Amino acid dipepetide frequency for Pigmentiphaga sp. NML080357

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
19.118AlaAla: 19.118 ± 0.159
1.44AlaCys: 1.44 ± 0.028
6.864AlaAsp: 6.864 ± 0.076
6.91AlaGlu: 6.91 ± 0.076
4.06AlaPhe: 4.06 ± 0.053
12.129AlaGly: 12.129 ± 0.12
2.649AlaHis: 2.649 ± 0.041
5.517AlaIle: 5.517 ± 0.065
3.415AlaLys: 3.415 ± 0.054
14.201AlaLeu: 14.201 ± 0.128
3.584AlaMet: 3.584 ± 0.049
2.687AlaAsn: 2.687 ± 0.045
6.644AlaPro: 6.644 ± 0.076
5.114AlaGln: 5.114 ± 0.061
10.393AlaArg: 10.393 ± 0.078
6.79AlaSer: 6.79 ± 0.064
5.722AlaThr: 5.722 ± 0.06
9.284AlaVal: 9.284 ± 0.083
1.965AlaTrp: 1.965 ± 0.041
2.722AlaTyr: 2.722 ± 0.038
0.0AlaXaa: 0.0 ± 0.0
Cys
1.239CysAla: 1.239 ± 0.029
0.142CysCys: 0.142 ± 0.009
0.523CysAsp: 0.523 ± 0.018
0.495CysGlu: 0.495 ± 0.02
0.313CysPhe: 0.313 ± 0.014
1.003CysGly: 1.003 ± 0.025
0.25CysHis: 0.25 ± 0.013
0.355CysIle: 0.355 ± 0.014
0.189CysLys: 0.189 ± 0.01
0.865CysLeu: 0.865 ± 0.023
0.195CysMet: 0.195 ± 0.011
0.218CysAsn: 0.218 ± 0.011
0.484CysPro: 0.484 ± 0.019
0.232CysGln: 0.232 ± 0.011
0.714CysArg: 0.714 ± 0.025
0.437CysSer: 0.437 ± 0.017
0.463CysThr: 0.463 ± 0.017
0.734CysVal: 0.734 ± 0.023
0.123CysTrp: 0.123 ± 0.01
0.209CysTyr: 0.209 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
7.031AspAla: 7.031 ± 0.074
0.458AspCys: 0.458 ± 0.017
2.789AspAsp: 2.789 ± 0.05
3.386AspGlu: 3.386 ± 0.053
2.044AspPhe: 2.044 ± 0.037
4.692AspGly: 4.692 ± 0.054
1.085AspHis: 1.085 ± 0.026
2.572AspIle: 2.572 ± 0.041
1.47AspLys: 1.47 ± 0.032
5.505AspLeu: 5.505 ± 0.055
1.314AspMet: 1.314 ± 0.029
1.063AspAsn: 1.063 ± 0.023
3.385AspPro: 3.385 ± 0.044
1.465AspGln: 1.465 ± 0.029
3.936AspArg: 3.936 ± 0.049
2.03AspSer: 2.03 ± 0.042
2.623AspThr: 2.623 ± 0.039
4.144AspVal: 4.144 ± 0.047
0.922AspTrp: 0.922 ± 0.025
1.481AspTyr: 1.481 ± 0.034
0.0AspXaa: 0.0 ± 0.0
Glu
7.138GluAla: 7.138 ± 0.068
0.379GluCys: 0.379 ± 0.014
2.392GluAsp: 2.392 ± 0.038
2.757GluGlu: 2.757 ± 0.045
1.848GluPhe: 1.848 ± 0.037
3.864GluGly: 3.864 ± 0.05
1.404GluHis: 1.404 ± 0.032
2.827GluIle: 2.827 ± 0.041
1.657GluLys: 1.657 ± 0.037
6.016GluLeu: 6.016 ± 0.068
1.234GluMet: 1.234 ± 0.026
1.379GluAsn: 1.379 ± 0.026
2.695GluPro: 2.695 ± 0.039
2.426GluGln: 2.426 ± 0.042
5.131GluArg: 5.131 ± 0.061
2.591GluSer: 2.591 ± 0.035
2.696GluThr: 2.696 ± 0.041
3.934GluVal: 3.934 ± 0.049
0.717GluTrp: 0.717 ± 0.022
1.139GluTyr: 1.139 ± 0.026
0.0GluXaa: 0.0 ± 0.0
Phe
4.071PheAla: 4.071 ± 0.055
0.37PheCys: 0.37 ± 0.015
2.378PheAsp: 2.378 ± 0.036
2.005PheGlu: 2.005 ± 0.036
1.225PhePhe: 1.225 ± 0.026
3.304PheGly: 3.304 ± 0.048
0.774PheHis: 0.774 ± 0.02
1.403PheIle: 1.403 ± 0.028
1.005PheLys: 1.005 ± 0.025
3.019PheLeu: 3.019 ± 0.051
0.765PheMet: 0.765 ± 0.023
0.965PheAsn: 0.965 ± 0.023
1.652PhePro: 1.652 ± 0.032
0.962PheGln: 0.962 ± 0.021
2.064PheArg: 2.064 ± 0.033
2.046PheSer: 2.046 ± 0.036
1.692PheThr: 1.692 ± 0.035
2.694PheVal: 2.694 ± 0.04
0.45PheTrp: 0.45 ± 0.016
0.834PheTyr: 0.834 ± 0.023
0.0PheXaa: 0.0 ± 0.0
Gly
9.541GlyAla: 9.541 ± 0.086
0.858GlyCys: 0.858 ± 0.026
4.067GlyAsp: 4.067 ± 0.057
4.514GlyGlu: 4.514 ± 0.05
3.2GlyPhe: 3.2 ± 0.046
7.489GlyGly: 7.489 ± 0.115
1.967GlyHis: 1.967 ± 0.037
4.253GlyIle: 4.253 ± 0.052
3.302GlyLys: 3.302 ± 0.052
8.998GlyLeu: 8.998 ± 0.08
2.567GlyMet: 2.567 ± 0.046
2.173GlyAsn: 2.173 ± 0.042
3.543GlyPro: 3.543 ± 0.046
3.225GlyGln: 3.225 ± 0.043
6.593GlyArg: 6.593 ± 0.07
4.71GlySer: 4.71 ± 0.06
4.781GlyThr: 4.781 ± 0.056
6.493GlyVal: 6.493 ± 0.074
1.375GlyTrp: 1.375 ± 0.032
2.577GlyTyr: 2.577 ± 0.042
0.0GlyXaa: 0.0 ± 0.0
His
2.98HisAla: 2.98 ± 0.049
0.271HisCys: 0.271 ± 0.012
1.181HisAsp: 1.181 ± 0.028
1.088HisGlu: 1.088 ± 0.026
0.847HisPhe: 0.847 ± 0.024
2.199HisGly: 2.199 ± 0.039
0.606HisHis: 0.606 ± 0.022
0.979HisIle: 0.979 ± 0.026
0.439HisLys: 0.439 ± 0.017
2.224HisLeu: 2.224 ± 0.036
0.483HisMet: 0.483 ± 0.019
0.435HisAsn: 0.435 ± 0.015
1.672HisPro: 1.672 ± 0.037
0.635HisGln: 0.635 ± 0.021
1.677HisArg: 1.677 ± 0.029
0.947HisSer: 0.947 ± 0.025
0.982HisThr: 0.982 ± 0.025
1.779HisVal: 1.779 ± 0.035
0.354HisTrp: 0.354 ± 0.015
0.606HisTyr: 0.606 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
6.198IleAla: 6.198 ± 0.069
0.394IleCys: 0.394 ± 0.016
3.095IleAsp: 3.095 ± 0.05
3.114IleGlu: 3.114 ± 0.048
1.221IlePhe: 1.221 ± 0.031
4.196IleGly: 4.196 ± 0.056
0.832IleHis: 0.832 ± 0.024
1.538IleIle: 1.538 ± 0.034
1.291IleLys: 1.291 ± 0.033
3.555IleLeu: 3.555 ± 0.049
0.801IleMet: 0.801 ± 0.02
1.236IleAsn: 1.236 ± 0.028
2.217IlePro: 2.217 ± 0.036
1.279IleGln: 1.279 ± 0.03
3.07IleArg: 3.07 ± 0.046
2.246IleSer: 2.246 ± 0.041
2.112IleThr: 2.112 ± 0.033
3.85IleVal: 3.85 ± 0.044
0.494IleTrp: 0.494 ± 0.018
0.972IleTyr: 0.972 ± 0.027
0.0IleXaa: 0.0 ± 0.0
Lys
3.524LysAla: 3.524 ± 0.059
0.14LysCys: 0.14 ± 0.009
1.361LysAsp: 1.361 ± 0.033
1.466LysGlu: 1.466 ± 0.034
0.754LysPhe: 0.754 ± 0.023
2.15LysGly: 2.15 ± 0.034
0.559LysHis: 0.559 ± 0.019
1.215LysIle: 1.215 ± 0.028
1.042LysLys: 1.042 ± 0.03
3.276LysLeu: 3.276 ± 0.047
0.689LysMet: 0.689 ± 0.021
0.767LysAsn: 0.767 ± 0.022
1.859LysPro: 1.859 ± 0.037
1.128LysGln: 1.128 ± 0.026
2.18LysArg: 2.18 ± 0.037
1.534LysSer: 1.534 ± 0.032
1.658LysThr: 1.658 ± 0.034
2.237LysVal: 2.237 ± 0.044
0.381LysTrp: 0.381 ± 0.014
0.62LysTyr: 0.62 ± 0.024
0.0LysXaa: 0.0 ± 0.0
Leu
15.827LeuAla: 15.827 ± 0.12
1.016LeuCys: 1.016 ± 0.022
6.034LeuAsp: 6.034 ± 0.061
5.433LeuGlu: 5.433 ± 0.064
3.361LeuPhe: 3.361 ± 0.053
8.803LeuGly: 8.803 ± 0.07
2.258LeuHis: 2.258 ± 0.041
4.108LeuIle: 4.108 ± 0.054
3.128LeuLys: 3.128 ± 0.046
10.598LeuLeu: 10.598 ± 0.122
2.307LeuMet: 2.307 ± 0.04
2.527LeuAsn: 2.527 ± 0.046
6.287LeuPro: 6.287 ± 0.063
3.346LeuGln: 3.346 ± 0.047
8.171LeuArg: 8.171 ± 0.079
5.849LeuSer: 5.849 ± 0.064
4.938LeuThr: 4.938 ± 0.058
7.683LeuVal: 7.683 ± 0.075
1.179LeuTrp: 1.179 ± 0.031
2.185LeuTyr: 2.185 ± 0.042
0.0LeuXaa: 0.0 ± 0.0
Met
3.112MetAla: 3.112 ± 0.043
0.158MetCys: 0.158 ± 0.009
1.119MetAsp: 1.119 ± 0.028
1.134MetGlu: 1.134 ± 0.028
0.669MetPhe: 0.669 ± 0.02
1.825MetGly: 1.825 ± 0.035
0.561MetHis: 0.561 ± 0.019
0.959MetIle: 0.959 ± 0.024
0.91MetLys: 0.91 ± 0.022
2.78MetLeu: 2.78 ± 0.044
0.562MetMet: 0.562 ± 0.018
0.753MetAsn: 0.753 ± 0.021
1.628MetPro: 1.628 ± 0.029
1.023MetGln: 1.023 ± 0.027
1.958MetArg: 1.958 ± 0.035
1.518MetSer: 1.518 ± 0.029
1.447MetThr: 1.447 ± 0.029
1.676MetVal: 1.676 ± 0.032
0.197MetTrp: 0.197 ± 0.011
0.374MetTyr: 0.374 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
2.879AsnAla: 2.879 ± 0.043
0.214AsnCys: 0.214 ± 0.01
1.195AsnAsp: 1.195 ± 0.027
1.167AsnGlu: 1.167 ± 0.027
0.831AsnPhe: 0.831 ± 0.022
2.182AsnGly: 2.182 ± 0.044
0.482AsnHis: 0.482 ± 0.018
1.111AsnIle: 1.111 ± 0.029
0.694AsnLys: 0.694 ± 0.021
2.526AsnLeu: 2.526 ± 0.037
0.564AsnMet: 0.564 ± 0.018
0.634AsnAsn: 0.634 ± 0.026
1.686AsnPro: 1.686 ± 0.031
0.75AsnGln: 0.75 ± 0.021
1.798AsnArg: 1.798 ± 0.031
1.053AsnSer: 1.053 ± 0.032
1.225AsnThr: 1.225 ± 0.03
1.899AsnVal: 1.899 ± 0.037
0.388AsnTrp: 0.388 ± 0.016
0.668AsnTyr: 0.668 ± 0.02
0.0AsnXaa: 0.0 ± 0.0
Pro
8.168ProAla: 8.168 ± 0.083
0.389ProCys: 0.389 ± 0.016
3.697ProAsp: 3.697 ± 0.048
3.605ProGlu: 3.605 ± 0.048
1.82ProPhe: 1.82 ± 0.035
5.496ProGly: 5.496 ± 0.063
1.244ProHis: 1.244 ± 0.028
2.12ProIle: 2.12 ± 0.04
1.236ProLys: 1.236 ± 0.031
5.282ProLeu: 5.282 ± 0.057
1.313ProMet: 1.313 ± 0.032
1.191ProAsn: 1.191 ± 0.025
3.03ProPro: 3.03 ± 0.045
1.896ProGln: 1.896 ± 0.035
3.538ProArg: 3.538 ± 0.049
3.004ProSer: 3.004 ± 0.042
2.417ProThr: 2.417 ± 0.046
4.579ProVal: 4.579 ± 0.05
0.788ProTrp: 0.788 ± 0.022
1.531ProTyr: 1.531 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
5.488GlnAla: 5.488 ± 0.067
0.263GlnCys: 0.263 ± 0.011
1.602GlnAsp: 1.602 ± 0.032
1.679GlnGlu: 1.679 ± 0.034
1.053GlnPhe: 1.053 ± 0.027
2.881GlnGly: 2.881 ± 0.041
0.766GlnHis: 0.766 ± 0.018
1.615GlnIle: 1.615 ± 0.033
0.891GlnLys: 0.891 ± 0.026
3.43GlnLeu: 3.43 ± 0.051
0.845GlnMet: 0.845 ± 0.023
0.697GlnAsn: 0.697 ± 0.019
2.174GlnPro: 2.174 ± 0.038
1.479GlnGln: 1.479 ± 0.038
3.023GlnArg: 3.023 ± 0.049
1.746GlnSer: 1.746 ± 0.036
1.627GlnThr: 1.627 ± 0.034
2.759GlnVal: 2.759 ± 0.045
0.586GlnTrp: 0.586 ± 0.017
0.767GlnTyr: 0.767 ± 0.019
0.0GlnXaa: 0.0 ± 0.0
Arg
8.865ArgAla: 8.865 ± 0.089
0.672ArgCys: 0.672 ± 0.021
4.027ArgAsp: 4.027 ± 0.048
4.606ArgGlu: 4.606 ± 0.058
2.833ArgPhe: 2.833 ± 0.045
5.307ArgGly: 5.307 ± 0.057
2.173ArgHis: 2.173 ± 0.036
4.059ArgIle: 4.059 ± 0.047
2.237ArgLys: 2.237 ± 0.04
8.803ArgLeu: 8.803 ± 0.075
2.092ArgMet: 2.092 ± 0.035
1.954ArgAsn: 1.954 ± 0.028
4.088ArgPro: 4.088 ± 0.048
3.177ArgGln: 3.177 ± 0.045
6.519ArgArg: 6.519 ± 0.075
3.78ArgSer: 3.78 ± 0.045
3.689ArgThr: 3.689 ± 0.056
5.274ArgVal: 5.274 ± 0.06
1.188ArgTrp: 1.188 ± 0.026
2.136ArgTyr: 2.136 ± 0.031
0.0ArgXaa: 0.0 ± 0.0
Ser
6.195SerAla: 6.195 ± 0.071
0.482SerCys: 0.482 ± 0.016
2.4SerAsp: 2.4 ± 0.041
2.447SerGlu: 2.447 ± 0.038
1.912SerPhe: 1.912 ± 0.034
5.144SerGly: 5.144 ± 0.059
1.207SerHis: 1.207 ± 0.026
2.316SerIle: 2.316 ± 0.037
1.317SerLys: 1.317 ± 0.029
5.511SerLeu: 5.511 ± 0.062
1.387SerMet: 1.387 ± 0.028
1.231SerAsn: 1.231 ± 0.031
3.12SerPro: 3.12 ± 0.048
1.728SerGln: 1.728 ± 0.033
3.937SerArg: 3.937 ± 0.046
3.137SerSer: 3.137 ± 0.045
2.698SerThr: 2.698 ± 0.039
3.885SerVal: 3.885 ± 0.048
0.748SerTrp: 0.748 ± 0.021
1.279SerTyr: 1.279 ± 0.029
0.0SerXaa: 0.0 ± 0.0
Thr
5.694ThrAla: 5.694 ± 0.069
0.397ThrCys: 0.397 ± 0.015
2.421ThrAsp: 2.421 ± 0.035
2.268ThrGlu: 2.268 ± 0.04
1.632ThrPhe: 1.632 ± 0.035
4.714ThrGly: 4.714 ± 0.061
1.087ThrHis: 1.087 ± 0.026
2.112ThrIle: 2.112 ± 0.036
0.956ThrLys: 0.956 ± 0.026
5.965ThrLeu: 5.965 ± 0.063
1.065ThrMet: 1.065 ± 0.026
1.021ThrAsn: 1.021 ± 0.028
3.576ThrPro: 3.576 ± 0.045
1.552ThrGln: 1.552 ± 0.031
3.573ThrArg: 3.573 ± 0.045
2.532ThrSer: 2.532 ± 0.038
2.427ThrThr: 2.427 ± 0.042
4.169ThrVal: 4.169 ± 0.056
0.638ThrTrp: 0.638 ± 0.017
1.082ThrTyr: 1.082 ± 0.027
0.0ThrXaa: 0.0 ± 0.0
Val
9.964ValAla: 9.964 ± 0.078
0.74ValCys: 0.74 ± 0.021
4.236ValAsp: 4.236 ± 0.051
4.329ValGlu: 4.329 ± 0.049
2.668ValPhe: 2.668 ± 0.04
5.606ValGly: 5.606 ± 0.063
1.61ValHis: 1.61 ± 0.032
3.24ValIle: 3.24 ± 0.044
2.208ValLys: 2.208 ± 0.037
8.131ValLeu: 8.131 ± 0.068
1.761ValMet: 1.761 ± 0.034
2.008ValAsn: 2.008 ± 0.041
4.521ValPro: 4.521 ± 0.058
2.494ValGln: 2.494 ± 0.043
5.851ValArg: 5.851 ± 0.062
4.26ValSer: 4.26 ± 0.053
3.726ValThr: 3.726 ± 0.049
6.458ValVal: 6.458 ± 0.072
0.867ValTrp: 0.867 ± 0.022
1.605ValTyr: 1.605 ± 0.03
0.0ValXaa: 0.0 ± 0.0
Trp
1.288TrpAla: 1.288 ± 0.031
0.137TrpCys: 0.137 ± 0.008
0.578TrpAsp: 0.578 ± 0.021
0.595TrpGlu: 0.595 ± 0.02
0.542TrpPhe: 0.542 ± 0.016
0.955TrpGly: 0.955 ± 0.029
0.38TrpHis: 0.38 ± 0.016
0.67TrpIle: 0.67 ± 0.021
0.472TrpLys: 0.472 ± 0.016
1.871TrpLeu: 1.871 ± 0.036
0.423TrpMet: 0.423 ± 0.016
0.436TrpAsn: 0.436 ± 0.017
0.743TrpPro: 0.743 ± 0.021
0.642TrpGln: 0.642 ± 0.018
1.312TrpArg: 1.312 ± 0.027
0.761TrpSer: 0.761 ± 0.02
0.705TrpThr: 0.705 ± 0.022
0.935TrpVal: 0.935 ± 0.022
0.237TrpTrp: 0.237 ± 0.011
0.292TrpTyr: 0.292 ± 0.014
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.887TyrAla: 2.887 ± 0.044
0.266TyrCys: 0.266 ± 0.013
1.436TyrAsp: 1.436 ± 0.027
1.226TyrGlu: 1.226 ± 0.025
0.849TyrPhe: 0.849 ± 0.02
2.288TyrGly: 2.288 ± 0.041
0.492TyrHis: 0.492 ± 0.017
0.741TyrIle: 0.741 ± 0.02
0.678TyrLys: 0.678 ± 0.023
2.482TyrLeu: 2.482 ± 0.043
0.41TyrMet: 0.41 ± 0.016
0.573TyrAsn: 0.573 ± 0.018
1.344TyrPro: 1.344 ± 0.031
0.816TyrGln: 0.816 ± 0.02
2.036TyrArg: 2.036 ± 0.038
1.109TyrSer: 1.109 ± 0.026
1.251TyrThr: 1.251 ± 0.027
1.817TyrVal: 1.817 ± 0.034
0.377TyrTrp: 0.377 ± 0.016
0.605TyrTyr: 0.605 ± 0.018
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5314 proteins (1716856 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski