Amino acid dipepetide frequency for Streptomyces alboniger

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.187AlaAla: 21.187 ± 0.167	1.133AlaCys: 1.133 ± 0.022	8.332AlaAsp: 8.332 ± 0.071	9.087AlaGlu: 9.087 ± 0.086	3.529AlaPhe: 3.529 ± 0.044	12.737AlaGly: 12.737 ± 0.097	3.013AlaHis: 3.013 ± 0.043	3.494AlaIle: 3.494 ± 0.048	3.138AlaLys: 3.138 ± 0.06	14.632AlaLeu: 14.632 ± 0.134	2.532AlaMet: 2.532 ± 0.041	1.84AlaAsn: 1.84 ± 0.033	7.407AlaPro: 7.407 ± 0.08	3.754AlaGln: 3.754 ± 0.046	10.488AlaArg: 10.488 ± 0.091	6.031AlaSer: 6.031 ± 0.061	6.824AlaThr: 6.824 ± 0.061	11.978AlaVal: 11.978 ± 0.105	1.873AlaTrp: 1.873 ± 0.03	2.903AlaTyr: 2.903 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	1.198CysAla: 1.198 ± 0.025	0.092CysCys: 0.092 ± 0.007	0.486CysAsp: 0.486 ± 0.016	0.432CysGlu: 0.432 ± 0.014	0.224CysPhe: 0.224 ± 0.01	1.01CysGly: 1.01 ± 0.022	0.187CysHis: 0.187 ± 0.01	0.155CysIle: 0.155 ± 0.009	0.12CysLys: 0.12 ± 0.007	0.751CysLeu: 0.751 ± 0.018	0.142CysMet: 0.142 ± 0.008	0.12CysAsn: 0.12 ± 0.008	0.49CysPro: 0.49 ± 0.016	0.171CysGln: 0.171 ± 0.009	0.618CysArg: 0.618 ± 0.017	0.416CysSer: 0.416 ± 0.014	0.491CysThr: 0.491 ± 0.015	0.704CysVal: 0.704 ± 0.019	0.126CysTrp: 0.126 ± 0.007	0.152CysTyr: 0.152 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	7.824AspAla: 7.824 ± 0.069	0.441AspCys: 0.441 ± 0.016	3.703AspAsp: 3.703 ± 0.048	3.994AspGlu: 3.994 ± 0.048	1.659AspPhe: 1.659 ± 0.031	6.241AspGly: 6.241 ± 0.067	1.403AspHis: 1.403 ± 0.026	1.964AspIle: 1.964 ± 0.032	1.414AspLys: 1.414 ± 0.033	6.245AspLeu: 6.245 ± 0.061	0.865AspMet: 0.865 ± 0.022	0.893AspAsn: 0.893 ± 0.022	4.466AspPro: 4.466 ± 0.044	1.519AspGln: 1.519 ± 0.026	4.887AspArg: 4.887 ± 0.058	2.621AspSer: 2.621 ± 0.035	3.084AspThr: 3.084 ± 0.042	4.702AspVal: 4.702 ± 0.046	0.996AspTrp: 0.996 ± 0.02	1.058AspTyr: 1.058 ± 0.023	0.0AspXaa: 0.0 ± 0.0
Glu	7.689GluAla: 7.689 ± 0.076	0.382GluCys: 0.382 ± 0.013	2.83GluAsp: 2.83 ± 0.036	3.637GluGlu: 3.637 ± 0.05	1.472GluPhe: 1.472 ± 0.032	4.744GluGly: 4.744 ± 0.047	1.506GluHis: 1.506 ± 0.03	2.235GluIle: 2.235 ± 0.034	1.651GluLys: 1.651 ± 0.036	6.996GluLeu: 6.996 ± 0.067	0.888GluMet: 0.888 ± 0.02	1.016GluAsn: 1.016 ± 0.023	3.434GluPro: 3.434 ± 0.04	2.284GluGln: 2.284 ± 0.034	5.878GluArg: 5.878 ± 0.06	2.675GluSer: 2.675 ± 0.034	2.922GluThr: 2.922 ± 0.039	4.535GluVal: 4.535 ± 0.05	0.79GluTrp: 0.79 ± 0.021	1.103GluTyr: 1.103 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	3.648PheAla: 3.648 ± 0.044	0.284PheCys: 0.284 ± 0.012	1.963PheAsp: 1.963 ± 0.035	1.45PheGlu: 1.45 ± 0.027	0.879PhePhe: 0.879 ± 0.023	3.061PheGly: 3.061 ± 0.039	0.604PheHis: 0.604 ± 0.017	0.753PheIle: 0.753 ± 0.019	0.571PheLys: 0.571 ± 0.019	2.598PheLeu: 2.598 ± 0.034	0.416PheMet: 0.416 ± 0.015	0.568PheAsn: 0.568 ± 0.017	1.351PhePro: 1.351 ± 0.025	0.67PheGln: 0.67 ± 0.017	1.836PheArg: 1.836 ± 0.031	1.45PheSer: 1.45 ± 0.025	1.988PheThr: 1.988 ± 0.032	2.199PheVal: 2.199 ± 0.032	0.434PheTrp: 0.434 ± 0.014	0.535PheTyr: 0.535 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	11.468GlyAla: 11.468 ± 0.093	0.84GlyCys: 0.84 ± 0.019	5.287GlyAsp: 5.287 ± 0.056	5.471GlyGlu: 5.471 ± 0.046	2.856GlyPhe: 2.856 ± 0.041	9.169GlyGly: 9.169 ± 0.104	2.349GlyHis: 2.349 ± 0.033	3.386GlyIle: 3.386 ± 0.045	2.723GlyLys: 2.723 ± 0.045	9.4GlyLeu: 9.4 ± 0.07	1.977GlyMet: 1.977 ± 0.029	1.699GlyAsn: 1.699 ± 0.033	5.291GlyPro: 5.291 ± 0.056	2.655GlyGln: 2.655 ± 0.035	7.763GlyArg: 7.763 ± 0.064	5.283GlySer: 5.283 ± 0.06	6.098GlyThr: 6.098 ± 0.053	7.54GlyVal: 7.54 ± 0.073	1.639GlyTrp: 1.639 ± 0.027	2.206GlyTyr: 2.206 ± 0.035	0.0GlyXaa: 0.0 ± 0.0
His	2.76HisAla: 2.76 ± 0.034	0.223HisCys: 0.223 ± 0.009	1.344HisAsp: 1.344 ± 0.027	1.254HisGlu: 1.254 ± 0.024	0.659HisPhe: 0.659 ± 0.02	2.391HisGly: 2.391 ± 0.031	0.705HisHis: 0.705 ± 0.022	0.699HisIle: 0.699 ± 0.019	0.403HisLys: 0.403 ± 0.014	2.392HisLeu: 2.392 ± 0.036	0.35HisMet: 0.35 ± 0.012	0.366HisAsn: 0.366 ± 0.013	1.829HisPro: 1.829 ± 0.032	0.667HisGln: 0.667 ± 0.017	2.118HisArg: 2.118 ± 0.036	1.018HisSer: 1.018 ± 0.022	1.358HisThr: 1.358 ± 0.025	1.661HisVal: 1.661 ± 0.026	0.388HisTrp: 0.388 ± 0.011	0.483HisTyr: 0.483 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	4.755IleAla: 4.755 ± 0.055	0.301IleCys: 0.301 ± 0.012	2.26IleAsp: 2.26 ± 0.035	2.066IleGlu: 2.066 ± 0.034	0.732IlePhe: 0.732 ± 0.02	3.536IleGly: 3.536 ± 0.046	0.626IleHis: 0.626 ± 0.018	0.866IleIle: 0.866 ± 0.024	0.786IleLys: 0.786 ± 0.02	2.434IleLeu: 2.434 ± 0.034	0.428IleMet: 0.428 ± 0.015	0.692IleAsn: 0.692 ± 0.018	1.728IlePro: 1.728 ± 0.031	0.697IleGln: 0.697 ± 0.018	2.166IleArg: 2.166 ± 0.034	1.655IleSer: 1.655 ± 0.03	2.165IleThr: 2.165 ± 0.034	2.668IleVal: 2.668 ± 0.036	0.387IleTrp: 0.387 ± 0.012	0.529IleTyr: 0.529 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	3.272LysAla: 3.272 ± 0.047	0.13LysCys: 0.13 ± 0.009	1.541LysAsp: 1.541 ± 0.032	1.411LysGlu: 1.411 ± 0.03	0.524LysPhe: 0.524 ± 0.016	2.109LysGly: 2.109 ± 0.04	0.456LysHis: 0.456 ± 0.014	0.896LysIle: 0.896 ± 0.021	1.105LysLys: 1.105 ± 0.036	2.188LysLeu: 2.188 ± 0.037	0.428LysMet: 0.428 ± 0.014	0.571LysAsn: 0.571 ± 0.019	1.516LysPro: 1.516 ± 0.035	0.74LysGln: 0.74 ± 0.02	1.598LysArg: 1.598 ± 0.031	1.28LysSer: 1.28 ± 0.029	1.355LysThr: 1.355 ± 0.031	2.035LysVal: 2.035 ± 0.037	0.289LysTrp: 0.289 ± 0.011	0.474LysTyr: 0.474 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	15.137LeuAla: 15.137 ± 0.117	0.888LeuCys: 0.888 ± 0.02	6.639LeuAsp: 6.639 ± 0.067	4.677LeuGlu: 4.677 ± 0.055	2.669LeuPhe: 2.669 ± 0.039	9.303LeuGly: 9.303 ± 0.079	2.317LeuHis: 2.317 ± 0.036	3.378LeuIle: 3.378 ± 0.048	2.196LeuLys: 2.196 ± 0.037	11.262LeuLeu: 11.262 ± 0.099	1.701LeuMet: 1.701 ± 0.027	1.673LeuAsn: 1.673 ± 0.03	6.566LeuPro: 6.566 ± 0.07	2.061LeuGln: 2.061 ± 0.032	8.771LeuArg: 8.771 ± 0.086	5.38LeuSer: 5.38 ± 0.052	6.935LeuThr: 6.935 ± 0.065	8.589LeuVal: 8.589 ± 0.071	1.302LeuTrp: 1.302 ± 0.027	1.835LeuTyr: 1.835 ± 0.029	0.0LeuXaa: 0.0 ± 0.0
Met	2.298MetAla: 2.298 ± 0.035	0.146MetCys: 0.146 ± 0.009	0.909MetAsp: 0.909 ± 0.02	0.789MetGlu: 0.789 ± 0.019	0.457MetPhe: 0.457 ± 0.014	1.362MetGly: 1.362 ± 0.03	0.348MetHis: 0.348 ± 0.014	0.666MetIle: 0.666 ± 0.019	0.447MetLys: 0.447 ± 0.015	1.724MetLeu: 1.724 ± 0.027	0.319MetMet: 0.319 ± 0.014	0.451MetAsn: 0.451 ± 0.013	1.151MetPro: 1.151 ± 0.023	0.427MetGln: 0.427 ± 0.015	1.447MetArg: 1.447 ± 0.027	1.304MetSer: 1.304 ± 0.024	1.476MetThr: 1.476 ± 0.025	1.295MetVal: 1.295 ± 0.025	0.213MetTrp: 0.213 ± 0.008	0.342MetTyr: 0.342 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.114AsnAla: 2.114 ± 0.036	0.162AsnCys: 0.162 ± 0.009	0.934AsnAsp: 0.934 ± 0.021	0.815AsnGlu: 0.815 ± 0.018	0.476AsnPhe: 0.476 ± 0.016	1.802AsnGly: 1.802 ± 0.033	0.382AsnHis: 0.382 ± 0.013	0.636AsnIle: 0.636 ± 0.015	0.449AsnLys: 0.449 ± 0.017	1.592AsnLeu: 1.592 ± 0.032	0.289AsnMet: 0.289 ± 0.012	0.418AsnAsn: 0.418 ± 0.014	1.308AsnPro: 1.308 ± 0.025	0.488AsnGln: 0.488 ± 0.015	1.232AsnArg: 1.232 ± 0.026	0.928AsnSer: 0.928 ± 0.021	1.083AsnThr: 1.083 ± 0.022	1.304AsnVal: 1.304 ± 0.023	0.277AsnTrp: 0.277 ± 0.012	0.39AsnTyr: 0.39 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	8.431ProAla: 8.431 ± 0.081	0.367ProCys: 0.367 ± 0.012	4.488ProAsp: 4.488 ± 0.051	4.422ProGlu: 4.422 ± 0.047	1.537ProPhe: 1.537 ± 0.027	6.756ProGly: 6.756 ± 0.07	1.46ProHis: 1.46 ± 0.03	1.275ProIle: 1.275 ± 0.024	1.38ProLys: 1.38 ± 0.03	5.508ProLeu: 5.508 ± 0.067	1.044ProMet: 1.044 ± 0.024	0.86ProAsn: 0.86 ± 0.02	3.63ProPro: 3.63 ± 0.061	1.782ProGln: 1.782 ± 0.041	4.243ProArg: 4.243 ± 0.053	3.224ProSer: 3.224 ± 0.041	3.168ProThr: 3.168 ± 0.042	5.321ProVal: 5.321 ± 0.053	0.909ProTrp: 0.909 ± 0.019	1.37ProTyr: 1.37 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	3.605GlnAla: 3.605 ± 0.055	0.172GlnCys: 0.172 ± 0.01	1.425GlnAsp: 1.425 ± 0.027	1.509GlnGlu: 1.509 ± 0.026	0.662GlnPhe: 0.662 ± 0.018	2.377GlnGly: 2.377 ± 0.039	0.655GlnHis: 0.655 ± 0.017	1.032GlnIle: 1.032 ± 0.024	0.638GlnLys: 0.638 ± 0.018	3.091GlnLeu: 3.091 ± 0.039	0.482GlnMet: 0.482 ± 0.017	0.488GlnAsn: 0.488 ± 0.014	1.622GlnPro: 1.622 ± 0.034	1.24GlnGln: 1.24 ± 0.037	2.358GlnArg: 2.358 ± 0.035	1.241GlnSer: 1.241 ± 0.024	1.267GlnThr: 1.267 ± 0.024	2.256GlnVal: 2.256 ± 0.035	0.452GlnTrp: 0.452 ± 0.013	0.624GlnTyr: 0.624 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	10.108ArgAla: 10.108 ± 0.082	0.624ArgCys: 0.624 ± 0.02	4.401ArgAsp: 4.401 ± 0.049	4.993ArgGlu: 4.993 ± 0.048	2.335ArgPhe: 2.335 ± 0.035	6.221ArgGly: 6.221 ± 0.063	2.155ArgHis: 2.155 ± 0.034	3.055ArgIle: 3.055 ± 0.042	1.799ArgLys: 1.799 ± 0.035	8.758ArgLeu: 8.758 ± 0.082	1.769ArgMet: 1.769 ± 0.028	1.311ArgAsn: 1.311 ± 0.025	4.962ArgPro: 4.962 ± 0.057	2.308ArgGln: 2.308 ± 0.031	7.705ArgArg: 7.705 ± 0.076	3.95ArgSer: 3.95 ± 0.051	5.42ArgThr: 5.42 ± 0.056	6.019ArgVal: 6.019 ± 0.056	1.387ArgTrp: 1.387 ± 0.025	1.791ArgTyr: 1.791 ± 0.026	0.0ArgXaa: 0.0 ± 0.0
Ser	6.785SerAla: 6.785 ± 0.065	0.431SerCys: 0.431 ± 0.014	2.646SerAsp: 2.646 ± 0.035	2.5SerGlu: 2.5 ± 0.039	1.536SerPhe: 1.536 ± 0.026	5.94SerGly: 5.94 ± 0.055	1.051SerHis: 1.051 ± 0.019	1.407SerIle: 1.407 ± 0.027	1.132SerLys: 1.132 ± 0.027	4.903SerLeu: 4.903 ± 0.06	1.089SerMet: 1.089 ± 0.024	0.837SerAsn: 0.837 ± 0.019	3.139SerPro: 3.139 ± 0.038	1.237SerGln: 1.237 ± 0.025	3.711SerArg: 3.711 ± 0.038	2.735SerSer: 2.735 ± 0.04	2.913SerThr: 2.913 ± 0.038	4.299SerVal: 4.299 ± 0.049	0.858SerTrp: 0.858 ± 0.019	1.26SerTyr: 1.26 ± 0.026	0.0SerXaa: 0.0 ± 0.0
Thr	8.57ThrAla: 8.57 ± 0.072	0.391ThrCys: 0.391 ± 0.014	3.547ThrAsp: 3.547 ± 0.043	3.274ThrGlu: 3.274 ± 0.044	1.572ThrPhe: 1.572 ± 0.027	6.501ThrGly: 6.501 ± 0.069	1.213ThrHis: 1.213 ± 0.025	1.649ThrIle: 1.649 ± 0.031	1.266ThrLys: 1.266 ± 0.026	5.712ThrLeu: 5.712 ± 0.054	0.908ThrMet: 0.908 ± 0.021	0.94ThrAsn: 0.94 ± 0.023	4.151ThrPro: 4.151 ± 0.049	1.332ThrGln: 1.332 ± 0.022	3.903ThrArg: 3.903 ± 0.047	3.142ThrSer: 3.142 ± 0.036	3.618ThrThr: 3.618 ± 0.046	5.738ThrVal: 5.738 ± 0.05	0.874ThrTrp: 0.874 ± 0.023	1.423ThrTyr: 1.423 ± 0.027	0.0ThrXaa: 0.0 ± 0.0
Val	10.552ValAla: 10.552 ± 0.093	0.756ValCys: 0.756 ± 0.02	4.919ValAsp: 4.919 ± 0.048	4.747ValGlu: 4.747 ± 0.045	2.337ValPhe: 2.337 ± 0.034	6.504ValGly: 6.504 ± 0.069	1.888ValHis: 1.888 ± 0.031	2.904ValIle: 2.904 ± 0.038	1.869ValLys: 1.869 ± 0.031	9.303ValLeu: 9.303 ± 0.085	1.412ValMet: 1.412 ± 0.028	1.577ValAsn: 1.577 ± 0.028	5.283ValPro: 5.283 ± 0.059	1.999ValGln: 1.999 ± 0.03	7.179ValArg: 7.179 ± 0.064	4.24ValSer: 4.24 ± 0.045	5.472ValThr: 5.472 ± 0.057	7.747ValVal: 7.747 ± 0.086	1.082ValTrp: 1.082 ± 0.021	1.522ValTyr: 1.522 ± 0.028	0.0ValXaa: 0.0 ± 0.0
Trp	1.663TrpAla: 1.663 ± 0.026	0.153TrpCys: 0.153 ± 0.008	0.823TrpAsp: 0.823 ± 0.022	0.735TrpGlu: 0.735 ± 0.019	0.511TrpPhe: 0.511 ± 0.015	1.062TrpGly: 1.062 ± 0.024	0.371TrpHis: 0.371 ± 0.013	0.547TrpIle: 0.547 ± 0.015	0.395TrpLys: 0.395 ± 0.013	1.759TrpLeu: 1.759 ± 0.034	0.273TrpMet: 0.273 ± 0.011	0.39TrpAsn: 0.39 ± 0.013	0.787TrpPro: 0.787 ± 0.022	0.595TrpGln: 0.595 ± 0.015	1.364TrpArg: 1.364 ± 0.028	0.906TrpSer: 0.906 ± 0.021	0.983TrpThr: 0.983 ± 0.022	0.95TrpVal: 0.95 ± 0.023	0.328TrpTrp: 0.328 ± 0.013	0.352TrpTyr: 0.352 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.852TyrAla: 2.852 ± 0.039	0.169TyrCys: 0.169 ± 0.009	1.503TyrAsp: 1.503 ± 0.031	1.405TyrGlu: 1.405 ± 0.029	0.631TyrPhe: 0.631 ± 0.018	2.272TyrGly: 2.272 ± 0.031	0.378TyrHis: 0.378 ± 0.013	0.48TyrIle: 0.48 ± 0.015	0.439TyrLys: 0.439 ± 0.016	2.03TyrLeu: 2.03 ± 0.032	0.255TyrMet: 0.255 ± 0.011	0.37TyrAsn: 0.37 ± 0.014	1.065TyrPro: 1.065 ± 0.022	0.573TyrGln: 0.573 ± 0.018	1.805TyrArg: 1.805 ± 0.032	0.927TyrSer: 0.927 ± 0.018	1.103TyrThr: 1.103 ± 0.025	1.753TyrVal: 1.753 ± 0.031	0.343TyrTrp: 0.343 ± 0.013	0.442TyrTyr: 0.442 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6612 proteins (2294150 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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