Amino acid dipepetide frequency for Salmonella phage St161

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.458AlaAla: 12.458 ± 1.988
0.556AlaCys: 0.556 ± 0.275
6.897AlaAsp: 6.897 ± 0.863
6.452AlaGlu: 6.452 ± 0.902
3.893AlaPhe: 3.893 ± 0.61
9.121AlaGly: 9.121 ± 1.099
1.335AlaHis: 1.335 ± 0.383
5.006AlaIle: 5.006 ± 0.982
6.118AlaLys: 6.118 ± 0.952
7.564AlaLeu: 7.564 ± 1.053
2.002AlaMet: 2.002 ± 0.62
4.672AlaAsn: 4.672 ± 0.805
3.56AlaPro: 3.56 ± 0.641
4.894AlaGln: 4.894 ± 0.803
5.784AlaArg: 5.784 ± 0.865
6.785AlaSer: 6.785 ± 0.946
6.34AlaThr: 6.34 ± 0.967
7.786AlaVal: 7.786 ± 0.884
1.557AlaTrp: 1.557 ± 0.528
3.003AlaTyr: 3.003 ± 0.574
0.0AlaXaa: 0.0 ± 0.0
Cys
0.667CysAla: 0.667 ± 0.281
0.0CysCys: 0.0 ± 0.0
0.667CysAsp: 0.667 ± 0.259
0.556CysGlu: 0.556 ± 0.25
0.0CysPhe: 0.0 ± 0.0
1.112CysGly: 1.112 ± 0.376
0.222CysHis: 0.222 ± 0.151
0.0CysIle: 0.0 ± 0.0
0.667CysLys: 0.667 ± 0.259
0.779CysLeu: 0.779 ± 0.383
0.111CysMet: 0.111 ± 0.096
0.334CysAsn: 0.334 ± 0.186
0.222CysPro: 0.222 ± 0.138
0.222CysGln: 0.222 ± 0.135
0.556CysArg: 0.556 ± 0.282
0.222CysSer: 0.222 ± 0.147
0.556CysThr: 0.556 ± 0.207
0.334CysVal: 0.334 ± 0.232
0.222CysTrp: 0.222 ± 0.161
0.667CysTyr: 0.667 ± 0.246
0.0CysXaa: 0.0 ± 0.0
Asp
8.009AspAla: 8.009 ± 0.914
0.667AspCys: 0.667 ± 0.329
2.892AspAsp: 2.892 ± 0.474
4.004AspGlu: 4.004 ± 0.747
2.002AspPhe: 2.002 ± 0.437
5.673AspGly: 5.673 ± 1.0
0.779AspHis: 0.779 ± 0.278
4.004AspIle: 4.004 ± 0.622
3.671AspLys: 3.671 ± 0.574
4.227AspLeu: 4.227 ± 0.588
1.557AspMet: 1.557 ± 0.518
3.226AspAsn: 3.226 ± 0.489
1.446AspPro: 1.446 ± 0.518
1.112AspGln: 1.112 ± 0.448
1.669AspArg: 1.669 ± 0.386
3.337AspSer: 3.337 ± 0.553
4.116AspThr: 4.116 ± 0.575
3.782AspVal: 3.782 ± 0.631
1.224AspTrp: 1.224 ± 0.354
2.336AspTyr: 2.336 ± 0.542
0.0AspXaa: 0.0 ± 0.0
Glu
6.897GluAla: 6.897 ± 1.296
0.222GluCys: 0.222 ± 0.176
4.004GluAsp: 4.004 ± 0.743
2.892GluGlu: 2.892 ± 0.53
2.225GluPhe: 2.225 ± 0.37
4.004GluGly: 4.004 ± 0.621
0.89GluHis: 0.89 ± 0.413
3.782GluIle: 3.782 ± 0.523
3.448GluLys: 3.448 ± 0.685
5.673GluLeu: 5.673 ± 0.909
2.225GluMet: 2.225 ± 0.479
1.891GluAsn: 1.891 ± 0.383
1.891GluPro: 1.891 ± 0.502
3.337GluGln: 3.337 ± 0.66
3.003GluArg: 3.003 ± 0.46
3.448GluSer: 3.448 ± 0.454
3.337GluThr: 3.337 ± 0.582
3.782GluVal: 3.782 ± 0.588
0.667GluTrp: 0.667 ± 0.24
3.115GluTyr: 3.115 ± 0.592
0.0GluXaa: 0.0 ± 0.0
Phe
2.447PheAla: 2.447 ± 0.457
0.334PheCys: 0.334 ± 0.215
2.67PheAsp: 2.67 ± 0.526
2.67PheGlu: 2.67 ± 0.436
1.335PhePhe: 1.335 ± 0.314
3.337PheGly: 3.337 ± 0.492
0.667PheHis: 0.667 ± 0.286
2.225PheIle: 2.225 ± 0.511
1.446PheLys: 1.446 ± 0.355
1.78PheLeu: 1.78 ± 0.43
0.445PheMet: 0.445 ± 0.222
2.336PheAsn: 2.336 ± 0.581
1.001PhePro: 1.001 ± 0.537
0.667PheGln: 0.667 ± 0.249
1.78PheArg: 1.78 ± 0.384
2.781PheSer: 2.781 ± 0.725
2.781PheThr: 2.781 ± 0.803
2.558PheVal: 2.558 ± 0.472
1.112PheTrp: 1.112 ± 0.388
0.556PheTyr: 0.556 ± 0.204
0.0PheXaa: 0.0 ± 0.0
Gly
7.675GlyAla: 7.675 ± 0.837
0.779GlyCys: 0.779 ± 0.36
5.006GlyAsp: 5.006 ± 0.634
5.006GlyGlu: 5.006 ± 0.58
2.558GlyPhe: 2.558 ± 0.445
7.119GlyGly: 7.119 ± 1.445
1.446GlyHis: 1.446 ± 0.525
4.116GlyIle: 4.116 ± 0.711
3.226GlyLys: 3.226 ± 0.606
4.894GlyLeu: 4.894 ± 0.946
1.891GlyMet: 1.891 ± 0.518
4.338GlyAsn: 4.338 ± 0.86
1.891GlyPro: 1.891 ± 0.424
3.115GlyGln: 3.115 ± 0.575
3.671GlyArg: 3.671 ± 0.611
5.562GlySer: 5.562 ± 0.852
4.783GlyThr: 4.783 ± 0.83
6.674GlyVal: 6.674 ± 0.551
0.779GlyTrp: 0.779 ± 0.266
3.337GlyTyr: 3.337 ± 0.534
0.0GlyXaa: 0.0 ± 0.0
His
0.89HisAla: 0.89 ± 0.31
0.334HisCys: 0.334 ± 0.165
1.001HisAsp: 1.001 ± 0.291
0.445HisGlu: 0.445 ± 0.235
0.779HisPhe: 0.779 ± 0.392
0.89HisGly: 0.89 ± 0.403
0.89HisHis: 0.89 ± 0.308
1.112HisIle: 1.112 ± 0.416
1.112HisLys: 1.112 ± 0.377
1.001HisLeu: 1.001 ± 0.401
0.222HisMet: 0.222 ± 0.192
0.667HisAsn: 0.667 ± 0.255
1.335HisPro: 1.335 ± 0.369
0.89HisGln: 0.89 ± 0.24
0.667HisArg: 0.667 ± 0.225
0.779HisSer: 0.779 ± 0.214
0.556HisThr: 0.556 ± 0.259
1.224HisVal: 1.224 ± 0.404
0.111HisTrp: 0.111 ± 0.107
0.334HisTyr: 0.334 ± 0.239
0.0HisXaa: 0.0 ± 0.0
Ile
6.34IleAla: 6.34 ± 0.907
0.779IleCys: 0.779 ± 0.27
2.558IleAsp: 2.558 ± 0.674
3.337IleGlu: 3.337 ± 0.435
1.224IlePhe: 1.224 ± 0.395
3.782IleGly: 3.782 ± 0.625
0.334IleHis: 0.334 ± 0.2
2.781IleIle: 2.781 ± 0.452
2.781IleLys: 2.781 ± 0.475
3.003IleLeu: 3.003 ± 0.601
1.224IleMet: 1.224 ± 0.34
2.892IleAsn: 2.892 ± 0.605
2.892IlePro: 2.892 ± 0.471
2.225IleGln: 2.225 ± 0.446
2.892IleArg: 2.892 ± 0.501
3.893IleSer: 3.893 ± 0.633
4.783IleThr: 4.783 ± 0.841
3.671IleVal: 3.671 ± 0.5
0.779IleTrp: 0.779 ± 0.38
1.891IleTyr: 1.891 ± 0.483
0.0IleXaa: 0.0 ± 0.0
Lys
6.118LysAla: 6.118 ± 0.939
0.556LysCys: 0.556 ± 0.275
2.113LysAsp: 2.113 ± 0.508
3.226LysGlu: 3.226 ± 0.742
2.336LysPhe: 2.336 ± 0.345
3.893LysGly: 3.893 ± 0.633
1.891LysHis: 1.891 ± 0.572
2.67LysIle: 2.67 ± 0.473
3.115LysLys: 3.115 ± 0.596
5.006LysLeu: 5.006 ± 0.902
1.891LysMet: 1.891 ± 0.553
2.113LysAsn: 2.113 ± 0.547
2.781LysPro: 2.781 ± 0.559
1.446LysGln: 1.446 ± 0.462
2.447LysArg: 2.447 ± 0.551
2.336LysSer: 2.336 ± 0.632
4.116LysThr: 4.116 ± 0.62
2.67LysVal: 2.67 ± 0.482
0.779LysTrp: 0.779 ± 0.296
2.781LysTyr: 2.781 ± 0.544
0.0LysXaa: 0.0 ± 0.0
Leu
7.675LeuAla: 7.675 ± 0.793
0.667LeuCys: 0.667 ± 0.285
4.338LeuAsp: 4.338 ± 0.575
4.338LeuGlu: 4.338 ± 0.772
2.002LeuPhe: 2.002 ± 0.451
5.228LeuGly: 5.228 ± 0.669
0.556LeuHis: 0.556 ± 0.276
3.448LeuIle: 3.448 ± 0.46
5.117LeuLys: 5.117 ± 0.845
5.784LeuLeu: 5.784 ± 0.889
2.002LeuMet: 2.002 ± 0.472
4.004LeuAsn: 4.004 ± 0.665
3.337LeuPro: 3.337 ± 0.591
4.338LeuGln: 4.338 ± 0.627
3.56LeuArg: 3.56 ± 0.603
4.783LeuSer: 4.783 ± 0.799
4.561LeuThr: 4.561 ± 0.797
5.228LeuVal: 5.228 ± 0.774
0.779LeuTrp: 0.779 ± 0.264
2.113LeuTyr: 2.113 ± 0.436
0.0LeuXaa: 0.0 ± 0.0
Met
2.781MetAla: 2.781 ± 0.554
0.334MetCys: 0.334 ± 0.196
1.001MetAsp: 1.001 ± 0.371
1.891MetGlu: 1.891 ± 0.473
1.001MetPhe: 1.001 ± 0.357
1.557MetGly: 1.557 ± 0.376
0.445MetHis: 0.445 ± 0.204
1.557MetIle: 1.557 ± 0.472
0.89MetLys: 0.89 ± 0.305
1.001MetLeu: 1.001 ± 0.331
0.779MetMet: 0.779 ± 0.301
0.89MetAsn: 0.89 ± 0.334
0.779MetPro: 0.779 ± 0.286
1.335MetGln: 1.335 ± 0.327
1.335MetArg: 1.335 ± 0.415
2.113MetSer: 2.113 ± 0.449
1.891MetThr: 1.891 ± 0.53
1.891MetVal: 1.891 ± 0.423
0.111MetTrp: 0.111 ± 0.102
0.779MetTyr: 0.779 ± 0.343
0.0MetXaa: 0.0 ± 0.0
Asn
4.449AsnAla: 4.449 ± 0.623
0.334AsnCys: 0.334 ± 0.217
4.004AsnAsp: 4.004 ± 0.712
3.003AsnGlu: 3.003 ± 0.442
1.446AsnPhe: 1.446 ± 0.38
4.338AsnGly: 4.338 ± 0.797
0.89AsnHis: 0.89 ± 0.309
4.338AsnIle: 4.338 ± 0.704
2.225AsnLys: 2.225 ± 0.599
3.226AsnLeu: 3.226 ± 0.446
0.779AsnMet: 0.779 ± 0.327
3.115AsnAsn: 3.115 ± 0.653
1.891AsnPro: 1.891 ± 0.436
1.446AsnGln: 1.446 ± 0.481
2.781AsnArg: 2.781 ± 0.587
2.113AsnSer: 2.113 ± 0.433
3.115AsnThr: 3.115 ± 0.719
2.781AsnVal: 2.781 ± 0.53
0.779AsnTrp: 0.779 ± 0.26
1.335AsnTyr: 1.335 ± 0.412
0.0AsnXaa: 0.0 ± 0.0
Pro
4.116ProAla: 4.116 ± 0.803
0.334ProCys: 0.334 ± 0.199
2.892ProAsp: 2.892 ± 0.484
3.782ProGlu: 3.782 ± 0.427
1.557ProPhe: 1.557 ± 0.322
1.669ProGly: 1.669 ± 0.471
0.222ProHis: 0.222 ± 0.141
1.446ProIle: 1.446 ± 0.387
1.891ProLys: 1.891 ± 0.498
2.892ProLeu: 2.892 ± 0.631
0.89ProMet: 0.89 ± 0.366
2.002ProAsn: 2.002 ± 0.63
0.667ProPro: 0.667 ± 0.279
1.446ProGln: 1.446 ± 0.399
1.446ProArg: 1.446 ± 0.377
2.113ProSer: 2.113 ± 0.411
2.113ProThr: 2.113 ± 0.434
4.338ProVal: 4.338 ± 0.657
0.222ProTrp: 0.222 ± 0.148
1.669ProTyr: 1.669 ± 0.454
0.0ProXaa: 0.0 ± 0.0
Gln
5.117GlnAla: 5.117 ± 0.915
0.222GlnCys: 0.222 ± 0.151
2.558GlnAsp: 2.558 ± 0.544
3.115GlnGlu: 3.115 ± 0.652
1.001GlnPhe: 1.001 ± 0.334
2.336GlnGly: 2.336 ± 0.544
1.001GlnHis: 1.001 ± 0.344
3.115GlnIle: 3.115 ± 0.626
2.225GlnLys: 2.225 ± 0.684
3.56GlnLeu: 3.56 ± 0.632
1.78GlnMet: 1.78 ± 0.451
2.113GlnAsn: 2.113 ± 0.526
1.78GlnPro: 1.78 ± 0.537
3.56GlnGln: 3.56 ± 1.021
2.781GlnArg: 2.781 ± 0.562
1.224GlnSer: 1.224 ± 0.319
2.225GlnThr: 2.225 ± 0.552
2.892GlnVal: 2.892 ± 0.547
0.445GlnTrp: 0.445 ± 0.252
1.669GlnTyr: 1.669 ± 0.462
0.0GlnXaa: 0.0 ± 0.0
Arg
4.116ArgAla: 4.116 ± 0.657
0.334ArgCys: 0.334 ± 0.17
3.115ArgAsp: 3.115 ± 0.582
2.336ArgGlu: 2.336 ± 0.547
1.669ArgPhe: 1.669 ± 0.395
3.782ArgGly: 3.782 ± 0.435
0.667ArgHis: 0.667 ± 0.252
2.67ArgIle: 2.67 ± 0.495
3.115ArgLys: 3.115 ± 0.816
4.116ArgLeu: 4.116 ± 0.684
1.001ArgMet: 1.001 ± 0.293
4.004ArgAsn: 4.004 ± 0.674
1.112ArgPro: 1.112 ± 0.371
3.671ArgGln: 3.671 ± 0.648
3.003ArgArg: 3.003 ± 0.802
2.002ArgSer: 2.002 ± 0.379
3.448ArgThr: 3.448 ± 0.569
4.672ArgVal: 4.672 ± 0.595
0.89ArgTrp: 0.89 ± 0.297
1.335ArgTyr: 1.335 ± 0.371
0.0ArgXaa: 0.0 ± 0.0
Ser
7.786SerAla: 7.786 ± 1.263
0.111SerCys: 0.111 ± 0.096
3.115SerAsp: 3.115 ± 0.593
2.447SerGlu: 2.447 ± 0.516
2.781SerPhe: 2.781 ± 0.583
4.894SerGly: 4.894 ± 0.685
0.667SerHis: 0.667 ± 0.302
2.225SerIle: 2.225 ± 0.595
2.558SerLys: 2.558 ± 0.567
5.117SerLeu: 5.117 ± 0.709
1.446SerMet: 1.446 ± 0.458
2.113SerAsn: 2.113 ± 0.395
3.115SerPro: 3.115 ± 0.516
2.225SerGln: 2.225 ± 0.806
3.115SerArg: 3.115 ± 0.513
2.336SerSer: 2.336 ± 0.532
4.227SerThr: 4.227 ± 0.879
4.783SerVal: 4.783 ± 0.945
0.89SerTrp: 0.89 ± 0.307
1.891SerTyr: 1.891 ± 0.447
0.0SerXaa: 0.0 ± 0.0
Thr
7.453ThrAla: 7.453 ± 1.45
0.334ThrCys: 0.334 ± 0.207
2.781ThrAsp: 2.781 ± 0.535
3.448ThrGlu: 3.448 ± 0.699
2.67ThrPhe: 2.67 ± 0.66
7.119ThrGly: 7.119 ± 1.049
0.334ThrHis: 0.334 ± 0.156
3.671ThrIle: 3.671 ± 0.437
2.781ThrLys: 2.781 ± 0.556
6.34ThrLeu: 6.34 ± 0.877
1.335ThrMet: 1.335 ± 0.398
2.558ThrAsn: 2.558 ± 0.647
3.893ThrPro: 3.893 ± 0.598
2.336ThrGln: 2.336 ± 0.45
2.336ThrArg: 2.336 ± 0.467
4.672ThrSer: 4.672 ± 0.826
4.338ThrThr: 4.338 ± 0.844
4.894ThrVal: 4.894 ± 0.772
0.89ThrTrp: 0.89 ± 0.353
3.003ThrTyr: 3.003 ± 0.568
0.0ThrXaa: 0.0 ± 0.0
Val
7.23ValAla: 7.23 ± 0.773
0.667ValCys: 0.667 ± 0.282
4.338ValAsp: 4.338 ± 0.559
4.116ValGlu: 4.116 ± 0.823
2.225ValPhe: 2.225 ± 0.655
4.561ValGly: 4.561 ± 0.602
1.224ValHis: 1.224 ± 0.419
4.227ValIle: 4.227 ± 0.478
4.561ValLys: 4.561 ± 0.722
4.338ValLeu: 4.338 ± 0.641
1.446ValMet: 1.446 ± 0.541
3.226ValAsn: 3.226 ± 0.507
2.67ValPro: 2.67 ± 0.665
3.115ValGln: 3.115 ± 0.527
4.561ValArg: 4.561 ± 0.609
4.449ValSer: 4.449 ± 0.664
6.007ValThr: 6.007 ± 0.809
6.563ValVal: 6.563 ± 1.016
0.779ValTrp: 0.779 ± 0.411
3.337ValTyr: 3.337 ± 0.61
0.0ValXaa: 0.0 ± 0.0
Trp
0.779TrpAla: 0.779 ± 0.24
0.111TrpCys: 0.111 ± 0.093
1.001TrpAsp: 1.001 ± 0.293
0.556TrpGlu: 0.556 ± 0.259
1.001TrpPhe: 1.001 ± 0.345
0.556TrpGly: 0.556 ± 0.203
0.445TrpHis: 0.445 ± 0.253
0.334TrpIle: 0.334 ± 0.165
0.779TrpLys: 0.779 ± 0.327
1.335TrpLeu: 1.335 ± 0.429
0.334TrpMet: 0.334 ± 0.195
0.667TrpAsn: 0.667 ± 0.236
0.111TrpPro: 0.111 ± 0.096
1.001TrpGln: 1.001 ± 0.358
1.112TrpArg: 1.112 ± 0.349
1.001TrpSer: 1.001 ± 0.324
1.001TrpThr: 1.001 ± 0.293
1.335TrpVal: 1.335 ± 0.294
0.334TrpTrp: 0.334 ± 0.176
0.222TrpTyr: 0.222 ± 0.173
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.781TyrAla: 2.781 ± 0.459
0.445TyrCys: 0.445 ± 0.218
2.781TyrAsp: 2.781 ± 0.563
3.115TyrGlu: 3.115 ± 0.545
1.224TyrPhe: 1.224 ± 0.438
2.892TyrGly: 2.892 ± 0.689
0.334TyrHis: 0.334 ± 0.177
1.335TyrIle: 1.335 ± 0.335
2.558TyrLys: 2.558 ± 0.591
2.225TyrLeu: 2.225 ± 0.449
0.89TyrMet: 0.89 ± 0.346
1.224TyrAsn: 1.224 ± 0.357
1.335TyrPro: 1.335 ± 0.367
2.336TyrGln: 2.336 ± 0.614
2.558TyrArg: 2.558 ± 0.491
2.002TyrSer: 2.002 ± 0.476
2.892TyrThr: 2.892 ± 0.562
1.78TyrVal: 1.78 ± 0.462
0.667TyrTrp: 0.667 ± 0.368
1.112TyrTyr: 1.112 ± 0.307
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 47 proteins (8991 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski