGlu: 0.919 ± 0.031	0.802HisPhe: 0.802 ± 0.03	1.544HisGly: 1.544 ± 0.05	0.534HisHis: 0.534 ± 0.027	1.161HisIle: 1.161 ± 0.037	0.694HisLys: 0.694 ± 0.03	2.073HisLeu: 2.073 ± 0.059	0.428HisMet: 0.428 ± 0.021	0.584HisAsn: 0.584 ± 0.026	1.362HisPro: 1.362 ± 0.043	0.718HisGln: 0.718 ± 0.029	1.507HisArg: 1.507 ± 0.047	1.039HisSer: 1.039 ± 0.042	0.901HisThr: 0.901 ± 0.033	1.211HisVal: 1.211 ± 0.04	0.269HisTrp: 0.269 ± 0.016	0.628HisTyr: 0.628 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	6.21IleAla: 6.21 ± 0.091	0.686IleCys: 0.686 ± 0.03	3.831IleAsp: 3.831 ± 0.071	4.039IleGlu: 4.039 ± 0.076	2.054IlePhe: 2.054 ± 0.052	4.893IleGly: 4.893 ± 0.097	1.27IleHis: 1.27 ± 0.039	3.565IleIle: 3.565 ± 0.08	2.475IleLys: 2.475 ± 0.069	5.517IleLeu: 5.517 ± 0.104	1.243IleMet: 1.243 ± 0.043	1.932IleAsn: 1.932 ± 0.056	3.103IlePro: 3.103 ± 0.064	1.992IleGln: 1.992 ± 0.052	3.899IleArg: 3.899 ± 0.074	3.211IleSer: 3.211 ± 0.078	3.31IleThr: 3.31 ± 0.078	4.58IleVal: 4.58 ± 0.073	0.492IleTrp: 0.492 ± 0.023	1.581IleTyr: 1.581 ± 0.041	0.0IleXaa: 0.0 ± 0.0
Lys	5.389LysAla: 5.389 ± 0.097	0.337LysCys: 0.337 ± 0.025	2.581LysAsp: 2.581 ± 0.062	4.156LysGlu: 4.156 ± 0.083	1.099LysPhe: 1.099 ± 0.038	4.091LysGly: 4.091 ± 0.08	0.725LysHis: 0.725 ± 0.03	2.693LysIle: 2.693 ± 0.073	3.179LysLys: 3.179 ± 0.08	3.915LysLeu: 3.915 ± 0.077	1.247LysMet: 1.247 ± 0.043	1.724LysAsn: 1.724 ± 0.055	2.162LysPro: 2.162 ± 0.051	1.736LysGln: 1.736 ± 0.05	3.092LysArg: 3.092 ± 0.063	2.399LysSer: 2.399 ± 0.058	2.801LysThr: 2.801 ± 0.059	3.664LysVal: 3.664 ± 0.08	0.469LysTrp: 0.469 ± 0.022	1.158LysTyr: 1.158 ± 0.046	0.0LysXaa: 0.0 ± 0.0
Leu	10.752LeuAla: 10.752 ± 0.158	1.107LeuCys: 1.107 ± 0.038	5.057LeuAsp: 5.057 ± 0.081	6.511LeuGlu: 6.511 ± 0.11	4.093LeuPhe: 4.093 ± 0.093	7.211LeuGly: 7.211 ± 0.121	1.919LeuHis: 1.919 ± 0.045	5.653LeuIle: 5.653 ± 0.099	4.63LeuLys: 4.63 ± 0.073	10.638LeuLeu: 10.638 ± 0.185	2.227LeuMet: 2.227 ± 0.056	2.86LeuAsn: 2.86 ± 0.055	5.333LeuPro: 5.333 ± 0.088	3.716LeuGln: 3.716 ± 0.067	6.83LeuArg: 6.83 ± 0.114	6.47LeuSer: 6.47 ± 0.112	5.718LeuThr: 5.718 ± 0.095	6.615LeuVal: 6.615 ± 0.1	1.018LeuTrp: 1.018 ± 0.038	2.568LeuTyr: 2.568 ± 0.058	0.0LeuXaa: 0.0 ± 0.0
Met	2.935MetAla: 2.935 ± 0.06	0.162MetCys: 0.162 ± 0.014	1.421MetAsp: 1.421 ± 0.04	1.933MetGlu: 1.933 ± 0.046	0.653MetPhe: 0.653 ± 0.029	2.038MetGly: 2.038 ± 0.052	0.408MetHis: 0.408 ± 0.026	1.502MetIle: 1.502 ± 0.049	1.45MetLys: 1.45 ± 0.039	2.238MetLeu: 2.238 ± 0.055	0.663MetMet: 0.663 ± 0.03	0.97MetAsn: 0.97 ± 0.034	1.085MetPro: 1.085 ± 0.033	0.89MetGln: 0.89 ± 0.036	1.519MetArg: 1.519 ± 0.043	1.354MetSer: 1.354 ± 0.04	1.651MetThr: 1.651 ± 0.046	1.9MetVal: 1.9 ± 0.055	0.154MetTrp: 0.154 ± 0.014	0.465MetTyr: 0.465 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	2.634AsnAla: 2.634 ± 0.066	0.354AsnCys: 0.354 ± 0.021	1.46AsnAsp: 1.46 ± 0.047	1.647AsnGlu: 1.647 ± 0.049	1.01AsnPhe: 1.01 ± 0.035	2.426AsnGly: 2.426 ± 0.065	0.63AsnHis: 0.63 ± 0.028	1.975AsnIle: 1.975 ± 0.058	1.39AsnLys: 1.39 ± 0.045	3.244AsnLeu: 3.244 ± 0.059	0.717AsnMet: 0.717 ± 0.029	0.931AsnAsn: 0.931 ± 0.041	1.95AsnPro: 1.95 ± 0.056	1.106AsnGln: 1.106 ± 0.037	2.358AsnArg: 2.358 ± 0.05	1.458AsnSer: 1.458 ± 0.05	1.444AsnThr: 1.444 ± 0.046	2.099AsnVal: 2.099 ± 0.05	0.372AsnTrp: 0.372 ± 0.022	0.889AsnTyr: 0.889 ± 0.038	0.0AsnXaa: 0.0 ± 0.0
Pro	4.703ProAla: 4.703 ± 0.094	0.449ProCys: 0.449 ± 0.025	2.637ProAsp: 2.637 ± 0.057	3.919ProGlu: 3.919 ± 0.073	1.889ProPhe: 1.889 ± 0.048	4.015ProGly: 4.015 ± 0.097	0.867ProHis: 0.867 ± 0.034	2.455ProIle: 2.455 ± 0.049	2.038ProLys: 2.038 ± 0.056	4.566ProLeu: 4.566 ± 0.081	1.079ProMet: 1.079 ± 0.038	1.207ProAsn: 1.207 ± 0.044	2.305ProPro: 2.305 ± 0.133	1.636ProGln: 1.636 ± 0.041	2.261ProArg: 2.261 ± 0.052	2.547ProSer: 2.547 ± 0.067	2.161ProThr: 2.161 ± 0.064	4.265ProVal: 4.265 ± 0.078	0.657ProTrp: 0.657 ± 0.031	1.301ProTyr: 1.301 ± 0.047	0.0ProXaa: 0.0 ± 0.0
Gln	3.998GlnAla: 3.998 ± 0.077	0.309GlnCys: 0.309 ± 0.022	1.464GlnAsp: 1.464 ± 0.043	2.602GlnGlu: 2.602 ± 0.06	1.136GlnPhe: 1.136 ± 0.043	2.867GlnGly: 2.867 ± 0.061	0.648GlnHis: 0.648 ± 0.03	2.21GlnIle: 2.21 ± 0.049	2.078GlnLys: 2.078 ± 0.059	3.314GlnLeu: 3.314 ± 0.071	1.113GlnMet: 1.113 ± 0.034	1.005GlnAsn: 1.005 ± 0.036	1.609GlnPro: 1.609 ± 0.047	1.538GlnGln: 1.538 ± 0.058	2.577GlnArg: 2.577 ± 0.076	1.846GlnSer: 1.846 ± 0.06	1.81GlnThr: 1.81 ± 0.05	3.106GlnVal: 3.106 ± 0.063	0.481GlnTrp: 0.481 ± 0.028	0.848GlnTyr: 0.848 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	4.909ArgAla: 4.909 ± 0.089	0.843ArgCys: 0.843 ± 0.035	3.171ArgAsp: 3.171 ± 0.072	5.197ArgGlu: 5.197 ± 0.091	2.887ArgPhe: 2.887 ± 0.063	4.241ArgGly: 4.241 ± 0.082	1.468ArgHis: 1.468 ± 0.041	4.229ArgIle: 4.229 ± 0.079	3.12ArgLys: 3.12 ± 0.059	7.902ArgLeu: 7.902 ± 0.119	1.92ArgMet: 1.92 ± 0.056	1.853ArgAsn: 1.853 ± 0.053	2.912ArgPro: 2.912 ± 0.069	3.361ArgGln: 3.361 ± 0.081	5.477ArgArg: 5.477 ± 0.114	3.228ArgSer: 3.228 ± 0.065	2.805ArgThr: 2.805 ± 0.075	4.277ArgVal: 4.277 ± 0.071	1.072ArgTrp: 1.072 ± 0.04	2.1ArgTyr: 2.1 ± 0.054	0.0ArgXaa: 0.0 ± 0.0
Ser	5.009SerAla: 5.009 ± 0.091	0.533SerCys: 0.533 ± 0.024	2.603SerAsp: 2.603 ± 0.059	3.092SerGlu: 3.092 ± 0.062	2.153SerPhe: 2.153 ± 0.051	4.839SerGly: 4.839 ± 0.1	1.037SerHis: 1.037 ± 0.04	2.941SerIle: 2.941 ± 0.066	2.127SerLys: 2.127 ± 0.053	5.716SerLeu: 5.716 ± 0.09	1.239SerMet: 1.239 ± 0.035	1.574SerAsn: 1.574 ± 0.05	2.9SerPro: 2.9 ± 0.066	1.812SerGln: 1.812 ± 0.055	3.668SerArg: 3.668 ± 0.07	2.9SerSer: 2.9 ± 0.071	2.481SerThr: 2.481 ± 0.059	3.852SerVal: 3.852 ± 0.07	0.595SerTrp: 0.595 ± 0.025	1.358SerTyr: 1.358 ± 0.047	0.0SerXaa: 0.0 ± 0.0
Thr	5.533ThrAla: 5.533 ± 0.152	0.547ThrCys: 0.547 ± 0.027	2.589ThrAsp: 2.589 ± 0.061	2.973ThrGlu: 2.973 ± 0.063	1.875ThrPhe: 1.875 ± 0.047	5.091ThrGly: 5.091 ± 0.098	0.9ThrHis: 0.9 ± 0.034	3.165ThrIle: 3.165 ± 0.073	1.952ThrLys: 1.952 ± 0.052	5.162ThrLeu: 5.162 ± 0.099	1.246ThrMet: 1.246 ± 0.04	1.412ThrAsn: 1.412 ± 0.042	2.826ThrPro: 2.826 ± 0.067	1.471ThrGln: 1.471 ± 0.046	2.487ThrArg: 2.487 ± 0.063	2.536ThrSer: 2.536 ± 0.065	2.738ThrThr: 2.738 ± 0.1	4.861ThrVal: 4.861 ± 0.128	0.499ThrTrp: 0.499 ± 0.026	1.408ThrTyr: 1.408 ± 0.045	0.0ThrXaa: 0.0 ± 0.0
Val	7.412ValAla: 7.412 ± 0.106	0.804ValCys: 0.804 ± 0.029	4.389ValAsp: 4.389 ± 0.085	5.196ValGlu: 5.196 ± 0.083	2.669ValPhe: 2.669 ± 0.059	5.277ValGly: 5.277 ± 0.093	1.329ValHis: 1.329 ± 0.039	5.011ValIle: 5.011 ± 0.074	3.5ValLys: 3.5 ± 0.082	7.06ValLeu: 7.06 ± 0.097	1.731ValMet: 1.731 ± 0.051	2.556ValAsn: 2.556 ± 0.067	3.402ValPro: 3.402 ± 0.066	2.331ValGln: 2.331 ± 0.048	4.58ValArg: 4.58 ± 0.075	4.145ValSer: 4.145 ± 0.075	4.56ValThr: 4.56 ± 0.118	5.681ValVal: 5.681 ± 0.099	0.632ValTrp: 0.632 ± 0.031	1.97ValTyr: 1.97 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	0.828TrpAla: 0.828 ± 0.033	0.107TrpCys: 0.107 ± 0.012	0.585TrpAsp: 0.585 ± 0.03	0.791TrpGlu: 0.791 ± 0.024	0.391TrpPhe: 0.391 ± 0.021	0.811TrpGly: 0.811 ± 0.035	0.223TrpHis: 0.223 ± 0.016	0.601TrpIle: 0.601 ± 0.029	0.556TrpLys: 0.556 ± 0.025	1.248TrpLeu: 1.248 ± 0.048	0.326TrpMet: 0.326 ± 0.023	0.411TrpAsn: 0.411 ± 0.021	0.46TrpPro: 0.46 ± 0.025	0.51TrpGln: 0.51 ± 0.029	0.903TrpArg: 0.903 ± 0.034	0.662TrpSer: 0.662 ± 0.03	0.553TrpThr: 0.553 ± 0.024	0.754TrpVal: 0.754 ± 0.029	0.168TrpTrp: 0.168 ± 0.016	0.33TrpTyr: 0.33 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.343TyrAla: 2.343 ± 0.052	0.415TyrCys: 0.415 ± 0.023	1.572TyrAsp: 1.572 ± 0.051	1.484TyrGlu: 1.484 ± 0.047	1.107TyrPhe: 1.107 ± 0.039	2.524TyrGly: 2.524 ± 0.05	0.631TyrHis: 0.631 ± 0.03	1.449TyrIle: 1.449 ± 0.045	1.077TyrLys: 1.077 ± 0.039	2.849TyrLeu: 2.849 ± 0.061	0.529TyrMet: 0.529 ± 0.026	0.915TyrAsn: 0.915 ± 0.038	1.356TyrPro: 1.356 ± 0.042	1.01TyrGln: 1.01 ± 0.034	2.244TyrArg: 2.244 ± 0.058	1.457TyrSer: 1.457 ± 0.042	1.45TyrThr: 1.45 ± 0.055	1.76TyrVal: 1.76 ± 0.041	0.391TyrTrp: 0.391 ± 0.023	0.919TyrTyr: 0.919 ± 0.036	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2924 proteins (852455 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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