Amino acid dipepetide frequency for Salmonella phage SS1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.777AlaAla: 10.777 ± 1.651
0.61AlaCys: 0.61 ± 0.284
8.235AlaAsp: 8.235 ± 0.847
7.32AlaGlu: 7.32 ± 0.944
4.372AlaPhe: 4.372 ± 0.803
7.523AlaGly: 7.523 ± 0.936
1.22AlaHis: 1.22 ± 0.348
4.168AlaIle: 4.168 ± 0.69
5.795AlaLys: 5.795 ± 1.013
8.235AlaLeu: 8.235 ± 1.127
2.643AlaMet: 2.643 ± 0.564
3.05AlaAsn: 3.05 ± 0.524
3.152AlaPro: 3.152 ± 0.607
3.558AlaGln: 3.558 ± 0.733
5.083AlaArg: 5.083 ± 0.91
6.812AlaSer: 6.812 ± 1.066
5.388AlaThr: 5.388 ± 0.878
7.422AlaVal: 7.422 ± 1.055
1.22AlaTrp: 1.22 ± 0.347
2.847AlaTyr: 2.847 ± 0.473
0.0AlaXaa: 0.0 ± 0.0
Cys
0.813CysAla: 0.813 ± 0.256
0.0CysCys: 0.0 ± 0.0
0.407CysAsp: 0.407 ± 0.164
1.017CysGlu: 1.017 ± 0.433
0.407CysPhe: 0.407 ± 0.208
0.61CysGly: 0.61 ± 0.28
0.102CysHis: 0.102 ± 0.102
0.102CysIle: 0.102 ± 0.096
0.712CysLys: 0.712 ± 0.278
1.017CysLeu: 1.017 ± 0.367
0.305CysMet: 0.305 ± 0.164
0.407CysAsn: 0.407 ± 0.243
0.203CysPro: 0.203 ± 0.124
0.102CysGln: 0.102 ± 0.084
0.508CysArg: 0.508 ± 0.245
0.0CysSer: 0.0 ± 0.0
0.508CysThr: 0.508 ± 0.202
0.407CysVal: 0.407 ± 0.18
0.203CysTrp: 0.203 ± 0.149
0.305CysTyr: 0.305 ± 0.176
0.0CysXaa: 0.0 ± 0.0
Asp
8.032AspAla: 8.032 ± 0.974
0.407AspCys: 0.407 ± 0.251
4.067AspAsp: 4.067 ± 0.678
3.66AspGlu: 3.66 ± 0.728
3.05AspPhe: 3.05 ± 0.54
6.1AspGly: 6.1 ± 1.105
0.407AspHis: 0.407 ± 0.175
3.457AspIle: 3.457 ± 0.427
3.355AspLys: 3.355 ± 0.408
5.185AspLeu: 5.185 ± 0.599
1.423AspMet: 1.423 ± 0.329
2.847AspAsn: 2.847 ± 0.502
2.135AspPro: 2.135 ± 0.464
0.813AspGln: 0.813 ± 0.244
2.847AspArg: 2.847 ± 0.471
3.66AspSer: 3.66 ± 0.646
4.677AspThr: 4.677 ± 0.519
3.66AspVal: 3.66 ± 0.535
0.915AspTrp: 0.915 ± 0.26
2.033AspTyr: 2.033 ± 0.576
0.0AspXaa: 0.0 ± 0.0
Glu
5.998GluAla: 5.998 ± 0.955
0.407GluCys: 0.407 ± 0.198
3.762GluAsp: 3.762 ± 0.598
4.778GluGlu: 4.778 ± 1.003
2.847GluPhe: 2.847 ± 0.71
4.27GluGly: 4.27 ± 0.693
0.813GluHis: 0.813 ± 0.299
3.762GluIle: 3.762 ± 0.506
4.88GluLys: 4.88 ± 0.757
6.913GluLeu: 6.913 ± 1.1
2.643GluMet: 2.643 ± 0.494
2.338GluAsn: 2.338 ± 0.49
1.322GluPro: 1.322 ± 0.508
3.457GluGln: 3.457 ± 0.71
4.067GluArg: 4.067 ± 0.753
4.473GluSer: 4.473 ± 0.549
3.66GluThr: 3.66 ± 0.617
4.88GluVal: 4.88 ± 0.612
0.915GluTrp: 0.915 ± 0.301
1.83GluTyr: 1.83 ± 0.487
0.0GluXaa: 0.0 ± 0.0
Phe
2.542PheAla: 2.542 ± 0.448
0.61PheCys: 0.61 ± 0.238
2.745PheAsp: 2.745 ± 0.519
3.152PheGlu: 3.152 ± 0.712
0.813PhePhe: 0.813 ± 0.26
3.355PheGly: 3.355 ± 0.619
0.813PheHis: 0.813 ± 0.345
2.948PheIle: 2.948 ± 0.546
1.728PheLys: 1.728 ± 0.433
1.627PheLeu: 1.627 ± 0.419
0.407PheMet: 0.407 ± 0.189
1.83PheAsn: 1.83 ± 0.495
1.525PhePro: 1.525 ± 0.447
1.525PheGln: 1.525 ± 0.326
2.135PheArg: 2.135 ± 0.334
2.542PheSer: 2.542 ± 0.585
3.762PheThr: 3.762 ± 0.75
2.745PheVal: 2.745 ± 0.615
0.813PheTrp: 0.813 ± 0.338
0.813PheTyr: 0.813 ± 0.254
0.0PheXaa: 0.0 ± 0.0
Gly
7.523GlyAla: 7.523 ± 0.766
1.017GlyCys: 1.017 ± 0.393
3.66GlyAsp: 3.66 ± 0.756
6.303GlyGlu: 6.303 ± 0.924
3.355GlyPhe: 3.355 ± 0.745
6.1GlyGly: 6.1 ± 0.98
1.423GlyHis: 1.423 ± 0.497
3.965GlyIle: 3.965 ± 0.673
5.083GlyLys: 5.083 ± 0.684
5.49GlyLeu: 5.49 ± 0.555
1.932GlyMet: 1.932 ± 0.428
4.067GlyAsn: 4.067 ± 0.719
2.135GlyPro: 2.135 ± 0.405
2.542GlyGln: 2.542 ± 0.434
3.863GlyArg: 3.863 ± 0.636
5.998GlySer: 5.998 ± 1.178
3.762GlyThr: 3.762 ± 0.74
5.693GlyVal: 5.693 ± 0.789
1.322GlyTrp: 1.322 ± 0.335
2.44GlyTyr: 2.44 ± 0.505
0.0GlyXaa: 0.0 ± 0.0
His
0.915HisAla: 0.915 ± 0.247
0.203HisCys: 0.203 ± 0.149
0.813HisAsp: 0.813 ± 0.276
0.915HisGlu: 0.915 ± 0.295
0.407HisPhe: 0.407 ± 0.219
0.813HisGly: 0.813 ± 0.37
0.508HisHis: 0.508 ± 0.263
0.407HisIle: 0.407 ± 0.184
1.017HisLys: 1.017 ± 0.303
1.423HisLeu: 1.423 ± 0.441
0.407HisMet: 0.407 ± 0.184
0.407HisAsn: 0.407 ± 0.19
0.915HisPro: 0.915 ± 0.329
0.813HisGln: 0.813 ± 0.197
1.017HisArg: 1.017 ± 0.28
0.915HisSer: 0.915 ± 0.329
0.203HisThr: 0.203 ± 0.145
0.712HisVal: 0.712 ± 0.305
0.0HisTrp: 0.0 ± 0.0
0.712HisTyr: 0.712 ± 0.28
0.0HisXaa: 0.0 ± 0.0
Ile
4.778IleAla: 4.778 ± 0.947
0.407IleCys: 0.407 ± 0.21
3.762IleAsp: 3.762 ± 0.671
3.05IleGlu: 3.05 ± 0.511
1.525IlePhe: 1.525 ± 0.327
3.355IleGly: 3.355 ± 0.513
0.508IleHis: 0.508 ± 0.232
2.338IleIle: 2.338 ± 0.419
2.745IleLys: 2.745 ± 0.552
3.253IleLeu: 3.253 ± 0.579
1.22IleMet: 1.22 ± 0.4
2.135IleAsn: 2.135 ± 0.529
2.338IlePro: 2.338 ± 0.38
2.338IleGln: 2.338 ± 0.536
2.643IleArg: 2.643 ± 0.462
3.66IleSer: 3.66 ± 0.59
4.982IleThr: 4.982 ± 0.73
2.948IleVal: 2.948 ± 0.594
0.712IleTrp: 0.712 ± 0.251
1.118IleTyr: 1.118 ± 0.428
0.0IleXaa: 0.0 ± 0.0
Lys
6.303LysAla: 6.303 ± 1.046
0.712LysCys: 0.712 ± 0.298
4.168LysAsp: 4.168 ± 0.655
4.168LysGlu: 4.168 ± 0.824
2.643LysPhe: 2.643 ± 0.419
3.152LysGly: 3.152 ± 0.544
1.22LysHis: 1.22 ± 0.273
1.627LysIle: 1.627 ± 0.412
2.948LysLys: 2.948 ± 0.637
5.083LysLeu: 5.083 ± 0.729
2.847LysMet: 2.847 ± 0.63
2.542LysAsn: 2.542 ± 0.469
2.135LysPro: 2.135 ± 0.597
2.033LysGln: 2.033 ± 0.504
3.66LysArg: 3.66 ± 0.77
2.44LysSer: 2.44 ± 0.544
4.372LysThr: 4.372 ± 0.499
3.05LysVal: 3.05 ± 0.553
0.508LysTrp: 0.508 ± 0.185
2.338LysTyr: 2.338 ± 0.477
0.0LysXaa: 0.0 ± 0.0
Leu
7.015LeuAla: 7.015 ± 0.852
0.61LeuCys: 0.61 ± 0.278
4.982LeuAsp: 4.982 ± 0.652
5.287LeuGlu: 5.287 ± 0.895
1.118LeuPhe: 1.118 ± 0.316
5.185LeuGly: 5.185 ± 0.613
1.118LeuHis: 1.118 ± 0.346
4.575LeuIle: 4.575 ± 0.525
5.287LeuLys: 5.287 ± 0.83
7.015LeuLeu: 7.015 ± 0.712
1.627LeuMet: 1.627 ± 0.333
4.473LeuAsn: 4.473 ± 0.708
3.863LeuPro: 3.863 ± 0.708
3.152LeuGln: 3.152 ± 0.495
5.897LeuArg: 5.897 ± 0.817
4.168LeuSer: 4.168 ± 0.494
5.693LeuThr: 5.693 ± 0.63
5.49LeuVal: 5.49 ± 0.686
0.915LeuTrp: 0.915 ± 0.376
2.237LeuTyr: 2.237 ± 0.377
0.0LeuXaa: 0.0 ± 0.0
Met
3.152MetAla: 3.152 ± 0.368
0.305MetCys: 0.305 ± 0.181
1.22MetAsp: 1.22 ± 0.373
1.423MetGlu: 1.423 ± 0.368
0.915MetPhe: 0.915 ± 0.324
1.423MetGly: 1.423 ± 0.358
0.203MetHis: 0.203 ± 0.127
1.22MetIle: 1.22 ± 0.402
1.525MetLys: 1.525 ± 0.505
2.338MetLeu: 2.338 ± 0.47
0.203MetMet: 0.203 ± 0.156
1.322MetAsn: 1.322 ± 0.425
0.915MetPro: 0.915 ± 0.275
0.813MetGln: 0.813 ± 0.254
1.525MetArg: 1.525 ± 0.36
2.135MetSer: 2.135 ± 0.381
1.322MetThr: 1.322 ± 0.325
2.135MetVal: 2.135 ± 0.488
0.407MetTrp: 0.407 ± 0.173
0.203MetTyr: 0.203 ± 0.135
0.0MetXaa: 0.0 ± 0.0
Asn
3.965AsnAla: 3.965 ± 0.661
0.508AsnCys: 0.508 ± 0.273
3.355AsnAsp: 3.355 ± 0.533
2.033AsnGlu: 2.033 ± 0.583
2.135AsnPhe: 2.135 ± 0.375
4.677AsnGly: 4.677 ± 0.793
0.508AsnHis: 0.508 ± 0.196
3.152AsnIle: 3.152 ± 0.473
1.525AsnLys: 1.525 ± 0.428
3.558AsnLeu: 3.558 ± 0.435
0.915AsnMet: 0.915 ± 0.354
1.932AsnAsn: 1.932 ± 0.417
1.728AsnPro: 1.728 ± 0.43
1.22AsnGln: 1.22 ± 0.392
2.237AsnArg: 2.237 ± 0.408
1.83AsnSer: 1.83 ± 0.327
1.932AsnThr: 1.932 ± 0.438
4.575AsnVal: 4.575 ± 0.515
0.813AsnTrp: 0.813 ± 0.273
1.728AsnTyr: 1.728 ± 0.436
0.0AsnXaa: 0.0 ± 0.0
Pro
2.948ProAla: 2.948 ± 0.589
0.407ProCys: 0.407 ± 0.184
2.948ProAsp: 2.948 ± 0.61
3.05ProGlu: 3.05 ± 0.522
1.525ProPhe: 1.525 ± 0.341
3.152ProGly: 3.152 ± 0.655
0.407ProHis: 0.407 ± 0.186
1.22ProIle: 1.22 ± 0.361
2.338ProLys: 2.338 ± 0.425
3.457ProLeu: 3.457 ± 0.658
0.813ProMet: 0.813 ± 0.27
1.118ProAsn: 1.118 ± 0.406
0.813ProPro: 0.813 ± 0.247
1.322ProGln: 1.322 ± 0.35
1.525ProArg: 1.525 ± 0.375
2.237ProSer: 2.237 ± 0.449
1.423ProThr: 1.423 ± 0.355
3.558ProVal: 3.558 ± 0.534
0.407ProTrp: 0.407 ± 0.262
1.627ProTyr: 1.627 ± 0.396
0.0ProXaa: 0.0 ± 0.0
Gln
4.372GlnAla: 4.372 ± 0.783
0.203GlnCys: 0.203 ± 0.136
1.423GlnAsp: 1.423 ± 0.327
2.44GlnGlu: 2.44 ± 0.565
1.322GlnPhe: 1.322 ± 0.368
2.745GlnGly: 2.745 ± 0.567
0.813GlnHis: 0.813 ± 0.282
1.728GlnIle: 1.728 ± 0.427
2.338GlnLys: 2.338 ± 0.456
3.253GlnLeu: 3.253 ± 0.613
1.118GlnMet: 1.118 ± 0.341
1.932GlnAsn: 1.932 ± 0.392
2.135GlnPro: 2.135 ± 0.457
2.338GlnGln: 2.338 ± 0.689
2.135GlnArg: 2.135 ± 0.412
1.627GlnSer: 1.627 ± 0.367
1.83GlnThr: 1.83 ± 0.439
2.948GlnVal: 2.948 ± 0.572
0.813GlnTrp: 0.813 ± 0.289
1.423GlnTyr: 1.423 ± 0.334
0.0GlnXaa: 0.0 ± 0.0
Arg
4.778ArgAla: 4.778 ± 0.513
0.102ArgCys: 0.102 ± 0.097
3.558ArgAsp: 3.558 ± 0.567
3.253ArgGlu: 3.253 ± 0.534
1.728ArgPhe: 1.728 ± 0.401
4.27ArgGly: 4.27 ± 0.522
0.712ArgHis: 0.712 ± 0.28
2.745ArgIle: 2.745 ± 0.549
3.762ArgLys: 3.762 ± 0.717
4.27ArgLeu: 4.27 ± 0.629
1.83ArgMet: 1.83 ± 0.459
2.948ArgAsn: 2.948 ± 0.586
2.135ArgPro: 2.135 ± 0.428
3.762ArgGln: 3.762 ± 0.689
4.372ArgArg: 4.372 ± 0.847
2.542ArgSer: 2.542 ± 0.462
3.253ArgThr: 3.253 ± 0.56
4.27ArgVal: 4.27 ± 0.628
1.118ArgTrp: 1.118 ± 0.306
1.118ArgTyr: 1.118 ± 0.373
0.0ArgXaa: 0.0 ± 0.0
Ser
6.913SerAla: 6.913 ± 1.221
0.102SerCys: 0.102 ± 0.096
2.745SerAsp: 2.745 ± 0.523
3.66SerGlu: 3.66 ± 0.667
2.44SerPhe: 2.44 ± 0.473
7.015SerGly: 7.015 ± 0.966
0.813SerHis: 0.813 ± 0.264
2.948SerIle: 2.948 ± 0.617
2.948SerLys: 2.948 ± 0.581
4.677SerLeu: 4.677 ± 0.656
1.118SerMet: 1.118 ± 0.338
2.948SerAsn: 2.948 ± 0.564
1.322SerPro: 1.322 ± 0.395
1.932SerGln: 1.932 ± 0.405
3.152SerArg: 3.152 ± 0.708
2.542SerSer: 2.542 ± 0.609
4.372SerThr: 4.372 ± 0.59
5.998SerVal: 5.998 ± 0.9
0.61SerTrp: 0.61 ± 0.209
1.932SerTyr: 1.932 ± 0.365
0.0SerXaa: 0.0 ± 0.0
Thr
6.812ThrAla: 6.812 ± 0.788
0.407ThrCys: 0.407 ± 0.188
4.067ThrAsp: 4.067 ± 0.569
3.355ThrGlu: 3.355 ± 0.514
3.355ThrPhe: 3.355 ± 0.545
6.1ThrGly: 6.1 ± 1.008
0.508ThrHis: 0.508 ± 0.243
2.745ThrIle: 2.745 ± 0.534
2.542ThrLys: 2.542 ± 0.46
4.575ThrLeu: 4.575 ± 0.691
1.017ThrMet: 1.017 ± 0.383
2.44ThrAsn: 2.44 ± 0.656
3.762ThrPro: 3.762 ± 0.582
2.033ThrGln: 2.033 ± 0.45
3.355ThrArg: 3.355 ± 0.547
3.965ThrSer: 3.965 ± 0.673
4.067ThrThr: 4.067 ± 0.598
5.083ThrVal: 5.083 ± 0.884
1.017ThrTrp: 1.017 ± 0.316
2.44ThrTyr: 2.44 ± 0.547
0.0ThrXaa: 0.0 ± 0.0
Val
7.828ValAla: 7.828 ± 1.016
0.712ValCys: 0.712 ± 0.241
4.372ValAsp: 4.372 ± 0.544
6.405ValGlu: 6.405 ± 0.631
2.338ValPhe: 2.338 ± 0.546
3.762ValGly: 3.762 ± 0.591
0.712ValHis: 0.712 ± 0.233
5.083ValIle: 5.083 ± 0.799
4.575ValLys: 4.575 ± 0.758
4.575ValLeu: 4.575 ± 0.686
0.712ValMet: 0.712 ± 0.305
3.457ValAsn: 3.457 ± 0.639
2.237ValPro: 2.237 ± 0.715
2.745ValGln: 2.745 ± 0.475
3.558ValArg: 3.558 ± 0.599
6.1ValSer: 6.1 ± 0.953
5.49ValThr: 5.49 ± 0.68
6.507ValVal: 6.507 ± 1.217
1.118ValTrp: 1.118 ± 0.347
2.643ValTyr: 2.643 ± 0.458
0.0ValXaa: 0.0 ± 0.0
Trp
1.22TrpAla: 1.22 ± 0.57
0.102TrpCys: 0.102 ± 0.084
0.813TrpAsp: 0.813 ± 0.281
0.407TrpGlu: 0.407 ± 0.161
0.915TrpPhe: 0.915 ± 0.358
1.22TrpGly: 1.22 ± 0.327
0.305TrpHis: 0.305 ± 0.239
0.305TrpIle: 0.305 ± 0.17
0.407TrpLys: 0.407 ± 0.202
1.525TrpLeu: 1.525 ± 0.368
0.61TrpMet: 0.61 ± 0.233
0.61TrpAsn: 0.61 ± 0.34
0.305TrpPro: 0.305 ± 0.215
0.813TrpGln: 0.813 ± 0.284
1.22TrpArg: 1.22 ± 0.423
0.61TrpSer: 0.61 ± 0.245
0.915TrpThr: 0.915 ± 0.27
1.322TrpVal: 1.322 ± 0.308
0.203TrpTrp: 0.203 ± 0.134
0.203TrpTyr: 0.203 ± 0.147
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.745TyrAla: 2.745 ± 0.614
0.305TyrCys: 0.305 ± 0.163
1.627TyrAsp: 1.627 ± 0.443
2.338TyrGlu: 2.338 ± 0.542
1.22TyrPhe: 1.22 ± 0.326
2.847TyrGly: 2.847 ± 0.468
0.407TyrHis: 0.407 ± 0.168
1.322TyrIle: 1.322 ± 0.314
2.542TyrLys: 2.542 ± 0.562
2.237TyrLeu: 2.237 ± 0.46
0.813TyrMet: 0.813 ± 0.265
1.525TyrAsn: 1.525 ± 0.368
1.22TyrPro: 1.22 ± 0.372
1.627TyrGln: 1.627 ± 0.377
1.728TyrArg: 1.728 ± 0.409
1.932TyrSer: 1.932 ± 0.451
2.033TyrThr: 2.033 ± 0.355
1.525TyrVal: 1.525 ± 0.361
0.0TyrTrp: 0.0 ± 0.0
1.017TyrTyr: 1.017 ± 0.259
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 44 proteins (9837 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski