Amino acid dipepetide frequency for Frondihabitans sp. PAMC 28766

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.412AlaAla: 19.412 ± 0.208	0.655AlaCys: 0.655 ± 0.023	7.702AlaAsp: 7.702 ± 0.072	6.747AlaGlu: 6.747 ± 0.082	3.929AlaPhe: 3.929 ± 0.052	11.866AlaGly: 11.866 ± 0.119	2.38AlaHis: 2.38 ± 0.043	5.726AlaIle: 5.726 ± 0.068	2.949AlaLys: 2.949 ± 0.066	13.512AlaLeu: 13.512 ± 0.122	2.442AlaMet: 2.442 ± 0.047	2.473AlaAsn: 2.473 ± 0.056	6.302AlaPro: 6.302 ± 0.101	3.712AlaGln: 3.712 ± 0.067	8.421AlaArg: 8.421 ± 0.107	8.58AlaSer: 8.58 ± 0.092	8.522AlaThr: 8.522 ± 0.115	11.106AlaVal: 11.106 ± 0.113	1.768AlaTrp: 1.768 ± 0.043	2.263AlaTyr: 2.263 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	0.582CysAla: 0.582 ± 0.023	0.057CysCys: 0.057 ± 0.007	0.29CysAsp: 0.29 ± 0.017	0.209CysGlu: 0.209 ± 0.013	0.177CysPhe: 0.177 ± 0.012	0.529CysGly: 0.529 ± 0.02	0.119CysHis: 0.119 ± 0.009	0.209CysIle: 0.209 ± 0.013	0.059CysLys: 0.059 ± 0.007	0.464CysLeu: 0.464 ± 0.021	0.075CysMet: 0.075 ± 0.007	0.099CysAsn: 0.099 ± 0.01	0.268CysPro: 0.268 ± 0.014	0.128CysGln: 0.128 ± 0.008	0.32CysArg: 0.32 ± 0.016	0.408CysSer: 0.408 ± 0.017	0.33CysThr: 0.33 ± 0.018	0.423CysVal: 0.423 ± 0.019	0.073CysTrp: 0.073 ± 0.008	0.096CysTyr: 0.096 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.849AspAla: 7.849 ± 0.091	0.254AspCys: 0.254 ± 0.013	4.549AspAsp: 4.549 ± 0.092	4.205AspGlu: 4.205 ± 0.072	1.913AspPhe: 1.913 ± 0.039	5.754AspGly: 5.754 ± 0.083	1.301AspHis: 1.301 ± 0.034	2.411AspIle: 2.411 ± 0.054	1.147AspLys: 1.147 ± 0.034	6.326AspLeu: 6.326 ± 0.071	0.773AspMet: 0.773 ± 0.027	1.04AspAsn: 1.04 ± 0.034	3.93AspPro: 3.93 ± 0.056	1.662AspGln: 1.662 ± 0.044	4.296AspArg: 4.296 ± 0.075	3.237AspSer: 3.237 ± 0.058	3.228AspThr: 3.228 ± 0.068	5.513AspVal: 5.513 ± 0.066	0.883AspTrp: 0.883 ± 0.028	1.349AspTyr: 1.349 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	6.676GluAla: 6.676 ± 0.094	0.2GluCys: 0.2 ± 0.014	1.917GluAsp: 1.917 ± 0.038	2.179GluGlu: 2.179 ± 0.05	1.667GluPhe: 1.667 ± 0.037	3.693GluGly: 3.693 ± 0.062	1.41GluHis: 1.41 ± 0.038	2.642GluIle: 2.642 ± 0.051	1.504GluLys: 1.504 ± 0.043	5.505GluLeu: 5.505 ± 0.083	0.857GluMet: 0.857 ± 0.025	1.137GluAsn: 1.137 ± 0.03	2.665GluPro: 2.665 ± 0.053	1.884GluGln: 1.884 ± 0.046	4.158GluArg: 4.158 ± 0.083	2.894GluSer: 2.894 ± 0.053	3.154GluThr: 3.154 ± 0.054	4.1GluVal: 4.1 ± 0.071	0.835GluTrp: 0.835 ± 0.026	0.999GluTyr: 0.999 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	4.303PheAla: 4.303 ± 0.065	0.194PheCys: 0.194 ± 0.012	2.621PheAsp: 2.621 ± 0.05	1.751PheGlu: 1.751 ± 0.035	1.142PhePhe: 1.142 ± 0.038	3.504PheGly: 3.504 ± 0.061	0.618PheHis: 0.618 ± 0.023	1.185PheIle: 1.185 ± 0.033	0.463PheLys: 0.463 ± 0.022	2.676PheLeu: 2.676 ± 0.048	0.473PheMet: 0.473 ± 0.022	0.665PheAsn: 0.665 ± 0.024	1.383PhePro: 1.383 ± 0.034	0.813PheGln: 0.813 ± 0.03	1.807PheArg: 1.807 ± 0.045	1.955PheSer: 1.955 ± 0.047	2.381PheThr: 2.381 ± 0.05	3.131PheVal: 3.131 ± 0.055	0.506PheTrp: 0.506 ± 0.022	0.658PheTyr: 0.658 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	10.486GlyAla: 10.486 ± 0.103	0.504GlyCys: 0.504 ± 0.023	5.113GlyAsp: 5.113 ± 0.078	4.065GlyGlu: 4.065 ± 0.067	3.419GlyPhe: 3.419 ± 0.053	7.694GlyGly: 7.694 ± 0.108	1.917GlyHis: 1.917 ± 0.041	4.648GlyIle: 4.648 ± 0.072	2.175GlyLys: 2.175 ± 0.05	9.09GlyLeu: 9.09 ± 0.092	1.671GlyMet: 1.671 ± 0.038	1.789GlyAsn: 1.789 ± 0.045	3.835GlyPro: 3.835 ± 0.063	2.688GlyGln: 2.688 ± 0.048	6.239GlyArg: 6.239 ± 0.083	6.484GlySer: 6.484 ± 0.093	6.069GlyThr: 6.069 ± 0.134	7.862GlyVal: 7.862 ± 0.085	1.529GlyTrp: 1.529 ± 0.038	2.321GlyTyr: 2.321 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.291HisAla: 2.291 ± 0.045	0.111HisCys: 0.111 ± 0.01	1.514HisAsp: 1.514 ± 0.038	1.124HisGlu: 1.124 ± 0.032	0.683HisPhe: 0.683 ± 0.026	2.014HisGly: 2.014 ± 0.041	0.527HisHis: 0.527 ± 0.024	0.728HisIle: 0.728 ± 0.025	0.287HisLys: 0.287 ± 0.017	2.15HisLeu: 2.15 ± 0.042	0.271HisMet: 0.271 ± 0.017	0.348HisAsn: 0.348 ± 0.017	1.467HisPro: 1.467 ± 0.039	0.586HisGln: 0.586 ± 0.022	1.519HisArg: 1.519 ± 0.037	1.169HisSer: 1.169 ± 0.029	1.027HisThr: 1.027 ± 0.032	1.838HisVal: 1.838 ± 0.045	0.302HisTrp: 0.302 ± 0.015	0.435HisTyr: 0.435 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	6.53IleAla: 6.53 ± 0.074	0.233IleCys: 0.233 ± 0.012	3.479IleAsp: 3.479 ± 0.062	2.557IleGlu: 2.557 ± 0.045	1.175IlePhe: 1.175 ± 0.043	4.5IleGly: 4.5 ± 0.069	0.749IleHis: 0.749 ± 0.023	1.708IleIle: 1.708 ± 0.048	0.852IleLys: 0.852 ± 0.03	4.105IleLeu: 4.105 ± 0.063	0.598IleMet: 0.598 ± 0.024	0.923IleAsn: 0.923 ± 0.031	2.201IlePro: 2.201 ± 0.047	1.073IleGln: 1.073 ± 0.03	2.68IleArg: 2.68 ± 0.052	2.531IleSer: 2.531 ± 0.047	3.11IleThr: 3.11 ± 0.052	4.728IleVal: 4.728 ± 0.072	0.482IleTrp: 0.482 ± 0.02	0.775IleTyr: 0.775 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	2.992LysAla: 2.992 ± 0.06	0.075LysCys: 0.075 ± 0.007	1.057LysAsp: 1.057 ± 0.034	0.86LysGlu: 0.86 ± 0.032	0.576LysPhe: 0.576 ± 0.022	1.779LysGly: 1.779 ± 0.043	0.485LysHis: 0.485 ± 0.022	1.049LysIle: 1.049 ± 0.034	0.967LysLys: 0.967 ± 0.036	1.985LysLeu: 1.985 ± 0.045	0.415LysMet: 0.415 ± 0.019	0.712LysAsn: 0.712 ± 0.031	1.358LysPro: 1.358 ± 0.034	0.834LysGln: 0.834 ± 0.026	1.535LysArg: 1.535 ± 0.038	1.548LysSer: 1.548 ± 0.038	1.679LysThr: 1.679 ± 0.048	1.807LysVal: 1.807 ± 0.048	0.294LysTrp: 0.294 ± 0.016	0.527LysTyr: 0.527 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	13.628LeuAla: 13.628 ± 0.112	0.51LeuCys: 0.51 ± 0.023	6.732LeuAsp: 6.732 ± 0.092	5.015LeuGlu: 5.015 ± 0.073	2.922LeuPhe: 2.922 ± 0.064	9.123LeuGly: 9.123 ± 0.094	1.946LeuHis: 1.946 ± 0.044	4.192LeuIle: 4.192 ± 0.075	1.983LeuLys: 1.983 ± 0.046	9.583LeuLeu: 9.583 ± 0.127	1.591LeuMet: 1.591 ± 0.032	1.843LeuAsn: 1.843 ± 0.041	5.498LeuPro: 5.498 ± 0.067	2.51LeuGln: 2.51 ± 0.05	6.748LeuArg: 6.748 ± 0.085	6.148LeuSer: 6.148 ± 0.073	6.615LeuThr: 6.615 ± 0.078	9.268LeuVal: 9.268 ± 0.118	1.205LeuTrp: 1.205 ± 0.032	1.684LeuTyr: 1.684 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	2.109MetAla: 2.109 ± 0.047	0.097MetCys: 0.097 ± 0.009	0.723MetAsp: 0.723 ± 0.025	0.595MetGlu: 0.595 ± 0.024	0.498MetPhe: 0.498 ± 0.019	1.17MetGly: 1.17 ± 0.032	0.334MetHis: 0.334 ± 0.018	0.889MetIle: 0.889 ± 0.026	0.493MetLys: 0.493 ± 0.02	1.653MetLeu: 1.653 ± 0.043	0.293MetMet: 0.293 ± 0.015	0.483MetAsn: 0.483 ± 0.02	1.072MetPro: 1.072 ± 0.031	0.486MetGln: 0.486 ± 0.019	1.297MetArg: 1.297 ± 0.031	1.43MetSer: 1.43 ± 0.03	1.741MetThr: 1.741 ± 0.037	1.255MetVal: 1.255 ± 0.033	0.166MetTrp: 0.166 ± 0.012	0.263MetTyr: 0.263 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.545AsnAla: 2.545 ± 0.044	0.112AsnCys: 0.112 ± 0.01	1.235AsnAsp: 1.235 ± 0.034	0.983AsnGlu: 0.983 ± 0.031	0.643AsnPhe: 0.643 ± 0.024	2.107AsnGly: 2.107 ± 0.046	0.41AsnHis: 0.41 ± 0.019	0.826AsnIle: 0.826 ± 0.029	0.502AsnLys: 0.502 ± 0.023	1.978AsnLeu: 1.978 ± 0.041	0.329AsnMet: 0.329 ± 0.015	0.558AsnAsn: 0.558 ± 0.023	1.484AsnPro: 1.484 ± 0.034	0.617AsnGln: 0.617 ± 0.025	1.293AsnArg: 1.293 ± 0.034	1.255AsnSer: 1.255 ± 0.034	1.319AsnThr: 1.319 ± 0.04	1.837AsnVal: 1.837 ± 0.037	0.314AsnTrp: 0.314 ± 0.016	0.57AsnTyr: 0.57 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	7.107ProAla: 7.107 ± 0.101	0.175ProCys: 0.175 ± 0.011	3.65ProAsp: 3.65 ± 0.065	3.158ProGlu: 3.158 ± 0.064	1.734ProPhe: 1.734 ± 0.034	5.113ProGly: 5.113 ± 0.077	1.023ProHis: 1.023 ± 0.028	2.14ProIle: 2.14 ± 0.044	1.158ProLys: 1.158 ± 0.032	4.799ProLeu: 4.799 ± 0.069	0.889ProMet: 0.889 ± 0.025	1.127ProAsn: 1.127 ± 0.03	2.179ProPro: 2.179 ± 0.051	1.486ProGln: 1.486 ± 0.037	3.177ProArg: 3.177 ± 0.053	3.667ProSer: 3.667 ± 0.068	3.925ProThr: 3.925 ± 0.065	4.793ProVal: 4.793 ± 0.075	0.814ProTrp: 0.814 ± 0.026	1.023ProTyr: 1.023 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	3.625GlnAla: 3.625 ± 0.061	0.116GlnCys: 0.116 ± 0.009	1.538GlnAsp: 1.538 ± 0.036	1.106GlnGlu: 1.106 ± 0.031	0.905GlnPhe: 0.905 ± 0.029	2.293GlnGly: 2.293 ± 0.044	0.68GlnHis: 0.68 ± 0.025	1.409GlnIle: 1.409 ± 0.036	0.873GlnLys: 0.873 ± 0.027	3.069GlnLeu: 3.069 ± 0.058	0.519GlnMet: 0.519 ± 0.023	0.697GlnAsn: 0.697 ± 0.026	1.547GlnPro: 1.547 ± 0.039	1.284GlnGln: 1.284 ± 0.041	2.175GlnArg: 2.175 ± 0.049	1.738GlnSer: 1.738 ± 0.039	1.822GlnThr: 1.822 ± 0.041	2.378GlnVal: 2.378 ± 0.047	0.445GlnTrp: 0.445 ± 0.018	0.619GlnTyr: 0.619 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	8.038ArgAla: 8.038 ± 0.108	0.289ArgCys: 0.289 ± 0.016	4.225ArgAsp: 4.225 ± 0.072	3.689ArgGlu: 3.689 ± 0.063	2.309ArgPhe: 2.309 ± 0.05	5.071ArgGly: 5.071 ± 0.073	1.617ArgHis: 1.617 ± 0.038	3.419ArgIle: 3.419 ± 0.049	1.313ArgLys: 1.313 ± 0.032	7.124ArgLeu: 7.124 ± 0.096	1.512ArgMet: 1.512 ± 0.033	1.232ArgAsn: 1.232 ± 0.036	3.579ArgPro: 3.579 ± 0.063	2.123ArgGln: 2.123 ± 0.046	6.144ArgArg: 6.144 ± 0.105	4.26ArgSer: 4.26 ± 0.074	3.849ArgThr: 3.849 ± 0.061	5.642ArgVal: 5.642 ± 0.083	1.014ArgTrp: 1.014 ± 0.032	1.465ArgTyr: 1.465 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	7.954SerAla: 7.954 ± 0.096	0.33SerCys: 0.33 ± 0.019	3.587SerAsp: 3.587 ± 0.058	2.693SerGlu: 2.693 ± 0.056	2.129SerPhe: 2.129 ± 0.044	6.426SerGly: 6.426 ± 0.086	1.288SerHis: 1.288 ± 0.029	3.141SerIle: 3.141 ± 0.058	1.557SerLys: 1.557 ± 0.041	6.059SerLeu: 6.059 ± 0.076	1.34SerMet: 1.34 ± 0.034	1.485SerAsn: 1.485 ± 0.041	3.604SerPro: 3.604 ± 0.052	1.719SerGln: 1.719 ± 0.036	4.251SerArg: 4.251 ± 0.059	4.827SerSer: 4.827 ± 0.096	4.975SerThr: 4.975 ± 0.089	5.352SerVal: 5.352 ± 0.074	1.005SerTrp: 1.005 ± 0.032	1.351SerTyr: 1.351 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	8.694ThrAla: 8.694 ± 0.121	0.322ThrCys: 0.322 ± 0.018	3.692ThrAsp: 3.692 ± 0.069	2.831ThrGlu: 2.831 ± 0.053	2.109ThrPhe: 2.109 ± 0.042	6.606ThrGly: 6.606 ± 0.112	1.215ThrHis: 1.215 ± 0.027	3.113ThrIle: 3.113 ± 0.068	1.572ThrLys: 1.572 ± 0.041	6.416ThrLeu: 6.416 ± 0.085	1.049ThrMet: 1.049 ± 0.027	1.498ThrAsn: 1.498 ± 0.044	4.266ThrPro: 4.266 ± 0.066	1.679ThrGln: 1.679 ± 0.041	3.932ThrArg: 3.932 ± 0.065	4.65ThrSer: 4.65 ± 0.08	5.079ThrThr: 5.079 ± 0.116	6.367ThrVal: 6.367 ± 0.128	0.998ThrTrp: 0.998 ± 0.032	1.411ThrTyr: 1.411 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	11.693ValAla: 11.693 ± 0.114	0.462ValCys: 0.462 ± 0.018	5.958ValAsp: 5.958 ± 0.069	4.697ValGlu: 4.697 ± 0.081	2.944ValPhe: 2.944 ± 0.059	7.411ValGly: 7.411 ± 0.087	1.7ValHis: 1.7 ± 0.039	4.286ValIle: 4.286 ± 0.068	1.87ValLys: 1.87 ± 0.046	8.524ValLeu: 8.524 ± 0.11	1.404ValMet: 1.404 ± 0.038	1.79ValAsn: 1.79 ± 0.036	4.715ValPro: 4.715 ± 0.075	2.314ValGln: 2.314 ± 0.039	5.336ValArg: 5.336 ± 0.082	5.848ValSer: 5.848 ± 0.079	6.488ValThr: 6.488 ± 0.112	9.328ValVal: 9.328 ± 0.11	1.087ValTrp: 1.087 ± 0.032	1.635ValTyr: 1.635 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.595TrpAla: 1.595 ± 0.039	0.102TrpCys: 0.102 ± 0.008	0.643TrpAsp: 0.643 ± 0.023	0.567TrpGlu: 0.567 ± 0.022	0.598TrpPhe: 0.598 ± 0.022	1.05TrpGly: 1.05 ± 0.029	0.336TrpHis: 0.336 ± 0.018	0.624TrpIle: 0.624 ± 0.027	0.382TrpLys: 0.382 ± 0.015	1.626TrpLeu: 1.626 ± 0.033	0.292TrpMet: 0.292 ± 0.015	0.472TrpAsn: 0.472 ± 0.018	0.738TrpPro: 0.738 ± 0.026	0.612TrpGln: 0.612 ± 0.024	1.103TrpArg: 1.103 ± 0.03	1.105TrpSer: 1.105 ± 0.034	0.852TrpThr: 0.852 ± 0.031	1.061TrpVal: 1.061 ± 0.028	0.3TrpTrp: 0.3 ± 0.015	0.259TrpTyr: 0.259 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.362TyrAla: 2.362 ± 0.053	0.119TyrCys: 0.119 ± 0.01	1.396TyrAsp: 1.396 ± 0.037	1.044TyrGlu: 1.044 ± 0.031	0.758TyrPhe: 0.758 ± 0.024	1.894TyrGly: 1.894 ± 0.043	0.334TyrHis: 0.334 ± 0.016	0.644TyrIle: 0.644 ± 0.025	0.427TyrLys: 0.427 ± 0.02	2.101TyrLeu: 2.101 ± 0.044	0.252TyrMet: 0.252 ± 0.014	0.547TyrAsn: 0.547 ± 0.021	1.048TyrPro: 1.048 ± 0.031	0.629TyrGln: 0.629 ± 0.026	1.484TyrArg: 1.484 ± 0.044	1.338TyrSer: 1.338 ± 0.033	1.33TyrThr: 1.33 ± 0.04	1.704TyrVal: 1.704 ± 0.036	0.296TyrTrp: 0.296 ± 0.016	0.493TyrTyr: 0.493 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4103 proteins (1237931 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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