Amino acid dipepetide frequency for Streptococcus phage phiARI0468-2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.757AlaAla: 2.757 ± 0.938
0.418AlaCys: 0.418 ± 0.221
5.431AlaAsp: 5.431 ± 0.559
5.932AlaGlu: 5.932 ± 0.858
2.674AlaPhe: 2.674 ± 0.712
5.681AlaGly: 5.681 ± 1.231
0.835AlaHis: 0.835 ± 0.306
4.929AlaIle: 4.929 ± 1.12
6.183AlaLys: 6.183 ± 0.764
6.266AlaLeu: 6.266 ± 0.931
2.423AlaMet: 2.423 ± 0.536
4.177AlaAsn: 4.177 ± 0.602
1.587AlaPro: 1.587 ± 0.324
2.172AlaGln: 2.172 ± 0.471
2.841AlaArg: 2.841 ± 0.615
2.924AlaSer: 2.924 ± 1.002
5.013AlaThr: 5.013 ± 0.833
5.932AlaVal: 5.932 ± 0.795
1.42AlaTrp: 1.42 ± 0.471
1.838AlaTyr: 1.838 ± 0.405
0.0AlaXaa: 0.0 ± 0.0
Cys
0.334CysAla: 0.334 ± 0.152
0.084CysCys: 0.084 ± 0.084
0.334CysAsp: 0.334 ± 0.166
0.334CysGlu: 0.334 ± 0.163
0.334CysPhe: 0.334 ± 0.195
0.167CysGly: 0.167 ± 0.176
0.084CysHis: 0.084 ± 0.065
0.334CysIle: 0.334 ± 0.208
0.668CysLys: 0.668 ± 0.2
0.418CysLeu: 0.418 ± 0.171
0.084CysMet: 0.084 ± 0.095
0.167CysAsn: 0.167 ± 0.167
0.418CysPro: 0.418 ± 0.234
0.251CysGln: 0.251 ± 0.15
0.251CysArg: 0.251 ± 0.144
0.251CysSer: 0.251 ± 0.164
0.167CysThr: 0.167 ± 0.136
0.167CysVal: 0.167 ± 0.113
0.167CysTrp: 0.167 ± 0.098
0.334CysTyr: 0.334 ± 0.137
0.0CysXaa: 0.0 ± 0.0
Asp
3.342AspAla: 3.342 ± 0.837
0.585AspCys: 0.585 ± 0.271
3.175AspAsp: 3.175 ± 0.799
4.679AspGlu: 4.679 ± 1.078
3.175AspPhe: 3.175 ± 0.553
4.679AspGly: 4.679 ± 0.679
0.167AspHis: 0.167 ± 0.114
5.264AspIle: 5.264 ± 0.549
5.013AspLys: 5.013 ± 0.844
5.096AspLeu: 5.096 ± 0.755
1.587AspMet: 1.587 ± 0.321
2.59AspAsn: 2.59 ± 0.458
1.922AspPro: 1.922 ± 0.479
2.005AspGln: 2.005 ± 0.486
2.59AspArg: 2.59 ± 0.501
3.509AspSer: 3.509 ± 0.581
3.175AspThr: 3.175 ± 0.458
3.843AspVal: 3.843 ± 0.379
1.671AspTrp: 1.671 ± 0.365
2.841AspTyr: 2.841 ± 0.49
0.0AspXaa: 0.0 ± 0.0
Glu
6.684GluAla: 6.684 ± 0.831
0.334GluCys: 0.334 ± 0.159
3.927GluAsp: 3.927 ± 0.649
6.099GluGlu: 6.099 ± 1.301
3.927GluPhe: 3.927 ± 0.627
3.76GluGly: 3.76 ± 0.596
1.086GluHis: 1.086 ± 0.325
6.016GluIle: 6.016 ± 0.664
6.684GluLys: 6.684 ± 1.488
8.271GluLeu: 8.271 ± 0.929
1.838GluMet: 1.838 ± 0.485
3.426GluAsn: 3.426 ± 0.662
1.003GluPro: 1.003 ± 0.343
3.175GluGln: 3.175 ± 0.803
3.76GluArg: 3.76 ± 0.505
4.846GluSer: 4.846 ± 0.632
4.177GluThr: 4.177 ± 0.687
5.431GluVal: 5.431 ± 0.705
1.337GluTrp: 1.337 ± 0.295
3.175GluTyr: 3.175 ± 0.541
0.0GluXaa: 0.0 ± 0.0
Phe
2.423PheAla: 2.423 ± 0.57
0.334PheCys: 0.334 ± 0.227
4.01PheAsp: 4.01 ± 0.538
4.261PheGlu: 4.261 ± 0.672
1.587PhePhe: 1.587 ± 0.365
2.59PheGly: 2.59 ± 0.724
0.251PheHis: 0.251 ± 0.17
2.172PheIle: 2.172 ± 0.405
3.509PheLys: 3.509 ± 0.791
2.339PheLeu: 2.339 ± 0.416
1.17PheMet: 1.17 ± 0.37
2.757PheAsn: 2.757 ± 0.51
0.752PhePro: 0.752 ± 0.252
1.42PheGln: 1.42 ± 0.342
1.671PheArg: 1.671 ± 0.307
3.342PheSer: 3.342 ± 0.732
2.924PheThr: 2.924 ± 0.509
1.504PheVal: 1.504 ± 0.321
0.585PheTrp: 0.585 ± 0.216
2.005PheTyr: 2.005 ± 0.423
0.0PheXaa: 0.0 ± 0.0
Gly
3.843GlyAla: 3.843 ± 0.712
0.167GlyCys: 0.167 ± 0.132
3.426GlyAsp: 3.426 ± 0.636
4.261GlyGlu: 4.261 ± 0.781
2.841GlyPhe: 2.841 ± 0.673
5.264GlyGly: 5.264 ± 1.385
0.835GlyHis: 0.835 ± 0.2
3.342GlyIle: 3.342 ± 0.59
5.18GlyLys: 5.18 ± 0.577
6.35GlyLeu: 6.35 ± 1.156
1.922GlyMet: 1.922 ± 0.306
3.76GlyAsn: 3.76 ± 0.518
1.253GlyPro: 1.253 ± 0.35
3.676GlyGln: 3.676 ± 0.521
3.593GlyArg: 3.593 ± 0.598
4.094GlySer: 4.094 ± 0.825
3.258GlyThr: 3.258 ± 0.552
4.428GlyVal: 4.428 ± 0.791
1.086GlyTrp: 1.086 ± 0.475
3.091GlyTyr: 3.091 ± 0.558
0.0GlyXaa: 0.0 ± 0.0
His
0.585HisAla: 0.585 ± 0.236
0.0HisCys: 0.0 ± 0.0
0.752HisAsp: 0.752 ± 0.328
1.253HisGlu: 1.253 ± 0.31
0.835HisPhe: 0.835 ± 0.316
1.003HisGly: 1.003 ± 0.269
0.251HisHis: 0.251 ± 0.142
0.919HisIle: 0.919 ± 0.369
0.501HisLys: 0.501 ± 0.31
1.42HisLeu: 1.42 ± 0.366
0.251HisMet: 0.251 ± 0.15
0.919HisAsn: 0.919 ± 0.25
0.752HisPro: 0.752 ± 0.263
0.418HisGln: 0.418 ± 0.189
0.501HisArg: 0.501 ± 0.176
1.671HisSer: 1.671 ± 0.527
0.668HisThr: 0.668 ± 0.225
0.585HisVal: 0.585 ± 0.201
0.167HisTrp: 0.167 ± 0.143
0.585HisTyr: 0.585 ± 0.214
0.0HisXaa: 0.0 ± 0.0
Ile
5.18IleAla: 5.18 ± 0.82
0.585IleCys: 0.585 ± 0.135
3.593IleAsp: 3.593 ± 0.601
6.016IleGlu: 6.016 ± 0.722
3.008IlePhe: 3.008 ± 0.633
4.345IleGly: 4.345 ± 0.833
0.585IleHis: 0.585 ± 0.265
2.924IleIle: 2.924 ± 0.462
6.935IleLys: 6.935 ± 0.751
3.843IleLeu: 3.843 ± 0.675
1.42IleMet: 1.42 ± 0.359
3.342IleAsn: 3.342 ± 0.582
1.755IlePro: 1.755 ± 0.381
2.256IleGln: 2.256 ± 0.352
3.426IleArg: 3.426 ± 0.64
4.345IleSer: 4.345 ± 0.804
4.428IleThr: 4.428 ± 0.591
3.509IleVal: 3.509 ± 0.62
0.501IleTrp: 0.501 ± 0.184
2.089IleTyr: 2.089 ± 0.54
0.0IleXaa: 0.0 ± 0.0
Lys
5.431LysAla: 5.431 ± 0.7
0.501LysCys: 0.501 ± 0.278
6.016LysAsp: 6.016 ± 0.705
7.185LysGlu: 7.185 ± 0.996
3.175LysPhe: 3.175 ± 0.742
5.013LysGly: 5.013 ± 0.72
1.922LysHis: 1.922 ± 0.443
5.013LysIle: 5.013 ± 0.714
7.436LysLys: 7.436 ± 1.176
7.102LysLeu: 7.102 ± 0.739
2.423LysMet: 2.423 ± 0.386
4.679LysAsn: 4.679 ± 0.664
2.506LysPro: 2.506 ± 0.596
3.342LysGln: 3.342 ± 0.583
3.676LysArg: 3.676 ± 0.426
4.846LysSer: 4.846 ± 0.556
5.848LysThr: 5.848 ± 0.775
5.347LysVal: 5.347 ± 0.747
1.337LysTrp: 1.337 ± 0.396
3.091LysTyr: 3.091 ± 0.508
0.0LysXaa: 0.0 ± 0.0
Leu
7.018LeuAla: 7.018 ± 0.854
0.501LeuCys: 0.501 ± 0.259
5.096LeuAsp: 5.096 ± 0.683
6.767LeuGlu: 6.767 ± 0.936
2.506LeuPhe: 2.506 ± 0.448
5.932LeuGly: 5.932 ± 1.43
1.086LeuHis: 1.086 ± 0.32
4.428LeuIle: 4.428 ± 0.6
7.185LeuLys: 7.185 ± 0.86
6.016LeuLeu: 6.016 ± 0.845
2.089LeuMet: 2.089 ± 0.444
3.593LeuAsn: 3.593 ± 0.655
3.175LeuPro: 3.175 ± 0.606
3.008LeuGln: 3.008 ± 0.625
3.342LeuArg: 3.342 ± 0.638
5.013LeuSer: 5.013 ± 0.857
5.096LeuThr: 5.096 ± 0.808
4.762LeuVal: 4.762 ± 0.965
0.501LeuTrp: 0.501 ± 0.189
2.089LeuTyr: 2.089 ± 0.296
0.0LeuXaa: 0.0 ± 0.0
Met
1.838MetAla: 1.838 ± 0.444
0.0MetCys: 0.0 ± 0.0
1.17MetAsp: 1.17 ± 0.237
1.838MetGlu: 1.838 ± 0.467
1.003MetPhe: 1.003 ± 0.246
1.42MetGly: 1.42 ± 0.466
0.167MetHis: 0.167 ± 0.124
1.755MetIle: 1.755 ± 0.468
2.172MetLys: 2.172 ± 0.412
1.671MetLeu: 1.671 ± 0.372
0.334MetMet: 0.334 ± 0.166
1.42MetAsn: 1.42 ± 0.449
1.086MetPro: 1.086 ± 0.275
0.585MetGln: 0.585 ± 0.293
1.253MetArg: 1.253 ± 0.309
1.337MetSer: 1.337 ± 0.396
1.838MetThr: 1.838 ± 0.43
1.755MetVal: 1.755 ± 0.314
0.251MetTrp: 0.251 ± 0.138
0.752MetTyr: 0.752 ± 0.22
0.0MetXaa: 0.0 ± 0.0
Asn
4.428AsnAla: 4.428 ± 1.038
0.334AsnCys: 0.334 ± 0.138
2.757AsnAsp: 2.757 ± 0.531
3.008AsnGlu: 3.008 ± 0.593
2.423AsnPhe: 2.423 ± 0.465
3.927AsnGly: 3.927 ± 0.664
0.835AsnHis: 0.835 ± 0.272
2.674AsnIle: 2.674 ± 0.478
4.345AsnLys: 4.345 ± 0.529
4.512AsnLeu: 4.512 ± 0.628
1.253AsnMet: 1.253 ± 0.388
2.506AsnAsn: 2.506 ± 0.681
2.256AsnPro: 2.256 ± 0.375
3.258AsnGln: 3.258 ± 0.602
2.339AsnArg: 2.339 ± 0.554
3.342AsnSer: 3.342 ± 0.764
2.674AsnThr: 2.674 ± 0.474
3.258AsnVal: 3.258 ± 0.454
0.919AsnTrp: 0.919 ± 0.243
2.172AsnTyr: 2.172 ± 0.355
0.0AsnXaa: 0.0 ± 0.0
Pro
2.256ProAla: 2.256 ± 0.582
0.084ProCys: 0.084 ± 0.088
2.005ProAsp: 2.005 ± 0.438
3.091ProGlu: 3.091 ± 0.439
0.835ProPhe: 0.835 ± 0.302
1.086ProGly: 1.086 ± 0.221
0.334ProHis: 0.334 ± 0.146
2.005ProIle: 2.005 ± 0.535
3.008ProLys: 3.008 ± 0.467
1.671ProLeu: 1.671 ± 0.501
0.668ProMet: 0.668 ± 0.276
1.755ProAsn: 1.755 ± 0.473
0.418ProPro: 0.418 ± 0.201
0.835ProGln: 0.835 ± 0.293
1.253ProArg: 1.253 ± 0.346
1.838ProSer: 1.838 ± 0.573
0.919ProThr: 0.919 ± 0.293
2.339ProVal: 2.339 ± 0.495
0.418ProTrp: 0.418 ± 0.173
1.42ProTyr: 1.42 ± 0.457
0.0ProXaa: 0.0 ± 0.0
Gln
4.177GlnAla: 4.177 ± 0.655
0.084GlnCys: 0.084 ± 0.084
1.504GlnAsp: 1.504 ± 0.359
3.426GlnGlu: 3.426 ± 0.727
1.42GlnPhe: 1.42 ± 0.343
1.838GlnGly: 1.838 ± 0.385
0.585GlnHis: 0.585 ± 0.253
3.091GlnIle: 3.091 ± 0.471
3.593GlnLys: 3.593 ± 0.444
2.674GlnLeu: 2.674 ± 0.408
0.919GlnMet: 0.919 ± 0.265
1.838GlnAsn: 1.838 ± 0.442
1.337GlnPro: 1.337 ± 0.38
1.671GlnGln: 1.671 ± 0.451
1.838GlnArg: 1.838 ± 0.413
2.423GlnSer: 2.423 ± 0.363
3.509GlnThr: 3.509 ± 0.46
3.258GlnVal: 3.258 ± 0.508
0.418GlnTrp: 0.418 ± 0.159
1.086GlnTyr: 1.086 ± 0.353
0.0GlnXaa: 0.0 ± 0.0
Arg
3.593ArgAla: 3.593 ± 0.597
0.334ArgCys: 0.334 ± 0.175
2.423ArgAsp: 2.423 ± 0.506
3.008ArgGlu: 3.008 ± 0.631
1.755ArgPhe: 1.755 ± 0.441
1.838ArgGly: 1.838 ± 0.475
0.919ArgHis: 0.919 ± 0.303
3.091ArgIle: 3.091 ± 0.498
3.008ArgLys: 3.008 ± 0.755
4.428ArgLeu: 4.428 ± 0.647
1.504ArgMet: 1.504 ± 0.391
2.924ArgAsn: 2.924 ± 0.647
0.919ArgPro: 0.919 ± 0.292
2.59ArgGln: 2.59 ± 0.626
3.091ArgArg: 3.091 ± 0.72
2.256ArgSer: 2.256 ± 0.528
3.091ArgThr: 3.091 ± 0.872
2.423ArgVal: 2.423 ± 0.346
0.501ArgTrp: 0.501 ± 0.181
2.005ArgTyr: 2.005 ± 0.478
0.0ArgXaa: 0.0 ± 0.0
Ser
4.345SerAla: 4.345 ± 1.077
0.084SerCys: 0.084 ± 0.065
3.426SerAsp: 3.426 ± 0.518
4.595SerGlu: 4.595 ± 0.621
2.005SerPhe: 2.005 ± 0.367
5.013SerGly: 5.013 ± 0.71
1.253SerHis: 1.253 ± 0.414
4.094SerIle: 4.094 ± 0.629
4.428SerLys: 4.428 ± 0.586
5.013SerLeu: 5.013 ± 0.598
1.003SerMet: 1.003 ± 0.337
3.593SerAsn: 3.593 ± 0.64
1.42SerPro: 1.42 ± 0.32
2.172SerGln: 2.172 ± 0.461
3.175SerArg: 3.175 ± 0.717
3.593SerSer: 3.593 ± 0.909
4.261SerThr: 4.261 ± 0.545
3.927SerVal: 3.927 ± 0.938
1.086SerTrp: 1.086 ± 0.391
3.008SerTyr: 3.008 ± 0.612
0.0SerXaa: 0.0 ± 0.0
Thr
4.595ThrAla: 4.595 ± 0.978
0.167ThrCys: 0.167 ± 0.13
4.595ThrAsp: 4.595 ± 0.582
4.261ThrGlu: 4.261 ± 0.596
3.342ThrPhe: 3.342 ± 0.729
4.01ThrGly: 4.01 ± 0.682
0.585ThrHis: 0.585 ± 0.267
4.762ThrIle: 4.762 ± 0.608
5.347ThrLys: 5.347 ± 0.746
4.428ThrLeu: 4.428 ± 0.58
0.835ThrMet: 0.835 ± 0.355
3.509ThrAsn: 3.509 ± 0.479
1.838ThrPro: 1.838 ± 0.59
3.091ThrGln: 3.091 ± 0.656
1.504ThrArg: 1.504 ± 0.312
3.843ThrSer: 3.843 ± 0.556
4.595ThrThr: 4.595 ± 0.883
4.01ThrVal: 4.01 ± 0.604
0.585ThrTrp: 0.585 ± 0.256
2.59ThrTyr: 2.59 ± 0.515
0.0ThrXaa: 0.0 ± 0.0
Val
5.598ValAla: 5.598 ± 0.863
0.251ValCys: 0.251 ± 0.151
3.843ValAsp: 3.843 ± 0.523
5.347ValGlu: 5.347 ± 0.675
2.005ValPhe: 2.005 ± 0.432
5.18ValGly: 5.18 ± 0.713
1.17ValHis: 1.17 ± 0.374
4.261ValIle: 4.261 ± 0.747
5.347ValLys: 5.347 ± 0.657
3.843ValLeu: 3.843 ± 0.623
1.086ValMet: 1.086 ± 0.367
3.927ValAsn: 3.927 ± 0.766
2.005ValPro: 2.005 ± 0.311
1.42ValGln: 1.42 ± 0.358
2.757ValArg: 2.757 ± 0.301
5.013ValSer: 5.013 ± 0.581
4.345ValThr: 4.345 ± 0.682
4.679ValVal: 4.679 ± 0.871
0.835ValTrp: 0.835 ± 0.241
1.838ValTyr: 1.838 ± 0.404
0.0ValXaa: 0.0 ± 0.0
Trp
1.17TrpAla: 1.17 ± 0.374
0.167TrpCys: 0.167 ± 0.122
0.919TrpAsp: 0.919 ± 0.404
1.003TrpGlu: 1.003 ± 0.369
1.003TrpPhe: 1.003 ± 0.494
0.585TrpGly: 0.585 ± 0.209
0.167TrpHis: 0.167 ± 0.142
0.668TrpIle: 0.668 ± 0.232
1.42TrpLys: 1.42 ± 0.397
0.835TrpLeu: 0.835 ± 0.351
0.251TrpMet: 0.251 ± 0.143
0.835TrpAsn: 0.835 ± 0.321
0.0TrpPro: 0.0 ± 0.0
1.003TrpGln: 1.003 ± 0.374
0.418TrpArg: 0.418 ± 0.229
0.418TrpSer: 0.418 ± 0.162
0.919TrpThr: 0.919 ± 0.287
1.253TrpVal: 1.253 ± 0.254
0.167TrpTrp: 0.167 ± 0.098
0.919TrpTyr: 0.919 ± 0.518
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.838TyrAla: 1.838 ± 0.299
0.334TyrCys: 0.334 ± 0.168
2.506TyrAsp: 2.506 ± 0.435
2.59TyrGlu: 2.59 ± 0.489
1.838TyrPhe: 1.838 ± 0.431
2.339TyrGly: 2.339 ± 0.441
0.919TyrHis: 0.919 ± 0.265
2.339TyrIle: 2.339 ± 0.578
3.927TyrLys: 3.927 ± 0.74
3.008TyrLeu: 3.008 ± 0.613
0.501TyrMet: 0.501 ± 0.267
1.504TyrAsn: 1.504 ± 0.299
1.838TyrPro: 1.838 ± 0.473
2.339TyrGln: 2.339 ± 0.42
2.423TyrArg: 2.423 ± 0.556
2.59TyrSer: 2.59 ± 0.557
1.587TyrThr: 1.587 ± 0.329
2.339TyrVal: 2.339 ± 0.496
0.167TyrTrp: 0.167 ± 0.094
1.587TyrTyr: 1.587 ± 0.537
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 49 proteins (11970 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski