Amino acid dipepetide frequency for Testudo hermanni ranavirus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.675AlaAla: 10.675 ± 1.101
1.779AlaCys: 1.779 ± 0.265
4.522AlaAsp: 4.522 ± 0.363
5.931AlaGlu: 5.931 ± 0.48
2.891AlaPhe: 2.891 ± 0.374
6.931AlaGly: 6.931 ± 0.59
1.927AlaHis: 1.927 ± 0.23
2.372AlaIle: 2.372 ± 0.318
4.67AlaLys: 4.67 ± 0.45
7.265AlaLeu: 7.265 ± 0.521
3.076AlaMet: 3.076 ± 0.328
1.705AlaAsn: 1.705 ± 0.243
5.412AlaPro: 5.412 ± 1.023
2.669AlaGln: 2.669 ± 0.479
5.004AlaArg: 5.004 ± 0.542
6.19AlaSer: 6.19 ± 0.63
4.485AlaThr: 4.485 ± 0.361
8.673AlaVal: 8.673 ± 0.603
1.557AlaTrp: 1.557 ± 0.266
2.595AlaTyr: 2.595 ± 0.273
0.0AlaXaa: 0.0 ± 0.0
Cys
1.779CysAla: 1.779 ± 0.275
0.667CysCys: 0.667 ± 0.179
1.334CysAsp: 1.334 ± 0.21
1.112CysGlu: 1.112 ± 0.19
0.519CysPhe: 0.519 ± 0.162
1.52CysGly: 1.52 ± 0.251
0.519CysHis: 0.519 ± 0.139
0.704CysIle: 0.704 ± 0.187
1.297CysLys: 1.297 ± 0.244
1.594CysLeu: 1.594 ± 0.322
0.704CysMet: 0.704 ± 0.179
0.519CysAsn: 0.519 ± 0.167
1.52CysPro: 1.52 ± 0.292
0.667CysGln: 0.667 ± 0.183
1.52CysArg: 1.52 ± 0.249
1.483CysSer: 1.483 ± 0.236
0.853CysThr: 0.853 ± 0.181
1.779CysVal: 1.779 ± 0.248
0.556CysTrp: 0.556 ± 0.142
0.556CysTyr: 0.556 ± 0.158
0.0CysXaa: 0.0 ± 0.0
Asp
5.819AspAla: 5.819 ± 0.475
1.446AspCys: 1.446 ± 0.228
3.336AspAsp: 3.336 ± 0.37
3.076AspGlu: 3.076 ± 0.418
1.927AspPhe: 1.927 ± 0.325
4.819AspGly: 4.819 ± 0.564
1.001AspHis: 1.001 ± 0.181
2.261AspIle: 2.261 ± 0.301
2.706AspLys: 2.706 ± 0.308
5.893AspLeu: 5.893 ± 0.633
2.039AspMet: 2.039 ± 0.255
2.076AspAsn: 2.076 ± 0.381
4.077AspPro: 4.077 ± 0.418
1.446AspGln: 1.446 ± 0.293
4.077AspArg: 4.077 ± 0.417
4.596AspSer: 4.596 ± 0.516
2.595AspThr: 2.595 ± 0.312
4.819AspVal: 4.819 ± 0.442
0.927AspTrp: 0.927 ± 0.195
2.483AspTyr: 2.483 ± 0.344
0.0AspXaa: 0.0 ± 0.0
Glu
6.338GluAla: 6.338 ± 0.497
1.594GluCys: 1.594 ± 0.323
3.966GluAsp: 3.966 ± 0.474
3.929GluGlu: 3.929 ± 0.634
2.002GluPhe: 2.002 ± 0.246
3.966GluGly: 3.966 ± 0.403
0.89GluHis: 0.89 ± 0.218
1.853GluIle: 1.853 ± 0.226
3.262GluLys: 3.262 ± 0.345
3.781GluLeu: 3.781 ± 0.498
2.076GluMet: 2.076 ± 0.277
1.075GluAsn: 1.075 ± 0.229
2.928GluPro: 2.928 ± 0.428
1.89GluGln: 1.89 ± 0.426
4.04GluArg: 4.04 ± 0.377
3.558GluSer: 3.558 ± 0.418
3.781GluThr: 3.781 ± 0.311
3.67GluVal: 3.67 ± 0.394
1.334GluTrp: 1.334 ± 0.181
2.15GluTyr: 2.15 ± 0.27
0.0GluXaa: 0.0 ± 0.0
Phe
2.891PheAla: 2.891 ± 0.379
0.741PheCys: 0.741 ± 0.157
1.631PheAsp: 1.631 ± 0.261
1.927PheGlu: 1.927 ± 0.217
1.594PhePhe: 1.594 ± 0.371
2.817PheGly: 2.817 ± 0.314
0.704PheHis: 0.704 ± 0.175
1.075PheIle: 1.075 ± 0.214
1.446PheLys: 1.446 ± 0.235
2.965PheLeu: 2.965 ± 0.316
0.853PheMet: 0.853 ± 0.143
1.186PheAsn: 1.186 ± 0.188
2.039PhePro: 2.039 ± 0.318
0.778PheGln: 0.778 ± 0.138
2.298PheArg: 2.298 ± 0.359
2.743PheSer: 2.743 ± 0.255
2.52PheThr: 2.52 ± 0.652
3.076PheVal: 3.076 ± 0.36
0.297PheTrp: 0.297 ± 0.109
1.075PheTyr: 1.075 ± 0.205
0.0PheXaa: 0.0 ± 0.0
Gly
5.782GlyAla: 5.782 ± 0.464
1.483GlyCys: 1.483 ± 0.257
5.041GlyAsp: 5.041 ± 0.53
3.855GlyGlu: 3.855 ± 0.473
2.78GlyPhe: 2.78 ± 0.321
5.782GlyGly: 5.782 ± 0.604
1.631GlyHis: 1.631 ± 0.298
2.261GlyIle: 2.261 ± 0.318
4.374GlyLys: 4.374 ± 0.408
5.486GlyLeu: 5.486 ± 0.427
2.002GlyMet: 2.002 ± 0.253
1.297GlyAsn: 1.297 ± 0.258
4.226GlyPro: 4.226 ± 0.586
1.594GlyGln: 1.594 ± 0.221
4.93GlyArg: 4.93 ± 0.429
6.005GlySer: 6.005 ± 0.453
4.559GlyThr: 4.559 ± 0.491
5.486GlyVal: 5.486 ± 0.469
1.446GlyTrp: 1.446 ± 0.23
2.558GlyTyr: 2.558 ± 0.313
0.0GlyXaa: 0.0 ± 0.0
His
1.705HisAla: 1.705 ± 0.229
0.297HisCys: 0.297 ± 0.118
1.038HisAsp: 1.038 ± 0.21
0.593HisGlu: 0.593 ± 0.201
0.519HisPhe: 0.519 ± 0.132
1.557HisGly: 1.557 ± 0.266
0.519HisHis: 0.519 ± 0.212
0.815HisIle: 0.815 ± 0.192
0.778HisLys: 0.778 ± 0.177
2.039HisLeu: 2.039 ± 0.267
0.63HisMet: 0.63 ± 0.162
0.63HisAsn: 0.63 ± 0.233
1.371HisPro: 1.371 ± 0.216
0.667HisGln: 0.667 ± 0.153
1.186HisArg: 1.186 ± 0.202
1.409HisSer: 1.409 ± 0.229
1.186HisThr: 1.186 ± 0.215
2.15HisVal: 2.15 ± 0.293
0.222HisTrp: 0.222 ± 0.097
0.667HisTyr: 0.667 ± 0.153
0.0HisXaa: 0.0 ± 0.0
Ile
2.409IleAla: 2.409 ± 0.256
0.556IleCys: 0.556 ± 0.154
1.964IleAsp: 1.964 ± 0.247
1.668IleGlu: 1.668 ± 0.237
1.149IlePhe: 1.149 ± 0.219
1.779IleGly: 1.779 ± 0.3
0.815IleHis: 0.815 ± 0.182
1.149IleIle: 1.149 ± 0.199
2.335IleLys: 2.335 ± 0.285
3.076IleLeu: 3.076 ± 0.331
1.149IleMet: 1.149 ± 0.188
0.964IleAsn: 0.964 ± 0.208
2.113IlePro: 2.113 ± 0.286
0.927IleGln: 0.927 ± 0.209
2.928IleArg: 2.928 ± 0.328
2.483IleSer: 2.483 ± 0.282
1.483IleThr: 1.483 ± 0.239
2.743IleVal: 2.743 ± 0.37
0.185IleTrp: 0.185 ± 0.083
0.853IleTyr: 0.853 ± 0.221
0.0IleXaa: 0.0 ± 0.0
Lys
4.93LysAla: 4.93 ± 0.555
0.964LysCys: 0.964 ± 0.223
2.706LysAsp: 2.706 ± 0.337
3.225LysGlu: 3.225 ± 0.371
1.483LysPhe: 1.483 ± 0.209
4.151LysGly: 4.151 ± 0.392
0.741LysHis: 0.741 ± 0.134
2.558LysIle: 2.558 ± 0.317
3.707LysLys: 3.707 ± 0.453
4.226LysLeu: 4.226 ± 0.48
1.853LysMet: 1.853 ± 0.226
1.668LysAsn: 1.668 ± 0.249
3.744LysPro: 3.744 ± 0.641
1.334LysGln: 1.334 ± 0.268
4.707LysArg: 4.707 ± 0.564
3.41LysSer: 3.41 ± 0.464
4.3LysThr: 4.3 ± 0.343
3.558LysVal: 3.558 ± 0.319
0.63LysTrp: 0.63 ± 0.158
1.89LysTyr: 1.89 ± 0.235
0.0LysXaa: 0.0 ± 0.0
Leu
6.153LeuAla: 6.153 ± 0.472
1.927LeuCys: 1.927 ± 0.363
5.226LeuAsp: 5.226 ± 0.478
5.375LeuGlu: 5.375 ± 0.5
3.225LeuPhe: 3.225 ± 0.494
5.3LeuGly: 5.3 ± 0.457
1.705LeuHis: 1.705 ± 0.296
2.632LeuIle: 2.632 ± 0.319
5.078LeuLys: 5.078 ± 0.484
6.449LeuLeu: 6.449 ± 0.646
2.409LeuMet: 2.409 ± 0.298
2.372LeuAsn: 2.372 ± 0.279
4.003LeuPro: 4.003 ± 0.523
1.52LeuGln: 1.52 ± 0.252
6.449LeuArg: 6.449 ± 0.709
5.968LeuSer: 5.968 ± 0.413
5.449LeuThr: 5.449 ± 0.543
5.708LeuVal: 5.708 ± 0.506
1.038LeuTrp: 1.038 ± 0.183
2.076LeuTyr: 2.076 ± 0.222
0.0LeuXaa: 0.0 ± 0.0
Met
3.447MetAla: 3.447 ± 0.34
0.89MetCys: 0.89 ± 0.226
2.15MetAsp: 2.15 ± 0.224
2.002MetGlu: 2.002 ± 0.273
1.038MetPhe: 1.038 ± 0.198
2.52MetGly: 2.52 ± 0.282
0.815MetHis: 0.815 ± 0.175
0.556MetIle: 0.556 ± 0.122
0.927MetLys: 0.927 ± 0.18
1.89MetLeu: 1.89 ± 0.285
0.704MetMet: 0.704 ± 0.16
0.371MetAsn: 0.371 ± 0.11
1.483MetPro: 1.483 ± 0.219
0.63MetGln: 0.63 ± 0.149
2.224MetArg: 2.224 ± 0.297
2.965MetSer: 2.965 ± 0.372
2.224MetThr: 2.224 ± 0.233
2.372MetVal: 2.372 ± 0.34
0.482MetTrp: 0.482 ± 0.17
0.63MetTyr: 0.63 ± 0.208
0.0MetXaa: 0.0 ± 0.0
Asn
2.446AsnAla: 2.446 ± 0.273
0.519AsnCys: 0.519 ± 0.137
0.853AsnAsp: 0.853 ± 0.196
0.89AsnGlu: 0.89 ± 0.156
0.741AsnPhe: 0.741 ± 0.176
1.557AsnGly: 1.557 ± 0.253
0.482AsnHis: 0.482 ± 0.13
1.223AsnIle: 1.223 ± 0.259
1.112AsnLys: 1.112 ± 0.213
2.854AsnLeu: 2.854 ± 0.392
0.927AsnMet: 0.927 ± 0.213
0.704AsnAsn: 0.704 ± 0.231
2.261AsnPro: 2.261 ± 0.441
0.63AsnGln: 0.63 ± 0.127
1.594AsnArg: 1.594 ± 0.212
1.409AsnSer: 1.409 ± 0.215
1.334AsnThr: 1.334 ± 0.274
2.669AsnVal: 2.669 ± 0.314
0.482AsnTrp: 0.482 ± 0.119
0.89AsnTyr: 0.89 ± 0.199
0.0AsnXaa: 0.0 ± 0.0
Pro
6.857ProAla: 6.857 ± 1.185
1.149ProCys: 1.149 ± 0.227
3.67ProAsp: 3.67 ± 0.338
4.67ProGlu: 4.67 ± 0.569
2.372ProPhe: 2.372 ± 0.257
4.077ProGly: 4.077 ± 0.425
1.594ProHis: 1.594 ± 0.242
1.853ProIle: 1.853 ± 0.265
3.521ProLys: 3.521 ± 0.644
3.595ProLeu: 3.595 ± 0.429
1.334ProMet: 1.334 ± 0.219
1.446ProAsn: 1.446 ± 0.25
3.818ProPro: 3.818 ± 0.561
1.668ProGln: 1.668 ± 0.242
3.299ProArg: 3.299 ± 0.52
5.041ProSer: 5.041 ± 0.473
3.484ProThr: 3.484 ± 0.649
5.931ProVal: 5.931 ± 0.573
0.964ProTrp: 0.964 ± 0.218
1.594ProTyr: 1.594 ± 0.26
0.0ProXaa: 0.0 ± 0.0
Gln
2.372GlnAla: 2.372 ± 0.259
0.593GlnCys: 0.593 ± 0.135
1.705GlnAsp: 1.705 ± 0.295
1.853GlnGlu: 1.853 ± 0.299
0.741GlnPhe: 0.741 ± 0.14
1.52GlnGly: 1.52 ± 0.193
0.519GlnHis: 0.519 ± 0.164
1.038GlnIle: 1.038 ± 0.186
1.297GlnLys: 1.297 ± 0.196
1.927GlnLeu: 1.927 ± 0.377
0.704GlnMet: 0.704 ± 0.163
0.63GlnAsn: 0.63 ± 0.136
1.409GlnPro: 1.409 ± 0.306
2.261GlnGln: 2.261 ± 1.188
2.039GlnArg: 2.039 ± 0.485
2.15GlnSer: 2.15 ± 0.354
1.927GlnThr: 1.927 ± 0.359
1.89GlnVal: 1.89 ± 0.274
0.371GlnTrp: 0.371 ± 0.13
0.667GlnTyr: 0.667 ± 0.12
0.0GlnXaa: 0.0 ± 0.0
Arg
5.226ArgAla: 5.226 ± 0.551
1.075ArgCys: 1.075 ± 0.191
4.596ArgAsp: 4.596 ± 0.456
4.411ArgGlu: 4.411 ± 0.321
2.409ArgPhe: 2.409 ± 0.362
5.078ArgGly: 5.078 ± 0.554
1.557ArgHis: 1.557 ± 0.257
2.002ArgIle: 2.002 ± 0.286
4.077ArgLys: 4.077 ± 0.52
5.745ArgLeu: 5.745 ± 0.43
2.187ArgMet: 2.187 ± 0.311
2.187ArgAsn: 2.187 ± 0.449
4.596ArgPro: 4.596 ± 0.721
1.853ArgGln: 1.853 ± 0.262
5.745ArgArg: 5.745 ± 0.54
3.67ArgSer: 3.67 ± 0.422
4.003ArgThr: 4.003 ± 0.504
5.449ArgVal: 5.449 ± 0.457
0.964ArgTrp: 0.964 ± 0.211
2.15ArgTyr: 2.15 ± 0.248
0.0ArgXaa: 0.0 ± 0.0
Ser
6.412SerAla: 6.412 ± 0.651
1.557SerCys: 1.557 ± 0.237
5.263SerAsp: 5.263 ± 0.391
3.966SerGlu: 3.966 ± 0.415
2.669SerPhe: 2.669 ± 0.279
5.671SerGly: 5.671 ± 0.542
1.409SerHis: 1.409 ± 0.229
2.261SerIle: 2.261 ± 0.27
3.521SerLys: 3.521 ± 0.502
6.042SerLeu: 6.042 ± 0.55
1.927SerMet: 1.927 ± 0.315
1.705SerAsn: 1.705 ± 0.241
5.041SerPro: 5.041 ± 0.983
1.853SerGln: 1.853 ± 0.287
4.188SerArg: 4.188 ± 0.513
5.337SerSer: 5.337 ± 0.547
3.299SerThr: 3.299 ± 0.315
6.301SerVal: 6.301 ± 0.582
1.223SerTrp: 1.223 ± 0.187
1.742SerTyr: 1.742 ± 0.25
0.0SerXaa: 0.0 ± 0.0
Thr
5.745ThrAla: 5.745 ± 0.541
1.149ThrCys: 1.149 ± 0.215
3.892ThrAsp: 3.892 ± 0.36
2.854ThrGlu: 2.854 ± 0.362
2.372ThrPhe: 2.372 ± 0.292
5.782ThrGly: 5.782 ± 0.654
0.593ThrHis: 0.593 ± 0.13
2.002ThrIle: 2.002 ± 0.266
2.743ThrLys: 2.743 ± 0.361
4.633ThrLeu: 4.633 ± 0.422
1.853ThrMet: 1.853 ± 0.217
1.149ThrAsn: 1.149 ± 0.208
4.374ThrPro: 4.374 ± 0.589
1.927ThrGln: 1.927 ± 0.377
3.373ThrArg: 3.373 ± 0.359
2.928ThrSer: 2.928 ± 0.43
2.595ThrThr: 2.595 ± 0.709
6.894ThrVal: 6.894 ± 0.507
0.519ThrTrp: 0.519 ± 0.183
1.371ThrTyr: 1.371 ± 0.28
0.0ThrXaa: 0.0 ± 0.0
Val
6.005ValAla: 6.005 ± 0.452
1.816ValCys: 1.816 ± 0.279
4.93ValAsp: 4.93 ± 0.418
4.374ValGlu: 4.374 ± 0.46
2.817ValPhe: 2.817 ± 0.352
4.411ValGly: 4.411 ± 0.554
1.89ValHis: 1.89 ± 0.249
2.298ValIle: 2.298 ± 0.221
6.301ValLys: 6.301 ± 0.606
7.043ValLeu: 7.043 ± 0.626
2.669ValMet: 2.669 ± 0.361
2.632ValAsn: 2.632 ± 0.31
5.004ValPro: 5.004 ± 0.569
2.15ValGln: 2.15 ± 0.285
6.746ValArg: 6.746 ± 0.696
6.783ValSer: 6.783 ± 0.53
5.263ValThr: 5.263 ± 0.543
6.857ValVal: 6.857 ± 0.684
1.297ValTrp: 1.297 ± 0.174
2.595ValTyr: 2.595 ± 0.299
0.0ValXaa: 0.0 ± 0.0
Trp
0.964TrpAla: 0.964 ± 0.276
0.297TrpCys: 0.297 ± 0.096
1.112TrpAsp: 1.112 ± 0.192
0.778TrpGlu: 0.778 ± 0.187
0.63TrpPhe: 0.63 ± 0.152
0.964TrpGly: 0.964 ± 0.164
0.259TrpHis: 0.259 ± 0.101
0.519TrpIle: 0.519 ± 0.161
0.964TrpLys: 0.964 ± 0.192
1.557TrpLeu: 1.557 ± 0.225
0.408TrpMet: 0.408 ± 0.105
0.63TrpAsn: 0.63 ± 0.189
0.667TrpPro: 0.667 ± 0.162
0.259TrpGln: 0.259 ± 0.086
1.038TrpArg: 1.038 ± 0.206
0.815TrpSer: 0.815 ± 0.172
1.594TrpThr: 1.594 ± 0.277
0.815TrpVal: 0.815 ± 0.223
0.111TrpTrp: 0.111 ± 0.064
0.482TrpTyr: 0.482 ± 0.143
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.372TyrAla: 2.372 ± 0.342
0.704TyrCys: 0.704 ± 0.177
2.483TyrAsp: 2.483 ± 0.254
1.594TyrGlu: 1.594 ± 0.262
0.778TyrPhe: 0.778 ± 0.187
2.372TyrGly: 2.372 ± 0.272
0.408TyrHis: 0.408 ± 0.126
1.297TyrIle: 1.297 ± 0.213
1.668TyrLys: 1.668 ± 0.255
2.002TyrLeu: 2.002 ± 0.284
0.778TyrMet: 0.778 ± 0.151
0.63TyrAsn: 0.63 ± 0.18
1.853TyrPro: 1.853 ± 0.234
0.89TyrGln: 0.89 ± 0.164
1.594TyrArg: 1.594 ± 0.231
2.483TyrSer: 2.483 ± 0.284
1.816TyrThr: 1.816 ± 0.246
3.039TyrVal: 3.039 ± 0.364
0.259TyrTrp: 0.259 ± 0.116
0.853TyrTyr: 0.853 ± 0.198
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 75 proteins (26980 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski